TissGDB
Tissglogo

Home

Download

 Statistics

 Landscape

Help

Contact
Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

bullet point

TissGeneSummary

bullet point

TissGeneExp

bullet point

TissGene-miRNA

bullet point

TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

bullet point

TissGeneNet

bullet point

TissGeneProg

bullet point

TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for TRIB3
check button Gene summary
Basic gene informationGene symbolTRIB3
Gene nametribbles pseudokinase 3
SynonymsC20orf97|NIPK|SINK|SKIP3|TRB3
CytomapUCSC genome browser: 20p13-p12.2
Type of geneprotein-coding
RefGenesNM_001301188.1,
NM_001301190.1,NM_001301193.1,NM_001301196.1,NM_001301201.1,
NM_021158.4,
DescriptionTRB-3neuronal cell death inducible putative kinaseneuronal cell death-inducible putative kinasep65-interacting inhibitor of NF-kappa-Bp65-interacting inhibitor of NF-kappaBtribbles homolog 3
Modification date20141207
dbXrefs MIM : 607898
HGNC : HGNC
Ensembl : ENSG00000101255
HPRD : 09836
Vega : OTTHUMG00000031627
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_TRIB3
BioGPS: 57761
PathwayNCI Pathway Interaction Database: TRIB3
KEGG: TRIB3
REACTOME: TRIB3
Pathway Commons: TRIB3
ContextiHOP: TRIB3
ligand binding site mutation search in PubMed: TRIB3
UCL Cancer Institute: TRIB3
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)CervixLiver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)CESCLIHC
Reference showing the relevant tissue of TRIB3
Description by TissGene annotationsCancer gene
Fused withTSGene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0006469negative regulation of protein kinase activity12791994
GO:0034976response to endoplasmic reticulum stress15775988
GO:0043405regulation of MAP kinase activity15299019
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress15775988
GO:0006469negative regulation of protein kinase activity12791994
GO:0034976response to endoplasmic reticulum stress15775988
GO:0043405regulation of MAP kinase activity15299019
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress15775988


Top
TissGeneExp for TRIB3

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
BRCA1.771906630.2228776831.5490289476.65E-319.37E-30
KICH1.586971121-0.6353408792.2223122.67E-069.34E-06
STAD0.999090621-0.9417125041.9408031252.39E-075.43E-06
HNSC1.4363798660.2308100981.2055697674.11E-073.48E-06
KIRC1.858348955-0.9827718792.8411208331.44E-282.43E-27
COAD2.596256967-1.0399507253.6362076921.09E-252.39E-22
LUSC1.6732835130.4090384151.2642450987.18E-082.05E-07
ESCA1.577648576-0.5914423332.1690909090.001590.019866067
KIRP0.290018746-1.0727781291.3627968750.001450.00381561
BLCA1.244197858-0.4618547731.7060526320.0001080.001154769


Top
TissGene-miRNA for TRIB3

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


Top
TissGeneMut for TRIB3
TissGeneSNV for TRIB3

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
bullet point


check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.V226MSTAD1
p.R149*PAAD1
p.A112TSTAD1
p.E152KCESC1
p.L170PSTAD1
p.R289CSKCM1
p.L304VSKCM1
p.R36*UCEC1
p.K219ETHYM1
p.R316*ESCA1
p.A169TUCEC1
p.P300LESCA1
p.D218GCOAD1
p.V208MBLCA1
p.L52SLUSC1
p.P155SSKCM1
p.R56HUCEC1
p.A59VSTAD1
p.L329VBLCA1
p.R139QCOAD1
p.S206FBLCA1
p.G368VLUSC1
p.E302KBLCA1
p.A55VUCEC1
p.V62LLUAD1
p.R274CSTAD1
p.G211RLUAD1
p.R316XESCA1
p.R149XPAAD1
p.R29HSTAD1
p.A112TESCA1
p.R275HTHCA1
p.T168ISKCM1
p.V276LLUSC1
p.R29HUCEC1
p.R36QUCEC1
p.V226MUCEC1
p.R67SSKCM1
p.R81QREAD1
p.K299NCESC1
p.R191HUCEC1
p.R2*UCEC1
p.R293SSKCM1
p.P52SSKCM1
p.R108WLUSC1
p.Q32HBRCA1
p.A277TUCEC1
p.R326QLUAD1


Top
TissGeneCNV for TRIB3

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


Top
TissGeneFusions for TRIB3

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNABP240144TRIB3-NADK2chr20:368874chr5:36227578
Chimerdb3.0ChiTaRsNAU02019TRIB3-WASF2chr20:377410chr1:27783598
TCGAfusionPortalPRADALGGTCGA-DU-8163-01ABMP2-TRIB35UTR-CDSChr20:6749522Chr20:368655
TCGAfusionPortalPRADALUADTCGA-75-6211-01ATRIB3-DEFB125Out-of-frameChr20:368945Chr20:76646


Top
TissGeneNet for TRIB3

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
TRIB3, KAT5, SMAD3, UBC, RELA, SETDB1, BCL6, FN1, MAP2K1, GDF9, SMURF1, RPSA, GIT1, PSMA3, AKT2, EEF1G, BMPR2, CDC25A, HRSP12, LTBP4, RBM4 (tumor)TRIB3, COPS6, KAT5, UBC, RELA, SETDB1, FN1, ATF5, SMURF1, AKT1, DDIT3, GIT1, CSNK2B, PSMA3, SIAH1, BMPR2, ATF4, HRSP12, LTBP4, RBM4, TIAF1 (normal)
bullet pointbullet point
COAD (tumor)COAD (normal)
TRIB3, SMAD3, UBC, RELA, HLA-B, BCL6, GDF9, ATF5, RPSA, DDIT3, PSMA3, AKT2, SIAH1, EEF1G, BMPR2, MAP2K7, CDC25A, GRN, HRSP12, LTBP4, RBM4 (tumor)TRIB3, COPS6, KAT5, RELA, HLA-B, BCL6, FN1, DDIT3, GIT1, CSNK2B, AKT2, SIAH1, EEF1G, BMPR2, CDC25A, ATF4, GRN, HRSP12, MCM3AP, RFWD2, LTBP4 (normal)
bullet pointbullet point
HNSC (tumor)HNSC (normal)
TRIB3, COPS6, KAT5, SMAD3, RELA, SETDB1, HLA-B, BCL6, GDF9, RPSA, CSNK2B, SIAH1, EEF1G, BMPR2, ATF4, GRN, HRSP12, MCM3AP, RFWD2, LTBP4, RBM4 (tumor)TRIB3, COPS6, SMAD3, RELA, SETDB1, BCL6, RPSA, DDIT3, GIT1, CSNK2B, PSMA3, AKT2, EEF1G, BMPR2, ATF4, HRSP12, MCM3AP, RFWD2, LTBP4, RBM4, TIAF1 (normal)
bullet pointbullet point
KICH (tumor)KICH (normal)
TRIB3, KAT5, SMAD3, UBC, RELA, BCL6, FN1, MAP2K1, AKT1, RPSA, DDIT3, GIT1, CSNK2B, PSMA3, AKT2, BMPR2, MAP2K7, GRN, HRSP12, LTBP4, RBM4 (tumor)TRIB3, COPS6, SMAD3, FN1, MAP2K1, GDF9, ATF5, SMURF1, DDIT3, GIT1, CSNK2B, PSMA3, SIAH1, BMPR2, MAP2K7, CDC25A, ATF4, HRSP12, RFWD2, LTBP4, TIAF1 (normal)
bullet pointbullet point
KIRC (tumor)KIRC (normal)
TRIB3, COPS6, UBC, RELA, HLA-B, BCL6, FN1, MAP2K1, ATF5, AKT1, RPSA, CSNK2B, AKT2, EEF1G, BMPR2, ATF4, GRN, HRSP12, RFWD2, LTBP4, RBM4 (tumor)TRIB3, COPS6, KAT5, UBC, RELA, BCL6, FN1, GDF9, ATF5, AKT1, RPSA, DDIT3, GIT1, CSNK2B, PSMA3, EEF1G, BMPR2, CDC25A, ATF4, LTBP4, TIAF1 (normal)
bullet pointbullet point
KIRP (tumor)KIRP (normal)
TRIB3, COPS6, UBC, RELA, HLA-B, BCL6, FN1, MAP2K1, GDF9, SMURF1, AKT1, RPSA, DDIT3, AKT2, SIAH1, BMPR2, MAP2K7, ATF4, GRN, HRSP12, RBM4 (tumor)TRIB3, COPS6, UBC, RELA, FN1, MAP2K1, GDF9, ATF5, SMURF1, RPSA, DDIT3, GIT1, CSNK2B, PSMA3, EEF1G, MAP2K7, CDC25A, ATF4, GRN, HRSP12, RBM4 (normal)
bullet pointbullet point
LIHC (tumor)LIHC (normal)
TRIB3, COPS6, KAT5, RELA, SETDB1, HLA-B, FN1, GDF9, ATF5, AKT1, DDIT3, CSNK2B, PSMA3, SIAH1, EEF1G, BMPR2, MAP2K7, ATF4, LTBP4, RBM4, TIAF1 (tumor)TRIB3, COPS6, SMAD3, BCL6, ATF5, SMURF1, RPSA, DDIT3, GIT1, CSNK2B, AKT2, EEF1G, BMPR2, CDC25A, ATF4, GRN, HRSP12, MCM3AP, RFWD2, RBM4, TIAF1 (normal)
bullet pointbullet point
LUAD (tumor)LUAD (normal)
TRIB3, COPS6, KAT5, SMAD3, UBC, RELA, BCL6, SMURF1, AKT1, RPSA, CSNK2B, PSMA3, AKT2, EEF1G, BMPR2, CDC25A, GRN, MCM3AP, RFWD2, LTBP4, RBM4 (tumor)TRIB3, COPS6, SMAD3, UBC, BCL6, ATF5, RPSA, DDIT3, GIT1, CSNK2B, PSMA3, AKT2, EEF1G, BMPR2, CDC25A, ATF4, GRN, HRSP12, MCM3AP, LTBP4, RBM4 (normal)
bullet pointbullet point
LUSC (tumor)LUSC (normal)
TRIB3, COPS6, UBC, RELA, SETDB1, BCL6, ATF5, SMURF1, AKT1, RPSA, DDIT3, CSNK2B, SIAH1, EEF1G, BMPR2, CDC25A, ATF4, GRN, RFWD2, LTBP4, TIAF1 (tumor)TRIB3, COPS6, SMAD3, UBC, HLA-B, MAP2K1, ATF5, RPSA, DDIT3, GIT1, PSMA3, SIAH1, EEF1G, BMPR2, MAP2K7, CDC25A, ATF4, GRN, MCM3AP, RFWD2, LTBP4 (normal)
bullet pointbullet point
PRAD (tumor)PRAD (normal)
TRIB3, SMAD3, UBC, SETDB1, HLA-B, BCL6, FN1, MAP2K1, ATF5, SMURF1, AKT1, RPSA, CSNK2B, EEF1G, MAP2K7, CDC25A, HRSP12, RFWD2, LTBP4, RBM4, TIAF1 (tumor)TRIB3, COPS6, SMAD3, HLA-B, BCL6, FN1, ATF5, SMURF1, AKT1, RPSA, DDIT3, GIT1, CSNK2B, PSMA3, EEF1G, BMPR2, CDC25A, ATF4, RFWD2, LTBP4, RBM4 (normal)
bullet pointbullet point
STAD (tumor)STAD (normal)
TRIB3, COPS6, KAT5, SMAD3, UBC, RELA, SETDB1, FN1, MAP2K1, SMURF1, AKT1, DDIT3, GIT1, AKT2, SIAH1, EEF1G, BMPR2, CDC25A, ATF4, GRN, LTBP4 (tumor)TRIB3, COPS6, RELA, SETDB1, BCL6, ATF5, DDIT3, GIT1, CSNK2B, PSMA3, EEF1G, BMPR2, CDC25A, ATF4, GRN, HRSP12, MCM3AP, RFWD2, LTBP4, RBM4, TIAF1 (normal)
bullet pointbullet point
THCA (tumor)THCA (normal)
TRIB3, COPS6, SMAD3, HLA-B, BCL6, MAP2K1, ATF5, SMURF1, RPSA, DDIT3, GIT1, CSNK2B, PSMA3, SIAH1, EEF1G, BMPR2, CDC25A, GRN, HRSP12, MCM3AP, TIAF1 (tumor)TRIB3, SMAD3, UBC, SETDB1, BCL6, ATF5, SMURF1, AKT1, RPSA, DDIT3, GIT1, AKT2, SIAH1, EEF1G, BMPR2, CDC25A, ATF4, GRN, LTBP4, RBM4, TIAF1 (normal)
bullet pointbullet point


Top
TissGeneProg for TRIB3

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

Top
TissGeneClin for TRIB3
TissGeneDrug for TRIB3

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


Top
TissGeneDisease for TRIB3

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent8BeFree,GAD
umls:C0006142Malignant neoplasm of breast5BeFree
umls:C0678222Breast Carcinoma5BeFree
umls:C0007222Cardiovascular Diseases3BeFree
umls:C0020456Hyperglycemia3BeFree
umls:C1458155Mammary Neoplasms3BeFree
umls:C0003850Arteriosclerosis2BeFree
umls:C0004153Atherosclerosis2BeFree
umls:C0009402Colorectal Carcinoma2BeFree
umls:C0011847Diabetes2BeFree
umls:C0011849Diabetes Mellitus2BeFree
umls:C0021655Insulin Resistance2CTD_human,GAD
umls:C0027627Neoplasm Metastasis2BeFree
umls:C0271650Impaired glucose tolerance2BeFree
umls:C0524620Metabolic Syndrome X2BeFree,CTD_human,GAD
umls:C1527249Colorectal Cancer2BeFree
umls:C0002395Alzheimer's Disease1GAD
umls:C0003130Anoxia1LHGDN
umls:C0010054Coronary Arteriosclerosis1BeFree
umls:C0010068Coronary heart disease1BeFree
umls:C0023418leukemia1BeFree
umls:C0023467Leukemia, Myelocytic, Acute1BeFree
umls:C0027051Myocardial Infarction1BeFree
umls:C0028754Obesity1BeFree
umls:C0029408Degenerative polyarthritis1BeFree
umls:C0030297Pancreatic Neoplasm1BeFree
umls:C0151744Myocardial Ischemia1GAD
umls:C0243050Cardiovascular Abnormalities1BeFree
umls:C0311277Obesity, Abdominal1BeFree
umls:C0349566Squamous cell carcinoma of tongue1BeFree
umls:C0376358Malignant neoplasm of prostate1BeFree
umls:C0521158Recurrent tumor1BeFree
umls:C0577631Carotid Atherosclerosis1BeFree
umls:C0596263Carcinogenesis1BeFree
umls:C0598608Hyperhomocysteinemia1BeFree
umls:C0600139Prostate carcinoma1BeFree
umls:C0850666Helicobacter pylori infection1BeFree
umls:C1318485Liver regeneration disorder1BeFree
umls:C1956346Coronary Artery Disease1BeFree
umls:C3495426Homocysteinemia1BeFree