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| TissGeneSummary for BAG1 |
 Gene summary |
| Basic gene information | Gene symbol | BAG1 |
| Gene name | BCL2-associated athanogene | |
| Synonyms | BAG-1|HAP|RAP46 | |
| Cytomap | UCSC genome browser: 9p12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001172415.1, NM_004323.5, | |
| Description | BAG family molecular chaperone regulator 1Bcl-2 associating athanogene-1 proteinBcl-2-binding proteinglucocortoid receptor-associated protein RAP46receptor-associated protein, 46-KD | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601497 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000107262 | ||
| HPRD : 03292 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_BAG1 | |
| BioGPS: 573 | ||
| Pathway | NCI Pathway Interaction Database: BAG1 | |
| KEGG: BAG1 | ||
| REACTOME: BAG1 | ||
| Pathway Commons: BAG1 | ||
| Context | iHOP: BAG1 | |
| ligand binding site mutation search in PubMed: BAG1 | ||
| UCL Cancer Institute: BAG1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCTGCT | |
| Reference showing the relevant tissue of BAG1 | ||
| Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA TissgsLTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0070389 | chaperone cofactor-dependent protein refolding | 12853476 | GO:0070389 | chaperone cofactor-dependent protein refolding | 12853476 |
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| TissGeneExp for BAG1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | -0.465148164 | 0.925804614 | -1.390952778 | 1.25E-29 | 2.30E-28 |
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| TissGene-miRNA for BAG1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-146b-5p | MIMAT0002809 | 0.024 | -0.31 | 56 |
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| TissGeneMut for BAG1 |
| TissGeneSNV for BAG1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G45R | ACC | 6 |
| p.E237D | GBM | 1 |
| p.H119D | CESC | 1 |
| p.L94M | STAD | 1 |
| p.E290K | LUSC | 1 |
| p.N185I | READ | 1 |
| p.P43L | SKCM | 1 |
| p.F301V | UCEC | 1 |
| p.G45R | COAD | 1 |
| p.A141V | KIRC | 1 |
| p.E121* | HNSC | 1 |
| p.K74E | UCEC | 1 |
| p.E249Q | GBM | 1 |
| p.G219R | OV | 1 |
| p.G45R | READ | 1 |
| p.D275N | BLCA | 1 |
| p.A344V | UCEC | 1 |
| p.Q331* | OV | 1 |
| p.T339A | HNSC | 1 |
| p.K189I | PRAD | 1 |
| p.F285C | LGG | 1 |
| p.N328S | UCEC | 1 |
| p.Q225H | GBM | 1 |
| p.S338F | BLCA | 1 |
| p.T93A | PAAD | 1 |
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| TissGeneCNV for BAG1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for BAG1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AI471677 | BAG1-USP34 | chr9:33255092 | chr2:61694016 | |
| Chimerdb3.0 | ChiTaRs | NA | BQ072717 | BCYRN1-BAG1 | chrX:70753170 | chr9:33253223 | |
| Chimerdb3.0 | ChiTaRs | NA | BC073955 | BCYRN1-BAG1 | chrX:70753170 | chr9:33252469 | |
| Chimerdb3.0 | ChiTaRs | NA | AW393642 | DDAH2-BAG1 | chr6:3026266 | chr9:33264317 | |
| Chimerdb3.0 | ChiTaRs | NA | BE884609 | UBE3C-BAG1 | chr7:156968887 | chr9:33253446 | |
| Chimerdb3.0 | FusionScan | CESC | TCGA-EA-A1QS-01A | B4GALT1-BAG1 | In-Frame | chr9:33166755 | chr9:33262828 |
| Chimerdb3.0 | TopHat-Fusion | CESC | TCGA-EA-A1QS-01A | B4GALT1-BAG1 | In-Frame | chr9:33166755 | chr9:33262827 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-91-7771-01A | B4GALT1-BAG1 | In-frame | Chr9:33166756 | Chr9:33262828 |
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| TissGeneNet for BAG1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| BAG1, NR3C1, UBC, NCOR1, BCL2L1, NFKB1, HDAC3, HSPA8, CBL, AR, HSPA1B, BCL2, NCOR2, STUB1, TRIM23, EGFR, HSPA1A, PSMA3, RB1, MET, GCDH (tumor) | BAG1, NR3C1, BCL2L1, ESR1, RARA, PTGS2, HSPA8, PSMD1, CBL, RAF1, BCL2, STUB1, EGFR, ABL1, ARRB1, PDGFRB, SIAH1, VDR, MET, MAPT, GCDH (normal) |
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| COAD (tumor) | COAD (normal) |
| BAG1, NCOR1, NFKB1, HDAC3, ESR1, HSPA8, PSMD1, MYC, CBL, AR, BCL2, NCOR2, STUB1, EGFR, ABL1, ARRB1, PDGFRB, SIAH1, MAPT, PPP1R15A, HBEGF (tumor) | BAG1, UBC, BCL2L1, NFKB1, RARA, PTGS2, HSPA4, PSMD1, MYC, CBL, RAF1, BCL2, NCOR2, EGFR, HSPA1A, PDGFRB, SIAH1, VDR, MET, ST13, PYGL (normal) |
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| HNSC (tumor) | HNSC (normal) |
| BAG1, NR3C1, UBC, NCOR1, HDAC3, CBL, RAF1, AR, BCL2, NCOR2, STUB1, TRIM23, EGFR, ABL1, ARRB1, PSMA3, PDGFRB, RB1, MAPT, HBEGF, PYGL (tumor) | BAG1, NR3C1, UBC, NCOR1, NFKB1, HDAC3, RARA, CBL, AR, NCOR2, STUB1, TRIM23, EGFR, ABL1, PSMA3, PDGFRB, SIAH1, RB1, VDR, MET, GCDH (normal) |
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| KICH (tumor) | KICH (normal) |
| BAG1, NR3C1, BCL2L1, NFKB1, HDAC3, ESR1, RARA, PTGS2, MYC, CBL, RAF1, AR, BCL2, NCOR2, ABL1, ARRB1, PDGFRB, RB1, VDR, MAPT, PYGL (tumor) | BAG1, TP53, NCOR1, BCL2L1, RARA, PTGS2, MYC, CBL, RAF1, BCL2, TRIM23, EGFR, PSMA3, PDGFRB, VDR, MET, ST13, MAPT, GCDH, PPP1R15A, PYGL (normal) |
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| KIRC (tumor) | KIRC (normal) |
| BAG1, NR3C1, UBC, RELA, HDAC3, ESR1, RARA, CBL, RAF1, AR, HSPA1B, TRIM23, ABL1, ARRB1, HSPA1A, PDGFRB, SIAH1, VDR, ST13, MAPT, PYGL (tumor) | BAG1, TP53, NR3C1, NCOR1, BCL2L1, NFKB1, HDAC3, ESR1, RARA, MYC, CBL, RAF1, AR, NCOR2, STUB1, EGFR, PSMA3, PDGFRB, RB1, GCDH, PYGL (normal) |
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| KIRP (tumor) | KIRP (normal) |
| BAG1, NR3C1, UBC, HDAC3, ESR1, HSPA8, PSMD1, CBL, RAF1, AR, BCL2, STUB1, TRIM23, ABL1, ARRB1, PDGFRB, VDR, ST13, MAPT, GCDH, PYGL (tumor) | BAG1, TP53, NR3C1, NCOR1, HSPA4, MYC, CBL, AR, NCOR2, STUB1, TRIM23, EGFR, ABL1, ARRB1, PSMA3, PDGFRB, RB1, MET, GCDH, PPP1R15A, PYGL (normal) |
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| LIHC (tumor) | LIHC (normal) |
| BAG1, NR3C1, NCOR1, RELA, ESR1, HSPA4, CBL, RAF1, AR, BCL2, NCOR2, STUB1, TRIM23, EGFR, ARRB1, HSPA1A, PSMA3, PDGFRB, RB1, ST13, PPP1R15A (tumor) | BAG1, NR3C1, UBC, NCOR1, NFKB1, HDAC3, CBL, RAF1, AR, NCOR2, STUB1, TRIM23, EGFR, ABL1, ARRB1, SIAH1, RB1, VDR, MET, ST13, GCDH (normal) |
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| LUAD (tumor) | LUAD (normal) |
| BAG1, NCOR1, NFKB1, HDAC3, RARA, HSPA8, MYC, CBL, AR, BCL2, NCOR2, STUB1, EGFR, ABL1, PSMA3, PDGFRB, SIAH1, ST13, GCDH, PPP1R15A, HBEGF (tumor) | BAG1, NR3C1, BCL2L1, NFKB1, HDAC3, ESR1, RARA, HSPA4, PSMD1, CBL, RAF1, TRIM23, EGFR, ARRB1, PDGFRB, RB1, VDR, MET, MAPT, HBEGF, PYGL (normal) |
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| LUSC (tumor) | LUSC (normal) |
| BAG1, TP53, NCOR1, BCL2L1, HDAC3, ESR1, HSPA4, CBL, RAF1, AR, HSPA1B, BCL2, NCOR2, STUB1, EGFR, ABL1, ARRB1, PSMA3, PDGFRB, SIAH1, RB1 (tumor) | BAG1, UBC, NCOR1, NFKB1, HDAC3, PTGS2, HSPA4, PSMD1, MYC, CBL, NCOR2, STUB1, TRIM23, EGFR, ABL1, ARRB1, PSMA3, PDGFRB, MET, MAPT, PYGL (normal) |
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| PRAD (tumor) | PRAD (normal) |
| BAG1, TP53, UBC, NCOR1, RELA, BCL2L1, HDAC3, PSMD1, MYC, CBL, AR, HSPA1B, NCOR2, ABL1, HSPA1A, PDGFRB, RB1, VDR, MAPT, PPP1R15A, HBEGF (tumor) | BAG1, NR3C1, UBC, NCOR1, NFKB1, HDAC3, HSPA4, CBL, RAF1, AR, STUB1, TRIM23, EGFR, ABL1, ARRB1, PSMA3, PDGFRB, SIAH1, RB1, GCDH, HBEGF (normal) |
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| STAD (tumor) | STAD (normal) |
| BAG1, NR3C1, NCOR1, HDAC3, ESR1, PTGS2, CBL, RAF1, AR, BCL2, NCOR2, STUB1, TRIM23, EGFR, ABL1, HSPA1A, PSMA3, PDGFRB, MET, MAPT, HBEGF (tumor) | BAG1, NR3C1, NCOR1, HDAC3, ESR1, RARA, PTGS2, HSPA8, CBL, AR, BCL2, NCOR2, TRIM23, ABL1, HSPA1A, PSMA3, PDGFRB, SIAH1, VDR, MAPT, HBEGF (normal) |
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| THCA (tumor) | THCA (normal) |
| BAG1, NR3C1, NCOR1, NFKB1, HDAC3, PTGS2, PSMD1, CBL, RAF1, AR, BCL2, NCOR2, STUB1, TRIM23, EGFR, ABL1, PSMA3, SIAH1, RB1, MAPT, GCDH (tumor) | BAG1, NR3C1, UBC, NCOR1, BCL2L1, NFKB1, HDAC3, CBL, RAF1, AR, NCOR2, STUB1, TRIM23, EGFR, ABL1, PSMA3, PDGFRB, RB1, VDR, MAPT, GCDH (normal) |
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| TissGeneProg for BAG1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for BAG1 |
| TissGeneDrug for BAG1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for BAG1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 20 | BeFree |
| umls:C0678222 | Breast Carcinoma | 20 | BeFree |
| umls:C0596263 | Carcinogenesis | 12 | BeFree |
| umls:C0001430 | Adenoma | 5 | BeFree |
| umls:C0036341 | Schizophrenia | 5 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 4 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 4 | BeFree,CTD_human,LHGDN |
| umls:C1527249 | Colorectal Cancer | 4 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 3 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 3 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 3 | BeFree |
| umls:C0302592 | Cervix carcinoma | 3 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 3 | BeFree |
| umls:C1302401 | Adenoma of large intestine | 3 | BeFree |
| umls:C0002395 | Alzheimer's Disease | 2 | BeFree |
| umls:C0005586 | Bipolar Disorder | 2 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 2 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 2 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 2 | LHGDN |
| umls:C0017638 | Glioma | 2 | BeFree |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 2 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
| umls:C0178874 | Tumor Progression | 2 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
| umls:C0600139 | Prostate carcinoma | 2 | BeFree |
| umls:C0699790 | Colon Carcinoma | 2 | BeFree |
| umls:C0853193 | Bipolar I disorder | 2 | BeFree |
| umls:C0853879 | Invasive breast carcinoma | 2 | BeFree |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | BeFree |
| umls:C0007124 | Noninfiltrating Intraductal Carcinoma | 1 | BeFree |
| umls:C0009319 | Colitis | 1 | BeFree |
| umls:C0009375 | Colonic Neoplasms | 1 | LHGDN |
| umls:C0014859 | Esophageal Neoplasms | 1 | BeFree |
| umls:C0017152 | Gastritis | 1 | BeFree |
| umls:C0017636 | Glioblastoma | 1 | BeFree |
| umls:C0018671 | Head and Neck Neoplasms | 1 | GAD |
| umls:C0021400 | Influenza | 1 | BeFree |
| umls:C0023418 | leukemia | 1 | BeFree |
| umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | GAD |
| umls:C0027404 | Narcolepsy | 1 | GAD |
| umls:C0027643 | Neoplasm Recurrence, Local | 1 | GAD |
| umls:C0030567 | Parkinson Disease | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
| umls:C0033975 | Psychotic Disorders | 1 | BeFree |
| umls:C0035126 | Reperfusion Injury | 1 | RGD |
| umls:C0035335 | Retinoblastoma | 1 | BeFree |
| umls:C0036337 | Schizoaffective Disorder | 1 | BeFree |
| umls:C0085183 | Neoplasms, Second Primary | 1 | GAD |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 1 | BeFree |
| umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
| umls:C0235782 | Gallbladder Carcinoma | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0343401 | MRSA - Methicillin resistant Staphylococcus aureus infection | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0349204 | Nonorganic psychosis | 1 | BeFree |
| umls:C0546837 | Malignant neoplasm of esophagus | 1 | BeFree |
| umls:C0555198 | Malignant Glioma | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C0751072 | Frontotemporal Lobar Degeneration | 1 | BeFree |
| umls:C0751177 | Cancer of Head | 1 | BeFree |
| umls:C0850572 | Adenomatous polyp of colon | 1 | BeFree |
| umls:C0876973 | Infectious disease of lung | 1 | BeFree |
| umls:C0949083 | Nosocomial pneumonia | 1 | BeFree |
| umls:C1134719 | Invasive Ductal Breast Carcinoma | 1 | BeFree,CTD_human |
| umls:C1274282 | Acral pseudolymphomatous angiokeratoma of children (APACHE) | 1 | BeFree |
| umls:C1335377 | Periampullary Adenocarcinoma | 1 | BeFree |
| umls:C1621958 | Glioblastoma Multiforme | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C2986665 | Early-Stage Breast Carcinoma | 1 | BeFree |
| umls:C3811918 | GRN-related frontotemporal dementia | 1 | BeFree |
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