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| TissGeneSummary for SEMA3G |
 Gene summary |
| Basic gene information | Gene symbol | SEMA3G |
| Gene name | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G | |
| Synonyms | sem2 | |
| Cytomap | UCSC genome browser: 3p21.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_020163.1, | |
| Description | semaphorin sem2semaphorin-3G | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000010319 | ||
| HPRD : 14251 | ||
| Vega : OTTHUMG00000158570 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SEMA3G | |
| BioGPS: 56920 | ||
| Pathway | NCI Pathway Interaction Database: SEMA3G | |
| KEGG: SEMA3G | ||
| REACTOME: SEMA3G | ||
| Pathway Commons: SEMA3G | ||
| Context | iHOP: SEMA3G | |
| ligand binding site mutation search in PubMed: SEMA3G | ||
| UCL Cancer Institute: SEMA3G | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BreastSoft tissue | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BRCASARC | |
| Reference showing the relevant tissue of SEMA3G | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SEMA3G |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | 1.475536552 | 4.403403218 | -2.927866667 | 1.69E-45 | 7.77E-44 |
| KIRC | 1.805372882 | 3.821086771 | -2.015713889 | 8.92E-19 | 6.23E-18 |
| BLCA | -0.337884501 | 1.921073394 | -2.258957895 | 1.54E-06 | 4.57E-05 |
| LUAD | 0.162959329 | 3.266481742 | -3.103522414 | 3.78E-30 | 4.46E-28 |
| LUSC | -0.016236513 | 3.24614584 | -3.262382353 | 9.34E-27 | 2.60E-25 |
| HNSC | -0.446586582 | 0.906776209 | -1.353362791 | 4.00E-06 | 2.57E-05 |
| KICH | 1.347865604 | 3.897065604 | -2.5492 | 2.25E-11 | 1.98E-10 |
| KIRP | 0.095745104 | 3.988141979 | -3.892396875 | 1.96E-23 | 1.76E-21 |
| COAD | -0.218146242 | 1.60594222 | -1.824088462 | 2.26E-07 | 1.49E-06 |
| LIHC | 0.735741604 | -0.350432396 | 1.086174 | 7.46E-05 | 0.000265099 |
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| TissGene-miRNA for SEMA3G |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SEMA3G |
| TissGeneSNV for SEMA3G |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S236F | SKCM | 2 |
| p.P90S | SKCM | 2 |
| p.E186K | SKCM | 2 |
| p.G567C | PRAD | 1 |
| p.R151C | COAD | 1 |
| p.G168R | BLCA | 1 |
| p.A77T | ACC | 1 |
| p.A200D | PRAD | 1 |
| p.Q712X | COAD | 1 |
| p.V296M | SKCM | 1 |
| p.A756T | UCS | 1 |
| p.G27S | KIRC | 1 |
| p.S607F | SKCM | 1 |
| p.R777W | BLCA | 1 |
| p.E115* | LUSC | 1 |
| p.R198X | READ | 1 |
| p.L645P | SKCM | 1 |
| p.A650V | STAD | 1 |
| p.D307E | ESCA | 1 |
| p.L554F | SKCM | 1 |
| p.Y725* | HNSC | 1 |
| p.E531* | BLCA | 1 |
| p.M497T | COAD | 1 |
| p.R647C | SKCM | 1 |
| p.L405M | PAAD | 1 |
| p.R167L | BLCA | 1 |
| p.R744Q | LUAD | 1 |
| p.G473D | BLCA | 1 |
| p.S500F | SKCM | 1 |
| p.Q218R | LUAD | 1 |
| p.S80C | LUSC | 1 |
| p.R107* | ESCA | 1 |
| p.V343L | LUAD | 1 |
| p.P684S | SKCM | 1 |
| p.R204Q | SKCM | 1 |
| p.R45C | UCEC | 1 |
| p.G368W | LIHC | 1 |
| p.E631K | SKCM | 1 |
| p.G752D | HNSC | 1 |
| p.A388E | BLCA | 1 |
| p.A47V | DLBC | 1 |
| p.Y539H | STAD | 1 |
| p.P297L | HNSC | 1 |
| p.R409* | UCEC | 1 |
| p.L220I | BLCA | 1 |
| p.S258L | UCEC | 1 |
| p.E234D | STAD | 1 |
| p.V243M | HNSC | 1 |
| p.R278W | STAD | 1 |
| p.E186K | CESC | 1 |
| p.P141L | STAD | 1 |
| p.G185E | SKCM | 1 |
| p.S55F | SKCM | 1 |
| p.A230T | OV | 1 |
| p.R774W | UCEC | 1 |
| p.R511W | LUAD | 1 |
| p.S55C | LUSC | 1 |
| p.P493S | UCEC | 1 |
| p.R82Q | COAD | 1 |
| p.R643L | LUAD | 1 |
| p.R443H | LUAD | 1 |
| p.A570V | SKCM | 1 |
| p.S236P | STAD | 1 |
| p.X783Y | COAD | 1 |
| p.D241Y | CESC | 1 |
| p.L554I | SKCM | 1 |
| p.E778K | SKCM | 1 |
| p.R265C | ACC | 1 |
| p.R744G | SKCM | 1 |
| p.Y244H | STAD | 1 |
| p.Q578H | PAAD | 1 |
| p.E637K | SKCM | 1 |
| p.E496K | SKCM | 1 |
| p.E478G | SKCM | 1 |
| p.R668C | SKCM | 1 |
| p.V148G | SKCM | 1 |
| p.E496K | READ | 1 |
| p.E476K | BLCA | 1 |
| p.R557H | OV | 1 |
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| TissGeneCNV for SEMA3G |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SEMA3G |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BI052480 | SEMA3G-SEMA3G | chr3:52473350 | chr3:52473373 |
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| TissGeneNet for SEMA3G |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for SEMA3G |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SEMA3G |
| TissGeneDrug for SEMA3G |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SEMA3G |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0017638 | Glioma | 2 | BeFree,LHGDN |
| umls:C0345967 | Malignant mesothelioma | 1 | BeFree |
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