TissGDB
Tissglogo

Home

Download

 Statistics

 Landscape

Help

Contact

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

bullet point

TissGeneSummary

bullet point

TissGeneExp

bullet point

TissGene-miRNA

bullet point

TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

bullet point

TissGeneNet

bullet point

TissGeneProg

bullet point

TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for REG1A
check button Gene summary
Basic gene informationGene symbolREG1A
Gene nameregenerating islet-derived 1 alpha
SynonymsICRF|P19|PSP|PSPS|PSPS1|PTP|REG
CytomapUCSC genome browser: 2p12
Type of geneprotein-coding
RefGenesNM_002909.4,
DescriptionREG-1-alphaislet cells regeneration factorislet of langerhans regenerating proteinlithostathine 1 alphalithostathine-1-alphapancreatic stone protein, secretorypancreatic thread proteinprotein-Xregenerating islet-derived protein 1-alpharegeneratin
Modification date20141207
dbXrefs MIM : 167770
HGNC : HGNC
Ensembl : ENSG00000115386
HPRD : 01338
Vega : OTTHUMG00000130016
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_REG1A
BioGPS: 5967
PathwayNCI Pathway Interaction Database: REG1A
KEGG: REG1A
REACTOME: REG1A
Pathway Commons: REG1A
ContextiHOP: REG1A
ligand binding site mutation search in PubMed: REG1A
UCL Cancer Institute: REG1A
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Pancreas
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)PAAD
Reference showing the relevant tissue of REG1A
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


Top
TissGeneExp for REG1A

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRC6.1172399322.2041746543.9130652787.67E-112.76E-10
LUSC-0.696589725-1.9166563911.2200666678.57E-061.96E-05
LUAD-0.500429177-1.8528067631.3523775860.001360.002913543
COAD7.1900729452.7926460224.3974269230.0009040.002613013
KICH-1.8886949010.731125099-2.619820.0002810.000679829
LIHC1.148469099-1.4781289012.6265980.0001170.000397335


Top
TissGene-miRNA for REG1A

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


Top
TissGeneMut for REG1A
TissGeneSNV for REG1A

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
bullet point


check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.W113*SKCM2
p.W113XSKCM2
p.R109HCESC1
p.R33LLUAD1
p.G39DLUAD1
p.S123FSKCM1
p.S142LLUSC1
p.T93PLUSC1
p.R109HSTAD1
p.R54CUCEC1
p.R110HCOAD1
p.W57*SKCM1
p.Q147KHNSC1
p.R54SLUAD1
p.H112YHNSC1
p.K89TSTAD1
p.W149*SKCM1
p.P37LLGG1
p.W111*ESCA1
p.D151YLUAD1
p.G39SLUSC1
p.Y7*LUAD1
p.G101VLUSC1
p.K107TBRCA1
p.F158LUCEC1
p.F83IHNSC1
p.S159YLUAD1
p.D156NSKCM1
p.W124CLUAD1
p.N133DCOAD1
p.W149XSKCM1
p.E80DHNSC1
p.M67IHNSC1
p.R110HREAD1
p.W111XESCA1
p.D104NBLCA1
p.V161LLUSC1
p.R54CPRAD1
p.N66KLUAD1
p.R110HUCEC1
p.C137FLUSC1
p.A42DUCEC1
p.R110HBLCA1
p.H103YBLCA1
p.R54CTHCA1
p.K107NHNSC1
p.Q31HLUAD1
p.E55KCESC1
p.S131NLUAD1
p.80_81EG>DCHNSC1
p.R110LHNSC1
p.S117FSKCM1
p.V58ISKCM1
p.G81RSKCM1
p.S131ILUAD1
p.S69LSKCM1
p.A128VBLCA1
p.P105HHNSC1
p.E155KLUSC1
p.C137FLUAD1
p.R44HSTAD1
p.T93SHNSC1
p.S20RLUAD1
p.M67ISKCM1
p.R110CTHYM1
p.H112RLIHC1
p.K163NLUAD1
p.C47FHNSC1
p.C137YBLCA1
p.G81CLUAD1
p.P37ALUSC1
p.A85PLUSC1
p.P105QHNSC1
p.Q21KHNSC1
p.R110CUCEC1
p.R33GLUSC1
p.Q26KLUAD1
p.W57XSKCM1
p.E80KLUSC1
p.A2SBLCA1
p.Q3KLUAD1
p.E52KSKCM1
p.D151GCOAD1
p.S45FBLCA1
p.M15IBLCA1
p.G81CHNSC1
p.S91ILUAD1
p.Q31HHNSC1


Top
TissGeneCNV for REG1A

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


Top
TissGeneFusions for REG1A

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNACK818890REG1A-GNA11chr2:79350531chr19:3115035
Chimerdb3.0ChiTaRsNABM126025REG1A-GNA11chr2:79350535chr19:3118933
Chimerdb3.0ChiTaRsNACA842583REG1A-REG1Achr2:79350529chr2:79350465
Chimerdb3.0ChiTaRsNACK818891GNA11-REG1Achr19:3119254chr2:79350483


Top
TissGeneNet for REG1A

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
REG1A, VAV2, HNF4A, STAT3, REG3A (tumor)REG1A, VAV2, HNF4A, STAT3, REG3A (normal)
bullet pointbullet point
COAD (tumor)COAD (normal)
REG1A, VAV2, HNF4A, STAT3, REG3A (tumor)REG1A, VAV2, HNF4A, STAT3, REG3A (normal)
bullet pointbullet point
HNSC (tumor)HNSC (normal)
REG1A, VAV2, HNF4A, STAT3, REG3A (tumor)REG1A, VAV2, HNF4A, STAT3, REG3A (normal)
bullet pointbullet point
KICH (tumor)KICH (normal)
REG1A, VAV2, HNF4A, STAT3, REG3A (tumor)REG1A, VAV2, HNF4A, STAT3, REG3A (normal)
bullet pointbullet point
KIRC (tumor)KIRC (normal)
REG1A, VAV2, HNF4A, STAT3, REG3A (tumor)REG1A, VAV2, HNF4A, STAT3, REG3A (normal)
bullet pointbullet point
KIRP (tumor)KIRP (normal)
REG1A, VAV2, HNF4A, STAT3, REG3A (tumor)REG1A, VAV2, HNF4A, STAT3, REG3A (normal)
bullet pointbullet point
LIHC (tumor)LIHC (normal)
REG1A, VAV2, HNF4A, STAT3, REG3A (tumor)REG1A, VAV2, HNF4A, STAT3, REG3A (normal)
bullet pointbullet point
LUAD (tumor)LUAD (normal)
REG1A, VAV2, HNF4A, STAT3, REG3A (tumor)REG1A, VAV2, HNF4A, STAT3, REG3A (normal)
bullet pointbullet point
LUSC (tumor)LUSC (normal)
REG1A, VAV2, HNF4A, STAT3, REG3A (tumor)REG1A, VAV2, HNF4A, STAT3, REG3A (normal)
bullet pointbullet point
PRAD (tumor)PRAD (normal)
REG1A, VAV2, HNF4A, STAT3, REG3A (tumor)REG1A, VAV2, HNF4A, STAT3, REG3A (normal)
bullet pointbullet point
STAD (tumor)STAD (normal)
REG1A, VAV2, HNF4A, STAT3, REG3A (tumor)REG1A, VAV2, HNF4A, STAT3, REG3A (normal)
bullet pointbullet point
THCA (tumor)THCA (normal)
REG1A, VAV2, HNF4A, STAT3, REG3A (tumor)REG1A, VAV2, HNF4A, STAT3, REG3A (normal)
bullet pointbullet point


Top
TissGeneProg for REG1A

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

Top
TissGeneClin for REG1A
TissGeneDrug for REG1A

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


Top
TissGeneDisease for REG1A

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0206659Embryonal Carcinoma26BeFree
umls:C0596263Carcinogenesis12BeFree
umls:C0023493Adult T-Cell Lymphoma/Leukemia8BeFree
umls:C0009402Colorectal Carcinoma7BeFree
umls:C0011854Diabetes Mellitus, Insulin-Dependent7BeFree,LHGDN
umls:C0006142Malignant neoplasm of breast6BeFree
umls:C0038356Stomach Neoplasms5CTD_mouse,LHGDN
umls:C0678222Breast Carcinoma5BeFree
umls:C1527249Colorectal Cancer5BeFree
umls:C2239176Liver carcinoma5BeFree
umls:C0001418Adenocarcinoma4BeFree,LHGDN
umls:C0011849Diabetes Mellitus4BeFree
umls:C0021390Inflammatory Bowel Diseases4BeFree
umls:C0025202melanoma4BeFree
umls:C0699791Stomach Carcinoma4BeFree
umls:C0949664Tauopathies4BeFree
umls:C0002395Alzheimer's Disease3BeFree
umls:C0003873Rheumatoid Arthritis3BeFree
umls:C0009404Colorectal Neoplasms3BeFree,LHGDN
umls:C0011847Diabetes3BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent3BeFree,GAD
umls:C0019163Hepatitis B3BeFree
umls:C0023418leukemia3BeFree
umls:C0024623Malignant neoplasm of stomach3BeFree
umls:C0027627Neoplasm Metastasis3BeFree
umls:C0029925Ovarian Carcinoma3BeFree
umls:C0030305Pancreatitis3BeFree,GAD
umls:C0038868Progressive supranuclear palsy3BeFree
umls:C0149521Pancreatitis, Chronic3BeFree,RGD
umls:C0206664Teratocarcinoma3BeFree
umls:C0376358Malignant neoplasm of prostate3BeFree
umls:C0600139Prostate carcinoma3BeFree
umls:C0684249Carcinoma of lung3BeFree
umls:C1140680Malignant neoplasm of ovary3BeFree
umls:C0001430Adenoma2BeFree
umls:C0002736Amyotrophic Lateral Sclerosis2BeFree
umls:C0004364Autoimmune Diseases2BeFree
umls:C0007134Renal Cell Carcinoma2BeFree
umls:C0007570Celiac Disease2BeFree
umls:C0010346Crohn Disease2BeFree
umls:C0011853Diabetes Mellitus, Experimental2RGD
umls:C0014859Esophageal Neoplasms2BeFree,LHGDN
umls:C0017638Glioma2BeFree
umls:C0019693HIV Infections2BeFree
umls:C0023492Leukemia, T-Cell2BeFree
umls:C0026769Multiple Sclerosis2BeFree
umls:C0028326Noonan Syndrome2BeFree
umls:C0028754Obesity2BeFree
umls:C0029408Degenerative polyarthritis2BeFree
umls:C0031511Pheochromocytoma2BeFree
umls:C0033860Psoriasis2BeFree
umls:C0034345Pyruvate Dehydrogenase Complex Deficiency Disease2BeFree
umls:C0034885Rectal Neoplasms2BeFree
umls:C0149925Small cell carcinoma of lung2BeFree
umls:C0175704LEOPARD Syndrome2BeFree
umls:C0242379Malignant neoplasm of lung2BeFree
umls:C1527408Rectal Tumors2BeFree
umls:C0002793Anaplasia1BeFree
umls:C0004114Astrocytoma1BeFree
umls:C0004763Barrett Esophagus1LHGDN
umls:C0004943Behcet Syndrome1BeFree
umls:C0006663Calcinosis1GAD
umls:C0007131Non-Small Cell Lung Carcinoma1BeFree
umls:C0008312Primary biliary cirrhosis1BeFree
umls:C0008340Choledochal Cyst1LHGDN
umls:C0009324Ulcerative Colitis1BeFree
umls:C0009375Colonic Neoplasms1RGD
umls:C0010674Cystic Fibrosis1BeFree
umls:C0013336Dwarfism1BeFree
umls:C0014072Experimental Autoimmune Encephalomyelitis1BeFree
umls:C0014743Erythema Nodosum1BeFree
umls:C0019158Hepatitis1BeFree
umls:C0019159Hepatitis A1BeFree
umls:C0020456Hyperglycemia1BeFree
umls:C0020538Hypertensive disease1BeFree
umls:C0023470Myeloid Leukemia1BeFree
umls:C0023487Acute Promyelocytic Leukemia1BeFree
umls:C0023903Liver neoplasms1BeFree
umls:C0024121Lung Neoplasms1BeFree
umls:C0026269Mitral Valve Stenosis1BeFree
umls:C0027051Myocardial Infarction1RGD
umls:C0027430Nasal Polyps1BeFree
umls:C0027819Neuroblastoma1BeFree
umls:C0029463Osteosarcoma1BeFree
umls:C0030293Pancreatic Insufficiency1BeFree
umls:C0032000Pituitary Adenoma1BeFree
umls:C0032002Pituitary Diseases1BeFree
umls:C0032463Polycythemia Vera1BeFree
umls:C0035335Retinoblastoma1BeFree
umls:C0040336Tobacco Use Disorder1GAD
umls:C0042769Virus Diseases1BeFree
umls:C0079773Lymphoma, T-Cell, Cutaneous1BeFree
umls:C0085669Acute leukemia1BeFree
umls:C0086981Sicca Syndrome1BeFree
umls:C0152018Esophageal carcinoma1BeFree
umls:C0206093Neuroectodermal Tumors1BeFree
umls:C0206624Hepatoblastoma1BeFree
umls:C0206696Carcinoma, Signet Ring Cell1BeFree
umls:C0206716Ganglioglioma1BeFree
umls:C0233715Speech impairment1BeFree
umls:C0235782Gallbladder Carcinoma1BeFree
umls:C0263361Psoriasis vulgaris1BeFree
umls:C0266999Vesicular Stomatitis1BeFree
umls:C0267963Exocrine pancreatic insufficiency1BeFree
umls:C0271642Fibrocalculous pancreatic diabetes1BeFree
umls:C0278498Malignant neoplasm of stomach stage IV1BeFree
umls:C0278701Gastric Adenocarcinoma1BeFree
umls:C0338656Impaired cognition1BeFree
umls:C0349639Juvenile Myelomonocytic Leukemia1BeFree
umls:C0375019Human T-cell lymphotrophic virus, type I [HTLV-I]1BeFree
umls:C0375021Human immunodeficiency virus, type 2 [HIV-2] infection in conditions classified elsewhere and of unspecified site1BeFree
umls:C0376532Epilepsy, Rolandic1BeFree
umls:C0521158Recurrent tumor1BeFree
umls:C0524620Metabolic Syndrome X1RGD
umls:C0524851Neurodegenerative Disorders1BeFree
umls:C0546837Malignant neoplasm of esophagus1BeFree
umls:C0585442Osteosarcoma of bone1BeFree
umls:C0587248Costello syndrome (disorder)1BeFree
umls:C0699885Carcinoma of bladder1BeFree
umls:C0700095Central neuroblastoma1BeFree
umls:C0740457Malignant neoplasm of kidney1BeFree
umls:C0744310gastritis h pylori1BeFree
umls:C0751072Frontotemporal Lobar Degeneration1BeFree
umls:C0850666Helicobacter pylori infection1BeFree
umls:C0877008Enzyme inhibition disorder1BeFree
umls:C1292769Precursor B-cell lymphoblastic leukemia1BeFree
umls:C1319315Adenocarcinoma of large intestine1BeFree
umls:C1321872Stage IV Skin Melanoma1BeFree
umls:C1335302Pancreatic Ductal Adenocarcinoma1BeFree
umls:C1336735Treatment related acute myeloid leukaemia1BeFree
umls:C1458155Mammary Neoplasms1LHGDN
umls:C1845668Perisylvian syndrome1BeFree
umls:C2931352Familial renal cell carcinoma1BeFree
umls:C3826457Diabetes in children1BeFree