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| TissGeneSummary for PTGER3 |
 Gene summary |
| Basic gene information | Gene symbol | PTGER3 |
| Gene name | prostaglandin E receptor 3 (subtype EP3) | |
| Synonyms | EP3|EP3-I|EP3-II|EP3-III|EP3-IV|EP3e|PGE2-R | |
| Cytomap | UCSC genome browser: 1p31.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001126044.1, NM_198714.1,NM_198715.2,NM_198716.1,NM_198717.1, NM_198718.1,NM_198719.1,NR_028292.1,NR_028293.1, NR_028294.1,NM_000957.2,NM_198712.2,NM_198713.1, NM_198720.1, | |
| Description | PGE receptor, EP3 subtypePGE2 receptor EP3 subtypeprostaglandin E receotor EP3 subtype 3 isoformprostaglandin E2 receptor EP3 subtypeprostaglandin receptor (PGE-2)prostanoid EP3 receptor | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 176806 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000050628 | ||
| HPRD : 08906 | ||
| Vega : OTTHUMG00000009399 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PTGER3 | |
| BioGPS: 5733 | ||
| Pathway | NCI Pathway Interaction Database: PTGER3 | |
| KEGG: PTGER3 | ||
| REACTOME: PTGER3 | ||
| Pathway Commons: PTGER3 | ||
| Context | iHOP: PTGER3 | |
| ligand binding site mutation search in PubMed: PTGER3 | ||
| UCL Cancer Institute: PTGER3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyUterus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHUCEC,UCS | |
| Reference showing the relevant tissue of PTGER3 | ||
| Description by TissGene annotations | Protective TissGene in OS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for PTGER3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | -1.121967107 | 0.110095638 | -1.232062745 | 4.38E-05 | 9.39E-05 |
| BRCA | 3.233691975 | 4.804710396 | -1.571018421 | 1.04E-12 | 4.66E-12 |
| LUAD | -0.819242327 | 0.334207673 | -1.15345 | 1.32E-06 | 4.35E-06 |
| STAD | 0.395883751 | 2.420761876 | -2.024878125 | 2.64E-06 | 3.81E-05 |
| KIRC | 3.630534445 | 7.010283057 | -3.379748611 | 4.20E-19 | 3.03E-18 |
| HNSC | -0.341345173 | 1.497440873 | -1.838786047 | 4.10E-06 | 2.61E-05 |
| PRAD | 0.269214039 | 1.405171732 | -1.135957692 | 1.56E-07 | 1.40E-06 |
| KIRP | -1.530047499 | 6.761230626 | -8.291278125 | 3.20E-17 | 1.33E-15 |
| COAD | 0.358714039 | 1.468752501 | -1.110038462 | 0.0054 | 0.012818418 |
| BLCA | -0.299384341 | 1.824057764 | -2.123442105 | 0.0012 | 0.008314019 |
| ESCA | -0.943974772 | 4.384116137 | -5.328090909 | 6.22E-05 | 0.002195759 |
| Top |
| TissGene-miRNA for PTGER3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for PTGER3 |
| TissGeneSNV for PTGER3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E361K | SKCM | 5 |
| p.M301I | SKCM | 2 |
| p.R355* | SKCM | 2 |
| p.G364E | SKCM | 2 |
| p.A361G | LUAD | 1 |
| p.E45K | STAD | 1 |
| p.D10N | STAD | 1 |
| p.V244A | LGG | 1 |
| p.A166V | STAD | 1 |
| p.G218V | LUAD | 1 |
| p.V181L | THCA | 1 |
| p.A150V | LIHC | 1 |
| p.R259C | LIHC | 1 |
| p.H223R | LUAD | 1 |
| p.V201F | HNSC | 1 |
| p.R275H | LUAD | 1 |
| p.S378L | SKCM | 1 |
| p.T310I | LUSC | 1 |
| p.P343L | LUAD | 1 |
| p.G274C | LUAD | 1 |
| p.Q377K | CESC | 1 |
| p.E397D | SKCM | 1 |
| p.R84H | COAD | 1 |
| p.I377S | UCEC | 1 |
| p.C315Y | COAD | 1 |
| p.E400K | SKCM | 1 |
| p.A152T | UCEC | 1 |
| p.S413L | BLCA | 1 |
| p.G386E | SKCM | 1 |
| p.I210M | CESC | 1 |
| p.F371V | DLBC | 1 |
| p.R214X | STAD | 1 |
| p.N308I | LIHC | 1 |
| p.E389K | SKCM | 1 |
| p.R396K | SKCM | 1 |
| p.N224Y | COAD | 1 |
| p.V73L | LIHC | 1 |
| p.Q322R | HNSC | 1 |
| p.V312D | BRCA | 1 |
| p.N217K | STAD | 1 |
| p.W384R | UCEC | 1 |
| p.Q385K | STAD | 1 |
| p.R355Q | SKCM | 1 |
| p.P41A | LUSC | 1 |
| p.R333S | READ | 1 |
| p.L237M | LGG | 1 |
| p.P204T | COAD | 1 |
| p.A231T | BLCA | 1 |
| p.Q385R | STAD | 1 |
| p.R214* | STAD | 1 |
| p.K356T | LUAD | 1 |
| p.R333C | SKCM | 1 |
| p.M399I | SKCM | 1 |
| p.A176S | LUAD | 1 |
| p.Q374L | LUAD | 1 |
| p.E398K | SKCM | 1 |
| p.T174I | TGCT | 1 |
| p.Q268L | LUAD | 1 |
| p.L191Q | STAD | 1 |
| p.R380M | HNSC | 1 |
| p.K356T | ESCA | 1 |
| p.F328I | HNSC | 1 |
| p.R355L | COAD | 1 |
| p.A231T | STAD | 1 |
| p.R350K | COAD | 1 |
| p.T310S | LIHC | 1 |
| p.F209Y | LIHC | 1 |
| p.R392H | CESC | 1 |
| p.L303F | HNSC | 1 |
| p.E418K | UCEC | 1 |
| p.H163Q | LUAD | 1 |
| p.G216S | KIRP | 1 |
| p.A385V | UCEC | 1 |
| p.G8R | COAD | 1 |
| p.M301I | COAD | 1 |
| p.F362Y | BLCA | 1 |
| p.E324X | READ | 1 |
| p.L299V | BRCA | 1 |
| p.R214L | HNSC | 1 |
| p.E320K | SKCM | 1 |
| p.R355Q | THYM | 1 |
| p.Q377K | LUAD | 1 |
| p.D386N | UCEC | 1 |
| p.S51F | COAD | 1 |
| p.E154K | BLCA | 1 |
| p.A187D | STAD | 1 |
| p.E369Q | BRCA | 1 |
| p.L60I | KIRP | 1 |
| p.A176S | LUSC | 1 |
| Top |
| TissGeneCNV for PTGER3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for PTGER3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF333113 | RERE-PTGER3 | chr1:8456461 | chr1:71501824 | |
| TCGAfusionPortal | PRADA | LUAD | TCGA-05-4402-01A | ZNF644-PTGER3 | 5UTR-3UTR | Chr1:91487547 | Chr1:71318542 |
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| TissGeneNet for PTGER3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| PTGER3, PTGER1 (tumor) | PTGER3, PTGER1 (normal) |
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| COAD (tumor) | COAD (normal) |
| PTGER3, PTGER1 (tumor) | PTGER3, PTGER1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| PTGER3, PTGER1 (tumor) | PTGER3, PTGER1 (normal) |
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| KICH (tumor) | KICH (normal) |
| PTGER3, PTGER1 (tumor) | PTGER3, PTGER1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| PTGER3, PTGER1 (tumor) | PTGER3, PTGER1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| PTGER3, PTGER1 (tumor) | PTGER3, PTGER1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| PTGER3, PTGER1 (tumor) | PTGER3, PTGER1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| PTGER3, PTGER1 (tumor) | PTGER3, PTGER1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| PTGER3, PTGER1 (tumor) | PTGER3, PTGER1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| PTGER3, PTGER1 (tumor) | PTGER3, PTGER1 (normal) |
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| STAD (tumor) | STAD (normal) |
| PTGER3, PTGER1 (tumor) | PTGER3, PTGER1 (normal) |
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| THCA (tumor) | THCA (normal) |
| PTGER3, PTGER1 (tumor) | PTGER3, PTGER1 (normal) |
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| Top |
| TissGeneProg for PTGER3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Top |
| TissGeneClin for PTGER3 |
| TissGeneDrug for PTGER3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00917 | Dinoprostone | Agonist | Small molecule | Approved |
| DB00929 | Misoprostol | Agonist | Small molecule | Approved |
| DB00905 | Bimatoprost | Agonist | Small molecule | Approved|Investigational |
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| TissGeneDisease for PTGER3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0151526 | Premature Birth | 5 | GAD |
| umls:C0004096 | Asthma | 4 | BeFree,GAD,LHGDN,RGD |
| umls:C0021368 | Inflammation | 3 | GAD |
| umls:C0002395 | Alzheimer's Disease | 2 | BeFree,GAD |
| umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
| umls:C0600139 | Prostate carcinoma | 2 | BeFree |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0003850 | Arteriosclerosis | 1 | BeFree |
| umls:C0004114 | Astrocytoma | 1 | BeFree |
| umls:C0004153 | Atherosclerosis | 1 | BeFree |
| umls:C0005686 | Urinary Bladder Diseases | 1 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0008495 | Chorioamnionitis | 1 | GAD |
| umls:C0009375 | Colonic Neoplasms | 1 | RGD |
| umls:C0009782 | Connective Tissue Diseases | 1 | GAD |
| umls:C0010200 | Coughing | 1 | BeFree |
| umls:C0013182 | Drug Allergy | 1 | CTD_human |
| umls:C0013604 | Edema | 1 | RGD |
| umls:C0015929 | Fetal Diseases | 1 | GAD |
| umls:C0015934 | Fetal Growth Retardation | 1 | RGD |
| umls:C0015944 | Fetal Membranes, Premature Rupture | 1 | GAD |
| umls:C0017665 | Membranous glomerulonephritis | 1 | RGD |
| umls:C0020429 | Hyperalgesia | 1 | RGD |
| umls:C0020545 | Hypertension, Renovascular | 1 | RGD |
| umls:C0022876 | Premature Obstetric Labor | 1 | GAD |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0026857 | Musculoskeletal Diseases | 1 | GAD |
| umls:C0027055 | Myocardial Reperfusion Injury | 1 | RGD |
| umls:C0030804 | Pemphigoid, Benign Mucous Membrane | 1 | CTD_human |
| umls:C0030920 | Peptic Ulcer | 1 | RGD |
| umls:C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
| umls:C0032580 | Adenomatous Polyposis Coli | 1 | BeFree |
| umls:C0032584 | polyps | 1 | BeFree |
| umls:C0032914 | Pre-Eclampsia | 1 | GAD |
| umls:C0032964 | Pregnancy Complications, Hematologic | 1 | GAD |
| umls:C0036341 | Schizophrenia | 1 | BeFree |
| umls:C0037274 | Dermatologic disorders | 1 | GAD |
| umls:C0038325 | Stevens-Johnson Syndrome | 1 | CTD_human |
| umls:C0038587 | Substance Withdrawal Syndrome | 1 | RGD |
| umls:C0040053 | Thrombosis | 1 | CTD_human |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0243038 | Carcinoma, Lewis Lung | 1 | BeFree |
| umls:C0279000 | Liver and Intrahepatic Biliary Tract Carcinoma | 1 | BeFree |
| umls:C0345904 | Malignant neoplasm of liver | 1 | BeFree |
| umls:C0520679 | Sleep Apnea, Obstructive | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | GAD |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C2919032 | Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified | 1 | GAD |
| umls:C3714514 | Infection | 1 | GAD |
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