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| TissGeneSummary for PTPRB |
 Gene summary |
| Basic gene information | Gene symbol | PTPRB |
| Gene name | protein tyrosine phosphatase, receptor type, B | |
| Synonyms | HPTP-BETA|HPTPB|PTPB|R-PTP-BETA|VEPTP | |
| Cytomap | UCSC genome browser: 12q15-q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001109754.2, NM_001206971.1,NM_001206972.1,NM_002837.4, | |
| Description | VE-PTPprotein tyrosine phosphatase, receptor type, beta polypeptidereceptor-type tyrosine-protein phosphatase betavascular endothelial protein tyrosine phosphatase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 176882 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000127329 | ||
| HPRD : 01474 | ||
| Vega : OTTHUMG00000169499 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PTPRB | |
| BioGPS: 5787 | ||
| Pathway | NCI Pathway Interaction Database: PTPRB | |
| KEGG: PTPRB | ||
| REACTOME: PTPRB | ||
| Pathway Commons: PTPRB | ||
| Context | iHOP: PTPRB | |
| ligand binding site mutation search in PubMed: PTPRB | ||
| UCL Cancer Institute: PTPRB | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLung | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLUAD,LUSC | |
| Reference showing the relevant tissue of PTPRB | ||
| Description by TissGene annotations | Protective TissGene in OS Cancer gene Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0016311 | dephosphorylation | 19116766 | GO:0016311 | dephosphorylation | 19116766 |
| Top |
| TissGeneExp for PTPRB |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | -0.171223213 | 1.065918787 | -1.237142 | 1.03E-07 | 7.29E-07 |
| LUSC | -0.132032271 | 3.437510866 | -3.569543137 | 9.07E-33 | 7.04E-31 |
| BRCA | 0.5709297 | 2.178289349 | -1.607359649 | 5.51E-28 | 6.37E-27 |
| KIRP | -0.390035213 | 2.647749162 | -3.037784375 | 5.94E-20 | 3.70E-18 |
| KICH | 1.049894787 | 2.739306787 | -1.689412 | 4.33E-10 | 3.00E-09 |
| LUAD | 0.688132029 | 3.455244098 | -2.767112069 | 1.48E-29 | 1.58E-27 |
| Top |
| TissGene-miRNA for PTPRB |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-494-3p | MIMAT0002816 | 0.017 | -0.34 | 56 |
| UCS | hsa-miR-376c-3p | MIMAT0000720 | 0.0087 | -0.36 | 56 |
| UCS | hsa-miR-377-3p | MIMAT0000730 | 0.0074 | -0.38 | 56 |
| UCS | hsa-miR-410-3p | MIMAT0002171 | 0.0016 | -0.41 | 56 |
| Top |
| TissGeneMut for PTPRB |
| TissGeneSNV for PTPRB |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.D1778N | SKCM | 6 |
| p.G139E | SKCM | 4 |
| p.D1470N | SKCM | 4 |
| p.R747Q | SKCM | 4 |
| p.R439Q | SKCM | 3 |
| p.R1878C | SKCM | 3 |
| p.E1812K | SKCM | 2 |
| p.R1950* | SKCM | 2 |
| p.G453E | SKCM | 2 |
| p.D1510N | SKCM | 2 |
| p.P377S | SKCM | 2 |
| p.S718F | SKCM | 2 |
| p.H1083Y | SKCM | 2 |
| p.R1740W | SKCM | 2 |
| p.E1504K | SKCM | 2 |
| p.S88F | SKCM | 2 |
| p.G533E | SKCM | 2 |
| p.Q1577R | LUAD | 2 |
| p.W1499* | SKCM | 2 |
| p.R1432W | SKCM | 2 |
| p.D1202N | SKCM | 2 |
| p.G407E | SKCM | 2 |
| p.A1023E | UCEC | 2 |
| p.D844E | SKCM | 2 |
| p.P685S | SKCM | 2 |
| p.E1435K | SKCM | 2 |
| p.G671E | SKCM | 2 |
| p.S410F | SKCM | 2 |
| p.M455I | SKCM | 2 |
| p.N1291K | BLCA | 1 |
| p.N1403T | SKCM | 1 |
| p.R1300G | PAAD | 1 |
| p.S850F | SKCM | 1 |
| p.S923N | LUSC | 1 |
| p.T1154A | SKCM | 1 |
| p.E810D | UCEC | 1 |
| p.R1771G | SKCM | 1 |
| p.A1702T | HNSC | 1 |
| p.G1069E | SKCM | 1 |
| p.E1251* | BLCA | 1 |
| p.R94S | SKCM | 1 |
| p.G1787E | SKCM | 1 |
| p.A283S | LUAD | 1 |
| p.P331L | SKCM | 1 |
| p.E1271K | SKCM | 1 |
| p.L1442P | UCEC | 1 |
| p.P1173S | LUSC | 1 |
| p.G1231S | HNSC | 1 |
| p.S1898F | SKCM | 1 |
| p.S221X | KIRP | 1 |
| p.W130X | SKCM | 1 |
| p.H326Y | BLCA | 1 |
| p.R1582W | SKCM | 1 |
| p.S542F | SKCM | 1 |
| p.R1587Q | SKCM | 1 |
| p.P1755S | SKCM | 1 |
| p.R92* | LUAD | 1 |
| p.L1397F | SKCM | 1 |
| p.K59* | SKCM | 1 |
| p.E737K | PAAD | 1 |
| p.Q496K | HNSC | 1 |
| p.R449* | SKCM | 1 |
| p.G1907V | HNSC | 1 |
| p.D1245N | SKCM | 1 |
| p.T295R | BRCA | 1 |
| p.A1325T | STAD | 1 |
| p.A1023S | LUAD | 1 |
| p.R1039K | SKCM | 1 |
| p.M1582L | KIRC | 1 |
| p.E963K | SKCM | 1 |
| p.G2090A | BLCA | 1 |
| p.D653N | BLCA | 1 |
| p.S577I | PAAD | 1 |
| p.D1750H | HNSC | 1 |
| p.E1378V | STAD | 1 |
| p.P507L | SKCM | 1 |
| p.E960Q | BLCA | 1 |
| p.R86H | OV | 1 |
| p.S1580N | PAAD | 1 |
| p.R1988I | HNSC | 1 |
| p.P167L | SKCM | 1 |
| p.S40F | SKCM | 1 |
| p.D1740E | KIRP | 1 |
| p.E1261D | UCEC | 1 |
| p.R2079G | SKCM | 1 |
| p.V1931M | BRCA | 1 |
| p.G477V | LUAD | 1 |
| p.E1869K | THYM | 1 |
| p.H2160Y | SKCM | 1 |
| p.D2107G | LIHC | 1 |
| p.G1289D | UCEC | 1 |
| p.R1570K | SKCM | 1 |
| p.T1462A | SKCM | 1 |
| p.G1995R | SKCM | 1 |
| p.D1968H | HNSC | 1 |
| p.S430F | SKCM | 1 |
| p.E1785K | SKCM | 1 |
| p.N1145Y | HNSC | 1 |
| p.K761N | UCEC | 1 |
| p.E1160Q | LUSC | 1 |
| p.S827C | STAD | 1 |
| p.V1153I | PRAD | 1 |
| p.P289L | SKCM | 1 |
| p.K1532E | LUAD | 1 |
| p.G2068S | STAD | 1 |
| p.E902G | HNSC | 1 |
| p.D1075V | SARC | 1 |
| p.W1194R | HNSC | 1 |
| p.S918R | THYM | 1 |
| p.Q1891H | BLCA | 1 |
| p.Q1723* | HNSC | 1 |
| p.S1557F | SKCM | 1 |
| p.R851Q | SKCM | 1 |
| p.R2179K | SKCM | 1 |
| p.Q1170* | HNSC | 1 |
| p.R1881Q | ESCA | 1 |
| p.N310T | STAD | 1 |
| p.R874* | PAAD | 1 |
| p.D1152E | SKCM | 1 |
| p.R1770I | HNSC | 1 |
| p.E1840K | LUSC | 1 |
| p.S611Y | UCEC | 1 |
| p.E1188* | LUAD | 1 |
| p.L471I | LUSC | 1 |
| p.P480S | SKCM | 1 |
| p.Y1014N | LIHC | 1 |
| p.G1896D | UCEC | 1 |
| p.N606D | LUAD | 1 |
| p.E1812* | SKCM | 1 |
| p.V982L | CESC | 1 |
| p.F1696L | LUAD | 1 |
| p.Y826* | LUAD | 1 |
| p.S1618F | SKCM | 1 |
| p.R352Q | STAD | 1 |
| p.T522I | UCEC | 1 |
| p.R882H | STAD | 1 |
| p.R570Q | STAD | 1 |
| p.G1276D | UCEC | 1 |
| p.L1484V | LIHC | 1 |
| p.E1712D | LUAD | 1 |
| p.A284V | UCEC | 1 |
| p.G815R | PAAD | 1 |
| p.R1933Q | PRAD | 1 |
| p.A70T | COAD | 1 |
| p.S158L | READ | 1 |
| p.D1650E | KIRP | 1 |
| p.A1088S | LUAD | 1 |
| p.D1958E | KIRP | 1 |
| p.R312S | SKCM | 1 |
| p.D937N | SKCM | 1 |
| p.P2035T | LIHC | 1 |
| p.R828H | STAD | 1 |
| p.S119N | LUSC | 1 |
| p.L184F | SKCM | 1 |
| p.S1586P | LIHC | 1 |
| p.P1971S | SKCM | 1 |
| p.R1518G | PAAD | 1 |
| p.M214L | LUAD | 1 |
| p.M609I | LUAD | 1 |
| p.D899E | LUAD | 1 |
| p.D456N | SKCM | 1 |
| p.R72Q | SKCM | 1 |
| p.Y2108* | LUAD | 1 |
| p.L300P | LUAD | 1 |
| p.E1313D | SKCM | 1 |
| p.V8M | SKCM | 1 |
| p.D1123N | STAD | 1 |
| p.R92Q | HNSC | 1 |
| p.E810K | SKCM | 1 |
| p.V1713M | UCEC | 1 |
| p.R1092Q | UCEC | 1 |
| p.T1911N | LUSC | 1 |
| p.G1449S | HNSC | 1 |
| p.V860F | PAAD | 1 |
| p.P1482S | SKCM | 1 |
| p.E2192Q | STAD | 1 |
| p.L1071P | UCEC | 1 |
| p.P1482L | SKCM | 1 |
| p.V417L | HNSC | 1 |
| p.K1333T | PAAD | 1 |
| p.W1191X | SKCM | 1 |
| p.S18A | UCEC | 1 |
| p.M1582I | SKCM | 1 |
| p.E1474K | SKCM | 1 |
| p.Y1730C | BLCA | 1 |
| p.E105K | SKCM | 1 |
| p.R94K | COAD | 1 |
| p.T1803A | LUAD | 1 |
| p.W500* | SARC | 1 |
| p.W1459* | SKCM | 1 |
| p.G784E | SKCM | 1 |
| p.N92T | STAD | 1 |
| p.T842K | PRAD | 1 |
| p.T1443K | LUAD | 1 |
| p.P1194S | SKCM | 1 |
| p.E509K | SKCM | 1 |
| p.R2188W | SKCM | 1 |
| p.Y1733N | LUAD | 1 |
| p.N1641H | READ | 1 |
| p.V357D | LUAD | 1 |
| p.T1441N | STAD | 1 |
| p.A781T | UCEC | 1 |
| p.L2098M | THYM | 1 |
| p.E1832D | UCEC | 1 |
| p.R633* | GBM | 1 |
| p.G784R | SKCM | 1 |
| p.E58K | SKCM | 1 |
| p.P467S | LUSC | 1 |
| p.P1174L | SKCM | 1 |
| p.Y1061F | STAD | 1 |
| p.R1535H | UCEC | 1 |
| p.V800I | STAD | 1 |
| p.S1310F | SKCM | 1 |
| p.N1095T | SKCM | 1 |
| p.G115D | PAAD | 1 |
| p.G152S | SKCM | 1 |
| p.S916F | SKCM | 1 |
| p.L1344V | BLCA | 1 |
| p.L1408F | SKCM | 1 |
| p.S88P | STAD | 1 |
| p.D1308N | SKCM | 1 |
| p.S1798N | PAAD | 1 |
| p.G1145E | SKCM | 1 |
| p.L665M | UCEC | 1 |
| p.G533E | ESCA | 1 |
| p.G1844A | COAD | 1 |
| p.S787F | SKCM | 1 |
| p.F1822C | SKCM | 1 |
| p.R1566C | SKCM | 1 |
| p.E1005D | SKCM | 1 |
| p.E1120G | HNSC | 1 |
| p.G1377E | SKCM | 1 |
| p.E1974Q | STAD | 1 |
| p.R80L | LUAD | 1 |
| p.S1058X | THYM | 1 |
| p.E1444D | LUAD | 1 |
| p.W93* | SKCM | 1 |
| p.D2156N | SKCM | 1 |
| p.E1924K | SKCM | 1 |
| p.P1573H | SKCM | 1 |
| p.G900R | BRCA | 1 |
| p.E385K | SKCM | 1 |
| p.Q48* | LUSC | 1 |
| p.K1486I | STAD | 1 |
| p.G1407D | SKCM | 1 |
| p.Q2191K | LUAD | 1 |
| p.D1063A | CESC | 1 |
| p.G77V | PAAD | 1 |
| p.H62D | BLCA | 1 |
| p.R1868* | BRCA | 1 |
| p.H775Y | SKCM | 1 |
| p.E206* | LUAD | 1 |
| p.Y1705* | THCA | 1 |
| p.M131I | SKCM | 1 |
| p.E390X | COAD | 1 |
| p.E1226D | LUAD | 1 |
| p.G64E | SKCM | 1 |
| p.K1929T | UCEC | 1 |
| p.I1630V | LUSC | 1 |
| p.D1496E | LUAD | 1 |
| p.L1830M | LUAD | 1 |
| p.P1826S | BLCA | 1 |
| p.A90E | BRCA | 1 |
| p.E1294Q | LIHC | 1 |
| p.N632K | KIRC | 1 |
| p.R660I | HNSC | 1 |
| p.T2084M | THYM | 1 |
| p.R290Q | SKCM | 1 |
| p.A90S | LUAD | 1 |
| p.G975A | BLCA | 1 |
| p.G1342V | LUAD | 1 |
| p.K1760N | UCEC | 1 |
| p.E663K | CESC | 1 |
| p.G225S | SKCM | 1 |
| p.K1503R | SKCM | 1 |
| p.K2186E | SKCM | 1 |
| p.Y441F | SKCM | 1 |
| p.D1140Y | STAD | 1 |
| p.L1224P | UCEC | 1 |
| p.R1100H | STAD | 1 |
| p.E1624K | SKCM | 1 |
| p.G1034W | SKCM | 1 |
| p.G847E | SKCM | 1 |
| p.G546E | SKCM | 1 |
| p.E1225K | SKCM | 1 |
| p.S1580Y | SKCM | 1 |
| p.R1661S | LUSC | 1 |
| p.R312S | LUAD | 1 |
| p.A1241E | LUAD | 1 |
| p.G1543E | SKCM | 1 |
| p.K253N | PRAD | 1 |
| p.E367K | STAD | 1 |
| p.S1772C | LUAD | 1 |
| p.R439X | LGG | 1 |
| p.L1089F | SKCM | 1 |
| p.K150Q | UCEC | 1 |
| p.R92* | SKCM | 1 |
| p.G539E | SKCM | 1 |
| p.S1686F | SKCM | 1 |
| p.R1541H | UCEC | 1 |
| p.E1423* | LUAD | 1 |
| p.K733N | LUAD | 1 |
| p.A1241S | LUAD | 1 |
| p.Q625X | LIHC | 1 |
| p.Y1150* | LUAD | 1 |
| p.S1095F | SKCM | 1 |
| p.A403D | LUAD | 1 |
| p.D1112Y | KIRP | 1 |
| p.Y1368* | LUAD | 1 |
| p.Q952* | HNSC | 1 |
| p.Q1994E | BLCA | 1 |
| p.H940N | LIHC | 1 |
| p.G2044E | SKCM | 1 |
| p.R1642X | SKCM | 1 |
| p.E156K | SARC | 1 |
| p.H544Y | BLCA | 1 |
| p.A1241E | PAAD | 1 |
| p.P1482A | LUAD | 1 |
| p.H128Q | LUAD | 1 |
| p.R747L | HNSC | 1 |
| p.D1158G | LGG | 1 |
| p.S277R | HNSC | 1 |
| p.E1160V | STAD | 1 |
| p.T304I | UCEC | 1 |
| p.G2125V | HNSC | 1 |
| p.R1800* | SKCM | 1 |
| p.G2068S | SKCM | 1 |
| p.S439F | SKCM | 1 |
| p.F1478L | LUAD | 1 |
| p.S204N | COAD | 1 |
| p.G259V | LUAD | 1 |
| p.R1046H | UCEC | 1 |
| p.R1347K | SKCM | 1 |
| p.P1037S | SKCM | 1 |
| p.G533V | PAAD | 1 |
| p.S1356T | LGG | 1 |
| p.V1931M | UCEC | 1 |
| p.S225L | LUAD | 1 |
| p.T226A | BRCA | 1 |
| p.Y1397X | THCA | 1 |
| p.D57N | COAD | 1 |
| p.G768E | SKCM | 1 |
| p.G460E | SKCM | 1 |
| p.R692H | LGG | 1 |
| p.Y1279F | STAD | 1 |
| p.H213R | HNSC | 1 |
| p.V1680E | LUAD | 1 |
| p.R194K | SKCM | 1 |
| p.D279G | STAD | 1 |
| p.G954R | SKCM | 1 |
| p.D97N | UCEC | 1 |
| p.S59R | HNSC | 1 |
| p.P1447L | SKCM | 1 |
| p.R92X | SKCM | 1 |
| p.A1325T | UCEC | 1 |
| p.V635L | HNSC | 1 |
| p.G477R | SKCM | 1 |
| p.S1658N | SKCM | 1 |
| p.E318K | SKCM | 1 |
| p.T1659N | STAD | 1 |
| p.G2114D | UCEC | 1 |
| p.Q944H | TGCT | 1 |
| p.P210T | THYM | 1 |
| p.V157A | LIHC | 1 |
| p.R747Q | UCEC | 1 |
| p.E801D | KIRP | 1 |
| p.R1868Q | SKCM | 1 |
| p.E206K | SKCM | 1 |
| p.S260C | LUAD | 1 |
| p.A185D | LUAD | 1 |
| p.P1663S | SKCM | 1 |
| p.D2146N | BLCA | 1 |
| p.G282E | SKCM | 1 |
| p.P1502S | SKCM | 1 |
| p.D1406E | LUAD | 1 |
| p.D1418N | BLCA | 1 |
| p.E167K | SKCM | 1 |
| p.P262S | SKCM | 1 |
| p.M1582T | LUAD | 1 |
| p.V990A | STAD | 1 |
| p.N1509K | BLCA | 1 |
| p.E502K | SKCM | 1 |
| p.K1704I | STAD | 1 |
| p.P1755L | SKCM | 1 |
| p.N187K | KIRP | 1 |
| p.R1663Q | GBM | 1 |
| p.Q1448* | SKCM | 1 |
| p.G315V | PAAD | 1 |
| p.D596H | LIHC | 1 |
| p.E1533K | SKCM | 1 |
| p.E2093K | SKCM | 1 |
| p.E1512Q | HNSC | 1 |
| p.D1750Y | LUSC | 1 |
| p.D97N | SKCM | 1 |
| p.D435N | HNSC | 1 |
| p.P1414S | PRAD | 1 |
| p.G1850S | STAD | 1 |
| p.P210H | LUAD | 1 |
| p.R1895Q | SKCM | 1 |
| p.P1391T | BRCA | 1 |
| p.S718Y | THYM | 1 |
| p.P1482H | LUAD | 1 |
| p.S255C | SARC | 1 |
| p.G481D | UCEC | 1 |
| p.S763F | SKCM | 1 |
| p.W1412R | HNSC | 1 |
| p.A155E | KIRC | 1 |
| p.S609C | STAD | 1 |
| p.P1668S | SKCM | 1 |
| p.N1763S | UCS | 1 |
| p.R1933Q | SKCM | 1 |
| p.L673V | BLCA | 1 |
| p.S1356R | UCEC | 1 |
| p.E99K | READ | 1 |
| p.Y2171D | LUAD | 1 |
| p.K1811R | SKCM | 1 |
| p.R160S | SKCM | 1 |
| p.V2055I | THYM | 1 |
| p.R570Q | UCEC | 1 |
| p.T1585A | LUAD | 1 |
| p.G1342W | SKCM | 1 |
| p.D1714N | LUAD | 1 |
| p.G443S | SKCM | 1 |
| p.S519N | READ | 1 |
| p.L542M | LIHC | 1 |
| p.N1455D | COAD | 1 |
| p.R1895W | SKCM | 1 |
| p.D1466G | LGG | 1 |
| p.N1252Y | SKCM | 1 |
| p.Y1190C | STAD | 1 |
| p.L2048M | LUAD | 1 |
| p.L853P | UCEC | 1 |
| p.T890M | UCEC | 1 |
| p.D976H | LUAD | 1 |
| p.K37R | LUSC | 1 |
| p.S1652R | LUAD | 1 |
| p.R1874C | SKCM | 1 |
| p.R1560Q | SKCM | 1 |
| p.Y972C | STAD | 1 |
| p.S258F | SKCM | 1 |
| p.S1898F | STAD | 1 |
| p.W1151X | SKCM | 1 |
| p.S1164I | UCEC | 1 |
| p.V1963D | LUSC | 1 |
| p.T30N | LUAD | 1 |
| p.E236D | STAD | 1 |
| p.V990L | LUSC | 1 |
| p.K1637E | HNSC | 1 |
| p.E385K | BRCA | 1 |
| p.Y749F | SKCM | 1 |
| p.D922Y | STAD | 1 |
| p.L1126V | BLCA | 1 |
| p.G1453E | SKCM | 1 |
| p.Q904* | SKCM | 1 |
| p.E1987Q | LUSC | 1 |
| p.V1841L | HNSC | 1 |
| p.S1738Y | CESC | 1 |
| p.E1753* | BRCA | 1 |
| p.L455F | COAD | 1 |
| p.D653N | HNSC | 1 |
| p.R449Q | SKCM | 1 |
| p.P2204S | SKCM | 1 |
| p.M237I | SKCM | 1 |
| p.L1578F | SKCM | 1 |
| p.R1880W | COAD | 1 |
| p.R1322H | SARC | 1 |
| p.S359I | PAAD | 1 |
| p.E1178Q | BLCA | 1 |
| p.T248N | LUAD | 1 |
| p.P1608S | BLCA | 1 |
| p.R678H | UCEC | 1 |
| p.E448K | BLCA | 1 |
| p.L285F | LUAD | 1 |
| p.E1851K | HNSC | 1 |
| p.G315E | SKCM | 1 |
| p.R1210Q | SKCM | 1 |
| p.K59X | SKCM | 1 |
| p.S1315F | SKCM | 1 |
| p.T227S | LIHC | 1 |
| p.D1341H | CESC | 1 |
| p.R747* | LGG | 1 |
| p.R530T | OV | 1 |
| p.R374S | GBM | 1 |
| p.W54R | LUAD | 1 |
| p.E519K | PAAD | 1 |
| p.D1420H | LIHC | 1 |
| p.W130* | SKCM | 1 |
| p.V1208A | STAD | 1 |
| p.V2119M | LUAD | 1 |
| p.C1959Y | STAD | 1 |
| p.K1551T | PAAD | 1 |
| Top |
| TissGeneCNV for PTPRB |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for PTPRB |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChimerDB 2.0 | NA | NA | PTPRB-LEKR1 | chr12:69212142 | chr3:158193203 | |
| Chimerdb3.0 | ChiTaRs | NA | DA854786 | ZZZ3-PTPRB | chr1:78079992 | chr12:70964986 | |
| Chimerdb3.0 | FusionScan | LGG | TCGA-CS-4941-01A | CPSF6-PTPRB | Out-of-Frame | chr12:69633486 | chr12:70975082 |
| Chimerdb3.0 | TopHat-Fusion | LGG | TCGA-CS-4941-01A | CPSF6-PTPRB | Out-of-Frame | chr12:69633485 | chr12:70975081 |
| TCGAfusionPortal | PRADA | LGG | TCGA-CS-4941-01A | CPSF6-PTPRB | Out-of-frame | Chr12:69633486 | Chr12:70975082 |
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| TissGeneNet for PTPRB |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| PTPRB, LCK, ERBB2, GRIN2B, CBL, TEK, CDH5, EGFR, MAPK3, PDGFRB, NTRK1, MET, CNTN1, CSK, GAB1, MAGI3, CDH2, CNTNAP1, GHR, LGALS1, F11R (tumor) | PTPRB, LCK, SUMO1, CBL, TEK, CDH5, EGFR, PDGFRB, INSR, PXN, NTRK1, MET, CNTN1, TEC, CSK, GAB1, PDPK1, MAGI3, CNTNAP1, GHR, F11R (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| PTPRB, LCK, WAS, SUMO1, CBL, TEK, CDH5, EGFR, MAPK3, PDGFRB, INSR, ALK, MET, CNTN1, TEC, GAB1, PDPK1, MAGI3, CNTNAP1, NRCAM, GHR (tumor) | PTPRB, LCK, SUMO1, GRIN2B, CBL, TEK, CDH5, EGFR, PDGFRB, NTRK1, ALK, MET, CNTN1, CSK, GAB1, PDPK1, MAGI3, CDH2, CNTNAP1, NRCAM, GHR (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| PTPRB, LCK, ERBB2, TEK, CDH5, EGFR, MAPK3, PDGFRB, INSR, PXN, NTRK1, ALK, TEC, CSK, MAGI3, CDH2, CNTNAP1, NRCAM, GHR, LGALS1, F11R (tumor) | PTPRB, LCK, WAS, SUMO1, CBL, TEK, CDH5, EGFR, PDGFRB, INSR, NTRK1, ALK, CNTN1, GAB1, NSF, PDPK1, MAGI3, CDH2, CNTNAP1, NRCAM, GHR (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| PTPRB, LCK, SUMO1, GRIN2B, CBL, TEK, CDH5, EGFR, MAPK3, PDGFRB, INSR, NTRK1, CNTN1, CSK, GAB1, PDPK1, MAGI3, CNTNAP1, GHR, LGALS1, F11R (tumor) | PTPRB, LCK, WAS, ERBB2, CBL, TEK, CDH5, EGFR, MAPK3, PDGFRB, INSR, PXN, NTRK1, MET, CSK, GAB1, MAGI3, CDH2, NRCAM, LGALS1, F11R (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| PTPRB, LCK, ERBB2, SUMO1, CBL, TEK, CDH5, MAPK3, PDGFRB, INSR, NTRK1, ALK, MET, CNTN1, NSF, PDPK1, CDH2, CNTNAP1, NRCAM, GHR, F11R (tumor) | PTPRB, WAS, CBL, TEK, CDH5, EGFR, MAPK3, PDGFRB, INSR, NTRK1, ALK, MET, CNTN1, CSK, GAB1, PDPK1, MAGI3, CDH2, GHR, LGALS1, F11R (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| PTPRB, LCK, ERBB2, SUMO1, TEK, CDH5, MAPK3, PDGFRB, INSR, NTRK1, ALK, MET, CNTN1, CSK, NSF, PDPK1, CDH2, CNTNAP1, GHR, LGALS1, F11R (tumor) | PTPRB, LCK, WAS, ERBB2, GRIN2B, CBL, TEK, CDH5, EGFR, PDGFRB, INSR, PXN, NTRK1, MET, CNTN1, CSK, PDPK1, MAGI3, CDH2, CNTNAP1, GHR (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| PTPRB, LCK, WAS, SUMO1, CBL, TEK, CDH5, EGFR, MAPK3, PDGFRB, PXN, ALK, MET, CNTN1, CSK, GAB1, NSF, PDPK1, MAGI3, NRCAM, GHR (tumor) | PTPRB, LCK, WAS, ERBB2, SUMO1, CBL, TEK, CDH5, EGFR, MAPK3, PDGFRB, INSR, NTRK1, CNTN1, CSK, GAB1, PDPK1, MAGI3, CNTNAP1, GHR, F11R (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| PTPRB, SUMO1, CBL, TEK, CDH5, EGFR, MAPK3, PDGFRB, INSR, PXN, MET, CNTN1, CSK, GAB1, NSF, PDPK1, MAGI3, CNTNAP1, NRCAM, GHR, LGALS1 (tumor) | PTPRB, LCK, WAS, SUMO1, CBL, TEK, CDH5, PDGFRB, INSR, NTRK1, ALK, MET, CNTN1, GAB1, PDPK1, MAGI3, CDH2, CNTNAP1, NRCAM, GHR, LGALS1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| PTPRB, WAS, CBL, TEK, CDH5, EGFR, MAPK3, PDGFRB, PXN, NTRK1, ALK, CNTN1, CSK, GAB1, NSF, MAGI3, CDH2, NRCAM, GHR, LGALS1, F11R (tumor) | PTPRB, LCK, WAS, SUMO1, CBL, TEK, CDH5, PDGFRB, INSR, PXN, NTRK1, ALK, TEC, GAB1, PDPK1, MAGI3, CDH2, CNTNAP1, NRCAM, LGALS1, F11R (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| PTPRB, WAS, ERBB2, SUMO1, CBL, TEK, CDH5, EGFR, PDGFRB, INSR, NTRK1, MET, CNTN1, CSK, GAB1, NSF, PDPK1, CDH2, CNTNAP1, LGALS1, F11R (tumor) | PTPRB, WAS, SUMO1, CBL, TEK, CDH5, EGFR, MAPK3, PDGFRB, INSR, NTRK1, ALK, MET, CNTN1, CSK, GAB1, PDPK1, MAGI3, CDH2, CNTNAP1, LGALS1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| PTPRB, WAS, ERBB2, GRIN2B, TEK, CDH5, PDGFRB, INSR, PXN, NTRK1, ALK, TEC, CSK, NSF, MAGI3, CDH2, CNTNAP1, NRCAM, GHR, LGALS1, F11R (tumor) | PTPRB, WAS, SUMO1, CBL, TEK, CDH5, EGFR, PDGFRB, INSR, NTRK1, ALK, CNTN1, CSK, GAB1, PDPK1, MAGI3, CDH2, CNTNAP1, NRCAM, GHR, LGALS1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| PTPRB, ERBB2, SUMO1, CBL, TEK, CDH5, EGFR, PDGFRB, INSR, PXN, MET, CNTN1, CSK, GAB1, PDPK1, MAGI3, CDH2, CNTNAP1, GHR, LGALS1, F11R (tumor) | PTPRB, LCK, WAS, ERBB2, CBL, TEK, CDH5, PDGFRB, INSR, PXN, MET, TEC, CSK, GAB1, NSF, PDPK1, MAGI3, CDH2, GHR, LGALS1, F11R (normal) |
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| TissGeneProg for PTPRB |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for PTPRB |
| TissGeneDrug for PTPRB |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for PTPRB |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 2 | GAD |
| umls:C0018923 | Hemangiosarcoma | 2 | BeFree,CTD_human |
| umls:C0038580 | Substance Dependence | 1 | BeFree |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0236969 | Substance-Related Disorders | 1 | GAD |
| umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
| umls:C1510472 | Drug Dependence | 1 | BeFree |
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