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| TissGeneSummary for TMEM27 |
 Gene summary |
| Basic gene information | Gene symbol | TMEM27 |
| Gene name | transmembrane protein 27 | |
| Synonyms | NX-17|NX17 | |
| Cytomap | UCSC genome browser: Xp22 | |
| Type of gene | protein-coding | |
| RefGenes | NM_020665.5, | |
| Description | collectrinkidney-specific membrane protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 300631 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000147003 | ||
| HPRD : 06668 | ||
| Vega : OTTHUMG00000021181 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TMEM27 | |
| BioGPS: 57393 | ||
| Pathway | NCI Pathway Interaction Database: TMEM27 | |
| KEGG: TMEM27 | ||
| REACTOME: TMEM27 | ||
| Pathway Commons: TMEM27 | ||
| Context | iHOP: TMEM27 | |
| ligand binding site mutation search in PubMed: TMEM27 | ||
| UCL Cancer Institute: TMEM27 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTExHPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
| Reference showing the relevant tissue of TMEM27 | Lack of TMEM27 expression is associated with postoperative progression of clinically localized conventional renal cell carcinoma. J Cancer Res Clin Oncol. 2016 Sep;142(9):1947-53. doi: 10.1007/s00432-016-2207-3. Epub 2016 Jul 14. (pmid:27417314) go to article | |
| Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0035543 | positive regulation of SNARE complex assembly | 16330323 | GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus | 16330323 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis | 16330323 | GO:0035543 | positive regulation of SNARE complex assembly | 16330323 | GO:0035774 | positive regulation of insulin secretion involved in cellular response to glucose stimulus | 16330323 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis | 16330323 |
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| TissGeneExp for TMEM27 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -0.207380556 | 4.846383444 | -5.053764 | 1.06E-15 | 2.57E-14 |
| LIHC | -0.001046556 | 3.713243444 | -3.71429 | 6.51E-16 | 2.37E-14 |
| LUSC | -1.17112785 | -0.064747458 | -1.106380392 | 6.13E-06 | 1.43E-05 |
| STAD | -1.997305056 | -0.799789431 | -1.197515625 | 0.000187 | 0.001322525 |
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| TissGene-miRNA for TMEM27 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for TMEM27 |
| TissGeneSNV for TMEM27 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P129S | SKCM | 2 |
| p.E193K | SKCM | 1 |
| p.P221S | OV | 1 |
| p.D199N | BRCA | 1 |
| p.I154M | KIRC | 1 |
| p.G36R | BRCA | 1 |
| p.N63S | SKCM | 1 |
| p.R111Q | BRCA | 1 |
| p.P141S | STAD | 1 |
| p.P19R | LGG | 1 |
| p.E124Q | LUAD | 1 |
| p.S82* | UCEC | 1 |
| p.F50L | UCEC | 1 |
| p.F116L | UCEC | 1 |
| p.N63S | UCEC | 1 |
| p.P97L | SKCM | 1 |
| p.S130Y | UCEC | 1 |
| p.M189I | SKCM | 1 |
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| TissGeneCNV for TMEM27 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for TMEM27 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | TopHat-Fusion | BLCA | TCGA-GU-A42Q-01A | PIR-TMEM27 | Out-of-Frame | chrX:15509284 | chrX:15682517 |
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| TissGeneNet for TMEM27 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| TMEM27, HNF1A, RBM18 (tumor) | TMEM27, HNF1A, RBM18 (normal) |
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| COAD (tumor) | COAD (normal) |
| TMEM27, HNF1A, RBM18 (tumor) | TMEM27, HNF1A, RBM18 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| TMEM27, HNF1A, RBM18 (tumor) | TMEM27, HNF1A, RBM18 (normal) |
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| KICH (tumor) | KICH (normal) |
| TMEM27, HNF1A, RBM18 (tumor) | TMEM27, HNF1A, RBM18 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| TMEM27, HNF1A, RBM18 (tumor) | TMEM27, HNF1A, RBM18 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| TMEM27, HNF1A, RBM18 (tumor) | TMEM27, HNF1A, RBM18 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| TMEM27, HNF1A, RBM18 (tumor) | TMEM27, HNF1A, RBM18 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| TMEM27, HNF1A, RBM18 (tumor) | TMEM27, HNF1A, RBM18 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| TMEM27, HNF1A, RBM18 (tumor) | TMEM27, HNF1A, RBM18 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| TMEM27, HNF1A, RBM18 (tumor) | TMEM27, HNF1A, RBM18 (normal) |
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| STAD (tumor) | STAD (normal) |
| TMEM27, HNF1A, RBM18 (tumor) | TMEM27, HNF1A, RBM18 (normal) |
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| THCA (tumor) | THCA (normal) |
| TMEM27, HNF1A, RBM18 (tumor) | TMEM27, HNF1A, RBM18 (normal) |
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| TissGeneProg for TMEM27 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for TMEM27 |
| TissGeneDrug for TMEM27 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for TMEM27 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0018609 | Hartnup Disease | 3 | BeFree |
| umls:C0022658 | Kidney Diseases | 1 | GAD |
| umls:C0028860 | Oculocerebrorenal Syndrome | 1 | GAD |
| umls:C0041956 | Ureteral obstruction | 1 | CTD_human |
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