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| TissGeneSummary for RIT2 |
 Gene summary |
| Basic gene information | Gene symbol | RIT2 |
| Gene name | Ras-like without CAAX 2 | |
| Synonyms | RIBA|RIN|ROC2 | |
| Cytomap | UCSC genome browser: 18q12.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001272077.1, NM_002930.3, | |
| Description | GTP-binding protein Rit2GTP-binding protein Roc2Ric-like, expressed in neuronsras-like protein expressed in neuronsras-like without CAAX protein 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 609592 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000152214 | ||
| HPRD : 15253 | ||
| Vega : OTTHUMG00000132611 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RIT2 | |
| BioGPS: 6014 | ||
| Pathway | NCI Pathway Interaction Database: RIT2 | |
| KEGG: RIT2 | ||
| REACTOME: RIT2 | ||
| Pathway Commons: RIT2 | ||
| Context | iHOP: RIT2 | |
| ligand binding site mutation search in PubMed: RIT2 | ||
| UCL Cancer Institute: RIT2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of RIT2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for RIT2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for RIT2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for RIT2 |
| TissGeneSNV for RIT2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.Q119* | SKCM | 3 |
| p.G30R | SKCM | 2 |
| p.P127S | SKCM | 2 |
| p.T102S | STAD | 1 |
| p.P148H | SKCM | 1 |
| p.R197T | BLCA | 1 |
| p.E80Q | LUSC | 1 |
| p.R104H | SARC | 1 |
| p.P46S | SKCM | 1 |
| p.I53T | HNSC | 1 |
| p.R121S | LUAD | 1 |
| p.E146D | STAD | 1 |
| p.R182C | UCEC | 1 |
| p.E161_T162delinsX | COAD | 1 |
| p.R85W | UCEC | 1 |
| p.R213K | SKCM | 1 |
| p.E93K | SKCM | 1 |
| p.R182C | STAD | 1 |
| p.L195R | STAD | 1 |
| p.V131A | LUAD | 1 |
| p.K211T | LUAD | 1 |
| p.K112R | SKCM | 1 |
| p.P11Q | LUAD | 1 |
| p.G94S | SKCM | 1 |
| p.P127L | SKCM | 1 |
| p.K198N | STAD | 1 |
| p.R62K | SKCM | 1 |
| p.R121H | THYM | 1 |
| p.F174I | BLCA | 1 |
| p.T123S | THCA | 1 |
| p.A28G | LUAD | 1 |
| p.R19K | SKCM | 1 |
| p.R141H | LUAD | 1 |
| p.A14T | SARC | 1 |
| p.E86* | LUAD | 1 |
| p.S137L | LUAD | 1 |
| p.E180K | SKCM | 1 |
| p.T217A | COAD | 1 |
| p.S100F | SKCM | 1 |
| p.D199H | BLCA | 1 |
| p.L70F | LUAD | 1 |
| p.G158V | READ | 1 |
| p.R129K | SKCM | 1 |
| p.P11K | LUAD | 1 |
| p.E6K | SKCM | 1 |
| p.Q44* | BLCA | 1 |
| p.Q119X | SKCM | 1 |
| p.R179K | LUSC | 1 |
| p.G158V | STAD | 1 |
| p.Q153K | LUAD | 1 |
| p.P11T | LUAD | 1 |
| p.D172Y | LUSC | 1 |
| p.G29E | HNSC | 1 |
| p.K183N | LUAD | 1 |
| p.P148H | HNSC | 1 |
| p.E161Q | BLCA | 1 |
| p.E154K | SKCM | 1 |
| p.E151K | SARC | 1 |
| p.C98Y | UCEC | 1 |
| p.G16S | SKCM | 1 |
| p.Q142* | SKCM | 1 |
| p.D55N | OV | 1 |
| p.Y155F | SKCM | 1 |
| p.T75N | GBM | 1 |
| p.G113E | LUAD | 1 |
| p.R62S | LUAD | 1 |
| p.E4K | SKCM | 1 |
| p.H175R | BLCA | 1 |
| p.E154K | COAD | 1 |
| p.Q142X | SKCM | 1 |
| p.S13I | LUSC | 1 |
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| TissGeneCNV for RIT2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for RIT2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-AC-A23C-01A | LINC00340-RIT2 | 5'UTR-CDS | chr6:22020771 | chr18:40323685 |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-AC-A23C-01A | LINC00340-RIT2 | 5'UTR-CDS | chr6:21979291 | chr18:40323685 |
| Chimerdb3.0 | FusionScan | SARC | TCGA-DX-A6YR-01A | USP38-RIT2 | Out-of-Frame | chr4:144109114 | chr18:40323685 |
| Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-AC-A23C-01A | CASC15-RIT2 | Out-of-Frame | chr6:22020770 | chr18:40323684 |
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| TissGeneNet for RIT2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (tumor) | RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (normal) |
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| COAD (tumor) | COAD (normal) |
| RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (tumor) | RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (tumor) | RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (normal) |
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| KICH (tumor) | KICH (normal) |
| RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (tumor) | RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (tumor) | RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (tumor) | RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (tumor) | RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (tumor) | RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (tumor) | RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (tumor) | RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (normal) |
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| STAD (tumor) | STAD (normal) |
| RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (tumor) | RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (normal) |
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| THCA (tumor) | THCA (normal) |
| RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (tumor) | RIT2, HRAS, GRB2, CALM1, SOS1, VCL, RAB5A, MLLT4, RALGDS, PLXNB3, RLF, POU4F1, RGL1 (normal) |
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| TissGeneProg for RIT2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for RIT2 |
| TissGeneDrug for RIT2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for RIT2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0019196 | Hepatitis C | 17 | BeFree |
| umls:C0030567 | Parkinson Disease | 7 | BeFree,GAD,GWASCAT |
| umls:C0021670 | insulinoma | 5 | BeFree |
| umls:C0019158 | Hepatitis | 2 | BeFree |
| umls:C0019159 | Hepatitis A | 2 | BeFree |
| umls:C0341439 | Chronic liver disease | 2 | BeFree |
| umls:C0520463 | Chronic active hepatitis | 2 | BeFree |
| umls:C0524910 | Hepatitis C, Chronic | 2 | BeFree |
| umls:C0003873 | Rheumatoid Arthritis | 1 | GAD |
| umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
| umls:C0010403 | Cryoglobulinemia | 1 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
| umls:C0019189 | Hepatitis, Chronic | 1 | BeFree |
| umls:C0022116 | Ischemia | 1 | BeFree |
| umls:C0023895 | Liver diseases | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0036341 | Schizophrenia | 1 | BeFree,GAD |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0149654 | Conduct Disorder | 1 | GAD |
| umls:C1378703 | Renal carcinoma | 1 | BeFree |
| umls:C1519346 | Skin Carcinogenesis | 1 | BeFree |
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