TissGeneSummary for REG1B |
Gene summary |
Basic gene information | Gene symbol | REG1B |
Gene name | regenerating islet-derived 1 beta | |
Synonyms | PSPS2|REGH|REGI-BETA|REGL | |
Cytomap | UCSC genome browser: 2p12 | |
Type of gene | protein-coding | |
RefGenes | NM_006507.3, | |
Description | PSP-2REG-1-betalithostathine 1 betalithostathine-1-betapancreatic stone protein 2regenerating islet-derived 1 beta (pancreatic stone protein, pancreatic thread protein)regenerating islet-derived protein 1-betaregenerating protein I betasecretory p | |
Modification date | 20141207 | |
dbXrefs | MIM : 167771 | |
HGNC : HGNC | ||
Ensembl : ENSG00000172023 | ||
HPRD : 01339 | ||
Vega : OTTHUMG00000130019 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_REG1B | |
BioGPS: 5968 | ||
Pathway | NCI Pathway Interaction Database: REG1B | |
KEGG: REG1B | ||
REACTOME: REG1B | ||
Pathway Commons: REG1B | ||
Context | iHOP: REG1B | |
ligand binding site mutation search in PubMed: REG1B | ||
UCL Cancer Institute: REG1B | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Pancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAAD | |
Reference showing the relevant tissue of REG1B | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for REG1B |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 2.007349352 | -0.056188148 | 2.0635375 | 1.09E-08 | 3.30E-08 |
COAD | 5.773154267 | 1.702127344 | 4.071026923 | 0.000571 | 0.001730375 |
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TissGene-miRNA for REG1B |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for REG1B |
TissGeneSNV for REG1B |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.M67I | LUSC | 2 |
p.P32S | SKCM | 2 |
p.M67I | SKCM | 2 |
p.V73L | LUAD | 1 |
p.L17P | LUAD | 1 |
p.W124C | HNSC | 1 |
p.R33P | HNSC | 1 |
p.K147N | BLCA | 1 |
p.W149X | SKCM | 1 |
p.P129R | HNSC | 1 |
p.P30S | LUSC | 1 |
p.R110L | LUAD | 1 |
p.W124R | LGG | 1 |
p.G145_splice | LUSC | 1 |
p.R122K | UCEC | 1 |
p.D95Y | LUAD | 1 |
p.C64F | LUAD | 1 |
p.F16L | LUAD | 1 |
p.S6L | BRCA | 1 |
p.W57* | SKCM | 1 |
p.F158L | UCEC | 1 |
p.S114R | STAD | 1 |
p.S86L | LUAD | 1 |
p.P32L | SKCM | 1 |
p.N166K | LUSC | 1 |
p.E24A | LUAD | 1 |
p.N71S | SKCM | 1 |
p.W111C | ESCA | 1 |
p.K148T | STAD | 1 |
p.C47X | THYM | 1 |
p.S142L | SKCM | 1 |
p.W149C | LUAD | 1 |
p.D151Y | LUAD | 1 |
p.D61Y | LUSC | 1 |
p.G39C | LUAD | 1 |
p.E80K | BLCA | 1 |
p.P30S | COAD | 1 |
p.G22S | SKCM | 1 |
p.C143Y | UCEC | 1 |
p.E52* | LUAD | 1 |
p.L10M | LUAD | 1 |
p.G101V | STAD | 1 |
p.L14M | LIHC | 1 |
p.S12F | HNSC | 1 |
p.S20R | HNSC | 1 |
p.S153C | CESC | 1 |
p.R122I | UCEC | 1 |
p.L102P | LIHC | 1 |
p.L72M | LUAD | 1 |
p.T126P | HNSC | 1 |
p.P129S | SKCM | 1 |
p.W57L | LUAD | 1 |
p.D53N | HNSC | 1 |
p.Y121* | BRCA | 1 |
p.F158L | LUAD | 1 |
p.K165T | STAD | 1 |
p.E52K | SKCM | 1 |
p.P105Q | LUAD | 1 |
p.P30H | LUSC | 1 |
p.W57L | CESC | 1 |
p.M9I | LUAD | 1 |
p.T56S | LUAD | 1 |
p.L29M | LUSC | 1 |
p.W124L | BLCA | 1 |
p.S128F | SKCM | 1 |
p.L14M | LUAD | 1 |
p.S159T | LUSC | 1 |
p.E24G | GBM | 1 |
p.D61H | LUSC | 1 |
p.K106E | LUSC | 1 |
p.S159Y | LUSC | 1 |
p.Y136N | SKCM | 1 |
p.Y46* | LUAD | 1 |
p.L19V | BLCA | 1 |
p.E90K | SKCM | 1 |
p.A85D | HNSC | 1 |
p.D151N | SKCM | 1 |
p.S123Y | LUAD | 1 |
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TissGeneCNV for REG1B |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for REG1B |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for REG1B |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for REG1B |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for REG1B |
TissGeneDrug for REG1B |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for REG1B |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | LHGDN |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | GAD |
umls:C0021390 | Inflammatory Bowel Diseases | 1 | BeFree |