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| TissGeneSummary for S100A14 |
 Gene summary |
| Basic gene information | Gene symbol | S100A14 |
| Gene name | S100 calcium binding protein A14 | |
| Synonyms | BCMP84|S100A15 | |
| Cytomap | UCSC genome browser: 1q21.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_020672.2, | |
| Description | S100 calcium-binding protein A14S114breast cancer membrane protein 84protein S100-A14 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 607986 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000189334 | ||
| HPRD : 10467 | ||
| Vega : OTTHUMG00000035030 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_S100A14 | |
| BioGPS: 57402 | ||
| Pathway | NCI Pathway Interaction Database: S100A14 | |
| KEGG: S100A14 | ||
| REACTOME: S100A14 | ||
| Pathway Commons: S100A14 | ||
| Context | iHOP: S100A14 | |
| ligand binding site mutation search in PubMed: S100A14 | ||
| UCL Cancer Institute: S100A14 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | ||
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | EsophagusStomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCASTAD | |
| Reference showing the relevant tissue of S100A14 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0034142 | toll-like receptor 4 signaling pathway | 17625598 | GO:0071624 | positive regulation of granulocyte chemotaxis | 18606705 | GO:0090026 | positive regulation of monocyte chemotaxis | 18606705 | GO:0034142 | toll-like receptor 4 signaling pathway | 17625598 | GO:0071624 | positive regulation of granulocyte chemotaxis | 18606705 | GO:0090026 | positive regulation of monocyte chemotaxis | 18606705 |
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| TissGeneExp for S100A14 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | -2.930489591 | 0.318538187 | -3.249027778 | 2.44E-30 | 4.75E-29 |
| KICH | -3.283744535 | 0.940995465 | -4.22474 | 7.69E-08 | 3.58E-07 |
| KIRP | -1.98171216 | 0.367478465 | -2.349190625 | 5.60E-07 | 3.00E-06 |
| BRCA | 3.324849956 | 0.792449956 | 2.5324 | 3.50E-17 | 2.08E-16 |
| PRAD | -2.092540766 | 0.423811157 | -2.516351923 | 3.34E-12 | 1.44E-10 |
| HNSC | 5.50358486 | 6.514275558 | -1.010690698 | 0.00915 | 0.022977121 |
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| TissGene-miRNA for S100A14 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| LUAD | hsa-miR-365b-3p | MIMAT0022834 | 0.046 | -0.26 | 60 |
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| TissGeneMut for S100A14 |
| TissGeneSNV for S100A14 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.K27N | UCEC | 1 |
| p.G72R | BLCA | 1 |
| p.E80D | KIRC | 1 |
| p.A7V | COAD | 1 |
| p.I26M | HNSC | 1 |
| p.S83T | GBM | 1 |
| p.K67T | COAD | 1 |
| p.K67N | STAD | 1 |
| p.V101A | KIRC | 1 |
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| TissGeneCNV for S100A14 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for S100A14 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF799331 | TCF7-S100A14 | chr5:133451685 | chr1:153587333 | |
| Chimerdb3.0 | ChiTaRs | NA | AW385213 | S100A14-S100A14 | chr1:153587069 | chr1:153587342 | |
| Chimerdb3.0 | ChiTaRs | NA | AI637635 | PRSS8-S100A14 | chr16:31142850 | chr1:153587202 |
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| TissGeneNet for S100A14 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| S100A14, UCHL5, S100A16 (tumor) | S100A14, UCHL5, S100A16 (normal) |
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| COAD (tumor) | COAD (normal) |
| S100A14, UCHL5, S100A16 (tumor) | S100A14, UCHL5, S100A16 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| S100A14, UCHL5, S100A16 (tumor) | S100A14, UCHL5, S100A16 (normal) |
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| KICH (tumor) | KICH (normal) |
| S100A14, UCHL5, S100A16 (tumor) | S100A14, UCHL5, S100A16 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| S100A14, UCHL5, S100A16 (tumor) | S100A14, UCHL5, S100A16 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| S100A14, UCHL5, S100A16 (tumor) | S100A14, UCHL5, S100A16 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| S100A14, UCHL5, S100A16 (tumor) | S100A14, UCHL5, S100A16 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| S100A14, UCHL5, S100A16 (tumor) | S100A14, UCHL5, S100A16 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| S100A14, UCHL5, S100A16 (tumor) | S100A14, UCHL5, S100A16 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| S100A14, UCHL5, S100A16 (tumor) | S100A14, UCHL5, S100A16 (normal) |
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| STAD (tumor) | STAD (normal) |
| S100A14, UCHL5, S100A16 (tumor) | S100A14, UCHL5, S100A16 (normal) |
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| THCA (tumor) | THCA (normal) |
| S100A14, UCHL5, S100A16 (tumor) | S100A14, UCHL5, S100A16 (normal) |
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| TissGeneProg for S100A14 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for S100A14 |
| TissGeneDrug for S100A14 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for S100A14 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 6 | BeFree |
| umls:C0279626 | Squamous cell carcinoma of esophagus | 4 | BeFree |
| umls:C0678222 | Breast Carcinoma | 4 | BeFree |
| umls:C0596263 | Carcinogenesis | 3 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 2 | BeFree |
| umls:C0033860 | Psoriasis | 2 | BeFree |
| umls:C0220641 | Lip and Oral Cavity Carcinoma | 2 | BeFree |
| umls:C1832097 | EPIDERMAL DIFFERENTIATION COMPLEX | 2 | BeFree |
| umls:C0001144 | Acne Vulgaris | 1 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0011615 | Dermatitis, Atopic | 1 | GAD |
| umls:C0014859 | Esophageal Neoplasms | 1 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0037274 | Dermatologic disorders | 1 | BeFree |
| umls:C0151546 | Oral Cavity Carcinoma | 1 | BeFree |
| umls:C0152018 | Esophageal carcinoma | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0278984 | Non-small cell lung cancer stage IIIB | 1 | BeFree |
| umls:C0278987 | Non-small cell lung cancer metastatic | 1 | BeFree |
| umls:C0546837 | Malignant neoplasm of esophagus | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
| umls:C0677932 | Progressive Neoplastic Disease | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0702166 | Acne | 1 | BeFree |
| umls:C0853879 | Invasive breast carcinoma | 1 | BeFree |
| umls:C0919267 | ovarian neoplasm | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C3539781 | Progressive cGVHD | 1 | BeFree |
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