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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for REG1B
check button Gene summary
Basic gene informationGene symbolREG1B
Gene nameregenerating islet-derived 1 beta
SynonymsPSPS2|REGH|REGI-BETA|REGL
CytomapUCSC genome browser: 2p12
Type of geneprotein-coding
RefGenesNM_006507.3,
DescriptionPSP-2REG-1-betalithostathine 1 betalithostathine-1-betapancreatic stone protein 2regenerating islet-derived 1 beta (pancreatic stone protein, pancreatic thread protein)regenerating islet-derived protein 1-betaregenerating protein I betasecretory p
Modification date20141207
dbXrefs MIM : 167771
HGNC : HGNC
Ensembl : ENSG00000172023
HPRD : 01339
Vega : OTTHUMG00000130019
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_REG1B
BioGPS: 5968
PathwayNCI Pathway Interaction Database: REG1B
KEGG: REG1B
REACTOME: REG1B
Pathway Commons: REG1B
ContextiHOP: REG1B
ligand binding site mutation search in PubMed: REG1B
UCL Cancer Institute: REG1B
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Pancreas
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)PAAD
Reference showing the relevant tissue of REG1B
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for REG1B

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRC2.007349352-0.0561881482.06353751.09E-083.30E-08
COAD5.7731542671.7021273444.0710269230.0005710.001730375


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TissGene-miRNA for REG1B

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for REG1B
TissGeneSNV for REG1B

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.M67ILUSC2
p.P32SSKCM2
p.M67ISKCM2
p.V73LLUAD1
p.L17PLUAD1
p.W124CHNSC1
p.R33PHNSC1
p.K147NBLCA1
p.W149XSKCM1
p.P129RHNSC1
p.P30SLUSC1
p.R110LLUAD1
p.W124RLGG1
p.G145_spliceLUSC1
p.R122KUCEC1
p.D95YLUAD1
p.C64FLUAD1
p.F16LLUAD1
p.S6LBRCA1
p.W57*SKCM1
p.F158LUCEC1
p.S114RSTAD1
p.S86LLUAD1
p.P32LSKCM1
p.N166KLUSC1
p.E24ALUAD1
p.N71SSKCM1
p.W111CESCA1
p.K148TSTAD1
p.C47XTHYM1
p.S142LSKCM1
p.W149CLUAD1
p.D151YLUAD1
p.D61YLUSC1
p.G39CLUAD1
p.E80KBLCA1
p.P30SCOAD1
p.G22SSKCM1
p.C143YUCEC1
p.E52*LUAD1
p.L10MLUAD1
p.G101VSTAD1
p.L14MLIHC1
p.S12FHNSC1
p.S20RHNSC1
p.S153CCESC1
p.R122IUCEC1
p.L102PLIHC1
p.L72MLUAD1
p.T126PHNSC1
p.P129SSKCM1
p.W57LLUAD1
p.D53NHNSC1
p.Y121*BRCA1
p.F158LLUAD1
p.K165TSTAD1
p.E52KSKCM1
p.P105QLUAD1
p.P30HLUSC1
p.W57LCESC1
p.M9ILUAD1
p.T56SLUAD1
p.L29MLUSC1
p.W124LBLCA1
p.S128FSKCM1
p.L14MLUAD1
p.S159TLUSC1
p.E24GGBM1
p.D61HLUSC1
p.K106ELUSC1
p.S159YLUSC1
p.Y136NSKCM1
p.Y46*LUAD1
p.L19VBLCA1
p.E90KSKCM1
p.A85DHNSC1
p.D151NSKCM1
p.S123YLUAD1


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TissGeneCNV for REG1B

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for REG1B

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for REG1B

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
REG1B, HNF4A (tumor)REG1B, HNF4A (normal)
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COAD (tumor)COAD (normal)
REG1B, HNF4A (tumor)REG1B, HNF4A (normal)
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HNSC (tumor)HNSC (normal)
REG1B, HNF4A (tumor)REG1B, HNF4A (normal)
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KICH (tumor)KICH (normal)
REG1B, HNF4A (tumor)REG1B, HNF4A (normal)
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KIRC (tumor)KIRC (normal)
REG1B, HNF4A (tumor)REG1B, HNF4A (normal)
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KIRP (tumor)KIRP (normal)
REG1B, HNF4A (tumor)REG1B, HNF4A (normal)
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LIHC (tumor)LIHC (normal)
REG1B, HNF4A (tumor)REG1B, HNF4A (normal)
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LUAD (tumor)LUAD (normal)
REG1B, HNF4A (tumor)REG1B, HNF4A (normal)
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LUSC (tumor)LUSC (normal)
REG1B, HNF4A (tumor)REG1B, HNF4A (normal)
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PRAD (tumor)PRAD (normal)
REG1B, HNF4A (tumor)REG1B, HNF4A (normal)
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STAD (tumor)STAD (normal)
REG1B, HNF4A (tumor)REG1B, HNF4A (normal)
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THCA (tumor)THCA (normal)
REG1B, HNF4A (tumor)REG1B, HNF4A (normal)
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TissGeneProg for REG1B

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for REG1B
TissGeneDrug for REG1B

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for REG1B

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0011854Diabetes Mellitus, Insulin-Dependent1LHGDN
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1GAD
umls:C0021390Inflammatory Bowel Diseases1BeFree