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| TissGeneSummary for HRASLS |
 Gene summary |
| Basic gene information | Gene symbol | HRASLS |
| Gene name | HRAS-like suppressor | |
| Synonyms | A-C1|H-REV107|HRASLS1|HRSL1|HSD28 | |
| Cytomap | UCSC genome browser: 3q29 | |
| Type of gene | protein-coding | |
| RefGenes | NM_020386.4, | |
| Description | H-REV107 protein-related proteinHRAS-like suppressor 1phospholipase Aphospholipid-metabolizing enzyme A-C1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606487 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000127252 | ||
| HPRD : 07577 | ||
| Vega : OTTHUMG00000156104 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HRASLS | |
| BioGPS: 57110 | ||
| Pathway | NCI Pathway Interaction Database: HRASLS | |
| KEGG: HRASLS | ||
| REACTOME: HRASLS | ||
| Pathway Commons: HRASLS | ||
| Context | iHOP: HRASLS | |
| ligand binding site mutation search in PubMed: HRASLS | ||
| UCL Cancer Institute: HRASLS | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | OvaryTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | OVTGCT | |
| Reference showing the relevant tissue of HRASLS | ||
| Description by TissGene annotations | Protective TissGene in OS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for HRASLS |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 0.741260547 | -2.324468865 | 3.065729412 | 1.74E-13 | 8.77E-13 |
| HNSC | -0.316308172 | 1.727554619 | -2.043862791 | 7.81E-07 | 6.08E-06 |
| LUAD | -0.540913625 | -2.498660177 | 1.957746552 | 6.49E-10 | 3.50E-09 |
| STAD | -2.546407591 | -0.652313841 | -1.89409375 | 0.000165 | 0.001181799 |
| PRAD | -4.085384514 | -2.966840283 | -1.118544231 | 0.000187 | 0.000743027 |
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| TissGene-miRNA for HRASLS |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for HRASLS |
| TissGeneSNV for HRASLS |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E127K | PAAD | 1 |
| p.P15L | STAD | 1 |
| p.P94S | HNSC | 1 |
| p.A254D | STAD | 1 |
| p.R127C | COAD | 1 |
| p.R130C | PRAD | 1 |
| p.D87Y | LUSC | 1 |
| p.D87H | HNSC | 1 |
| p.E214K | SKCM | 1 |
| p.E22K | PAAD | 1 |
| p.A216P | ESCA | 1 |
| p.F24S | COAD | 1 |
| p.P199S | HNSC | 1 |
| p.E193K | BLCA | 1 |
| p.Y11H | COAD | 1 |
| p.H121R | LUSC | 1 |
| p.A149D | STAD | 1 |
| p.R130C | SKCM | 1 |
| p.R243G | BLCA | 1 |
| p.G123E | SKCM | 1 |
| p.F227S | HNSC | 1 |
| p.V143I | BRCA | 1 |
| p.E103* | CESC | 1 |
| p.R232C | SKCM | 1 |
| p.D178N | SKCM | 1 |
| p.R243* | SKCM | 1 |
| p.P94L | UCEC | 1 |
| p.N115Y | SKCM | 1 |
| p.D192H | HNSC | 1 |
| p.G181E | SKCM | 1 |
| p.V150D | PAAD | 1 |
| p.P117S | SKCM | 1 |
| p.A2V | UCEC | 1 |
| p.I148K | SKCM | 1 |
| p.R25H | READ | 1 |
| p.Y144D | HNSC | 1 |
| p.E22K | UCEC | 1 |
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| TissGeneCNV for HRASLS |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for HRASLS |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for HRASLS |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for HRASLS |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for HRASLS |
| TissGeneDrug for HRASLS |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for HRASLS |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0003850 | Arteriosclerosis | 2 | BeFree |
| umls:C0004153 | Atherosclerosis | 2 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
| umls:C0037773 | Spastic Paraplegia, Hereditary | 2 | BeFree |
| umls:C0374997 | Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site | 2 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
| umls:C0600139 | Prostate carcinoma | 2 | BeFree |
| umls:C0010054 | Coronary Arteriosclerosis | 1 | BeFree |
| umls:C0020445 | Hypercholesterolemia, Familial | 1 | BeFree |
| umls:C0020538 | Hypertensive disease | 1 | BeFree |
| umls:C0038354 | Stomach Diseases | 1 | BeFree |
| umls:C2931822 | Nasopharyngeal carcinoma | 1 | BeFree |
| umls:C3714756 | Intellectual Disability | 1 | BeFree |
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