TissGeneSummary for AHRR |
Gene summary |
Basic gene information | Gene symbol | AHRR |
Gene name | aryl-hydrocarbon receptor repressor | |
Synonyms | AHH|AHHR|bHLHe77 | |
Cytomap | UCSC genome browser: 5p15.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001242412.1, NM_020731.4, | |
Description | ahR repressoraryl hydrocarbon hydroxylase regulatoraryl hydrocarbon receptor repressorclass E basic helix-loop-helix protein 77dioxin receptor repressor | |
Modification date | 20141207 | |
dbXrefs | MIM : 606517 | |
HGNC : HGNC | ||
Ensembl : ENSG00000063438 | ||
HPRD : 07356 | ||
Vega : OTTHUMG00000162171 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_AHRR | |
BioGPS: 57491 | ||
Pathway | NCI Pathway Interaction Database: AHRR | |
KEGG: AHRR | ||
REACTOME: AHRR | ||
Pathway Commons: AHRR | ||
Context | iHOP: AHRR | |
ligand binding site mutation search in PubMed: AHRR | ||
UCL Cancer Institute: AHRR | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of AHRR | ||
Description by TissGene annotations | Cancer gene Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for AHRR |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | -1.4106011 | 0.20217967 | -1.612780769 | 1.51E-09 | 1.61E-08 |
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TissGene-miRNA for AHRR |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for AHRR |
TissGeneSNV for AHRR |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D645H | PCPG | 8 |
p.A301V | SKCM | 2 |
p.R626C | PAAD | 1 |
p.D344G | COAD | 1 |
p.D323Y | LGG | 1 |
p.A276V | STAD | 1 |
p.C666Y | CESC | 1 |
p.P382S | THYM | 1 |
p.A586V | DLBC | 1 |
p.L68F | UCEC | 1 |
p.T587I | SKCM | 1 |
p.A283V | SKCM | 1 |
p.A276V | PAAD | 1 |
p.P541L | PCPG | 1 |
p.P598A | BRCA | 1 |
p.P190L | PRAD | 1 |
p.A308V | PRAD | 1 |
p.R43H | UCEC | 1 |
p.P457L | COAD | 1 |
p.D627H | COAD | 1 |
p.C570S | LUAD | 1 |
p.A280V | SKCM | 1 |
p.S478F | CESC | 1 |
p.M529L | SKCM | 1 |
p.G279E | SKCM | 1 |
p.R659W | BRCA | 1 |
p.K33N | BLCA | 1 |
p.P283S | SKCM | 1 |
p.G494S | STAD | 1 |
p.P265S | SKCM | 1 |
p.S600Y | UCEC | 1 |
p.W558C | PAAD | 1 |
p.R228H | PAAD | 1 |
p.R379W | PAAD | 1 |
p.S430I | LUAD | 1 |
p.S53G | STAD | 1 |
p.R628T | BLCA | 1 |
p.R412W | HNSC | 1 |
p.N158H | BLCA | 1 |
p.V165M | GBM | 1 |
p.R361W | PAAD | 1 |
p.M511L | SKCM | 1 |
p.R614W | ESCA | 1 |
p.L65V | LUAD | 1 |
p.R79P | SKCM | 1 |
p.P506L | SKCM | 1 |
p.A371T | UCEC | 1 |
p.D180G | UCEC | 1 |
p.R79W | UCEC | 1 |
p.C252R | HNSC | 1 |
p.S487I | UCEC | 1 |
p.A363T | LGG | 1 |
p.E115G | LUAD | 1 |
p.R79Q | UCS | 1 |
p.G381D | UCEC | 1 |
p.R168H | PAAD | 1 |
p.A246D | STAD | 1 |
p.A31T | UCEC | 1 |
p.G615W | LUAD | 1 |
p.F84S | BLCA | 1 |
p.G30W | STAD | 1 |
p.R601L | LUAD | 1 |
p.R285W | BRCA | 1 |
p.R485Q | BLCA | 1 |
p.R628W | LUAD | 1 |
p.E216Q | THCA | 1 |
p.T590I | SKCM | 1 |
p.R608C | COAD | 1 |
p.A14S | LUSC | 1 |
p.A319T | ESCA | 1 |
p.K327Q | STAD | 1 |
p.T329A | UCEC | 1 |
p.W576C | PAAD | 1 |
p.G373V | COAD | 1 |
p.P475Q | UCEC | 1 |
p.R285Q | HNSC | 1 |
p.R379L | LUAD | 1 |
p.P488L | SKCM | 1 |
p.C375F | SARC | 1 |
p.A301V | LUSC | 1 |
p.P100L | HNSC | 1 |
p.A258V | PAAD | 1 |
p.A283V | COAD | 1 |
p.H156Q | DLBC | 1 |
p.G195E | UCEC | 1 |
p.A112V | STAD | 1 |
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TissGeneCNV for AHRR |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for AHRR |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BM723201 | AHRR-AHRR | chr5:428044 | chr5:428033 |
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TissGeneNet for AHRR |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for AHRR |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for AHRR |
TissGeneDrug for AHRR |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for AHRR |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0014175 | Endometriosis | 4 | BeFree,GAD,LHGDN |
umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 3 | BeFree,GAD |
umls:C0678222 | Breast Carcinoma | 3 | BeFree |
umls:C0684249 | Carcinoma of lung | 2 | BeFree |
umls:C1387005 | Penis agenesis | 2 | BeFree,GAD |
umls:C0004509 | Azoospermia | 1 | GAD |
umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | GAD |
umls:C0021364 | Male infertility | 1 | BeFree |
umls:C0023418 | leukemia | 1 | BeFree |
umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GAD |
umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
umls:C0028960 | Oligospermia | 1 | GAD |
umls:C0042131 | Uterine Diseases | 1 | GAD |
umls:C0206731 | Angiofibroma | 1 | BeFree |
umls:C1261473 | Sarcoma | 1 | BeFree |
umls:C1292769 | Precursor B-cell lymphoblastic leukemia | 1 | BeFree |