TissGeneSummary for G6PC2 |
Gene summary |
Basic gene information | Gene symbol | G6PC2 |
Gene name | glucose-6-phosphatase, catalytic, 2 | |
Synonyms | IGRP | |
Cytomap | UCSC genome browser: 2q24.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001081686.1, NM_021176.2, | |
Description | G-6-Pase 2G6Pase 2glucose-6-phosphatase 2islet-specific G6CP-related proteinislet-specific glucose-6-phosphatase catalytic subunit-related proteinislet-specific glucose-6-phosphatase-related protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 608058 | |
HGNC : HGNC | ||
HPRD : 16272 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_G6PC2 | |
BioGPS: 57818 | ||
Pathway | NCI Pathway Interaction Database: G6PC2 | |
KEGG: G6PC2 | ||
REACTOME: G6PC2 | ||
Pathway Commons: G6PC2 | ||
Context | iHOP: G6PC2 | |
ligand binding site mutation search in PubMed: G6PC2 | ||
UCL Cancer Institute: G6PC2 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Pancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAAD | |
Reference showing the relevant tissue of G6PC2 | Alternative splicing of G6PC2, the gene coding for the islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP), results in differential expression in human thymus and spleen compared with pancreas. Dogra RS, Vaidyanathan P, Prabakar KR, Marshall KE, Hutton JC, Pugliese A. Diabetologia. 2006 May;49(5):953-7. Epub 2006 Mar 7. (pmid:16520917) go to article | |
Description by TissGene annotations | High usage of specific isoform TissgsKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for G6PC2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | -0.363840226 | 0.648954602 | -1.012794828 | 4.39E-08 | 1.81E-07 |
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TissGene-miRNA for G6PC2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for G6PC2 |
TissGeneSNV for G6PC2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P102S | SKCM | 1 |
p.L153I | COAD | 1 |
p.A239D | HNSC | 1 |
p.P340S | SKCM | 1 |
p.T128I | LUSC | 1 |
p.W59R | PRAD | 1 |
p.H308Y | SKCM | 1 |
p.I160S | LUAD | 1 |
p.N27K | UCEC | 1 |
p.S163R | STAD | 1 |
p.F325I | HNSC | 1 |
p.F338L | UCEC | 1 |
p.G285E | SKCM | 1 |
p.R79Q | READ | 1 |
p.R283L | LUSC | 1 |
p.Y222N | HNSC | 1 |
p.L323M | UCEC | 1 |
p.P176L | SKCM | 1 |
p.P340H | LUAD | 1 |
p.Y90F | ACC | 1 |
p.W154C | LUAD | 1 |
p.G268C | LUAD | 1 |
p.N68D | UCEC | 1 |
p.R36M | COAD | 1 |
p.F49C | UCEC | 1 |
p.G182E | UCEC | 1 |
p.R20Q | PAAD | 1 |
p.V60I | SKCM | 1 |
p.H250Y | SKCM | 1 |
p.T254M | LUAD | 1 |
p.P197R | LUSC | 1 |
p.L269M | UCEC | 1 |
p.L225F | BLCA | 1 |
p.W73X | SKCM | 1 |
p.G268D | SKCM | 1 |
p.Q178* | LUAD | 1 |
p.D231Y | LUAD | 1 |
p.S324Y | UCEC | 1 |
p.V179A | UCEC | 1 |
p.E316K | SKCM | 1 |
p.E86D | LUAD | 1 |
p.D231E | CESC | 1 |
p.S291R | SARC | 1 |
p.A119T | UCEC | 1 |
p.E99K | BLCA | 1 |
p.A119T | THYM | 1 |
p.L298V | LGG | 1 |
p.V122F | BRCA | 1 |
p.H78N | READ | 1 |
p.Q51H | HNSC | 1 |
p.F28L | BRCA | 1 |
p.P332L | SKCM | 1 |
p.K241N | UCEC | 1 |
p.C165R | OV | 1 |
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TissGeneCNV for G6PC2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for G6PC2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for G6PC2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for G6PC2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for G6PC2 |
TissGeneDrug for G6PC2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for G6PC2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 15 | BeFree,GAD |
umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 13 | BeFree,GAD,MGD |
umls:C0011847 | Diabetes | 6 | BeFree |
umls:C0011849 | Diabetes Mellitus | 6 | BeFree |
umls:C0028754 | Obesity | 4 | BeFree,GAD |
umls:C0020456 | Hyperglycemia | 2 | BeFree |
umls:C0021655 | Insulin Resistance | 2 | GAD |
umls:C0524620 | Metabolic Syndrome X | 2 | GAD,GWASCAT |
umls:C0004153 | Atherosclerosis | 1 | GAD |
umls:C0017919 | Glycogen Storage Disease | 1 | LHGDN |
umls:C0020459 | Hyperinsulinism | 1 | BeFree |
umls:C0030286 | Pancreatic Diseases | 1 | GAD |
umls:C0085207 | Gestational Diabetes | 1 | BeFree |
umls:C0205734 | Diabetes, Autoimmune | 1 | BeFree |
umls:C0271650 | Impaired glucose tolerance | 1 | BeFree,GAD |