 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for PZP |
 Gene summary |
| Basic gene information | Gene symbol | PZP |
| Gene name | pregnancy-zone protein | |
| Synonyms | CPAMD6 | |
| Cytomap | UCSC genome browser: 12p13-p12.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_002864.2, | |
| Description | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6pregnancy zone protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 176420 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000126838 | ||
| HPRD : 07178 | ||
| Vega : OTTHUMG00000154915 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PZP | |
| BioGPS: 5858 | ||
| Pathway | NCI Pathway Interaction Database: PZP | |
| KEGG: PZP | ||
| REACTOME: PZP | ||
| Pathway Commons: PZP | ||
| Context | iHOP: PZP | |
| ligand binding site mutation search in PubMed: PZP | ||
| UCL Cancer Institute: PZP | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of PZP | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for PZP |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | -0.789821742 | 2.900442964 | -3.690264706 | 9.74E-17 | 7.59E-16 |
| KICH | -1.57020535 | -0.22637335 | -1.343832 | 8.92E-07 | 3.37E-06 |
| LIHC | 0.58399065 | 7.55512065 | -6.97113 | 4.20E-20 | 2.59E-18 |
| BRCA | -1.598972929 | 0.069981457 | -1.668954386 | 3.16E-41 | 1.05E-39 |
| LUAD | 0.026905202 | 2.978275891 | -2.95137069 | 1.52E-11 | 1.02E-10 |
| BLCA | -1.578272929 | -0.461699245 | -1.116573684 | 0.00545 | 0.028122506 |
| Top |
| TissGene-miRNA for PZP |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for PZP |
| TissGeneSNV for PZP |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S449F | SKCM | 2 |
| p.R446C | SKCM | 2 |
| p.S1161F | SKCM | 2 |
| p.P627S | SKCM | 2 |
| p.R738Q | UCEC | 2 |
| p.R173X | STAD | 1 |
| p.R157Q | STAD | 1 |
| p.T469M | GBM | 1 |
| p.P765H | LUAD | 1 |
| p.R594C | UCEC | 1 |
| p.G326E | SKCM | 1 |
| p.L426V | KIRC | 1 |
| p.G930_splice | LUSC | 1 |
| p.P360H | LUAD | 1 |
| p.V502I | COAD | 1 |
| p.N989S | ESCA | 1 |
| p.E470G | LIHC | 1 |
| p.T1432M | MESO | 1 |
| p.E152K | CESC | 1 |
| p.D1299H | BLCA | 1 |
| p.N54Y | HNSC | 1 |
| p.R829Q | LUAD | 1 |
| p.I906V | STAD | 1 |
| p.I1443N | COAD | 1 |
| p.P360L | SKCM | 1 |
| p.E709K | SKCM | 1 |
| p.M925V | UCEC | 1 |
| p.E935Q | BLCA | 1 |
| p.V349M | READ | 1 |
| p.S690Y | UCEC | 1 |
| p.I339N | LIHC | 1 |
| p.R1059G | BLCA | 1 |
| p.R1191H | LGG | 1 |
| p.T819M | BLCA | 1 |
| p.R173Q | SKCM | 1 |
| p.G785S | SKCM | 1 |
| p.P1472L | SKCM | 1 |
| p.S383F | CESC | 1 |
| p.S1464Y | LUAD | 1 |
| p.S1474R | STAD | 1 |
| p.A607V | SKCM | 1 |
| p.T926A | LIHC | 1 |
| p.P627S | KIRC | 1 |
| p.P574L | SKCM | 1 |
| p.F1132L | UCEC | 1 |
| p.A1010V | LUAD | 1 |
| p.Q398H | PRAD | 1 |
| p.E948X | COAD | 1 |
| p.E167A | READ | 1 |
| p.E68D | KIRP | 1 |
| p.I960V | LUSC | 1 |
| p.E546X | COAD | 1 |
| p.V1284I | READ | 1 |
| p.V412I | SKCM | 1 |
| p.D1344N | SKCM | 1 |
| p.S729R | STAD | 1 |
| p.S1434R | STAD | 1 |
| p.S383P | BLCA | 1 |
| p.L821I | UCEC | 1 |
| p.E735* | PRAD | 1 |
| p.R173* | STAD | 1 |
| p.S1108Y | HNSC | 1 |
| p.T310M | STAD | 1 |
| p.D1447N | READ | 1 |
| p.D1184_splice | LUSC | 1 |
| p.P975L | SKCM | 1 |
| p.V1286I | COAD | 1 |
| p.V1284F | LUAD | 1 |
| p.E1406A | SKCM | 1 |
| p.C978Y | COAD | 1 |
| p.N970T | UCEC | 1 |
| p.E1143G | HNSC | 1 |
| p.P765T | LUAD | 1 |
| p.A100T | PCPG | 1 |
| p.R480K | SKCM | 1 |
| p.E1463D | COAD | 1 |
| p.Q1080H | LUAD | 1 |
| p.G499R | SKCM | 1 |
| p.W1075L | STAD | 1 |
| p.A175S | STAD | 1 |
| p.T89N | CHOL | 1 |
| p.L50M | THYM | 1 |
| p.G1099E | SKCM | 1 |
| p.G545E | UCEC | 1 |
| p.S791P | LUAD | 1 |
| p.A931D | LUAD | 1 |
| p.G670R | SKCM | 1 |
| p.L1093P | LUSC | 1 |
| p.P11S | SKCM | 1 |
| p.E980X | COAD | 1 |
| p.T736A | LIHC | 1 |
| p.V1199L | STAD | 1 |
| p.G311R | HNSC | 1 |
| p.S431X | STAD | 1 |
| p.S1436F | SKCM | 1 |
| p.E635K | LUAD | 1 |
| p.R710K | SKCM | 1 |
| p.A1109T | READ | 1 |
| p.S686L | SKCM | 1 |
| p.K1196N | LUAD | 1 |
| p.A521D | ACC | 1 |
| p.S409C | LUAD | 1 |
| p.F101L | LUAD | 1 |
| p.P1450A | LUAD | 1 |
| p.E849K | CESC | 1 |
| p.E606K | UCEC | 1 |
| p.E898D | KIRC | 1 |
| p.F145L | ESCA | 1 |
| p.S1434G | ESCA | 1 |
| p.G140E | THCA | 1 |
| p.T89I | OV | 1 |
| p.N1185T | READ | 1 |
| p.A1067E | OV | 1 |
| p.R1037* | LUAD | 1 |
| p.V894A | SKCM | 1 |
| p.E1313Q | BLCA | 1 |
| p.D622N | SKCM | 1 |
| p.W1138* | SKCM | 1 |
| p.H301R | LIHC | 1 |
| p.Q1001H | READ | 1 |
| p.C777F | BLCA | 1 |
| p.S656* | CESC | 1 |
| p.N616T | UCEC | 1 |
| p.E324* | BLCA | 1 |
| p.L120M | UCEC | 1 |
| p.E555G | LIHC | 1 |
| p.A1451S | STAD | 1 |
| p.R418W | READ | 1 |
| p.P360L | LUAD | 1 |
| p.R594C | SKCM | 1 |
| p.V502I | STAD | 1 |
| p.T1235S | HNSC | 1 |
| p.P235Q | ACC | 1 |
| p.S1410C | HNSC | 1 |
| p.R829L | HNSC | 1 |
| p.E64K | LUAD | 1 |
| p.K1025R | SARC | 1 |
| p.E1190D | BRCA | 1 |
| p.E546K | UCEC | 1 |
| p.S1216F | SKCM | 1 |
| p.Q233E | BLCA | 1 |
| p.A1221T | SARC | 1 |
| p.G200D | SKCM | 1 |
| p.S87F | SKCM | 1 |
| p.L778M | PRAD | 1 |
| p.E167Q | UCEC | 1 |
| p.A534E | LUAD | 1 |
| p.F380L | READ | 1 |
| p.T469M | LGG | 1 |
| p.E1036G | SARC | 1 |
| p.A78V | LUAD | 1 |
| p.S431* | STAD | 1 |
| p.I247R | THCA | 1 |
| p.R738* | STAD | 1 |
| p.E748V | READ | 1 |
| p.G811R | SKCM | 1 |
| p.W1138X | SKCM | 1 |
| p.F876L | UCEC | 1 |
| p.R155C | SKCM | 1 |
| p.S1436F | BLCA | 1 |
| p.A474T | STAD | 1 |
| p.A320S | LUSC | 1 |
| p.T1432M | COAD | 1 |
| p.L1223I | HNSC | 1 |
| p.A184S | LUAD | 1 |
| p.I93M | OV | 1 |
| p.R1326I | COAD | 1 |
| p.L290I | UCEC | 1 |
| p.R738Q | STAD | 1 |
| p.G761R | SKCM | 1 |
| p.D1457N | SKCM | 1 |
| p.R901K | SKCM | 1 |
| p.L1330F | SKCM | 1 |
| p.S1345Y | LUSC | 1 |
| p.G358V | COAD | 1 |
| p.S194L | BLCA | 1 |
| p.E512D | LUAD | 1 |
| p.D1359H | KIRC | 1 |
| p.S686* | BLCA | 1 |
| p.A1130T | COAD | 1 |
| p.V1150A | STAD | 1 |
| p.P897L | SKCM | 1 |
| p.S787Y | BRCA | 1 |
| p.Q1258H | BRCA | 1 |
| p.P587L | SKCM | 1 |
| p.S409R | LUSC | 1 |
| p.K1153E | BLCA | 1 |
| p.G46S | LUAD | 1 |
| p.E1211K | CESC | 1 |
| p.A78V | HNSC | 1 |
| p.R155H | READ | 1 |
| p.R171K | SKCM | 1 |
| p.P1472S | SKCM | 1 |
| p.I382V | UCEC | 1 |
| p.A1237E | LUSC | 1 |
| p.L120M | CESC | 1 |
| p.C777S | BRCA | 1 |
| p.V708E | LUSC | 1 |
| p.S684L | SKCM | 1 |
| p.K45X | LIHC | 1 |
| p.K920T | STAD | 1 |
| p.T744A | LIHC | 1 |
| p.G761E | SKCM | 1 |
| p.P1397L | SKCM | 1 |
| p.A387T | COAD | 1 |
| p.Q1441K | LUAD | 1 |
| p.R171T | BLCA | 1 |
| p.S1434R | ESCA | 1 |
| p.R157Q | PAAD | 1 |
| p.R1413Q | HNSC | 1 |
| p.D597E | STAD | 1 |
| p.R1413Q | LGG | 1 |
| p.E743D | READ | 1 |
| p.G545V | THYM | 1 |
| p.D4N | SKCM | 1 |
| p.P1227Q | LUAD | 1 |
| p.S923I | KICH | 1 |
| p.K134T | READ | 1 |
| p.P1397S | LUSC | 1 |
| p.I906M | BLCA | 1 |
| p.R680Q | CESC | 1 |
| p.L939F | BLCA | 1 |
| Top |
| TissGeneCNV for PZP |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for PZP |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-E2-A14R-01A | TOP1-PZP | In-Frame | chr20:39690130 | chr12:9356547 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-E2-A14R-01A | TOP1-PZP | In-frame | Chr20:39690130 | Chr12:9356547 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-E2-A14R-01A | PZP-CPNE4 | In-frame | Chr12:9333579 | Chr3:131442469 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-53-A4EZ-01A | C16orf61-PZP | 5UTR-CDS | Chr16:81040339 | Chr12:9312621 |
| Top |
| TissGeneNet for PZP |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (tumor) | PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (normal) |
 |  |
| COAD (tumor) | COAD (normal) |
| PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (tumor) | PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (tumor) | PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (tumor) | PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (tumor) | PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (tumor) | PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (tumor) | PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (tumor) | PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (tumor) | PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (tumor) | PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (tumor) | PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (tumor) | PZP, HNF4A, MMP2, TGFB1, HNF1A, CPB2, KLK3, MMP9, TGFB2 (normal) |
 |  |
| Top |
| TissGeneProg for PZP |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for PZP |
| TissGeneDrug for PZP |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for PZP |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0002395 | Alzheimer's Disease | 1 | GAD |
| umls:C0015695 | Fatty Liver | 1 | GAD |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0400966 | Non-alcoholic Fatty Liver Disease | 1 | GAD |
| umls:C0860207 | Drug-Induced Liver Injury | 1 | CTD_human |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |