TissGeneSummary for PRODH2 |
Gene summary |
Basic gene information | Gene symbol | PRODH2 |
Gene name | proline dehydrogenase (oxidase) 2 | |
Synonyms | HSPOX1 | |
Cytomap | UCSC genome browser: 19q13.1 | |
Type of gene | protein-coding | |
RefGenes | NM_021232.1, | |
Description | kidney and liver proline oxidase 1probable proline dehydrogenase 2probable proline oxidase 2 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000250799 | ||
HPRD : 17911 | ||
Vega : OTTHUMG00000180688 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PRODH2 | |
BioGPS: 58510 | ||
Pathway | NCI Pathway Interaction Database: PRODH2 | |
KEGG: PRODH2 | ||
REACTOME: PRODH2 | ||
Pathway Commons: PRODH2 | ||
Context | iHOP: PRODH2 | |
ligand binding site mutation search in PubMed: PRODH2 | ||
UCL Cancer Institute: PRODH2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
Reference showing the relevant tissue of PRODH2 | ||
Description by TissGene annotations | Significant down-regulated DEG TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PRODH2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | 2.685448421 | 7.603529671 | -4.91808125 | 1.09E-07 | 6.52E-07 |
LIHC | 7.182101171 | 9.647361171 | -2.46526 | 5.04E-07 | 2.89E-06 |
KICH | -1.948216829 | 5.956507171 | -7.904724 | 1.49E-11 | 1.38E-10 |
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TissGene-miRNA for PRODH2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PRODH2 |
TissGeneSNV for PRODH2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.V169G | HNSC | 2 |
p.C44R | SKCM | 1 |
p.R525W | OV | 1 |
p.Q275K | COAD | 1 |
p.P322L | SKCM | 1 |
p.G395R | LUAD | 1 |
p.G53A | OV | 1 |
p.R500L | LUAD | 1 |
p.S14F | DLBC | 1 |
p.G220V | PAAD | 1 |
p.P338L | ESCA | 1 |
p.E265X | PAAD | 1 |
p.H368Y | LUAD | 1 |
p.P126S | COAD | 1 |
p.G257A | BLCA | 1 |
p.N276S | BRCA | 1 |
p.W95* | LAML | 1 |
p.P487A | SKCM | 1 |
p.G53C | LUAD | 1 |
p.Y383* | LUAD | 1 |
p.Q409H | LUAD | 1 |
p.E112K | UCEC | 1 |
p.P91S | SKCM | 1 |
p.L133M | LUSC | 1 |
p.N32H | COAD | 1 |
p.R369K | SKCM | 1 |
p.P256T | THYM | 1 |
p.M396I | SKCM | 1 |
p.G375V | UCS | 1 |
p.P193S | SKCM | 1 |
p.N207K | OV | 1 |
p.S2L | SKCM | 1 |
p.T238M | PAAD | 1 |
p.S86C | BRCA | 1 |
p.R219W | LUSC | 1 |
p.R79Q | CESC | 1 |
p.G342R | COAD | 1 |
p.R525Q | COAD | 1 |
p.G375R | SKCM | 1 |
p.L417M | SARC | 1 |
p.P3H | KIRC | 1 |
p.P322H | STAD | 1 |
p.E340D | SKCM | 1 |
p.V459A | LUAD | 1 |
p.A329T | SARC | 1 |
p.S155Y | KIRC | 1 |
p.P454L | SKCM | 1 |
p.A284D | UCEC | 1 |
p.H536Y | SKCM | 1 |
p.W335* | SARC | 1 |
p.E265* | PAAD | 1 |
p.R525W | STAD | 1 |
p.R146W | BLCA | 1 |
p.T24I | SKCM | 1 |
p.C44Y | COAD | 1 |
p.R532Q | SKCM | 1 |
p.M211I | LUSC | 1 |
p.S155F | ACC | 1 |
p.N276S | PRAD | 1 |
p.A137S | LUAD | 1 |
p.A186T | STAD | 1 |
p.L473P | LUAD | 1 |
p.R334L | UCEC | 1 |
p.A239V | LUAD | 1 |
p.S490F | SKCM | 1 |
p.V156I | UCEC | 1 |
p.G381S | BLCA | 1 |
p.N321S | SKCM | 1 |
p.H470Y | SKCM | 1 |
p.R424H | STAD | 1 |
p.V309M | PRAD | 1 |
p.T238M | STAD | 1 |
p.G94D | SKCM | 1 |
p.P535S | SKCM | 1 |
p.G55E | SKCM | 1 |
p.M467V | STAD | 1 |
p.A202E | ACC | 1 |
p.N207S | SKCM | 1 |
p.A367V | UCEC | 1 |
p.E265V | PAAD | 1 |
p.R513H | LIHC | 1 |
p.L78P | KIRC | 1 |
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TissGeneCNV for PRODH2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PRODH2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for PRODH2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PRODH2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PRODH2 |
TissGeneDrug for PRODH2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PRODH2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0020501 | Primary Hyperoxaluria | 1 | BeFree |
umls:C0036341 | Schizophrenia | 1 | BeFree |