TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for RHAG

Gene summary

Basic gene information	Gene symbol	RHAG
	Gene name	Rh-associated glycoprotein
	Synonyms	CD241\|RH2\|RH50A\|Rh50\|Rh50GP\|SLC42A1
	Cytomap	UCSC genome browser: 6p12.3
	Type of gene	protein-coding
	RefGenes	NM_000324.2,
	Description	Rhesus associated polypeptide, 50-KDRhesus blood group-associated glycoproteinammonium transporter Rh type Aerythrocyte membrane glycoprotein Rh50erythrocyte plasma membrane 50 kDa glycoproteinrh family type A glycoproteinrh type A glycoproteinrhes
	Modification date	20141207
dbXrefs	MIM : 180297
	HGNC : HGNC
	Ensembl : ENSG00000112077
	HPRD : 01582
	Vega : OTTHUMG00000016377
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_RHAG
	BioGPS: 6005
Pathway	NCI Pathway Interaction Database: RHAG
	KEGG: RHAG
	REACTOME: RHAG
	Pathway Commons: RHAG
Context	iHOP: RHAG
	ligand binding site mutation search in PubMed: RHAG
	UCL Cancer Institute: RHAG
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources	HPA,TiGER
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	Bone marrowLiver
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	LAMLLIHC
Reference showing the relevant tissue of RHAG
Description by TissGene annotations	TissgsKTS CNV lost TissGeneKTS

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0006873	cellular ion homeostasis	15856280
GO:0015670	carbon dioxide transport	16574458
GO:0015696	ammonium transport	15856280
GO:0072488	ammonium transmembrane transport	15856280
GO:0006873	cellular ion homeostasis	15856280
GO:0015670	carbon dioxide transport	16574458
GO:0015696	ammonium transport	15856280
GO:0072488	ammonium transmembrane transport	15856280

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TissGeneExp for RHAG

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
BLCA	-1.929040633	-0.816193264	-1.112847368	0.00172	0.01121783
COAD	-2.203373224	-1.064823224	-1.13855	0.000111	0.000398038

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TissGene-miRNA for RHAG

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for RHAG

TissGeneSNV for RHAG

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.P52S	SKCM	3
p.E13K	SKCM	2
p.E161K	SKCM	2
p.F151L	COAD	2
p.L22I	SKCM	2
p.R264*	LUSC	1
p.G233E	LUSC	1
p.V374A	STAD	1
p.G178E	LGG	1
p.G94D	SKCM	1
p.A344V	CESC	1
p.R323M	LUAD	1
p.R238M	LUAD	1
p.L85I	LUAD	1
p.L209*	UCEC	1
p.E199K	SKCM	1
p.G99E	SKCM	1
p.Y75*	LUAD	1
p.P52R	KIRC	1
p.T243M	CESC	1
p.Q102K	LUAD	1
p.H263Q	LUSC	1
p.Q30*	LUAD	1
p.M8V	SKCM	1
p.L216I	OV	1
p.G130R	SKCM	1
p.A230S	LUAD	1
p.H271N	HNSC	1
p.A123G	LUAD	1
p.G134E	SKCM	1
p.E231K	SKCM	1
p.G81D	KIRP	1
p.A249T	READ	1
p.G134R	LGG	1
p.L267F	LUSC	1
p.A287V	LGG	1
p.R409X	ESCA	1
p.A176D	LIHC	1
p.E49K	SKCM	1
p.Q106K	LUSC	1
p.T324S	LUAD	1
p.G64A	LUSC	1
p.P6L	SKCM	1
p.L33F	SARC	1
p.G21E	SKCM	1
p.V340G	SKCM	1
p.E262K	SKCM	1
p.Y157*	LUAD	1
p.V86I	COAD	1
p.M144I	BLCA	1
p.E231*	BLCA	1
p.V270I	COAD	1
p.I116V	READ	1
p.I229V	LUAD	1
p.P138S	LGG	1
p.G335S	UCEC	1
p.I229V	UCEC	1
p.P406R	LUAD	1
p.V270A	BRCA	1
p.W222L	GBM	1
p.A254S	PRAD	1
p.A350T	SKCM	1
p.Q98H	STAD	1
p.G389E	SKCM	1
p.A176D	OV	1
p.L343I	HNSC	1
p.D326N	SKCM	1
p.G99R	SKCM	1
p.F65V	READ	1
p.P52L	SKCM	1
p.S128Y	READ	1
p.F163L	UCEC	1
p.G279*	LUAD	1
p.M269I	SKCM	1
p.S227L	COAD	1
p.A287V	PRAD	1
p.S192Y	LGG	1
p.P223S	SKCM	1
p.K113N	HNSC	1
p.T243M	COAD	1

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TissGeneCNV for RHAG

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for RHAG

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
Chimerdb3.0	ChiTaRs	NA	H51698	RHAG-COMMD3		chr6:49598411	chr10:22609102
TCGAfusionPortal	PRADA	LUAD	TCGA-86-7953-01A	ARHGEF3-RHAG	Out-of-frame	Chr3:56916320	Chr6:49587075

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TissGeneNet for RHAG

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (tumor)	RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (normal)

COAD (tumor)	COAD (normal)
RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (tumor)	RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (normal)

HNSC (tumor)	HNSC (normal)
RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (tumor)	RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (normal)

KICH (tumor)	KICH (normal)
RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (tumor)	RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (normal)

KIRC (tumor)	KIRC (normal)
RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (tumor)	RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (normal)

KIRP (tumor)	KIRP (normal)
RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (tumor)	RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (normal)

LIHC (tumor)	LIHC (normal)
RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (tumor)	RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (normal)

LUAD (tumor)	LUAD (normal)
RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (tumor)	RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (normal)

LUSC (tumor)	LUSC (normal)
RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (tumor)	RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (normal)

PRAD (tumor)	PRAD (normal)
RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (tumor)	RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (normal)

STAD (tumor)	STAD (normal)
RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (tumor)	RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (normal)

THCA (tumor)	THCA (normal)
RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (tumor)	RHAG, CD47, ANK1, SLC4A1, ICAM4, GYPB (normal)

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TissGeneProg for RHAG

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for RHAG

TissGeneDrug for RHAG

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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TissGeneDisease for RHAG

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C1849387	Rh-Null, Regulator Type	3	CTD_human,UNIPROT
umls:C1861455	STOMATOCYTOSIS I	2	BeFree,CLINVAR,ORPHANET
umls:C0149931	Migraine Disorders	1	BeFree,GAD
umls:C1262483	Hereditary stomatocytosis	1	BeFree
umls:C0272052	Rh Deficiency Syndrome	0	ORPHANET