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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for BAAT
check button Gene summary
Basic gene informationGene symbolBAAT
Gene namebile acid CoA:amino acid N-acyltransferase
SynonymsBACAT|BAT
CytomapUCSC genome browser: 9q22.3
Type of geneprotein-coding
RefGenesNM_001127610.1,
NM_001701.3,
Descriptionbile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)bile acid-CoA:amino acid N-acyltransferaselong-chain fatty-acyl-CoA hydrolase
Modification date20141207
dbXrefs MIM : 602938
HGNC : HGNC
Ensembl : ENSG00000136881
HPRD : 08376
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_BAAT
BioGPS: 570
PathwayNCI Pathway Interaction Database: BAAT
KEGG: BAAT
REACTOME: BAAT
Pathway Commons: BAAT
ContextiHOP: BAAT
ligand binding site mutation search in PubMed: BAAT
UCL Cancer Institute: BAAT
Assigned class in TissGDB*A
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Liver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHC
Reference showing the relevant tissue of BAATQuantitative targeted bile acid profiling as new markers for DILI in a model of methapyrilene-induced liver injury in rats. Slopianka M, Herrmann A, Pavkovic M, Ellinger-Ziegelbauer H, Ernst R, Mally A, Keck M, Riefke B. Toxicology. 2017 May 19;386:1-10. doi: 10.1016/j.tox.2017.05.009. (pmid:28529062)
go to article
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0002152bile acid conjugation12810727
GO:0006544glycine metabolic process8034703
GO:0006637acyl-CoA metabolic process12810727
GO:0006699bile acid biosynthetic process12810727
GO:0019530taurine metabolic process8034703
GO:0002152bile acid conjugation12810727
GO:0006544glycine metabolic process8034703
GO:0006637acyl-CoA metabolic process12810727
GO:0006699bile acid biosynthetic process12810727
GO:0019530taurine metabolic process8034703


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TissGeneExp for BAAT

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LIHC10.017493311.1446373-1.1271441.29E-055.28E-05
KIRC0.680198575-1.6001764252.2803751.44E-084.29E-08
COAD-1.345966703-3.1437974721.7978307692.32E-071.52E-06
LUSC-0.9225882720.593229375-1.5158176476.45E-061.50E-05
STAD0.207383297-2.7668292032.97421252.84E-081.05E-06
ESCA0.284915115-2.9236576123.2085727270.002030.02291736


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TissGene-miRNA for BAAT

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for BAAT
TissGeneSNV for BAAT

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R139QSKCM3
p.R177WSKCM2
p.P312SSKCM2
p.S64PSKCM1
p.R177WHNSC1
p.T353NESCA1
p.H391QUCEC1
p.Y196FKIRC1
p.R148XREAD1
p.N332SLUAD1
p.T376MLAML1
p.S243YUCEC1
p.T254MLUAD1
p.L344PUCEC1
p.S356CLUAD1
p.L166FKIRP1
p.E300KLUAD1
p.S179NPAAD1
p.R346IUCEC1
p.L406FSKCM1
p.Y368CSKCM1
p.R143LUCEC1
p.G56VLUAD1
p.N288SLUAD1
p.A121TLUAD1
p.E37QLGG1
p.R201CBLCA1
p.H49YHNSC1
p.R148*SKCM1
p.S31NLUAD1
p.A192TUCEC1
p.P100SSKCM1
p.V229IKIRP1
p.L380FCESC1
p.Y210CSTAD1
p.G169DSKCM1
p.G237*UCEC1
p.D379NSKCM1
p.A289VMESO1
p.E39KSKCM1
p.R297CDLBC1
p.G145DSKCM1
p.P412LSKCM1
p.A253DUCEC1
p.E15KBRCA1
p.L4FCESC1
p.Q343HSTAD1
p.D14HBLCA1
p.E111QBLCA1
p.G230RSKCM1
p.I313TLUSC1
p.S369YACC1
p.G68ESKCM1
p.E57QCESC1
p.L371PSTAD1
p.Y270FSKCM1
p.G237ESKCM1
p.P367SLUSC1
p.L208SLIHC1
p.H74NUCEC1
p.R297HUCEC1
p.P263SSKCM1


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TissGeneCNV for BAAT

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for BAAT

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
TCGAfusionPortalPRADALUSCTCGA-18-3415-01AZNF189-BAATCDS-5UTRChr9:104162292Chr9:104133745


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TissGeneNet for BAAT

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
BAAT, NR1H4, SLC7A11, SLC7A8 (tumor)BAAT, NR1H4, SLC7A11, SLC7A8 (normal)
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COAD (tumor)COAD (normal)
BAAT, NR1H4, SLC7A11, SLC7A8 (tumor)BAAT, NR1H4, SLC7A11, SLC7A8 (normal)
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HNSC (tumor)HNSC (normal)
BAAT, NR1H4, SLC7A11, SLC7A8 (tumor)BAAT, NR1H4, SLC7A11, SLC7A8 (normal)
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KICH (tumor)KICH (normal)
BAAT, NR1H4, SLC7A11, SLC7A8 (tumor)BAAT, NR1H4, SLC7A11, SLC7A8 (normal)
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KIRC (tumor)KIRC (normal)
BAAT, NR1H4, SLC7A11, SLC7A8 (tumor)BAAT, NR1H4, SLC7A11, SLC7A8 (normal)
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KIRP (tumor)KIRP (normal)
BAAT, NR1H4, SLC7A11, SLC7A8 (tumor)BAAT, NR1H4, SLC7A11, SLC7A8 (normal)
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LIHC (tumor)LIHC (normal)
BAAT, NR1H4, SLC7A11, SLC7A8 (tumor)BAAT, NR1H4, SLC7A11, SLC7A8 (normal)
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LUAD (tumor)LUAD (normal)
BAAT, NR1H4, SLC7A11, SLC7A8 (tumor)BAAT, NR1H4, SLC7A11, SLC7A8 (normal)
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LUSC (tumor)LUSC (normal)
BAAT, NR1H4, SLC7A11, SLC7A8 (tumor)BAAT, NR1H4, SLC7A11, SLC7A8 (normal)
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PRAD (tumor)PRAD (normal)
BAAT, NR1H4, SLC7A11, SLC7A8 (tumor)BAAT, NR1H4, SLC7A11, SLC7A8 (normal)
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STAD (tumor)STAD (normal)
BAAT, NR1H4, SLC7A11, SLC7A8 (tumor)BAAT, NR1H4, SLC7A11, SLC7A8 (normal)
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THCA (tumor)THCA (normal)
BAAT, NR1H4, SLC7A11, SLC7A8 (tumor)BAAT, NR1H4, SLC7A11, SLC7A8 (normal)
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TissGeneProg for BAAT

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for BAAT
TissGeneDrug for BAAT

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for BAAT

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C1527249Colorectal Cancer7BeFree
umls:C0009402Colorectal Carcinoma5BeFree
umls:C0007102Malignant tumor of colon4BeFree
umls:C0024623Malignant neoplasm of stomach4BeFree
umls:C0699791Stomach Carcinoma4BeFree
umls:C0476089Endometrial Carcinoma3BeFree
umls:C1333990Hereditary Nonpolyposis Colorectal Cancer3BeFree
umls:C0001430Adenoma2BeFree
umls:C0006142Malignant neoplasm of breast2BeFree
umls:C0007115Malignant neoplasm of thyroid2BeFree
umls:C0009404Colorectal Neoplasms2BeFree
umls:C0028754Obesity2BeFree
umls:C0549473Thyroid carcinoma2BeFree
umls:C0678222Breast Carcinoma2BeFree
umls:C0007095Carcinoid Tumor1BeFree
umls:C0011854Diabetes Mellitus, Insulin-Dependent1BeFree
umls:C0023467Leukemia, Myelocytic, Acute1BeFree
umls:C0027404Narcolepsy1GAD
umls:C0036690Septicemia1BeFree
umls:C0038356Stomach Neoplasms1BeFree
umls:C0040136Thyroid Neoplasm1BeFree
umls:C0085624Burning sensation1BeFree
umls:C0243026Sepsis1BeFree,RGD
umls:C0280100Solid tumour1BeFree
umls:C0333983Hyperplastic Polyp1BeFree
umls:C0334299Carcinoid tumor no ICD-O subtype1BeFree
umls:C0494165Secondary malignant neoplasm of liver1BeFree
umls:C0555971Oral infection1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0745103Hyperlipoproteinemia Type IIa1BeFree
umls:C1302401Adenoma of large intestine1BeFree
umls:C1843139Hypercholanemia, Familial1BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT
umls:C2363142T-Cell Prolymphocytic Leukemia1BeFree
umls:C3241937Nonalcoholic Steatohepatitis1BeFree
umls:C2749604HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 10CLINVAR