 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for MEIS3 |
 Gene summary |
| Basic gene information | Gene symbol | MEIS3 |
| Gene name | Meis homeobox 3 | |
| Synonyms | MRG2 | |
| Cytomap | UCSC genome browser: 19q13.32 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001009813.2, NM_001301059.1,NM_020160.2, | |
| Description | Meis1, myeloid ecotropic viral integration site 1 homolog 3homeobox protein Meis3meis1-related protein 2 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000105419 | ||
| HPRD : 14386 | ||
| Vega : OTTHUMG00000172280 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_MEIS3 | |
| BioGPS: 56917 | ||
| Pathway | NCI Pathway Interaction Database: MEIS3 | |
| KEGG: MEIS3 | ||
| REACTOME: MEIS3 | ||
| Pathway Commons: MEIS3 | ||
| Context | iHOP: MEIS3 | |
| ligand binding site mutation search in PubMed: MEIS3 | ||
| UCL Cancer Institute: MEIS3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LungStomachUterus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSCSTADUCEC,UCS | |
| Reference showing the relevant tissue of MEIS3 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for MEIS3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -1.51242869 | -0.06357269 | -1.448856 | 2.06E-05 | 6.13E-05 |
| HNSC | 1.085340892 | -0.591614922 | 1.676955814 | 1.40E-06 | 1.01E-05 |
| KIRP | 1.32840281 | -0.59896594 | 1.92736875 | 7.94E-05 | 0.000278583 |
| Top |
| TissGene-miRNA for MEIS3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for MEIS3 |
| TissGeneSNV for MEIS3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.D236V | LIHC | 1 |
| p.P278Q | SKCM | 1 |
| p.S361L | HNSC | 1 |
| p.R348L | BLCA | 1 |
| p.S327F | CESC | 1 |
| p.R262* | STAD | 1 |
| p.G239R | STAD | 1 |
| p.R205* | UCEC | 1 |
| p.A401T | COAD | 1 |
| p.D372N | COAD | 1 |
| p.S23N | SKCM | 1 |
| p.P43A | ACC | 1 |
| p.P288S | STAD | 1 |
| p.A30S | LUAD | 1 |
| p.E322Q | LIHC | 1 |
| p.P32T | ESCA | 1 |
| p.P9Q | LIHC | 1 |
| p.P317R | BLCA | 1 |
| p.S286F | BLCA | 1 |
| p.M370V | LGG | 1 |
| p.G223R | LUAD | 1 |
| p.P12T | UCEC | 1 |
| p.D179N | STAD | 1 |
| p.D236H | LIHC | 1 |
| p.P35L | MESO | 1 |
| p.E339Q | LIHC | 1 |
| p.G206R | LUAD | 1 |
| p.A113V | COAD | 1 |
| p.W263C | LUAD | 1 |
| p.R188* | SKCM | 1 |
| p.M202I | HNSC | 1 |
| p.M353V | LGG | 1 |
| p.R262X | STAD | 1 |
| p.T174A | GBM | 1 |
| p.E321K | SKCM | 1 |
| p.R411C | GBM | 1 |
| p.M185I | HNSC | 1 |
| p.L285V | OV | 1 |
| p.P334S | STAD | 1 |
| p.E77K | BLCA | 1 |
| p.L21M | LUAD | 1 |
| p.V325L | LUSC | 1 |
| p.S390L | HNSC | 1 |
| p.S124F | SKCM | 1 |
| p.S384I | UCEC | 1 |
| p.P289H | LUAD | 1 |
| Top |
| TissGeneCNV for MEIS3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for MEIS3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BI051072 | ACTG1-MEIS3 | chr17:79479053 | chr19:47917374 | |
| Chimerdb3.0 | ChiTaRs | NA | CR749687 | SLC8A3-MEIS3 | chr14:70511641 | chr19:47906381 | |
| Chimerdb3.0 | ChiTaRs | NA | AI952798 | MEIS3-TSIX | chr19:47906439 | chrX:73046462 |
| Top |
| TissGeneNet for MEIS3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| MEIS3, HOXA13 (tumor) | MEIS3, HOXA13 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| MEIS3, HOXA13 (tumor) | MEIS3, HOXA13 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| MEIS3, HOXA13 (tumor) | MEIS3, HOXA13 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| MEIS3, HOXA13 (tumor) | MEIS3, HOXA13 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| MEIS3, HOXA13 (tumor) | MEIS3, HOXA13 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| MEIS3, HOXA13 (tumor) | MEIS3, HOXA13 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| MEIS3, HOXA13 (tumor) | MEIS3, HOXA13 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| MEIS3, HOXA13 (tumor) | MEIS3, HOXA13 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| MEIS3, HOXA13 (tumor) | MEIS3, HOXA13 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| MEIS3, HOXA13 (tumor) | MEIS3, HOXA13 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| MEIS3, HOXA13 (tumor) | MEIS3, HOXA13 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| MEIS3, HOXA13 (tumor) | MEIS3, HOXA13 (normal) |
 |  |
| Top |
| TissGeneProg for MEIS3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for MEIS3 |
| TissGeneDrug for MEIS3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for MEIS3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |