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| TissGeneSummary for PTPRZ1 |
 Gene summary |
| Basic gene information | Gene symbol | PTPRZ1 |
| Gene name | protein tyrosine phosphatase, receptor-type, Z polypeptide 1 | |
| Synonyms | HPTPZ|HPTPzeta|PTP-ZETA|PTP18|PTPRZ|PTPZ|R-PTP-zeta-2|RPTPB|RPTPbeta|phosphacan | |
| Cytomap | UCSC genome browser: 7q31.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001206838.1, NM_001206839.1,NM_002851.2, | |
| Description | protein tyrosine phosphatase, receptor-type, zeta polypeptide 1protein-tyrosine phosphatase receptor type Z polypeptide 2receptor-type tyrosine phosphatase beta/zetareceptor-type tyrosine-protein phosphatase zeta | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 176891 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000106278 | ||
| HPRD : 01481 | ||
| Vega : OTTHUMG00000157057 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PTPRZ1 | |
| BioGPS: 5803 | ||
| Pathway | NCI Pathway Interaction Database: PTPRZ1 | |
| KEGG: PTPRZ1 | ||
| REACTOME: PTPRZ1 | ||
| Pathway Commons: PTPRZ1 | ||
| Context | iHOP: PTPRZ1 | |
| ligand binding site mutation search in PubMed: PTPRZ1 | ||
| UCL Cancer Institute: PTPRZ1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of PTPRZ1 | ||
| Description by TissGene annotations | Cancer gene Fused withOncogene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for PTPRZ1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | -0.841094587 | 3.244354536 | -4.085449123 | 4.90E-27 | 5.34E-26 |
| KIRP | -3.117140968 | -1.327815968 | -1.789325 | 4.91E-10 | 4.85E-09 |
| COAD | -2.53133568 | 1.303606628 | -3.834942308 | 9.75E-12 | 1.92E-10 |
| LUSC | 4.977084154 | 1.223839056 | 3.753245098 | 4.20E-10 | 1.49E-09 |
| STAD | 0.906427782 | 3.772768407 | -2.866340625 | 8.84E-07 | 1.48E-05 |
| KIRC | -3.308008329 | -1.171595829 | -2.1364125 | 1.56E-20 | 1.30E-19 |
| HNSC | 6.48610627 | 5.40998534 | 1.07612093 | 0.00304 | 0.008837209 |
| KICH | -2.880239218 | -1.515271218 | -1.364968 | 0.00156 | 0.003262087 |
| PRAD | 0.44897009 | 1.837258551 | -1.388288462 | 9.04E-05 | 0.000382961 |
| Top |
| TissGene-miRNA for PTPRZ1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for PTPRZ1 |
| TissGeneSNV for PTPRZ1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.D1426G | KIRC | 4 |
| p.E612K | COAD | 2 |
| p.K973T | STAD | 2 |
| p.S636L | SKCM | 2 |
| p.S1254C | BLCA | 2 |
| p.S1175Y | UCEC | 2 |
| p.L2159V | STAD | 1 |
| p.P970T | LUAD | 1 |
| p.S1512Y | THYM | 1 |
| p.R447I | THYM | 1 |
| p.L2001M | LIHC | 1 |
| p.T846I | THCA | 1 |
| p.E287* | LUAD | 1 |
| p.M1456K | LUSC | 1 |
| p.E1821D | ESCA | 1 |
| p.M2219V | STAD | 1 |
| p.S1389* | BLCA | 1 |
| p.T941S | SKCM | 1 |
| p.Q2088K | LUAD | 1 |
| p.A195V | UCEC | 1 |
| p.S2063L | SKCM | 1 |
| p.P926A | LUAD | 1 |
| p.A1083V | STAD | 1 |
| p.S548Y | OV | 1 |
| p.E1463K | PRAD | 1 |
| p.E323D | UCEC | 1 |
| p.C1665* | UCEC | 1 |
| p.P2122L | SKCM | 1 |
| p.V495I | KIRC | 1 |
| p.E612K | BLCA | 1 |
| p.E1026* | UCEC | 1 |
| p.P315L | SKCM | 1 |
| p.E201K | READ | 1 |
| p.F1123C | UCEC | 1 |
| p.D2178N | OV | 1 |
| p.S542F | SKCM | 1 |
| p.E1980G | LIHC | 1 |
| p.E859D | READ | 1 |
| p.A1583S | LUAD | 1 |
| p.R469H | STAD | 1 |
| p.L1420I | COAD | 1 |
| p.F1246L | READ | 1 |
| p.P1506L | STAD | 1 |
| p.A885V | LGG | 1 |
| p.Q387K | OV | 1 |
| p.G667E | HNSC | 1 |
| p.N1874T | STAD | 1 |
| p.F363V | THCA | 1 |
| p.H2006D | HNSC | 1 |
| p.S576N | SKCM | 1 |
| p.E1479D | STAD | 1 |
| p.S921Y | UCEC | 1 |
| p.P1262S | SKCM | 1 |
| p.E1171D | READ | 1 |
| p.H1440R | COAD | 1 |
| p.E532D | STAD | 1 |
| p.L1655V | LUAD | 1 |
| p.P1200L | BLCA | 1 |
| p.V1830M | STAD | 1 |
| p.G493C | LUAD | 1 |
| p.S1093F | BLCA | 1 |
| p.D914N | LUAD | 1 |
| p.N1746K | OV | 1 |
| p.S1478F | LUSC | 1 |
| p.M1235V | LUAD | 1 |
| p.M965I | COAD | 1 |
| p.D109Y | LUSC | 1 |
| p.E1479D | READ | 1 |
| p.Q1951R | LUAD | 1 |
| p.I1783V | HNSC | 1 |
| p.F121Y | LUAD | 1 |
| p.A2267S | ESCA | 1 |
| p.L851S | COAD | 1 |
| p.K1832N | LUAD | 1 |
| p.Y300X | ACC | 1 |
| p.A1698V | OV | 1 |
| p.D1789Y | LUAD | 1 |
| p.Q2088* | LGG | 1 |
| p.E1634K | DLBC | 1 |
| p.D1009Y | ESCA | 1 |
| p.L1016F | SKCM | 1 |
| p.D2268Y | KICH | 1 |
| p.Y1982* | LUSC | 1 |
| p.T1741R | LUAD | 1 |
| p.T740K | LUAD | 1 |
| p.S1846I | STAD | 1 |
| p.E1479D | UCEC | 1 |
| p.D515N | SKCM | 1 |
| p.L2204H | BRCA | 1 |
| p.D370H | GBM | 1 |
| p.G84V | STAD | 1 |
| p.T575A | UCEC | 1 |
| p.D1749E | LUSC | 1 |
| p.V1929L | LUAD | 1 |
| p.T1010K | LUAD | 1 |
| p.S298F | SKCM | 1 |
| p.D633Y | COAD | 1 |
| p.R1835I | STAD | 1 |
| p.E333K | SKCM | 1 |
| p.V1316F | SKCM | 1 |
| p.D1557N | UCEC | 1 |
| p.D1844V | LUAD | 1 |
| p.S1247L | UCEC | 1 |
| p.P445S | SKCM | 1 |
| p.P751A | HNSC | 1 |
| p.D866Y | OV | 1 |
| p.D411N | SKCM | 1 |
| p.R336P | LUAD | 1 |
| p.F1099L | UCEC | 1 |
| p.V803I | BLCA | 1 |
| p.K1836I | KIRP | 1 |
| p.R833C | BRCA | 1 |
| p.P1886R | LUAD | 1 |
| p.D1430G | STAD | 1 |
| p.S1492L | LUSC | 1 |
| p.K1275T | UCEC | 1 |
| p.E1979K | BLCA | 1 |
| p.V1708A | LGG | 1 |
| p.P549A | BRCA | 1 |
| p.P1142H | CESC | 1 |
| p.N602D | STAD | 1 |
| p.S180P | SARC | 1 |
| p.Y2008H | DLBC | 1 |
| p.P2194L | STAD | 1 |
| p.V1644M | ESCA | 1 |
| p.D2123N | PAAD | 1 |
| p.Q1951K | LUAD | 1 |
| p.L1140F | SKCM | 1 |
| p.Q12E | BLCA | 1 |
| p.G1043E | SKCM | 1 |
| p.Y944C | LUAD | 1 |
| p.G1777C | LUAD | 1 |
| p.S1386F | SKCM | 1 |
| p.G1049E | BLCA | 1 |
| p.K1635T | SKCM | 1 |
| p.G667* | OV | 1 |
| p.P818H | THCA | 1 |
| p.E571D | UCEC | 1 |
| p.S1091F | SKCM | 1 |
| p.P1679R | OV | 1 |
| p.E640Q | KIRP | 1 |
| p.D1011Y | LUAD | 1 |
| p.D402N | UCEC | 1 |
| p.S62Y | CESC | 1 |
| p.S517F | SKCM | 1 |
| p.G115E | SKCM | 1 |
| p.S1279F | SKCM | 1 |
| p.A947S | LUAD | 1 |
| p.H1251N | UCEC | 1 |
| p.E625X | ESCA | 1 |
| p.H968Q | LUAD | 1 |
| p.S1478T | SKCM | 1 |
| p.Q259K | LUAD | 1 |
| p.I969L | BLCA | 1 |
| p.N444D | STAD | 1 |
| p.S877Y | UCEC | 1 |
| p.Q1228X | LGG | 1 |
| p.E1809K | BLCA | 1 |
| p.S636T | KIRC | 1 |
| p.P1212S | SKCM | 1 |
| p.C264S | LUAD | 1 |
| p.D2076E | LUAD | 1 |
| p.S576G | LGG | 1 |
| p.S224* | HNSC | 1 |
| p.F1312L | LIHC | 1 |
| p.S974Y | UCEC | 1 |
| p.S1549N | LGG | 1 |
| p.C1651F | LUAD | 1 |
| p.A1571T | KIRC | 1 |
| p.T236K | SARC | 1 |
| p.S762F | SKCM | 1 |
| p.R481L | UCEC | 1 |
| p.G1225D | READ | 1 |
| p.E615G | SKCM | 1 |
| p.R2286S | BLCA | 1 |
| p.V1915E | LUAD | 1 |
| p.P1200L | SKCM | 1 |
| p.F263V | UCEC | 1 |
| p.G367D | UCEC | 1 |
| p.Y274X | SKCM | 1 |
| p.S1683Y | KIRP | 1 |
| p.I617V | KIRC | 1 |
| p.N45K | ACC | 1 |
| p.G2124D | UCEC | 1 |
| p.S548Y | ESCA | 1 |
| p.H2004Y | STAD | 1 |
| p.L813V | THCA | 1 |
| p.R205H | COAD | 1 |
| p.G1777D | UCEC | 1 |
| p.D1408Y | KICH | 1 |
| p.S137F | UCEC | 1 |
| p.E1726K | SKCM | 1 |
| p.G923W | LUAD | 1 |
| p.G638D | LUAD | 1 |
| p.S1549R | LIHC | 1 |
| p.S559F | SKCM | 1 |
| p.I95L | STAD | 1 |
| p.A2267P | LUAD | 1 |
| p.I617M | COAD | 1 |
| p.E68K | LUAD | 1 |
| p.S1494I | KIRP | 1 |
| p.E1848Q | HNSC | 1 |
| p.Y1787S | LUAD | 1 |
| p.D1409Y | HNSC | 1 |
| p.K1664I | KIRC | 1 |
| p.I66M | UCEC | 1 |
| p.T241A | COAD | 1 |
| p.A390S | STAD | 1 |
| p.R286X | READ | 1 |
| p.N1464D | UCEC | 1 |
| p.R1868M | STAD | 1 |
| p.E68K | BLCA | 1 |
| p.D1838N | LIHC | 1 |
| p.S449R | STAD | 1 |
| p.V1063G | DLBC | 1 |
| p.V1214G | STAD | 1 |
| p.N1289D | STAD | 1 |
| p.W1816C | LUAD | 1 |
| p.Y1782H | LGG | 1 |
| p.I255M | HNSC | 1 |
| p.S113C | BRCA | 1 |
| p.P1305H | UCEC | 1 |
| p.H1105D | BLCA | 1 |
| p.D1192G | COAD | 1 |
| p.S62Y | STAD | 1 |
| p.L220V | LUAD | 1 |
| p.H529D | KIRC | 1 |
| p.I1133M | LGG | 1 |
| p.Q1771P | UCEC | 1 |
| p.S813P | UCS | 1 |
| p.L379V | KIRC | 1 |
| p.E2073K | UCEC | 1 |
| p.S237Y | COAD | 1 |
| p.D903Y | COAD | 1 |
| p.S894N | LUAD | 1 |
| p.E649K | SKCM | 1 |
| p.G1626V | BRCA | 1 |
| p.Q1667* | SARC | 1 |
| p.P496L | SARC | 1 |
| p.D1190N | LUAD | 1 |
| p.D804H | COAD | 1 |
| p.N754S | GBM | 1 |
| p.I343T | HNSC | 1 |
| p.S1676I | LUAD | 1 |
| p.T941I | SKCM | 1 |
| p.P2122S | SKCM | 1 |
| p.G1425D | STAD | 1 |
| p.S520Y | COAD | 1 |
| p.P549T | LUAD | 1 |
| p.A123T | SKCM | 1 |
| p.R833C | COAD | 1 |
| p.E333G | LIHC | 1 |
| p.S906P | LUAD | 1 |
| p.D1426G | COAD | 1 |
| p.P2218H | LUAD | 1 |
| p.S997F | LUAD | 1 |
| p.M382I | UCEC | 1 |
| p.N602K | LUAD | 1 |
| p.A929V | SKCM | 1 |
| p.S293F | SKCM | 1 |
| p.L1804V | SKCM | 1 |
| p.E615* | LGG | 1 |
| p.Y300* | ACC | 1 |
| p.E1267V | LIHC | 1 |
| p.A22V | BLCA | 1 |
| p.P1072H | LUAD | 1 |
| p.R1972I | COAD | 1 |
| p.R469C | UCEC | 1 |
| p.S1366Y | UCEC | 1 |
| p.S1219Y | UCEC | 1 |
| p.S2160C | BRCA | 1 |
| p.K1191N | READ | 1 |
| p.S1175Y | READ | 1 |
| p.E934D | LUAD | 1 |
| p.I2110T | LUAD | 1 |
| p.R1923C | THCA | 1 |
| p.P239H | LUAD | 1 |
| p.S1465N | LUSC | 1 |
| p.R833C | STAD | 1 |
| p.R111S | HNSC | 1 |
| p.Y1661C | LUAD | 1 |
| p.S2313Y | UCEC | 1 |
| p.N223H | UCEC | 1 |
| p.W2111X | STAD | 1 |
| p.L944V | SKCM | 1 |
| p.E438* | UCEC | 1 |
| p.F1852V | UCEC | 1 |
| p.P926H | SKCM | 1 |
| p.R1969L | LUAD | 1 |
| p.K2051N | LUAD | 1 |
| p.R1624C | SKCM | 1 |
| p.P496S | SKCM | 1 |
| p.P1262L | SKCM | 1 |
| p.R1972I | UCEC | 1 |
| p.H1764Y | SKCM | 1 |
| p.D804N | SKCM | 1 |
| p.I1993M | LGG | 1 |
| p.K2164E | SKCM | 1 |
| p.P2017L | LIHC | 1 |
| p.P1306Q | LUAD | 1 |
| p.L1168I | LIHC | 1 |
| p.K644N | UCEC | 1 |
| p.N1073Y | LUAD | 1 |
| p.W2111* | STAD | 1 |
| p.V1078A | UCEC | 1 |
| p.D852N | BLCA | 1 |
| p.F1649C | STAD | 1 |
| p.G1903E | SKCM | 1 |
| p.E2182D | DLBC | 1 |
| p.S1001F | HNSC | 1 |
| p.E1674* | LUSC | 1 |
| p.L375I | UCEC | 1 |
| p.C2188R | LGG | 1 |
| p.V2283E | LUAD | 1 |
| p.A511T | COAD | 1 |
| p.N1464H | READ | 1 |
| p.H129Y | SKCM | 1 |
| p.P773H | STAD | 1 |
| p.N324D | UCEC | 1 |
| p.P591H | LUAD | 1 |
| p.H1621R | BRCA | 1 |
| p.I95L | LUAD | 1 |
| p.P818L | UCEC | 1 |
| p.S637X | LIHC | 1 |
| p.S1032F | BRCA | 1 |
| p.G493V | THYM | 1 |
| p.L1437I | GBM | 1 |
| p.D620H | LUAD | 1 |
| p.E2210Q | THCA | 1 |
| p.E2024D | SKCM | 1 |
| p.S1153C | CESC | 1 |
| p.S826F | SKCM | 1 |
| p.E722G | SKCM | 1 |
| p.S482F | SKCM | 1 |
| p.I1092T | LIHC | 1 |
| p.G207W | HNSC | 1 |
| p.E34D | PAAD | 1 |
| p.E850K | READ | 1 |
| p.S2038T | OV | 1 |
| p.N2143D | ESCA | 1 |
| p.Y1943D | KIRP | 1 |
| p.S953F | LUAD | 1 |
| p.D411Y | LUAD | 1 |
| p.T593I | BLCA | 1 |
| p.L1631V | PAAD | 1 |
| p.K2051* | HNSC | 1 |
| p.P527S | ESCA | 1 |
| p.E1453K | READ | 1 |
| p.L1673V | THCA | 1 |
| p.I442F | LUAD | 1 |
| p.P2263S | STAD | 1 |
| p.Y274* | SKCM | 1 |
| p.I470L | OV | 1 |
| p.E641D | KIRC | 1 |
| p.S826F | READ | 1 |
| p.I565T | LUAD | 1 |
| p.K901I | UCEC | 1 |
| p.S626Y | UCEC | 1 |
| p.R833C | SKCM | 1 |
| p.K775T | SKCM | 1 |
| p.R447I | HNSC | 1 |
| p.S564C | LUAD | 1 |
| p.D370V | KIRC | 1 |
| p.D791V | COAD | 1 |
| p.E1061D | UCS | 1 |
| p.N105S | HNSC | 1 |
| p.S604F | LUSC | 1 |
| p.S1238F | SKCM | 1 |
| p.P1212L | BLCA | 1 |
| Top |
| TissGeneCNV for PTPRZ1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| Top |
| TissGeneFusions for PTPRZ1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | DA516298 | PTPRZ1-SND1 | chr7:121513614 | chr7:127714553 | |
| Chimerdb3.0 | ChiTaRs | NA | BG913369 | PTPRZ1-PTPRZ1 | chr7:121701252 | chr7:121701221 | |
| Chimerdb3.0 | ChiTaRs | NA | AA442546 | PTPRZ1-PIN1 | chr7:121538086 | chr19:9948823 | |
| Chimerdb3.0 | ChiTaRs | NA | AW149516 | PTPRZ1-PTPRZ1 | chr7:121652459 | chr7:121652442 | |
| Chimerdb3.0 | ChiTaRs | NA | BG958283 | PTPRZ1-HMCN1 | chr7:121598632 | chr1:185991008 | |
| Chimerdb3.0 | ChiTaRs | NA | BE765133 | ZNF708-PTPRZ1 | chr19:21506506 | chr7:121652002 | |
| Chimerdb3.0 | FusionScan | LGG | TCGA-HT-8111-01A | PTPRZ1-SND1 | In-Frame | chr7:121651363 | chr7:127630999 |
| Chimerdb3.0 | FusionScan | LGG | TCGA-DU-6407-02B | PTPRZ1-MET | CDS-5'UTR | chr7:121513611 | chr7:116339124 |
| Chimerdb3.0 | FusionScan | LGG | TCGA-DU-6407-02B | PTPRZ1-MET | Out-of-Frame | chr7:121513611 | chr7:116371721 |
| Chimerdb3.0 | TopHat-Fusion | LGG | TCGA-DU-6407-02B | PTPRZ1-MET | CDS-5'UTR | chr7:121513610 | chr7:116335803 |
| Chimerdb3.0 | TopHat-Fusion | LGG | TCGA-DU-6407-02B | PTPRZ1-MET | CDS-5'UTR | chr7:121513610 | chr7:116339124 |
| TCGAfusionPortal | PRADA | HNSC | TCGA-CV-5434-01A | PTPRZ1-TSPAN33 | In-frame | Chr7:121695141 | Chr7:128801520 |
| TCGAfusionPortal | PRADA | LGG | TCGA-DH-5144-01A | PTPRZ1-FYN | NA | Chr7:121684622 | Chr6:112062296 |
| TCGAfusionPortal | PRADA | LGG | TCGA-DU-7014-01A | PTPRZ1-FYN | NA | Chr7:121684622 | Chr6:112062296 |
| TCGAfusionPortal | PRADA | LGG | TCGA-HT-7860-01A | PTPRZ1-FYN | NA | Chr7:121684622 | Chr6:112062296 |
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| TissGeneNet for PTPRZ1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (tumor) | PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (normal) |
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| COAD (tumor) | COAD (normal) |
| PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (tumor) | PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (normal) |
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| HNSC (tumor) | HNSC (normal) |
| PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (tumor) | PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (normal) |
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| KICH (tumor) | KICH (normal) |
| PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (tumor) | PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (normal) |
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| KIRC (tumor) | KIRC (normal) |
| PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (tumor) | PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (normal) |
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| KIRP (tumor) | KIRP (normal) |
| PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (tumor) | PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (normal) |
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| LIHC (tumor) | LIHC (normal) |
| PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (tumor) | PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (normal) |
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| LUAD (tumor) | LUAD (normal) |
| PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (tumor) | PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (normal) |
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| LUSC (tumor) | LUSC (normal) |
| PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (tumor) | PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (normal) |
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| PRAD (tumor) | PRAD (normal) |
| PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (tumor) | PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (normal) |
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| STAD (tumor) | STAD (normal) |
| PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (tumor) | PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (normal) |
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| THCA (tumor) | THCA (normal) |
| PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (tumor) | PTPRZ1, HMGB1, LCK, WAS, PTN, ERBB2, CTNNB1, ITGAV, FYN, TNF, GIT1, ITGB3, PXN, ALK, CNTN1, TNR, CSK, ADD2, MDK (normal) |
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| TissGeneProg for PTPRZ1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for PTPRZ1 |
| TissGeneDrug for PTPRZ1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for PTPRZ1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0017636 | Glioblastoma | 5 | BeFree,LHGDN |
| umls:C0017638 | Glioma | 4 | BeFree |
| umls:C0036341 | Schizophrenia | 3 | BeFree,GAD |
| umls:C0004114 | Astrocytoma | 2 | BeFree |
| umls:C0004352 | Autistic Disorder | 2 | BeFree,GAD |
| umls:C0001973 | Alcoholic Intoxication, Chronic | 1 | GAD |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | RGD |
| umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0014556 | Epilepsy, Temporal Lobe | 1 | RGD |
| umls:C0026769 | Multiple Sclerosis | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0027765 | nervous system disorder | 1 | BeFree |
| umls:C0028945 | oligodendroglioma | 1 | LHGDN |
| umls:C0029463 | Osteosarcoma | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0032273 | Pneumoconiosis | 1 | CTD_human |
| umls:C0036572 | Seizures | 1 | RGD |
| umls:C0038220 | Status Epilepticus | 1 | RGD |
| umls:C0038356 | Stomach Neoplasms | 1 | LHGDN |
| umls:C0149925 | Small cell carcinoma of lung | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0206754 | Neuroendocrine Tumors | 1 | BeFree |
| umls:C0233794 | Memory impairment | 1 | BeFree |
| umls:C0268553 | Hyperlysinemias | 1 | BeFree |
| umls:C0476122 | ovarian serous tumor | 1 | BeFree |
| umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
| umls:C0740392 | Infarction, Middle Cerebral Artery | 1 | RGD |
| umls:C0752308 | Hypoxia-Ischemia, Brain | 1 | RGD |
| umls:C0919267 | ovarian neoplasm | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | LHGDN |
| umls:C1520166 | Xenograft Model | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C0079487 | Helicobacter Infections | 0 | CTD_human |
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