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TissGeneSummary for RFPL1 |
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Basic gene information | Gene symbol | RFPL1 |
Gene name | ret finger protein-like 1 | |
Synonyms | RNF78 | |
Cytomap | UCSC genome browser: 22q12.2 | |
Type of gene | protein-coding | |
RefGenes | NM_021026.2, | |
Description | RING finger protein 78 | |
Modification date | 20141207 | |
dbXrefs | MIM : 605968 | |
HGNC : HGNC | ||
Ensembl : ENSG00000128250 | ||
HPRD : 16182 | ||
Vega : OTTHUMG00000150516 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RFPL1 | |
BioGPS: 5988 | ||
Pathway | NCI Pathway Interaction Database: RFPL1 | |
KEGG: RFPL1 | ||
REACTOME: RFPL1 | ||
Pathway Commons: RFPL1 | ||
Context | iHOP: RFPL1 | |
ligand binding site mutation search in PubMed: RFPL1 | ||
UCL Cancer Institute: RFPL1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of RFPL1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID |
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TissGeneExp for RFPL1 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | -1.145882449 | -2.202280488 | 1.056398039 | 1.40E-06 | 3.44E-06 |
LIHC | -1.368082567 | 0.694919433 | -2.063002 | 2.49E-10 | 3.09E-09 |
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TissGene-miRNA for RFPL1 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for RFPL1 |
TissGeneSNV for RFPL1 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S224G | UVM | 7 |
p.L138F | COAD | 5 |
p.S224G | PCPG | 4 |
p.L138F | KICH | 3 |
p.L138F | KIRC | 3 |
p.R148Q | UCEC | 3 |
p.H15R | STAD | 1 |
p.G16E | HNSC | 1 |
p.P313A | LUAD | 1 |
p.V147I | STAD | 1 |
p.R203C | UCEC | 1 |
p.D239Y | UCEC | 1 |
p.Q86E | BLCA | 1 |
p.P173S | SKCM | 1 |
p.L114M | UCEC | 1 |
p.E199* | UCEC | 1 |
p.L47V | BLCA | 1 |
p.G16R | HNSC | 1 |
p.S257F | SKCM | 1 |
p.R156Q | BRCA | 1 |
p.A100S | THYM | 1 |
p.S265F | SKCM | 1 |
p.S146I | THYM | 1 |
p.R179C | STAD | 1 |
p.F123L | SKCM | 1 |
p.R240C | UCEC | 1 |
p.S93N | UCEC | 1 |
p.E183K | HNSC | 1 |
p.M127T | COAD | 1 |
p.P232S | PRAD | 1 |
p.P20L | LUAD | 1 |
p.H280R | KIRP | 1 |
p.M116I | SKCM | 1 |
p.R148Q | KIRC | 1 |
p.R156W | LUSC | 1 |
p.V201A | SKCM | 1 |
p.V256I | PRAD | 1 |
p.W192X | SKCM | 1 |
p.I113N | PAAD | 1 |
p.M251T | SARC | 1 |
p.E36K | HNSC | 1 |
p.F283S | STAD | 1 |
p.E199X | READ | 1 |
p.W192* | SKCM | 1 |
p.A316T | STAD | 1 |
p.L138F | READ | 1 |
p.P25S | SKCM | 1 |
p.S38N | BRCA | 1 |
p.K49N | LUAD | 1 |
p.T133R | LUAD | 1 |
p.R121W | PAAD | 1 |
p.D132H | ACC | 1 |
p.S13L | GBM | 1 |
p.V165M | COAD | 1 |
p.R145K | SKCM | 1 |
p.N17H | UCEC | 1 |
p.S166Y | LUAD | 1 |
p.M251I | SKCM | 1 |
p.A31T | UCEC | 1 |
p.P25A | SKCM | 1 |
p.K87N | UCEC | 1 |
p.C81S | THCA | 1 |
p.S265F | HNSC | 1 |
p.V186M | PAAD | 1 |
p.R121W | COAD | 1 |
p.D250N | SKCM | 1 |
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TissGeneCNV for RFPL1 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for RFPL1 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for RFPL1 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for RFPL1 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for RFPL1 |
TissGeneDrug for RFPL1 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for RFPL1 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007273 | Carotid Artery Diseases | 1 | GAD |