TissGeneSummary for IL22RA1 |
Gene summary |
Basic gene information | Gene symbol | IL22RA1 |
Gene name | interleukin 22 receptor, alpha 1 | |
Synonyms | CRF2-9|IL22R|IL22R1 | |
Cytomap | UCSC genome browser: 1p36.11 | |
Type of gene | protein-coding | |
RefGenes | NM_021258.3, | |
Description | IL-22 receptor subunit alpha-1IL-22R-alpha-1IL-22RA1cytokine receptor class-II member 9cytokine receptor family 2 member 9interleukin-22 receptor subunit alpha-1zcytoR11 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605457 | |
HGNC : HGNC | ||
Ensembl : ENSG00000142677 | ||
HPRD : 16108 | ||
Vega : OTTHUMG00000003041 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_IL22RA1 | |
BioGPS: 58985 | ||
Pathway | NCI Pathway Interaction Database: IL22RA1 | |
KEGG: IL22RA1 | ||
REACTOME: IL22RA1 | ||
Pathway Commons: IL22RA1 | ||
Context | iHOP: IL22RA1 | |
ligand binding site mutation search in PubMed: IL22RA1 | ||
UCL Cancer Institute: IL22RA1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ColonPancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COADPAAD | |
Reference showing the relevant tissue of IL22RA1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for IL22RA1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 0.786779758 | -0.752681353 | 1.539461111 | 3.03E-09 | 9.69E-09 |
BRCA | -2.500138517 | -0.800544657 | -1.69959386 | 2.26E-20 | 1.66E-19 |
LUSC | 1.227996262 | -1.020231189 | 2.248227451 | 2.09E-16 | 1.56E-15 |
KICH | -5.262697464 | -1.185441464 | -4.077256 | 3.50E-17 | 1.40E-15 |
PRAD | -2.322127079 | -1.223419387 | -1.098707692 | 1.63E-06 | 1.11E-05 |
BLCA | 1.010124641 | -2.146906938 | 3.157031579 | 4.51E-05 | 0.000590014 |
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TissGene-miRNA for IL22RA1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for IL22RA1 |
TissGeneSNV for IL22RA1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P375S | SKCM | 2 |
p.T40M | BRCA | 1 |
p.E323K | SKCM | 1 |
p.S510F | SKCM | 1 |
p.R276C | UCEC | 1 |
p.M1T | COAD | 1 |
p.L116V | LUAD | 1 |
p.R153P | LUAD | 1 |
p.D477N | BLCA | 1 |
p.A394D | SARC | 1 |
p.A355T | ESCA | 1 |
p.R63K | SKCM | 1 |
p.M202I | SKCM | 1 |
p.T557I | UCEC | 1 |
p.W41* | LUAD | 1 |
p.P337L | SKCM | 1 |
p.R153W | HNSC | 1 |
p.Y186H | CESC | 1 |
p.D552Y | UCEC | 1 |
p.S134L | SKCM | 1 |
p.Q336R | STAD | 1 |
p.P143A | LGG | 1 |
p.P260H | UCEC | 1 |
p.P467L | SKCM | 1 |
p.I138V | COAD | 1 |
p.T557A | PAAD | 1 |
p.V219L | LUAD | 1 |
p.L154Q | COAD | 1 |
p.A244E | LUAD | 1 |
p.P274L | UCEC | 1 |
p.I278M | BRCA | 1 |
p.W208L | SKCM | 1 |
p.S521F | SKCM | 1 |
p.E371K | SKCM | 1 |
p.R147C | ESCA | 1 |
p.E90K | SKCM | 1 |
p.G494D | SARC | 1 |
p.S439R | BLCA | 1 |
p.V132M | HNSC | 1 |
p.M109L | HNSC | 1 |
p.R153L | LUSC | 1 |
p.Q459* | SKCM | 1 |
p.G61E | SKCM | 1 |
p.R218L | KIRC | 1 |
p.D162G | LIHC | 1 |
p.Q459X | SKCM | 1 |
p.L536F | SKCM | 1 |
p.T40M | HNSC | 1 |
p.G494S | SARC | 1 |
p.W41C | UCEC | 1 |
p.P141S | SKCM | 1 |
p.R2S | LUAD | 1 |
p.D42E | KIRP | 1 |
p.L562H | SKCM | 1 |
p.R518G | COAD | 1 |
p.P400T | THYM | 1 |
p.A352T | THYM | 1 |
p.S561C | BLCA | 1 |
p.W530* | SKCM | 1 |
p.E311Q | LIHC | 1 |
p.P343S | SKCM | 1 |
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TissGeneCNV for IL22RA1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for IL22RA1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BG999454 | IL22RA1-MESDC2 | chr1:24447618 | chr15:81274435 | |
TCGAfusionPortal | PRADA | BLCA | TCGA-GV-A3JZ-01A | RNF213-IL22RA1 | In-frame | Chr17:78237577 | Chr1:24465204 |
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TissGeneNet for IL22RA1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for IL22RA1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for IL22RA1 |
TissGeneDrug for IL22RA1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for IL22RA1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0027430 | Nasal Polyps | 3 | BeFree,LHGDN |
umls:C0149516 | Chronic sinusitis | 2 | BeFree |
umls:C0033860 | Psoriasis | 1 | BeFree |
umls:C0035455 | Rhinitis | 1 | GAD |
umls:C0037199 | Sinusitis | 1 | GAD |