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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for REN
check button Gene summary
Basic gene informationGene symbolREN
Gene namerenin
SynonymsHNFJ2
CytomapUCSC genome browser: 1q32
Type of geneprotein-coding
RefGenesNM_000537.3,
Descriptionangiotensin-forming enzymeangiotensinogenaserenin precursor, renal
Modification date20141219
dbXrefs MIM : 179820
HGNC : HGNC
Ensembl : ENSG00000143839
HPRD : 01564
Vega : OTTHUMG00000036059
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_REN
BioGPS: 5972
PathwayNCI Pathway Interaction Database: REN
KEGG: REN
REACTOME: REN
Pathway Commons: REN
ContextiHOP: REN
ligand binding site mutation search in PubMed: REN
UCL Cancer Institute: REN
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)ColonKidney
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)COADKIRC,KIRP,KICH
Reference showing the relevant tissue of REN
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0002003angiotensin maturation12045255
GO:0006508proteolysis12045255
GO:0043408regulation of MAPK cascade12045255
GO:0002003angiotensin maturation12045255
GO:0006508proteolysis12045255
GO:0043408regulation of MAPK cascade12045255


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TissGeneExp for REN

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
HNSC-3.189332786-1.369118833-1.8202139537.19E-087.32E-07
THCA0.112776635-3.5242538743.6370305081.17E-205.51E-19
LUAD-1.484777574-0.346856884-1.137920691.56E-065.12E-06
LUSC-2.740049886-0.079365572-2.6606843141.23E-222.01E-21
KIRP-0.4186980483.929333202-4.348031252.34E-071.33E-06
LIHC0.200334702-0.9107992981.1111340.010.021072106
KICH0.6444727023.393724702-2.7492520.002860.005689025


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TissGene-miRNA for REN

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for REN
TissGeneSNV for REN

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.G11RSKCM1
p.S107LUCEC1
p.A402TBLCA1
p.P372QTHYM1
p.E189DCOAD1
p.A182VUCEC1
p.G376RUCEC1
p.T341ALUAD1
p.R148CGBM1
p.G294SSTAD1
p.G242ELUAD1
p.W10XSKCM1
p.A405TBLCA1
p.E281KLUAD1
p.R403HESCA1
p.I259VSTAD1
p.L129HSKCM1
p.S107XTHYM1
p.G251ESKCM1
p.Q201LKIRC1
p.A365VSKCM1
p.G294CSKCM1
p.R9CBLCA1
p.F385ISTAD1
p.S232FSKCM1
p.D131NCOAD1
p.R399HOV1
p.S357ILUAD1
p.L15PLUAD1
p.C287FCOAD1
p.R387QREAD1
p.L312FGBM1
p.W10*SKCM1
p.L78ISKCM1
p.R148HBRCA1
p.R119HSTAD1
p.S354ILUAD1
p.D333NUCEC1
p.T151AOV1
p.A362VSKCM1
p.S237LUCEC1
p.I256VSTAD1
p.R43QLUAD1
p.R43QSKCM1
p.L335PHNSC1
p.K315NREAD1
p.L338PHNSC1
p.R43PCESC1
p.A123VPAAD1
p.G142RSKCM1
p.V102IGBM1
p.E221QHNSC1
p.G325RSARC1
p.G142ESKCM1
p.V223IPAAD1


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TissGeneCNV for REN

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for REN

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
TCGAfusionPortalPRADAOVTCGA-24-2024-01APIAS3-REN5UTR-CDSChr1:145575404Chr1:204131291


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TissGeneNet for REN

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (tumor)REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (normal)
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COAD (tumor)COAD (normal)
REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (tumor)REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (normal)
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HNSC (tumor)HNSC (normal)
REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (tumor)REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (normal)
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KICH (tumor)KICH (normal)
REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (tumor)REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (normal)
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KIRC (tumor)KIRC (normal)
REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (tumor)REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (normal)
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KIRP (tumor)KIRP (normal)
REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (tumor)REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (normal)
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LIHC (tumor)LIHC (normal)
REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (tumor)REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (normal)
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LUAD (tumor)LUAD (normal)
REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (tumor)REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (normal)
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LUSC (tumor)LUSC (normal)
REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (tumor)REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (normal)
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PRAD (tumor)PRAD (normal)
REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (tumor)REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (normal)
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STAD (tumor)STAD (normal)
REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (tumor)REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (normal)
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THCA (tumor)THCA (normal)
REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (tumor)REN, CTSB, ATF1, KCTD15, PCSK5, PCSK1, M6PR, RENBP, ATP6AP2 (normal)
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TissGeneProg for REN

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for REN
TissGeneDrug for REN

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status
DB00212RemikirenInhibitorSmall moleculeApproved
DB09026AliskirenInhibitorSmall moleculeApproved|Investigational


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TissGeneDisease for REN

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0020538Hypertensive disease396BeFree,CTD_human,GAD,LHGDN,RGD
umls:C0085580Essential Hypertension96BeFree
umls:C0007222Cardiovascular Diseases75BeFree,GAD
umls:C0011881Diabetic Nephropathy52BeFree,GAD,LHGDN,RGD
umls:C0022658Kidney Diseases52BeFree,CTD_human,GAD
umls:C1956346Coronary Artery Disease42BeFree,GAD
umls:C0018802Congestive heart failure39BeFree
umls:C0010054Coronary Arteriosclerosis38BeFree
umls:C0018801Heart failure38BeFree,CTD_human,GAD
umls:C0010068Coronary heart disease35BeFree
umls:C0004153Atherosclerosis32BeFree
umls:C0003850Arteriosclerosis31BeFree
umls:C0022661Kidney Failure, Chronic29BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent28BeFree,GAD
umls:C0027051Myocardial Infarction28BeFree,CTD_human,GAD,LHGDN
umls:C0149721Left Ventricular Hypertrophy27BeFree,CTD_human,RGD
umls:C1384514Conn Syndrome27BeFree
umls:C1561643Chronic Kidney Diseases27BeFree
umls:C0011849Diabetes Mellitus26BeFree,GAD
umls:C0011847Diabetes21BeFree
umls:C0035078Kidney Failure21BeFree
umls:C0028754Obesity19BeFree
umls:C0038454Cerebrovascular accident18BeFree,GAD
umls:C0017661IGA Glomerulonephritis17BeFree
umls:C0403447Chronic Kidney Insufficiency17BeFree
umls:C2316810Chronic kidney disease stage 517BeFree
umls:C0006142Malignant neoplasm of breast11BeFree
umls:C0011854Diabetes Mellitus, Insulin-Dependent11BeFree
umls:C0085413Polycystic Kidney, Autosomal Dominant11BeFree
umls:C0678222Breast Carcinoma11BeFree
umls:C0333186Restenosis10BeFree
umls:C2936861Cortisol 11-beta-ketoreductase deficiency10BeFree
umls:C0001430Adenoma9BeFree
umls:C0524620Metabolic Syndrome X9BeFree
umls:C0020428Hyperaldosteronism8BeFree
umls:C0020540Malignant Hypertension8BeFree,CTD_human
umls:C0232197Fibrillation8BeFree
umls:C0266313Allanson Pantzar McLeod syndrome8BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT
umls:C0007194Hypertrophic Cardiomyopathy7BeFree
umls:C0340100High altitude pulmonary edema7BeFree
umls:C0002871Anemia6BeFree,CTD_human
umls:C0004775Bartter Disease6BeFree,CTD_human
umls:C0020545Hypertension, Renovascular6BeFree
umls:C0025517Metabolic Diseases6BeFree
umls:C0042373Vascular Diseases6BeFree
umls:C0042580Vesico-Ureteral Reflux6BeFree,GAD
umls:C0151744Myocardial Ischemia6BeFree
umls:C0155626Acute myocardial infarction6BeFree
umls:C0178664Glomerulosclerosis (disorder)6BeFree
umls:C0878544Cardiomyopathies6BeFree
umls:C0020456Hyperglycemia5BeFree,LHGDN
umls:C0221043Liddle Syndrome5BeFree,CTD_human
umls:C0376358Malignant neoplasm of prostate5BeFree
umls:C0596263Carcinogenesis5BeFree
umls:C0600139Prostate carcinoma5BeFree
umls:C0013537Eclampsia4BeFree
umls:C0017658Glomerulonephritis4BeFree
umls:C0018799Heart Diseases4BeFree,LHGDN
umls:C0020542Pulmonary Hypertension4BeFree
umls:C0020595Hypoaldosteronism4BeFree
umls:C0022680Polycystic Kidney Diseases4BeFree
umls:C0023418leukemia4BeFree,LHGDN
umls:C0025500Mesothelioma4BeFree
umls:C0027708Nephroblastoma4BeFree
umls:C0032002Pituitary Diseases4BeFree
umls:C0033805Pseudohypoaldosteronism4BeFree
umls:C0155616Secondary hypertension4BeFree
umls:C0264716Chronic heart failure4BeFree
umls:C0730345Microalbuminuria4BeFree
umls:C1260386Glucocorticoid-remediable aldosteronism4BeFree
umls:C1565489Renal Insufficiency4BeFree
umls:C0002063Alkalosis3BeFree
umls:C0002395Alzheimer's Disease3BeFree,GAD
umls:C0003507Aortic Valve Stenosis3BeFree
umls:C0007134Renal Cell Carcinoma3BeFree
umls:C0020649Hypotension3CTD_human
umls:C0022116Ischemia3BeFree,CTD_human
umls:C0023467Leukemia, Myelocytic, Acute3BeFree,LHGDN
umls:C0023895Liver diseases3BeFree
umls:C0024141Lupus Erythematosus, Systemic3BeFree
umls:C0026267Mitral Valve Prolapse Syndrome3BeFree
umls:C0032914Pre-Eclampsia3GAD,LHGDN
umls:C0085569Metabolic acidosis, NAG, acidifying salts3BeFree
umls:C0149931Migraine Disorders3BeFree
umls:C0155668Old myocardial infarction3BeFree
umls:C0162871Aortic Aneurysm, Abdominal3BeFree
umls:C0178874Tumor Progression3BeFree
umls:C0268436Pseudohypoaldosteronism, Type I3BeFree
umls:C0333497Segmental glomerulosclerosis3BeFree
umls:C0342488Mineralocorticoid Excess Syndrome, Apparent3BeFree
umls:C0565599Maternal hypertension3BeFree
umls:C0598428genetic hypertension3BeFree
umls:C0812413Malignant Pleural Mesothelioma3BeFree
umls:C1968949Cakut3BeFree
umls:C2733158Cerebral Small Vessel Diseases3BeFree
umls:C0001339Acute pancreatitis2BeFree
umls:C0001403Addison Disease2BeFree
umls:C0001627Congenital adrenal hyperplasia2BeFree
umls:C0001925Albuminuria2CTD_human
umls:C0003486Aortic Aneurysm2BeFree
umls:C0007282Carotid Stenosis2BeFree,GAD
umls:C0010072Coronary Thrombosis2BeFree
umls:C0010709Cyst2BeFree
umls:C0011570Mental Depression2BeFree
umls:C0011581Depressive disorder2BeFree
umls:C0011884Diabetic Retinopathy2BeFree
umls:C0014599Epithelial hyperplasia2BeFree
umls:C0015544Failure to Thrive2BeFree
umls:C0017601Glaucoma2GAD
umls:C0017668Focal glomerulosclerosis2BeFree
umls:C0018800Cardiomegaly2CTD_human
umls:C0019693HIV Infections2BeFree
umls:C0020443Hypercholesterolemia2BeFree
umls:C0020445Hypercholesterolemia, Familial2BeFree
umls:C0020459Hyperinsulinism2BeFree,LHGDN
umls:C0020488Hypernatremia2BeFree
umls:C0020546Hypertensive crisis2BeFree
umls:C0020615Hypoglycemia2BeFree
umls:C0022660Kidney Failure, Acute2BeFree
umls:C0022876Premature Obstetric Labor2GAD,LHGDN
umls:C0024131Lupus Vulgaris2BeFree
umls:C0024138Lupus Erythematosus, Discoid2BeFree
umls:C0024143Lupus Nephritis2BeFree
umls:C0025149Medulloblastoma2BeFree
umls:C0026846Muscular Atrophy2BeFree
umls:C0027720Nephrosis2CTD_human
umls:C0029899Otosclerosis2BeFree
umls:C0031099Periodontitis2BeFree
umls:C0031511Pheochromocytoma2BeFree
umls:C0032463Polycythemia Vera2BeFree
umls:C0032617Polyuria2BeFree
umls:C0032962Pregnancy Complications2BeFree
umls:C0033687Proteinuria2CTD_human
umls:C0033860Psoriasis2BeFree,CTD_human
umls:C0034152Henoch-Schoenlein Purpura2BeFree
umls:C0035067Renal Artery Stenosis2BeFree
umls:C0035222Respiratory Distress Syndrome, Adult2BeFree
umls:C0040336Tobacco Use Disorder2GAD
umls:C0041408Turner Syndrome2BeFree
umls:C0041956Ureteral obstruction2BeFree
umls:C0042420Vasovagal syncope2BeFree
umls:C0151650Renal fibrosis2BeFree
umls:C0154830Proliferative diabetic retinopathy2BeFree
umls:C0162770Right Ventricular Hypertrophy2BeFree
umls:C0206667Adrenal Cortical Adenoma2BeFree
umls:C0238506Congenital posterior urethral valves2BeFree
umls:C0239946Fibrosis, Liver2BeFree
umls:C0240035Interstitial fibrosis2BeFree
umls:C0264638Low-renin essential hypertension2BeFree
umls:C0267952Fibrosis of pancreas2BeFree
umls:C0333559Infarction, Lacunar2BeFree
umls:C0334331Juxtaglomerular tumor2BeFree
umls:C0338656Impaired cognition2BeFree
umls:C0339467Proliferative retinopathy2BeFree
umls:C0342492Adrenal hypertrophy or hyperplasia2BeFree
umls:C0403622Primary vesicoureteric reflux2BeFree
umls:C0409974Lupus Erythematosus2BeFree
umls:C0451718Non-obstructive reflux-associated chronic pyelonephritis (disorder)2BeFree
umls:C0520679Sleep Apnea, Obstructive2BeFree
umls:C0595921Intraocular pressure disorder2BeFree
umls:C0597048Neurogenic hypertension2BeFree
umls:C0597853high renin hypertension2BeFree
umls:C0740394Hyperuricemia2BeFree
umls:C0741949Cardiovascular Pathology2BeFree
umls:C0747845early pregnancy2BeFree
umls:C0877008Enzyme inhibition disorder2BeFree
umls:C0948008Ischemic stroke2BeFree
umls:C1096293Macroangiopathy2BeFree
umls:C1135196Heart Failure, Diastolic2BeFree
umls:C1260873Aortic valve disorder2BeFree
umls:C1301700Cardiovascular morbidity2BeFree
umls:C1397307Cardiac fibrosis2BeFree
umls:C1449844Pseudohypoaldosteronism, Type II2BeFree
umls:C1567741Alport Syndrome2BeFree
umls:C1621895Adrenal hyperplasia2BeFree
umls:C1862170Brachydactyly with hypertension2BeFree
umls:C3272363Ischemic Cerebrovascular Accident2BeFree
umls:C3469605PSEUDOHYPOALDOSTERONISM, TYPE IID2BeFree
umls:C3495566Reflux nephropathy (disorder)2BeFree
umls:C0000768Congenital Abnormality1BeFree
umls:C0001623Adrenal gland hypofunction1BeFree
umls:C0001973Alcoholic Intoxication, Chronic1GAD
umls:C0002940Aneurysm1BeFree
umls:C0002965Angina, Unstable1BeFree
umls:C0003469Anxiety Disorders1BeFree
umls:C0003504Aortic Valve Insufficiency1BeFree
umls:C0004936Mental disorders1BeFree
umls:C0007102Malignant tumor of colon1BeFree
umls:C0007193Cardiomyopathy, Dilated1BeFree
umls:C0007766Intracranial Aneurysm1BeFree
umls:C0007785Cerebral Infarction1BeFree
umls:C0007786Brain Ischemia1GAD
umls:C0008495Chorioamnionitis1GAD
umls:C0008767Cicatrization1GAD
umls:C0009319Colitis1BeFree
umls:C0009402Colorectal Carcinoma1BeFree
umls:C0010200Coughing1BeFree
umls:C0011265Presenile dementia1BeFree
umls:C0011853Diabetes Mellitus, Experimental1CTD_human
umls:C0011875Diabetic Angiopathies1GAD
umls:C0014130Endocrine System Diseases1BeFree
umls:C0014544Epilepsy1BeFree
umls:C0014556Epilepsy, Temporal Lobe1BeFree
umls:C0015934Fetal Growth Retardation1CTD_human
umls:C0015944Fetal Membranes, Premature Rupture1GAD
umls:C0016052Fibromuscular Dysplasia1BeFree
umls:C0016059Fibrosis1CTD_human
umls:C0017636Glioblastoma1BeFree
umls:C0017665Membranous glomerulonephritis1BeFree
umls:C0018798Congenital Heart Defects1BeFree
umls:C0019061Hemolytic-Uremic Syndrome1BeFree
umls:C0019080Hemorrhage1CTD_human
umls:C0020473Hyperlipidemia1LHGDN
umls:C0020541Hypertension, Portal1BeFree
umls:C0022679Cystic kidney1BeFree
umls:C0023449Acute lymphocytic leukemia1BeFree
umls:C0023787Lipodystrophy1BeFree
umls:C0023890Liver Cirrhosis1CTD_human
umls:C0023892Biliary cirrhosis1RGD
umls:C0024117Chronic Obstructive Airway Disease1BeFree
umls:C0024299Lymphoma1BeFree
umls:C0024623Malignant neoplasm of stomach1BeFree
umls:C0026266Mitral Valve Insufficiency1BeFree
umls:C0026850Muscular Dystrophy1BeFree
umls:C0027719Nephrosclerosis1BeFree
umls:C0028259Nodule1BeFree
umls:C0029456Osteoporosis1BeFree,CTD_human
umls:C0030552Paresis1BeFree
umls:C0032019Pituitary Neoplasms1BeFree
umls:C0033626Protein Deficiency1BeFree
umls:C0037090Signs and Symptoms, Respiratory1BeFree
umls:C0038358Gastric ulcer1BeFree
umls:C0038436Post-Traumatic Stress Disorder1BeFree
umls:C0038587Substance Withdrawal Syndrome1CTD_human
umls:C0039231Tachycardia1BeFree
umls:C0039235Tachycardia, Ectopic Junctional1BeFree
umls:C0040028Thrombocythemia, Essential1BeFree
umls:C0041755Adverse reaction to drug1CTD_human
umls:C0041948Uremia1BeFree
umls:C0042075Urologic Diseases1BeFree
umls:C0042514Tachycardia, Ventricular1LHGDN
umls:C0042755Virilism1BeFree
umls:C0042769Virus Diseases1BeFree
umls:C0042870Vitamin D Deficiency1BeFree
umls:C0085083Ovarian Hyperstimulation Syndrome1BeFree
umls:C0085215Ovarian Failure, Premature1BeFree
umls:C0149871Deep Vein Thrombosis1BeFree
umls:C0149925Small cell carcinoma of lung1BeFree
umls:C0149939Obstructive nephropathy1BeFree
umls:C0151526Premature Birth1GAD
umls:C0151747Renal tubular disorder1BeFree
umls:C0151786Muscle Weakness1BeFree
umls:C0152136Low Tension Glaucoma1BeFree
umls:C0152424Common ventricle1BeFree
umls:C0155800Chronic hypotension1BeFree
umls:C0175697Van der Woude syndrome1BeFree
umls:C0178879Urinary tract obstruction1BeFree
umls:C0205944Sarcoma, Epithelioid1BeFree
umls:C0206093Neuroectodermal Tumors1BeFree
umls:C0206686Adrenocortical carcinoma1BeFree
umls:C0233532Maladaptive behavior associated with physical illness1BeFree
umls:C0235031Neurologic Symptoms1BeFree
umls:C0235222Diastolic hypertension1BeFree
umls:C0242129Thrombotic stroke1BeFree
umls:C0242231Coronary Stenosis1BeFree
umls:C0242528Azotemia1CTD_human
umls:C0264639High-renin essential hypertension1BeFree
umls:C0264641Endocrine hypertension1BeFree
umls:C0265783Congenital hypoplasia of lung1BeFree
umls:C0266362Ambiguous Genitalia1BeFree
umls:C0266929Chronic Periodontitis1BeFree
umls:C0268450Gitelman Syndrome1BeFree
umls:C0268731Renal glomerular disease1BeFree
umls:C0268790Renal vascular disorder1BeFree
umls:C0268800Simple renal cyst1BeFree
umls:C0271650Impaired glucose tolerance1BeFree
umls:C0340288Stable angina1BeFree
umls:C0340427Familial dilated cardiomyopathy1BeFree
umls:C0340908Arteriovenous fistula stenosis1BeFree
umls:C0345967Malignant mesothelioma1BeFree
umls:C0349649Pulmonary lymphangioleiomyomatosis1BeFree
umls:C0376545Hematologic Neoplasms1BeFree
umls:C0393561Subcortical Vascular Dementia1BeFree
umls:C0398623Thrombophilia1BeFree
umls:C0403440Thin basement membrane disease1BeFree
umls:C0451819Simple obesity1BeFree
umls:C0497327Dementia1BeFree
umls:C0520463Chronic active hepatitis1BeFree
umls:C0524851Neurodegenerative Disorders1BeFree
umls:C0524910Hepatitis C, Chronic1BeFree
umls:C0546817Fluid overload1BeFree
umls:C0577631Carotid Atherosclerosis1BeFree
umls:C0595936Aqueous Humor Disorders1BeFree
umls:C0679247Terminal illness1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0699791Stomach Carcinoma1BeFree
umls:C0740898Hypokalemic metabolic alkalosis1BeFree
umls:C0748073psychosocial stressor1BeFree
umls:C0751674Lymphangioleiomyomatosis1BeFree
umls:C0751955Brain Infarction1BeFree
umls:C0848548hypertensive nephropathy1BeFree
umls:C0852733Completed Suicide1BeFree
umls:C0853897Diabetic Cardiomyopathies1BeFree
umls:C0856169Endothelial dysfunction1BeFree
umls:C0878787Growth failure1BeFree
umls:C0917798Cerebral Ischemia1BeFree
umls:C0917996Cerebral Aneurysm1BeFree
umls:C0920646Renal ischaemia1BeFree
umls:C1277187Left ventricular systolic dysfunction1BeFree
umls:C1328479Pancreatic Endocrine Carcinoma1BeFree
umls:C1328504Hormone refractory prostate cancer1BeFree
umls:C1334274Invasive Carcinoma1BeFree
umls:C1449842Pseudohypoaldosteronism, Type I, Autosomal Dominant1BeFree
umls:C1519670Tumor Angiogenesis1BeFree
umls:C1527249Colorectal Cancer1BeFree
umls:C1536220ST segment elevation myocardial infarction1BeFree
umls:C1567435Polycystic Kidney - body part1BeFree
umls:C1567742Alport Syndrome, X-Linked1BeFree
umls:C1704272Benign Prostatic Hyperplasia1BeFree
umls:C1709661Primary Focal Segmental Glomerulosclerosis1BeFree
umls:C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1BeFree
umls:C2062593Mesial temporal sclerosis1BeFree
umls:C2239176Liver carcinoma1BeFree
umls:C2242703Cardio-Renal Syndrome1BeFree
umls:C2751310Hyperuricemic Nephropathy, Familial Juvenile 21BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT
umls:C2919032Infection of amniotic sac and membranes, unspecified, unspecified trimester, not applicable or unspecified1GAD
umls:C3274516Single Ventricle Defect1BeFree
umls:C3536714Renal dysplasia1BeFree
umls:C3542024AORTIC VALVE DISEASE 21BeFree
umls:C3713420Familial Hyperaldosteronism1BeFree
umls:C3714581Multicystic Dysplastic Kidney1BeFree