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| TissGeneSummary for RBP4 |
 Gene summary |
| Basic gene information | Gene symbol | RBP4 |
| Gene name | retinol binding protein 4, plasma | |
| Synonyms | RDCCAS | |
| Cytomap | UCSC genome browser: 10q23.33 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006744.3, | |
| Description | PRBPRBPplasma retinol-binding proteinretinol-binding protein 4retinol-binding protein 4, interstitial | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 180250 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000138207 | ||
| HPRD : 01580 | ||
| Vega : OTTHUMG00000018773 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RBP4 | |
| BioGPS: 5950 | ||
| Pathway | NCI Pathway Interaction Database: RBP4 | |
| KEGG: RBP4 | ||
| REACTOME: RBP4 | ||
| Pathway Commons: RBP4 | ||
| Context | iHOP: RBP4 | |
| ligand binding site mutation search in PubMed: RBP4 | ||
| UCL Cancer Institute: RBP4 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of RBP4 | Liver retinol transporter and receptor for serum retinol-binding protein (RBP4). Alapatt P, Guo F, Komanetsky SM, Wang S, Cai J, Sargsyan A, Rodríguez Díaz E, Bacon BT, Aryal P, Graham TE. J Biol Chem. 2013 Jan 11;288(2):1250-65. doi: 10.1074/jbc.M112.369132. Epub 2012 Oct 26 (pmid:23105095) go to article | |
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0030277 | maintenance of gastrointestinal epithelium | 10944490 | GO:0032526 | response to retinoic acid | 571335 | GO:0042593 | glucose homeostasis | 17003346 | GO:0030277 | maintenance of gastrointestinal epithelium | 10944490 | GO:0032526 | response to retinoic acid | 571335 | GO:0042593 | glucose homeostasis | 17003346 |
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| TissGeneExp for RBP4 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -3.069392442 | 5.308419558 | -8.377812 | 4.78E-23 | 6.58E-21 |
| PRAD | -0.78632798 | 0.966031635 | -1.752359615 | 4.48E-08 | 4.65E-07 |
| LUAD | 1.054862869 | 4.432416317 | -3.377553448 | 1.16E-19 | 2.20E-18 |
| BRCA | 1.096011629 | 6.430043207 | -5.334031579 | 8.75E-38 | 2.14E-36 |
| LUSC | 0.044422774 | 4.342554147 | -4.298131373 | 1.54E-17 | 1.30E-16 |
| KIRP | 2.781955433 | 5.999183558 | -3.217228125 | 0.00049 | 0.0014455 |
| LIHC | 12.13920356 | 13.56772756 | -1.428524 | 0.000114 | 0.000388931 |
| HNSC | -1.490611791 | 0.480513791 | -1.971125581 | 7.35E-05 | 0.000341684 |
| KIRC | 3.114054392 | 5.219047447 | -2.104993056 | 6.56E-05 | 0.000140679 |
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| TissGene-miRNA for RBP4 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for RBP4 |
| TissGeneSNV for RBP4 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S156F | SKCM | 2 |
| p.A89T | COAD | 1 |
| p.E31K | BLCA | 1 |
| p.D128N | SKCM | 1 |
| p.E176K | SKCM | 1 |
| p.T131M | LUAD | 1 |
| p.E19Q | BLCA | 1 |
| p.T41I | LIHC | 1 |
| p.T131M | PAAD | 1 |
| p.W5R | HNSC | 1 |
| p.R173W | ESCA | 1 |
| p.G69C | HNSC | 1 |
| p.S137F | BLCA | 1 |
| p.A6T | PCPG | 1 |
| p.R139H | STAD | 1 |
| p.E197* | LUSC | 1 |
| p.D90N | STAD | 1 |
| p.G118E | SKCM | 1 |
| p.R28Q | BLCA | 1 |
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| TissGeneCNV for RBP4 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for RBP4 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AV660800 | SUCLG2-RBP4 | chr3:67454832 | chr10:95353763 | |
| Chimerdb3.0 | ChiTaRs | NA | AI207681 | HBG1-RBP4 | chr11:5275680 | chr10:95351593 | |
| Chimerdb3.0 | ChiTaRs | NA | AI444579 | RBP4-ZDHHC17 | chr10:95360488 | chr12:77230681 |
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| TissGeneNet for RBP4 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (tumor) | RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (normal) |
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| COAD (tumor) | COAD (normal) |
| RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (tumor) | RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (tumor) | RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (normal) |
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| KICH (tumor) | KICH (normal) |
| RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (tumor) | RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (tumor) | RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (tumor) | RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (tumor) | RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (tumor) | RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (tumor) | RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (tumor) | RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (normal) |
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| STAD (tumor) | STAD (normal) |
| RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (tumor) | RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (normal) |
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| THCA (tumor) | THCA (normal) |
| RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (tumor) | RBP4, SP1, GRB2, RBBP6, PSMB1, RARB, ALB, TTR, PSMA4, RPE65 (normal) |
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| TissGeneProg for RBP4 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for RBP4 |
| TissGeneDrug for RBP4 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for RBP4 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0028754 | Obesity | 25 | BeFree,RGD |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 22 | BeFree,GAD,RGD |
| umls:C0011847 | Diabetes | 9 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 9 | BeFree |
| umls:C0524620 | Metabolic Syndrome X | 9 | BeFree,GAD |
| umls:C0271650 | Impaired glucose tolerance | 7 | BeFree,LHGDN |
| umls:C0007222 | Cardiovascular Diseases | 5 | BeFree,LHGDN |
| umls:C0085207 | Gestational Diabetes | 5 | BeFree,LHGDN |
| umls:C0025517 | Metabolic Diseases | 4 | BeFree |
| umls:C0596263 | Carcinogenesis | 4 | BeFree |
| umls:C2239176 | Liver carcinoma | 4 | BeFree |
| umls:C0400966 | Non-alcoholic Fatty Liver Disease | 3 | BeFree |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 2 | BeFree |
| umls:C0010054 | Coronary Arteriosclerosis | 2 | BeFree |
| umls:C0010068 | Coronary heart disease | 2 | BeFree |
| umls:C0020557 | Hypertriglyceridemia | 2 | GAD,LHGDN |
| umls:C0023903 | Liver neoplasms | 2 | BeFree |
| umls:C0032460 | Polycystic Ovary Syndrome | 2 | BeFree,CTD_human,LHGDN |
| umls:C0042842 | Vitamin A Deficiency | 2 | BeFree,CTD_human |
| umls:C0524910 | Hepatitis C, Chronic | 2 | BeFree,LHGDN |
| umls:C1956346 | Coronary Artery Disease | 2 | BeFree |
| umls:C0000786 | Spontaneous abortion | 1 | CTD_human |
| umls:C0002395 | Alzheimer's Disease | 1 | GAD |
| umls:C0002871 | Anemia | 1 | BeFree |
| umls:C0003850 | Arteriosclerosis | 1 | BeFree |
| umls:C0004153 | Atherosclerosis | 1 | BeFree |
| umls:C0007847 | Malignant tumor of cervix | 1 | BeFree |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree |
| umls:C0011881 | Diabetic Nephropathy | 1 | LHGDN |
| umls:C0011884 | Diabetic Retinopathy | 1 | BeFree |
| umls:C0013080 | Down Syndrome | 1 | BeFree |
| umls:C0015397 | Disorder of eye | 1 | BeFree |
| umls:C0015695 | Fatty Liver | 1 | LHGDN |
| umls:C0017636 | Glioblastoma | 1 | BeFree |
| umls:C0019196 | Hepatitis C | 1 | BeFree |
| umls:C0019569 | Hirschsprung Disease | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | BeFree |
| umls:C0020459 | Hyperinsulinism | 1 | BeFree |
| umls:C0020541 | Hypertension, Portal | 1 | BeFree |
| umls:C0020676 | Hypothyroidism | 1 | LHGDN |
| umls:C0021655 | Insulin Resistance | 1 | GAD |
| umls:C0022658 | Kidney Diseases | 1 | CTD_human |
| umls:C0023493 | Adult T-Cell Lymphoma/Leukemia | 1 | BeFree |
| umls:C0023890 | Liver Cirrhosis | 1 | LHGDN |
| umls:C0023896 | Alcoholic Liver Diseases | 1 | CTD_human |
| umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
| umls:C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
| umls:C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
| umls:C0027540 | Necrosis | 1 | CTD_human |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0029928 | Ovarian Diseases | 1 | BeFree |
| umls:C0035304 | Retinal Degeneration | 1 | BeFree |
| umls:C0035309 | Retinal Diseases | 1 | BeFree |
| umls:C0037286 | Skin Neoplasms | 1 | BeFree |
| umls:C0038356 | Stomach Neoplasms | 1 | CTD_human |
| umls:C0039730 | Thalassemia | 1 | BeFree |
| umls:C0042373 | Vascular Diseases | 1 | BeFree |
| umls:C0152455 | Keratomalacia | 1 | CTD_human |
| umls:C0154830 | Proliferative diabetic retinopathy | 1 | BeFree |
| umls:C0206247 | Amyloid Neuropathies | 1 | LHGDN |
| umls:C0235272 | Retinal damage | 1 | BeFree |
| umls:C0239946 | Fibrosis, Liver | 1 | BeFree |
| umls:C0242339 | Dyslipidemias | 1 | BeFree |
| umls:C0278996 | Cancer of Head and Neck | 1 | BeFree |
| umls:C0302592 | Cervix carcinoma | 1 | BeFree |
| umls:C0341439 | Chronic liver disease | 1 | BeFree |
| umls:C0341702 | Acquired Fanconi syndrome | 1 | BeFree |
| umls:C0362046 | Prediabetes syndrome | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0494463 | Alzheimer Disease, Late Onset | 1 | BeFree |
| umls:C0497406 | Overweight | 1 | BeFree |
| umls:C0524851 | Neurodegenerative Disorders | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
| umls:C0746102 | Chronic lung disease | 1 | BeFree |
| umls:C0854723 | Retinal Dystrophies | 1 | BeFree |
| umls:C0878681 | Dent's disease | 1 | BeFree |
| umls:C0947751 | Vascular inflammations | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C1292753 | Primary Effusion Lymphoma | 1 | BeFree |
| umls:C1522137 | Hypertriglyceridemia result | 1 | GAD |
| umls:C1623038 | Cirrhosis | 1 | BeFree |
| umls:C1832661 | ANOPHTHALMIA AND PULMONARY HYPOPLASIA | 1 | BeFree |
| umls:C2936179 | Obesity, Visceral | 1 | BeFree |
| umls:C3241937 | Nonalcoholic Steatohepatitis | 1 | BeFree |
| umls:C3554593 | RETINAL DYSTROPHY, IRIS COLOBOMA, AND COMEDOGENIC ACNE SYNDROME | 1 | CLINVAR,ORPHANET,UNIPROT |
| umls:C3665346 | Unspecified visual loss | 1 | BeFree |
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