 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for RFPL1 |
 Gene summary |
| Basic gene information | Gene symbol | RFPL1 |
| Gene name | ret finger protein-like 1 | |
| Synonyms | RNF78 | |
| Cytomap | UCSC genome browser: 22q12.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_021026.2, | |
| Description | RING finger protein 78 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 605968 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000128250 | ||
| HPRD : 16182 | ||
| Vega : OTTHUMG00000150516 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RFPL1 | |
| BioGPS: 5988 | ||
| Pathway | NCI Pathway Interaction Database: RFPL1 | |
| KEGG: RFPL1 | ||
| REACTOME: RFPL1 | ||
| Pathway Commons: RFPL1 | ||
| Context | iHOP: RFPL1 | |
| ligand binding site mutation search in PubMed: RFPL1 | ||
| UCL Cancer Institute: RFPL1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of RFPL1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for RFPL1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | -1.145882449 | -2.202280488 | 1.056398039 | 1.40E-06 | 3.44E-06 |
| LIHC | -1.368082567 | 0.694919433 | -2.063002 | 2.49E-10 | 3.09E-09 |
| Top |
| TissGene-miRNA for RFPL1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for RFPL1 |
| TissGeneSNV for RFPL1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S224G | UVM | 7 |
| p.L138F | COAD | 5 |
| p.S224G | PCPG | 4 |
| p.L138F | KICH | 3 |
| p.L138F | KIRC | 3 |
| p.R148Q | UCEC | 3 |
| p.H15R | STAD | 1 |
| p.G16E | HNSC | 1 |
| p.P313A | LUAD | 1 |
| p.V147I | STAD | 1 |
| p.R203C | UCEC | 1 |
| p.D239Y | UCEC | 1 |
| p.Q86E | BLCA | 1 |
| p.P173S | SKCM | 1 |
| p.L114M | UCEC | 1 |
| p.E199* | UCEC | 1 |
| p.L47V | BLCA | 1 |
| p.G16R | HNSC | 1 |
| p.S257F | SKCM | 1 |
| p.R156Q | BRCA | 1 |
| p.A100S | THYM | 1 |
| p.S265F | SKCM | 1 |
| p.S146I | THYM | 1 |
| p.R179C | STAD | 1 |
| p.F123L | SKCM | 1 |
| p.R240C | UCEC | 1 |
| p.S93N | UCEC | 1 |
| p.E183K | HNSC | 1 |
| p.M127T | COAD | 1 |
| p.P232S | PRAD | 1 |
| p.P20L | LUAD | 1 |
| p.H280R | KIRP | 1 |
| p.M116I | SKCM | 1 |
| p.R148Q | KIRC | 1 |
| p.R156W | LUSC | 1 |
| p.V201A | SKCM | 1 |
| p.V256I | PRAD | 1 |
| p.W192X | SKCM | 1 |
| p.I113N | PAAD | 1 |
| p.M251T | SARC | 1 |
| p.E36K | HNSC | 1 |
| p.F283S | STAD | 1 |
| p.E199X | READ | 1 |
| p.W192* | SKCM | 1 |
| p.A316T | STAD | 1 |
| p.L138F | READ | 1 |
| p.P25S | SKCM | 1 |
| p.S38N | BRCA | 1 |
| p.K49N | LUAD | 1 |
| p.T133R | LUAD | 1 |
| p.R121W | PAAD | 1 |
| p.D132H | ACC | 1 |
| p.S13L | GBM | 1 |
| p.V165M | COAD | 1 |
| p.R145K | SKCM | 1 |
| p.N17H | UCEC | 1 |
| p.S166Y | LUAD | 1 |
| p.M251I | SKCM | 1 |
| p.A31T | UCEC | 1 |
| p.P25A | SKCM | 1 |
| p.K87N | UCEC | 1 |
| p.C81S | THCA | 1 |
| p.S265F | HNSC | 1 |
| p.V186M | PAAD | 1 |
| p.R121W | COAD | 1 |
| p.D250N | SKCM | 1 |
| Top |
| TissGeneCNV for RFPL1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for RFPL1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Top |
| TissGeneNet for RFPL1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| Top |
| TissGeneProg for RFPL1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for RFPL1 |
| TissGeneDrug for RFPL1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for RFPL1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0007273 | Carotid Artery Diseases | 1 | GAD |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |