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| TissGeneSummary for HAMP |
 Gene summary |
| Basic gene information | Gene symbol | HAMP |
| Gene name | hepcidin antimicrobial peptide | |
| Synonyms | HEPC|HFE2B|LEAP1|PLTR | |
| Cytomap | UCSC genome browser: 19q13.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_021175.2, | |
| Description | hepcidinliver-expressed antimicrobial peptide 1putative liver tumor regressor | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 606464 | |
| HGNC : HGNC | ||
| HPRD : 05925 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HAMP | |
| BioGPS: 57817 | ||
| Pathway | NCI Pathway Interaction Database: HAMP | |
| KEGG: HAMP | ||
| REACTOME: HAMP | ||
| Pathway Commons: HAMP | ||
| Context | iHOP: HAMP | |
| ligand binding site mutation search in PubMed: HAMP | ||
| UCL Cancer Institute: HAMP | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of HAMP | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for HAMP |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | 1.416921541 | -3.493240959 | 4.9101625 | 2.75E-16 | 9.94E-15 |
| KICH | -1.665614709 | -3.532114709 | 1.8665 | 2.21E-05 | 6.54E-05 |
| LIHC | 1.535519291 | 9.234607291 | -7.699088 | 6.24E-19 | 3.46E-17 |
| LUAD | -0.400755399 | -2.044088158 | 1.643332759 | 8.45E-07 | 2.86E-06 |
| KIRC | -0.846194432 | -3.599529154 | 2.753334722 | 1.89E-17 | 1.18E-16 |
| STAD | -1.553437834 | -3.172490959 | 1.619053125 | 0.000256 | 0.001723784 |
| COAD | -1.776723171 | -3.231892402 | 1.455169231 | 0.000343 | 0.001098703 |
| LUSC | -0.4199602 | -1.561987651 | 1.142027451 | 0.000351 | 0.000690955 |
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| TissGene-miRNA for HAMP |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for HAMP |
| TissGeneSNV for HAMP |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.W49* | SKCM | 1 |
| p.S48G | CHOL | 1 |
| p.Q54H | BRCA | 1 |
| p.R56Q | SKCM | 1 |
| p.H74Y | SKCM | 1 |
| p.T61N | LUAD | 1 |
| p.E36X | KIRP | 1 |
| p.W8G | KIRC | 1 |
| p.K83N | THYM | 1 |
| Top |
| TissGeneCNV for HAMP |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| Top |
| TissGeneFusions for HAMP |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for HAMP |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| HAMP, CKAP4, GATA4, SLC40A1, GATA6 (tumor) | HAMP, CKAP4, GATA4, SLC40A1, GATA6 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| HAMP, CKAP4, GATA4, SLC40A1, GATA6 (tumor) | HAMP, CKAP4, GATA4, SLC40A1, GATA6 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| HAMP, CKAP4, GATA4, SLC40A1, GATA6 (tumor) | HAMP, CKAP4, GATA4, SLC40A1, GATA6 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| HAMP, CKAP4, GATA4, SLC40A1, GATA6 (tumor) | HAMP, CKAP4, GATA4, SLC40A1, GATA6 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| HAMP, CKAP4, GATA4, SLC40A1, GATA6 (tumor) | HAMP, CKAP4, GATA4, SLC40A1, GATA6 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| HAMP, CKAP4, GATA4, SLC40A1, GATA6 (tumor) | HAMP, CKAP4, GATA4, SLC40A1, GATA6 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| HAMP, CKAP4, GATA4, SLC40A1, GATA6 (tumor) | HAMP, CKAP4, GATA4, SLC40A1, GATA6 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| HAMP, CKAP4, GATA4, SLC40A1, GATA6 (tumor) | HAMP, CKAP4, GATA4, SLC40A1, GATA6 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| HAMP, CKAP4, GATA4, SLC40A1, GATA6 (tumor) | HAMP, CKAP4, GATA4, SLC40A1, GATA6 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| HAMP, CKAP4, GATA4, SLC40A1, GATA6 (tumor) | HAMP, CKAP4, GATA4, SLC40A1, GATA6 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| HAMP, CKAP4, GATA4, SLC40A1, GATA6 (tumor) | HAMP, CKAP4, GATA4, SLC40A1, GATA6 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| HAMP, CKAP4, GATA4, SLC40A1, GATA6 (tumor) | HAMP, CKAP4, GATA4, SLC40A1, GATA6 (normal) |
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| TissGeneProg for HAMP |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Top |
| TissGeneClin for HAMP |
| TissGeneDrug for HAMP |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for HAMP |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0282193 | Iron Overload | 104 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0018995 | Hemochromatosis | 73 | BeFree,CTD_human,GAD,LHGDN |
| umls:C0002871 | Anemia | 65 | BeFree,CTD_human,LHGDN |
| umls:C0392514 | Hereditary hemochromatosis | 48 | BeFree,CLINVAR |
| umls:C0268060 | Juvenile hemochromatosis | 27 | BeFree,CTD_human,ORPHANET |
| umls:C0240066 | Iron deficiency | 23 | BeFree |
| umls:C0002873 | Anemia of chronic disease | 18 | BeFree |
| umls:C2239176 | Liver carcinoma | 18 | BeFree |
| umls:C0005283 | beta Thalassemia | 14 | BeFree,CTD_human,GAD |
| umls:C0023903 | Liver neoplasms | 13 | BeFree |
| umls:C0039730 | Thalassemia | 11 | BeFree,LHGDN |
| umls:C0085576 | Iron-Refractory Iron Deficiency Anemia | 11 | BeFree |
| umls:C0162316 | Iron deficiency anemia | 10 | BeFree |
| umls:C0019196 | Hepatitis C | 9 | BeFree,LHGDN |
| umls:C0002875 | Cooley's anemia | 8 | BeFree |
| umls:C0028754 | Obesity | 8 | BeFree |
| umls:C0012715 | Iron Metabolism Disorders | 7 | BeFree,GAD |
| umls:C0524910 | Hepatitis C, Chronic | 6 | BeFree |
| umls:C0023896 | Alcoholic Liver Diseases | 5 | BeFree |
| umls:C0004623 | Bacterial Infections | 4 | BeFree |
| umls:C0022661 | Kidney Failure, Chronic | 4 | BeFree,CTD_human,LHGDN |
| umls:C0023895 | Liver diseases | 4 | BeFree |
| umls:C0472767 | Beta thalassemia intermedia | 4 | BeFree |
| umls:C0524620 | Metabolic Syndrome X | 4 | BeFree |
| umls:C0878682 | Ceruloplasmin deficiency | 4 | BeFree |
| umls:C0002895 | Anemia, Sickle Cell | 3 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 3 | BeFree,LHGDN |
| umls:C0011847 | Diabetes | 3 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 3 | BeFree |
| umls:C0023890 | Liver Cirrhosis | 3 | BeFree |
| umls:C0024530 | Malaria | 3 | BeFree,LHGDN |
| umls:C0162309 | Adrenoleukodystrophy | 3 | BeFree |
| umls:C0596263 | Carcinogenesis | 3 | BeFree |
| umls:C1865616 | HEMOCHROMATOSIS, TYPE 2B | 3 | CLINVAR,CTD_human,UNIPROT |
| umls:C0003850 | Arteriosclerosis | 2 | BeFree |
| umls:C0004153 | Atherosclerosis | 2 | BeFree |
| umls:C0005411 | Biliary Atresia | 2 | BeFree,CTD_human |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0009319 | Colitis | 2 | BeFree |
| umls:C0014130 | Endocrine System Diseases | 2 | BeFree |
| umls:C0019693 | HIV Infections | 2 | BeFree |
| umls:C0021368 | Inflammation | 2 | LHGDN |
| umls:C0024535 | Malaria, Falciparum | 2 | BeFree,LHGDN |
| umls:C0026764 | Multiple Myeloma | 2 | BeFree |
| umls:C0029928 | Ovarian Diseases | 2 | BeFree |
| umls:C0035078 | Kidney Failure | 2 | BeFree |
| umls:C0037061 | Siderosis | 2 | BeFree,LHGDN |
| umls:C0042769 | Virus Diseases | 2 | BeFree |
| umls:C0239946 | Fibrosis, Liver | 2 | BeFree |
| umls:C0271901 | Microcytic hypochromic anemia (disorder) | 2 | BeFree |
| umls:C0341439 | Chronic liver disease | 2 | BeFree |
| umls:C0400966 | Non-alcoholic Fatty Liver Disease | 2 | BeFree |
| umls:C0403447 | Chronic Kidney Insufficiency | 2 | BeFree |
| umls:C0497406 | Overweight | 2 | BeFree |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C0878521 | Beta thalassemia trait | 2 | BeFree |
| umls:C1561643 | Chronic Kidney Diseases | 2 | BeFree |
| umls:C1623038 | Cirrhosis | 2 | BeFree |
| umls:C1858664 | HEMOCHROMATOSIS, TYPE 3 | 2 | BeFree |
| umls:C2316810 | Chronic kidney disease stage 5 | 2 | BeFree |
| umls:C3241937 | Nonalcoholic Steatohepatitis | 2 | BeFree |
| umls:C0000786 | Spontaneous abortion | 1 | GAD |
| umls:C0001430 | Adenoma | 1 | BeFree,LHGDN |
| umls:C0002893 | Refractory anemias | 1 | BeFree |
| umls:C0004114 | Astrocytoma | 1 | BeFree |
| umls:C0008313 | Cholangitis, Sclerosing | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | LHGDN |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
| umls:C0017152 | Gastritis | 1 | BeFree |
| umls:C0019163 | Hepatitis B | 1 | BeFree |
| umls:C0019202 | Hepatolenticular Degeneration | 1 | CTD_human |
| umls:C0021390 | Inflammatory Bowel Diseases | 1 | BeFree |
| umls:C0022658 | Kidney Diseases | 1 | BeFree |
| umls:C0024141 | Lupus Erythematosus, Systemic | 1 | LHGDN |
| umls:C0024299 | Lymphoma | 1 | BeFree |
| umls:C0028756 | Obesity, Morbid | 1 | BeFree |
| umls:C0031154 | Peritonitis | 1 | BeFree |
| umls:C0032460 | Polycystic Ovary Syndrome | 1 | BeFree |
| umls:C0032461 | Polycythemia | 1 | BeFree |
| umls:C0032708 | Disorders of Porphyrin Metabolism | 1 | LHGDN |
| umls:C0032962 | Pregnancy Complications | 1 | GAD |
| umls:C0033027 | Preleukemia | 1 | BeFree |
| umls:C0036117 | Salmonella infections | 1 | BeFree |
| umls:C0041296 | Tuberculosis | 1 | BeFree |
| umls:C0149520 | Acute Cholecystitis | 1 | BeFree |
| umls:C0162566 | Porphyria Cutanea Tarda | 1 | BeFree,LHGDN |
| umls:C0238644 | Anemia, severe | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0242723 | Parasitemia | 1 | BeFree |
| umls:C0268070 | Hypocupremia | 1 | BeFree |
| umls:C0271979 | Thalassemia Intermedia | 1 | BeFree |
| umls:C0275553 | Bacterial cholangitis | 1 | BeFree |
| umls:C0342793 | Malonic aciduria | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0472777 | Hemoglobin E/beta thalassemia disease | 1 | BeFree |
| umls:C0524909 | Hepatitis B, Chronic | 1 | BeFree |
| umls:C0566602 | Primary sclerosing cholangitis | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0740340 | Amyloidosis, Familial | 1 | LHGDN |
| umls:C0746102 | Chronic lung disease | 1 | BeFree |
| umls:C1142276 | Renal anemia | 1 | BeFree |
| umls:C1290884 | Inflammatory disorder | 1 | BeFree |
| umls:C1334815 | Multi-centric Castleman's Disease | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
| umls:C1565489 | Renal Insufficiency | 1 | BeFree |
| umls:C1636149 | Macular dystrophy, corneal type 1 | 1 | BeFree |
| umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | GAD |
| umls:C2981142 | Refractory anemia, without ringed sideroblasts, without excess blasts | 1 | BeFree |
| umls:C3463824 | MYELODYSPLASTIC SYNDROME | 1 | BeFree |
| umls:C3714514 | Infection | 1 | LHGDN |
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