TissGeneSummary for PSMG2 |
Gene summary |
Basic gene information | Gene symbol | PSMG2 |
Gene name | proteasome (prosome, macropain) assembly chaperone 2 | |
Synonyms | CLAST3|HCCA3|HsT1707|MDS003|PAC2|TNFSF5IP1 | |
Cytomap | UCSC genome browser: 18p11.21 | |
Type of gene | protein-coding | |
RefGenes | NM_020232.4, NM_147163.1, | |
Description | CD40 ligand-activated specific transcript 3HDCMC29PHSPC260PAC-2hepatocellular carcinoma susceptibility proteinhepatocellular carcinoma-susceptibility protein 3likely ortholog of mouse CD40 ligand-activated specific transcript 3 (Clast3)proteasome a | |
Modification date | 20141207 | |
dbXrefs | MIM : 609702 | |
HGNC : HGNC | ||
Ensembl : ENSG00000128789 | ||
HPRD : 11638 | ||
Vega : OTTHUMG00000131703 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PSMG2 | |
BioGPS: 56984 | ||
Pathway | NCI Pathway Interaction Database: PSMG2 | |
KEGG: PSMG2 | ||
REACTOME: PSMG2 | ||
Pathway Commons: PSMG2 | ||
Context | iHOP: PSMG2 | |
ligand binding site mutation search in PubMed: PSMG2 | ||
UCL Cancer Institute: PSMG2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BladderTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BLCATGCT | |
Reference showing the relevant tissue of PSMG2 | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0043248 | proteasome assembly | 16251969 | GO:0043248 | proteasome assembly | 16251969 |
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TissGeneExp for PSMG2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for PSMG2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PSMG2 |
TissGeneSNV for PSMG2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R135C | SKCM | 1 |
p.I172T | STAD | 1 |
p.N59K | SKCM | 1 |
p.E70K | BRCA | 1 |
p.P54S | SKCM | 1 |
p.W251* | UCS | 1 |
p.S68* | BLCA | 1 |
p.W251X | UCS | 1 |
p.S108F | SKCM | 1 |
p.R244W | LUAD | 1 |
p.W245S | ESCA | 1 |
p.E164D | COAD | 1 |
p.F207C | STAD | 1 |
p.S99L | LUAD | 1 |
p.L231I | UCEC | 1 |
p.P54L | UCEC | 1 |
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TissGeneCNV for PSMG2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PSMG2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BU941755 | NCL-PSMG2 | chr2:232329189 | chr18:12724568 | |
Chimerdb3.0 | ChiTaRs | NA | DW416891 | PSMG2-PI4KAP2 | chr18:12696700 | chr22:21831621 | |
Chimerdb3.0 | ChiTaRs | NA | BG007476 | PSMG2-PIP4K2A | chr18:12725566 | chr10:22834917 | |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A8NE-01A | PSMG2-OSBPL1A | Out-of-Frame | chr18:12703163 | chr18:21914294 |
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TissGeneNet for PSMG2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PSMG2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PSMG2 |
TissGeneDrug for PSMG2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PSMG2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0010346 | Crohn Disease | 3 | GAD |
umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 3 | GAD |
umls:C0019348 | Herpes Simplex Infections | 1 | BeFree |
umls:C0023903 | Liver neoplasms | 1 | LHGDN |
umls:C0024141 | Lupus Erythematosus, Systemic | 1 | GAD |