TissGeneSummary for PAK7 |
Gene summary |
Basic gene information | Gene symbol | PAK7 |
Gene name | p21 protein (Cdc42/Rac)-activated kinase 7 | |
Synonyms | PAK5 | |
Cytomap | UCSC genome browser: 20p12 | |
Type of gene | protein-coding | |
RefGenes | NM_020341.3, NM_177990.2, | |
Description | PAK-5PAK-7p21(CDKN1A)-activated kinase 7p21-activated kinase 5p21-activated kinase 7p21CDKN1A-activated kinase 7protein kinase PAK5serine/threonine-protein kinase PAK 7serine/threonine-protein kinase PAK7 | |
Modification date | 20141207 | |
dbXrefs | MIM : 608038 | |
HGNC : HGNC | ||
Ensembl : ENSG00000101349 | ||
HPRD : 06423 | ||
Vega : OTTHUMG00000031857 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PAK7 | |
BioGPS: 57144 | ||
Pathway | NCI Pathway Interaction Database: PAK7 | |
KEGG: PAK7 | ||
REACTOME: PAK7 | ||
Pathway Commons: PAK7 | ||
Context | iHOP: PAK7 | |
ligand binding site mutation search in PubMed: PAK7 | ||
UCL Cancer Institute: PAK7 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of PAK7 | ||
Description by TissGene annotations | Protective TissGene in OS Protective TissGene in RFS Cancer gene Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PAK7 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | -1.240409912 | 0.662462088 | -1.902872 | 1.13E-07 | 7.87E-07 |
LUAD | -0.788208464 | 0.638138088 | -1.426346552 | 7.72E-09 | 3.52E-08 |
BRCA | 0.090153 | 3.656280193 | -3.566127193 | 2.12E-30 | 2.97E-29 |
KIRP | -0.562155662 | 1.538819338 | -2.100975 | 2.66E-09 | 2.27E-08 |
PRAD | 1.451409242 | 3.231297704 | -1.779888462 | 6.44E-12 | 2.26E-10 |
KIRC | -1.541718856 | 1.617990866 | -3.159709722 | 4.11E-35 | 1.11E-33 |
STAD | -0.700846287 | 1.531719338 | -2.232565625 | 5.97E-07 | 1.08E-05 |
THCA | -1.207607675 | 0.260102495 | -1.467710169 | 5.67E-17 | 1.04E-15 |
KICH | 2.555870088 | 1.013594088 | 1.542276 | 0.0294 | 0.047856425 |
HNSC | 0.227491577 | 1.585742739 | -1.358251163 | 0.00327 | 0.009444801 |
ESCA | -0.582061912 | 2.349892634 | -2.931954545 | 0.000309 | 0.006941576 |
LUSC | 2.11129299 | 0.625496912 | 1.485796078 | 0.000525 | 0.00101747 |
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TissGene-miRNA for PAK7 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
ACC | hsa-miR-520d-3p | MIMAT0002856 | 0.023 | -0.26 | 78 |
ACC | hsa-miR-520d-3p | MIMAT0002856 | 0.023 | -0.26 | 78 |
THYM | hsa-miR-372-3p | MIMAT0000724 | 0.0025 | -0.28 | 122 |
ACC | hsa-miR-93-5p | MIMAT0000093 | 0.0036 | -0.33 | 78 |
ACC | hsa-miR-93-5p | MIMAT0000093 | 0.0036 | -0.33 | 78 |
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TissGeneMut for PAK7 |
TissGeneSNV for PAK7 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.M173I | SKCM | 6 |
p.S364L | SKCM | 4 |
p.R433W | SKCM | 3 |
p.E144K | SKCM | 3 |
p.S419F | SKCM | 3 |
p.R335* | SKCM | 3 |
p.E684K | SKCM | 2 |
p.A398T | SKCM | 2 |
p.A466T | STAD | 2 |
p.G443E | SKCM | 2 |
p.S367F | SKCM | 2 |
p.R433W | UCEC | 2 |
p.E447K | SKCM | 2 |
p.D421N | SKCM | 2 |
p.P607S | SKCM | 2 |
p.E613* | LUAD | 2 |
p.R335X | SKCM | 2 |
p.P698S | SKCM | 2 |
p.G621R | STAD | 1 |
p.G34D | SKCM | 1 |
p.E468K | COAD | 1 |
p.M326T | LIHC | 1 |
p.R488X | COAD | 1 |
p.P358L | SKCM | 1 |
p.M523I | SKCM | 1 |
p.R285M | COAD | 1 |
p.H378Q | LUAD | 1 |
p.A193V | SKCM | 1 |
p.P158T | LUAD | 1 |
p.G528S | LUAD | 1 |
p.L526P | LUAD | 1 |
p.P412L | PRAD | 1 |
p.S183C | BLCA | 1 |
p.E623D | COAD | 1 |
p.A691T | SKCM | 1 |
p.S459T | LUAD | 1 |
p.K145* | SKCM | 1 |
p.S190F | SKCM | 1 |
p.R488P | LUAD | 1 |
p.M480T | BLCA | 1 |
p.D88N | SKCM | 1 |
p.H177Q | ESCA | 1 |
p.P27S | SKCM | 1 |
p.G258V | LUAD | 1 |
p.P209S | SKCM | 1 |
p.S396F | SKCM | 1 |
p.D500N | SKCM | 1 |
p.P106L | HNSC | 1 |
p.D586N | SKCM | 1 |
p.E87Q | LUAD | 1 |
p.P227L | SKCM | 1 |
p.D579N | LUAD | 1 |
p.V94M | LGG | 1 |
p.G704R | STAD | 1 |
p.S399F | SKCM | 1 |
p.P598L | LGG | 1 |
p.E613V | LIHC | 1 |
p.V463I | LUAD | 1 |
p.D665N | DLBC | 1 |
p.P158L | READ | 1 |
p.P351L | LUSC | 1 |
p.P661T | ESCA | 1 |
p.G13V | LUAD | 1 |
p.T547N | UCEC | 1 |
p.D45N | THCA | 1 |
p.P607L | SKCM | 1 |
p.R554S | LIHC | 1 |
p.E18K | SKCM | 1 |
p.T281S | LIHC | 1 |
p.F589S | LIHC | 1 |
p.G84S | STAD | 1 |
p.S41R | THYM | 1 |
p.R266W | LUAD | 1 |
p.G704V | HNSC | 1 |
p.R320H | LGG | 1 |
p.A651V | LGG | 1 |
p.E294K | SKCM | 1 |
p.Y373F | LIHC | 1 |
p.R488Q | SKCM | 1 |
p.T397M | CESC | 1 |
p.P27L | SKCM | 1 |
p.S392L | READ | 1 |
p.R446K | BLCA | 1 |
p.A555D | LUSC | 1 |
p.S290L | STAD | 1 |
p.S364L | LUAD | 1 |
p.P280S | DLBC | 1 |
p.Q592P | SKCM | 1 |
p.V604F | KIRP | 1 |
p.S418F | SKCM | 1 |
p.G365V | LUAD | 1 |
p.I631L | SKCM | 1 |
p.S246T | SKCM | 1 |
p.L203V | ESCA | 1 |
p.L357I | BRCA | 1 |
p.R335* | HNSC | 1 |
p.M67I | SKCM | 1 |
p.G563V | PAAD | 1 |
p.P236S | LUAD | 1 |
p.Q309* | HNSC | 1 |
p.R656W | OV | 1 |
p.R483Q | THCA | 1 |
p.Q293X | SKCM | 1 |
p.S364L | UCEC | 1 |
p.D517N | GBM | 1 |
p.S551* | ACC | 1 |
p.E184K | LUAD | 1 |
p.H22Y | SKCM | 1 |
p.V710F | LIHC | 1 |
p.T143N | LIHC | 1 |
p.G696R | SKCM | 1 |
p.K102E | LIHC | 1 |
p.V682M | UCEC | 1 |
p.S322P | UCEC | 1 |
p.I395L | BRCA | 1 |
p.E542K | BLCA | 1 |
p.E122X | READ | 1 |
p.P642S | SKCM | 1 |
p.V463A | STAD | 1 |
p.E543* | UCEC | 1 |
p.A139S | BLCA | 1 |
p.S425F | SARC | 1 |
p.P424L | SKCM | 1 |
p.V496M | PRAD | 1 |
p.Y318* | LUAD | 1 |
p.E294* | HNSC | 1 |
p.S511N | COAD | 1 |
p.G588S | SKCM | 1 |
p.R96L | BLCA | 1 |
p.D568N | SKCM | 1 |
p.E542K | SKCM | 1 |
p.G84C | LUAD | 1 |
p.D517N | SKCM | 1 |
p.L677I | LUAD | 1 |
p.M652I | LUAD | 1 |
p.R266S | LUAD | 1 |
p.P598Q | LUAD | 1 |
p.L629F | SKCM | 1 |
p.D214V | LUAD | 1 |
p.V440A | LIHC | 1 |
p.M636I | SKCM | 1 |
p.T690A | STAD | 1 |
p.A120E | LUAD | 1 |
p.P298S | SKCM | 1 |
p.S369R | LUAD | 1 |
p.E144K | READ | 1 |
p.E640A | LUSC | 1 |
p.G605D | THYM | 1 |
p.E323K | SKCM | 1 |
p.Q293* | SKCM | 1 |
p.Q486K | LUAD | 1 |
p.G472R | HNSC | 1 |
p.A555P | PRAD | 1 |
p.V710D | KIRC | 1 |
p.E144D | SKCM | 1 |
p.S420F | SKCM | 1 |
p.E457V | SKCM | 1 |
p.D157N | SKCM | 1 |
p.Q233* | SKCM | 1 |
p.G291R | SKCM | 1 |
p.S551X | ACC | 1 |
p.L559I | LUSC | 1 |
p.E248K | SKCM | 1 |
p.E684Q | HNSC | 1 |
p.R96H | COAD | 1 |
p.G116C | LUAD | 1 |
p.E248D | HNSC | 1 |
p.S628F | SKCM | 1 |
p.E457* | ACC | 1 |
p.D533N | SKCM | 1 |
p.G241E | UCEC | 1 |
p.E211K | SKCM | 1 |
p.Q110* | SKCM | 1 |
p.R20K | SKCM | 1 |
p.V506L | CESC | 1 |
p.G258R | SKCM | 1 |
p.S428P | LUSC | 1 |
p.C549S | ESCA | 1 |
p.L404H | LIHC | 1 |
p.S237F | SKCM | 1 |
p.S183Y | ESCA | 1 |
p.R488Q | STAD | 1 |
p.Q423E | OV | 1 |
p.S213N | SKCM | 1 |
p.S41R | LUAD | 1 |
p.P374L | LUSC | 1 |
p.E144K | COAD | 1 |
p.E635K | SKCM | 1 |
p.S15Y | ESCA | 1 |
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TissGeneCNV for PAK7 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PAK7 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BF110430 | PAK7-AARS | chr20:9596298 | chr16:70299507 | |
Chimerdb3.0 | FusionScan | COAD | TCGA-DM-A1HA-01A | PANK2-PAK7 | 5'UTR-5'UTR | chr20:3870375 | chr20:9624987 |
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TissGeneNet for PAK7 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PAK7 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PAK7 |
TissGeneDrug for PAK7 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PAK7 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0596263 | Carcinogenesis | 4 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 3 | BeFree |
umls:C0017638 | Glioma | 2 | BeFree |
umls:C2239176 | Liver carcinoma | 2 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0017601 | Glaucoma | 1 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0029463 | Osteosarcoma | 1 | BeFree |
umls:C0030567 | Parkinson Disease | 1 | GAD |
umls:C0033975 | Psychotic Disorders | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0178874 | Tumor Progression | 1 | BeFree |
umls:C0349204 | Nonorganic psychosis | 1 | BeFree |
umls:C0442874 | Neuropathy | 1 | BeFree |
umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
umls:C1527249 | Colorectal Cancer | 1 | BeFree |