TissGeneSummary for KIF17 |
Gene summary |
Basic gene information | Gene symbol | KIF17 |
Gene name | kinesin family member 17 | |
Synonyms | KIF17B|KIF3X|KLP-2|OSM-3 | |
Cytomap | UCSC genome browser: 1p36.12 | |
Type of gene | protein-coding | |
RefGenes | NM_001122819.2, NM_001287212.1,NM_020816.3, | |
Description | KIF17 variant proteinKIF3-related motor proteinkinesin-like protein KIF17 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605037 | |
HGNC : HGNC | ||
Ensembl : ENSG00000117245 | ||
HPRD : 10388 | ||
Vega : OTTHUMG00000002863 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KIF17 | |
BioGPS: 57576 | ||
Pathway | NCI Pathway Interaction Database: KIF17 | |
KEGG: KIF17 | ||
REACTOME: KIF17 | ||
Pathway Commons: KIF17 | ||
Context | iHOP: KIF17 | |
ligand binding site mutation search in PubMed: KIF17 | ||
UCL Cancer Institute: KIF17 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of KIF17 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for KIF17 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -0.287354528 | 2.425421942 | -2.712776471 | 1.25E-25 | 3.03E-24 |
BRCA | -0.522875994 | 0.769145936 | -1.29202193 | 2.24E-22 | 1.90E-21 |
KICH | -0.219387783 | 1.790348217 | -2.009736 | 9.43E-15 | 1.78E-13 |
LUAD | 0.131335803 | 2.275790976 | -2.144455172 | 5.61E-23 | 1.75E-21 |
BLCA | -1.018907573 | 0.304045059 | -1.322952632 | 0.000683 | 0.005149125 |
HNSC | 0.300271008 | -0.703382481 | 1.003653488 | 5.94E-05 | 0.000283758 |
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TissGene-miRNA for KIF17 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KIF17 |
TissGeneSNV for KIF17 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D802N | UCEC | 2 |
p.R442C | COAD | 2 |
p.R770C | UCEC | 2 |
p.A988V | ESCA | 1 |
p.R433S | TGCT | 1 |
p.R226W | LUSC | 1 |
p.D871Y | LUAD | 1 |
p.M15I | BLCA | 1 |
p.R448K | LIHC | 1 |
p.R148W | SKCM | 1 |
p.S530P | BLCA | 1 |
p.Y170H | UCEC | 1 |
p.R410Q | UCEC | 1 |
p.A758V | STAD | 1 |
p.D511Y | LIHC | 1 |
p.Q110H | LUAD | 1 |
p.P917S | SKCM | 1 |
p.R954* | STAD | 1 |
p.R769W | UCEC | 1 |
p.S963R | OV | 1 |
p.P898H | LUAD | 1 |
p.H177Y | UCEC | 1 |
p.T178M | COAD | 1 |
p.I113M | BLCA | 1 |
p.V79I | UCEC | 1 |
p.V125I | OV | 1 |
p.V285I | LGG | 1 |
p.L373P | UCEC | 1 |
p.E485K | SKCM | 1 |
p.S513F | LUAD | 1 |
p.R294Q | PAAD | 1 |
p.R778M | UCEC | 1 |
p.S444L | SKCM | 1 |
p.G103V | LUSC | 1 |
p.E807K | SKCM | 1 |
p.I188M | BLCA | 1 |
p.G587R | BRCA | 1 |
p.R351H | STAD | 1 |
p.R148Q | SKCM | 1 |
p.E1006K | STAD | 1 |
p.S679L | SKCM | 1 |
p.R869C | UCEC | 1 |
p.A682S | LIHC | 1 |
p.E603K | SKCM | 1 |
p.S548C | LUAD | 1 |
p.S518F | SKCM | 1 |
p.R442C | STAD | 1 |
p.R869C | SKCM | 1 |
p.R957Q | SKCM | 1 |
p.G467V | COAD | 1 |
p.V495E | LUAD | 1 |
p.S210L | SKCM | 1 |
p.R869S | ESCA | 1 |
p.S248F | SARC | 1 |
p.A222V | LUAD | 1 |
p.R442H | STAD | 1 |
p.D634N | LUAD | 1 |
p.P601L | BLCA | 1 |
p.W193* | SKCM | 1 |
p.A824T | STAD | 1 |
p.E545K | SKCM | 1 |
p.R1017P | BLCA | 1 |
p.D511N | SARC | 1 |
p.P487L | PAAD | 1 |
p.L151F | SKCM | 1 |
p.R331W | GBM | 1 |
p.S268L | CESC | 1 |
p.N985K | BLCA | 1 |
p.S313L | UCEC | 1 |
p.E888K | LUAD | 1 |
p.L938I | SARC | 1 |
p.E533Q | ESCA | 1 |
p.E528K | LUAD | 1 |
p.V800I | BRCA | 1 |
p.A699T | SKCM | 1 |
p.W795L | LUAD | 1 |
p.R770C | READ | 1 |
p.S369R | DLBC | 1 |
p.E835K | SKCM | 1 |
p.S788L | GBM | 1 |
p.H120R | STAD | 1 |
p.V899I | STAD | 1 |
p.S884P | KIRC | 1 |
p.K132* | UCEC | 1 |
p.G755E | BRCA | 1 |
p.P605L | BRCA | 1 |
p.E765K | SKCM | 1 |
p.R327L | LUAD | 1 |
p.P605T | SARC | 1 |
p.A260V | LGG | 1 |
p.T729I | COAD | 1 |
p.R256Q | STAD | 1 |
p.A35G | LUAD | 1 |
p.E119K | READ | 1 |
p.K642N | UCEC | 1 |
p.P115L | PAAD | 1 |
p.S955C | BLCA | 1 |
p.R457W | COAD | 1 |
p.R869H | COAD | 1 |
p.V647I | COAD | 1 |
p.A522E | LUSC | 1 |
p.A810T | LUSC | 1 |
p.R869S | THYM | 1 |
p.V402M | COAD | 1 |
p.G227D | SKCM | 1 |
p.R419G | LUAD | 1 |
p.L104M | UCEC | 1 |
p.G692D | UCEC | 1 |
p.S290L | HNSC | 1 |
p.S275L | STAD | 1 |
p.L1029V | BRCA | 1 |
p.Q583H | BLCA | 1 |
p.L350F | UCEC | 1 |
p.H284Y | LUAD | 1 |
p.E862* | CESC | 1 |
p.S543L | SKCM | 1 |
p.R281C | PAAD | 1 |
p.T250I | HNSC | 1 |
p.P42L | COAD | 1 |
p.M101I | COAD | 1 |
p.E579K | BLCA | 1 |
p.L323I | LGG | 1 |
p.L938H | LUAD | 1 |
p.E790K | SKCM | 1 |
p.R1004H | UCEC | 1 |
p.R954X | STAD | 1 |
p.R457Q | COAD | 1 |
p.A918S | STAD | 1 |
p.L798R | SKCM | 1 |
p.P107L | STAD | 1 |
p.E321Q | BLCA | 1 |
p.R327H | COAD | 1 |
p.D316N | SKCM | 1 |
p.Q17X | DLBC | 1 |
p.R232W | STAD | 1 |
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TissGeneCNV for KIF17 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KIF17 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for KIF17 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KIF17 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KIF17 |
TissGeneDrug for KIF17 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KIF17 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0036341 | Schizophrenia | 2 | BeFree |
umls:C0004509 | Azoospermia | 1 | GAD |
umls:C0028960 | Oligospermia | 1 | GAD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0233794 | Memory impairment | 1 | BeFree |
umls:C0341106 | Eosinophilic esophagitis | 1 | GWASCAT |