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| TissGeneSummary for BAAT |
 Gene summary |
| Basic gene information | Gene symbol | BAAT |
| Gene name | bile acid CoA:amino acid N-acyltransferase | |
| Synonyms | BACAT|BAT | |
| Cytomap | UCSC genome browser: 9q22.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001127610.1, NM_001701.3, | |
| Description | bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)bile acid Coenzyme A: amino acid N-acyltransferase (glycine N-choloyltransferase)bile acid-CoA:amino acid N-acyltransferaselong-chain fatty-acyl-CoA hydrolase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602938 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000136881 | ||
| HPRD : 08376 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_BAAT | |
| BioGPS: 570 | ||
| Pathway | NCI Pathway Interaction Database: BAAT | |
| KEGG: BAAT | ||
| REACTOME: BAAT | ||
| Pathway Commons: BAAT | ||
| Context | iHOP: BAAT | |
| ligand binding site mutation search in PubMed: BAAT | ||
| UCL Cancer Institute: BAAT | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of BAAT | Quantitative targeted bile acid profiling as new markers for DILI in a model of methapyrilene-induced liver injury in rats. Slopianka M, Herrmann A, Pavkovic M, Ellinger-Ziegelbauer H, Ernst R, Mally A, Keck M, Riefke B. Toxicology. 2017 May 19;386:1-10. doi: 10.1016/j.tox.2017.05.009. (pmid:28529062) go to article | |
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0002152 | bile acid conjugation | 12810727 | GO:0006544 | glycine metabolic process | 8034703 | GO:0006637 | acyl-CoA metabolic process | 12810727 | GO:0006699 | bile acid biosynthetic process | 12810727 | GO:0019530 | taurine metabolic process | 8034703 | GO:0002152 | bile acid conjugation | 12810727 | GO:0006544 | glycine metabolic process | 8034703 | GO:0006637 | acyl-CoA metabolic process | 12810727 | GO:0006699 | bile acid biosynthetic process | 12810727 | GO:0019530 | taurine metabolic process | 8034703 |
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| TissGeneExp for BAAT |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 10.0174933 | 11.1446373 | -1.127144 | 1.29E-05 | 5.28E-05 |
| KIRC | 0.680198575 | -1.600176425 | 2.280375 | 1.44E-08 | 4.29E-08 |
| COAD | -1.345966703 | -3.143797472 | 1.797830769 | 2.32E-07 | 1.52E-06 |
| LUSC | -0.922588272 | 0.593229375 | -1.515817647 | 6.45E-06 | 1.50E-05 |
| STAD | 0.207383297 | -2.766829203 | 2.9742125 | 2.84E-08 | 1.05E-06 |
| ESCA | 0.284915115 | -2.923657612 | 3.208572727 | 0.00203 | 0.02291736 |
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| TissGene-miRNA for BAAT |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for BAAT |
| TissGeneSNV for BAAT |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R139Q | SKCM | 3 |
| p.R177W | SKCM | 2 |
| p.P312S | SKCM | 2 |
| p.S64P | SKCM | 1 |
| p.R177W | HNSC | 1 |
| p.T353N | ESCA | 1 |
| p.H391Q | UCEC | 1 |
| p.Y196F | KIRC | 1 |
| p.R148X | READ | 1 |
| p.N332S | LUAD | 1 |
| p.T376M | LAML | 1 |
| p.S243Y | UCEC | 1 |
| p.T254M | LUAD | 1 |
| p.L344P | UCEC | 1 |
| p.S356C | LUAD | 1 |
| p.L166F | KIRP | 1 |
| p.E300K | LUAD | 1 |
| p.S179N | PAAD | 1 |
| p.R346I | UCEC | 1 |
| p.L406F | SKCM | 1 |
| p.Y368C | SKCM | 1 |
| p.R143L | UCEC | 1 |
| p.G56V | LUAD | 1 |
| p.N288S | LUAD | 1 |
| p.A121T | LUAD | 1 |
| p.E37Q | LGG | 1 |
| p.R201C | BLCA | 1 |
| p.H49Y | HNSC | 1 |
| p.R148* | SKCM | 1 |
| p.S31N | LUAD | 1 |
| p.A192T | UCEC | 1 |
| p.P100S | SKCM | 1 |
| p.V229I | KIRP | 1 |
| p.L380F | CESC | 1 |
| p.Y210C | STAD | 1 |
| p.G169D | SKCM | 1 |
| p.G237* | UCEC | 1 |
| p.D379N | SKCM | 1 |
| p.A289V | MESO | 1 |
| p.E39K | SKCM | 1 |
| p.R297C | DLBC | 1 |
| p.G145D | SKCM | 1 |
| p.P412L | SKCM | 1 |
| p.A253D | UCEC | 1 |
| p.E15K | BRCA | 1 |
| p.L4F | CESC | 1 |
| p.Q343H | STAD | 1 |
| p.D14H | BLCA | 1 |
| p.E111Q | BLCA | 1 |
| p.G230R | SKCM | 1 |
| p.I313T | LUSC | 1 |
| p.S369Y | ACC | 1 |
| p.G68E | SKCM | 1 |
| p.E57Q | CESC | 1 |
| p.L371P | STAD | 1 |
| p.Y270F | SKCM | 1 |
| p.G237E | SKCM | 1 |
| p.P367S | LUSC | 1 |
| p.L208S | LIHC | 1 |
| p.H74N | UCEC | 1 |
| p.R297H | UCEC | 1 |
| p.P263S | SKCM | 1 |
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| TissGeneCNV for BAAT |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for BAAT |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | LUSC | TCGA-18-3415-01A | ZNF189-BAAT | CDS-5UTR | Chr9:104162292 | Chr9:104133745 |
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| TissGeneNet for BAAT |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| BAAT, NR1H4, SLC7A11, SLC7A8 (tumor) | BAAT, NR1H4, SLC7A11, SLC7A8 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| BAAT, NR1H4, SLC7A11, SLC7A8 (tumor) | BAAT, NR1H4, SLC7A11, SLC7A8 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| BAAT, NR1H4, SLC7A11, SLC7A8 (tumor) | BAAT, NR1H4, SLC7A11, SLC7A8 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| BAAT, NR1H4, SLC7A11, SLC7A8 (tumor) | BAAT, NR1H4, SLC7A11, SLC7A8 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| BAAT, NR1H4, SLC7A11, SLC7A8 (tumor) | BAAT, NR1H4, SLC7A11, SLC7A8 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| BAAT, NR1H4, SLC7A11, SLC7A8 (tumor) | BAAT, NR1H4, SLC7A11, SLC7A8 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| BAAT, NR1H4, SLC7A11, SLC7A8 (tumor) | BAAT, NR1H4, SLC7A11, SLC7A8 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| BAAT, NR1H4, SLC7A11, SLC7A8 (tumor) | BAAT, NR1H4, SLC7A11, SLC7A8 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| BAAT, NR1H4, SLC7A11, SLC7A8 (tumor) | BAAT, NR1H4, SLC7A11, SLC7A8 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| BAAT, NR1H4, SLC7A11, SLC7A8 (tumor) | BAAT, NR1H4, SLC7A11, SLC7A8 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| BAAT, NR1H4, SLC7A11, SLC7A8 (tumor) | BAAT, NR1H4, SLC7A11, SLC7A8 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| BAAT, NR1H4, SLC7A11, SLC7A8 (tumor) | BAAT, NR1H4, SLC7A11, SLC7A8 (normal) |
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| TissGeneProg for BAAT |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for BAAT |
| TissGeneDrug for BAAT |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for BAAT |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C1527249 | Colorectal Cancer | 7 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 5 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 4 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 4 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 4 | BeFree |
| umls:C0476089 | Endometrial Carcinoma | 3 | BeFree |
| umls:C1333990 | Hereditary Nonpolyposis Colorectal Cancer | 3 | BeFree |
| umls:C0001430 | Adenoma | 2 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0007115 | Malignant neoplasm of thyroid | 2 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 2 | BeFree |
| umls:C0028754 | Obesity | 2 | BeFree |
| umls:C0549473 | Thyroid carcinoma | 2 | BeFree |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C0007095 | Carcinoid Tumor | 1 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
| umls:C0027404 | Narcolepsy | 1 | GAD |
| umls:C0036690 | Septicemia | 1 | BeFree |
| umls:C0038356 | Stomach Neoplasms | 1 | BeFree |
| umls:C0040136 | Thyroid Neoplasm | 1 | BeFree |
| umls:C0085624 | Burning sensation | 1 | BeFree |
| umls:C0243026 | Sepsis | 1 | BeFree,RGD |
| umls:C0280100 | Solid tumour | 1 | BeFree |
| umls:C0333983 | Hyperplastic Polyp | 1 | BeFree |
| umls:C0334299 | Carcinoid tumor no ICD-O subtype | 1 | BeFree |
| umls:C0494165 | Secondary malignant neoplasm of liver | 1 | BeFree |
| umls:C0555971 | Oral infection | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C0745103 | Hyperlipoproteinemia Type IIa | 1 | BeFree |
| umls:C1302401 | Adenoma of large intestine | 1 | BeFree |
| umls:C1843139 | Hypercholanemia, Familial | 1 | BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT |
| umls:C2363142 | T-Cell Prolymphocytic Leukemia | 1 | BeFree |
| umls:C3241937 | Nonalcoholic Steatohepatitis | 1 | BeFree |
| umls:C2749604 | HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1 | 0 | CLINVAR |
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