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TissGeneSummary for RIT2 |
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Basic gene information | Gene symbol | RIT2 |
Gene name | Ras-like without CAAX 2 | |
Synonyms | RIBA|RIN|ROC2 | |
Cytomap | UCSC genome browser: 18q12.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001272077.1, NM_002930.3, | |
Description | GTP-binding protein Rit2GTP-binding protein Roc2Ric-like, expressed in neuronsras-like protein expressed in neuronsras-like without CAAX protein 2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 609592 | |
HGNC : HGNC | ||
Ensembl : ENSG00000152214 | ||
HPRD : 15253 | ||
Vega : OTTHUMG00000132611 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RIT2 | |
BioGPS: 6014 | ||
Pathway | NCI Pathway Interaction Database: RIT2 | |
KEGG: RIT2 | ||
REACTOME: RIT2 | ||
Pathway Commons: RIT2 | ||
Context | iHOP: RIT2 | |
ligand binding site mutation search in PubMed: RIT2 | ||
UCL Cancer Institute: RIT2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of RIT2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID |
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TissGeneExp for RIT2 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for RIT2 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for RIT2 |
TissGeneSNV for RIT2 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.Q119* | SKCM | 3 |
p.G30R | SKCM | 2 |
p.P127S | SKCM | 2 |
p.T102S | STAD | 1 |
p.P148H | SKCM | 1 |
p.R197T | BLCA | 1 |
p.E80Q | LUSC | 1 |
p.R104H | SARC | 1 |
p.P46S | SKCM | 1 |
p.I53T | HNSC | 1 |
p.R121S | LUAD | 1 |
p.E146D | STAD | 1 |
p.R182C | UCEC | 1 |
p.E161_T162delinsX | COAD | 1 |
p.R85W | UCEC | 1 |
p.R213K | SKCM | 1 |
p.E93K | SKCM | 1 |
p.R182C | STAD | 1 |
p.L195R | STAD | 1 |
p.V131A | LUAD | 1 |
p.K211T | LUAD | 1 |
p.K112R | SKCM | 1 |
p.P11Q | LUAD | 1 |
p.G94S | SKCM | 1 |
p.P127L | SKCM | 1 |
p.K198N | STAD | 1 |
p.R62K | SKCM | 1 |
p.R121H | THYM | 1 |
p.F174I | BLCA | 1 |
p.T123S | THCA | 1 |
p.A28G | LUAD | 1 |
p.R19K | SKCM | 1 |
p.R141H | LUAD | 1 |
p.A14T | SARC | 1 |
p.E86* | LUAD | 1 |
p.S137L | LUAD | 1 |
p.E180K | SKCM | 1 |
p.T217A | COAD | 1 |
p.S100F | SKCM | 1 |
p.D199H | BLCA | 1 |
p.L70F | LUAD | 1 |
p.G158V | READ | 1 |
p.R129K | SKCM | 1 |
p.P11K | LUAD | 1 |
p.E6K | SKCM | 1 |
p.Q44* | BLCA | 1 |
p.Q119X | SKCM | 1 |
p.R179K | LUSC | 1 |
p.G158V | STAD | 1 |
p.Q153K | LUAD | 1 |
p.P11T | LUAD | 1 |
p.D172Y | LUSC | 1 |
p.G29E | HNSC | 1 |
p.K183N | LUAD | 1 |
p.P148H | HNSC | 1 |
p.E161Q | BLCA | 1 |
p.E154K | SKCM | 1 |
p.E151K | SARC | 1 |
p.C98Y | UCEC | 1 |
p.G16S | SKCM | 1 |
p.Q142* | SKCM | 1 |
p.D55N | OV | 1 |
p.Y155F | SKCM | 1 |
p.T75N | GBM | 1 |
p.G113E | LUAD | 1 |
p.R62S | LUAD | 1 |
p.E4K | SKCM | 1 |
p.H175R | BLCA | 1 |
p.E154K | COAD | 1 |
p.Q142X | SKCM | 1 |
p.S13I | LUSC | 1 |
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TissGeneCNV for RIT2 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for RIT2 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | BRCA | TCGA-AC-A23C-01A | LINC00340-RIT2 | 5'UTR-CDS | chr6:22020771 | chr18:40323685 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-AC-A23C-01A | LINC00340-RIT2 | 5'UTR-CDS | chr6:21979291 | chr18:40323685 |
Chimerdb3.0 | FusionScan | SARC | TCGA-DX-A6YR-01A | USP38-RIT2 | Out-of-Frame | chr4:144109114 | chr18:40323685 |
Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-AC-A23C-01A | CASC15-RIT2 | Out-of-Frame | chr6:22020770 | chr18:40323684 |
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TissGeneNet for RIT2 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for RIT2 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for RIT2 |
TissGeneDrug for RIT2 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for RIT2 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0019196 | Hepatitis C | 17 | BeFree |
umls:C0030567 | Parkinson Disease | 7 | BeFree,GAD,GWASCAT |
umls:C0021670 | insulinoma | 5 | BeFree |
umls:C0019158 | Hepatitis | 2 | BeFree |
umls:C0019159 | Hepatitis A | 2 | BeFree |
umls:C0341439 | Chronic liver disease | 2 | BeFree |
umls:C0520463 | Chronic active hepatitis | 2 | BeFree |
umls:C0524910 | Hepatitis C, Chronic | 2 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 1 | GAD |
umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
umls:C0010403 | Cryoglobulinemia | 1 | BeFree |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
umls:C0019189 | Hepatitis, Chronic | 1 | BeFree |
umls:C0022116 | Ischemia | 1 | BeFree |
umls:C0023895 | Liver diseases | 1 | BeFree |
umls:C0028754 | Obesity | 1 | BeFree |
umls:C0036341 | Schizophrenia | 1 | BeFree,GAD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0149654 | Conduct Disorder | 1 | GAD |
umls:C1378703 | Renal carcinoma | 1 | BeFree |
umls:C1519346 | Skin Carcinogenesis | 1 | BeFree |