TissGeneSummary for RLBP1 |
Gene summary |
Basic gene information | Gene symbol | RLBP1 |
Gene name | retinaldehyde binding protein 1 | |
Synonyms | CRALBP | |
Cytomap | UCSC genome browser: 15q26 | |
Type of gene | protein-coding | |
RefGenes | NM_000326.4, | |
Description | cellular retinaldehyde-binding proteincellular retinaldehyde-binding protein-1retinaldehyde-binding protein 1 | |
Modification date | 20141219 | |
dbXrefs | MIM : 180090 | |
HGNC : HGNC | ||
Ensembl : ENSG00000140522 | ||
HPRD : 01572 | ||
Vega : OTTHUMG00000172884 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_RLBP1 | |
BioGPS: 6017 | ||
Pathway | NCI Pathway Interaction Database: RLBP1 | |
KEGG: RLBP1 | ||
REACTOME: RLBP1 | ||
Pathway Commons: RLBP1 | ||
Context | iHOP: RLBP1 | |
ligand binding site mutation search in PubMed: RLBP1 | ||
UCL Cancer Institute: RLBP1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BrainEye | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGGUVM | |
Reference showing the relevant tissue of RLBP1 | ||
Description by TissGene annotations | Protective TissGene in RFS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
Top |
TissGeneExp for RLBP1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
STAD | -1.687611202 | -0.651264327 | -1.036346875 | 0.00332 | 0.013852839 |
COAD | -1.547298221 | -0.359190529 | -1.188107692 | 0.000478 | 0.001483425 |
Top |
TissGene-miRNA for RLBP1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for RLBP1 |
TissGeneSNV for RLBP1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D288G | LIHC | 1 |
p.R42H | BLCA | 1 |
p.R234Q | STAD | 1 |
p.R101H | PRAD | 1 |
p.V158I | STAD | 1 |
p.Q309R | COAD | 1 |
p.A72V | BLCA | 1 |
p.L148I | PAAD | 1 |
p.E282V | SKCM | 1 |
p.R64* | CESC | 1 |
p.P36L | THYM | 1 |
p.D281N | READ | 1 |
p.P36L | UCEC | 1 |
p.Y124* | OV | 1 |
p.F99L | UCEC | 1 |
p.E3K | BRCA | 1 |
p.G307S | SKCM | 1 |
p.E279K | SKCM | 1 |
p.G77E | KIRC | 1 |
p.F161S | GBM | 1 |
p.V136L | BLCA | 1 |
p.A102T | STAD | 1 |
p.G31R | SKCM | 1 |
p.I176M | BLCA | 1 |
p.R216Q | SKCM | 1 |
p.R103W | STAD | 1 |
p.E3D | DLBC | 1 |
p.E54K | COAD | 1 |
p.E192V | SKCM | 1 |
p.G4R | SKCM | 1 |
p.L220I | LUAD | 1 |
p.Q67K | STAD | 1 |
p.E164Q | BLCA | 1 |
p.G290R | UCEC | 1 |
p.A85V | PRAD | 1 |
p.M223I | HNSC | 1 |
p.R64* | HNSC | 1 |
p.A74V | STAD | 1 |
p.E78K | SKCM | 1 |
p.L131Q | LUAD | 1 |
p.D50Y | UCEC | 1 |
p.N106S | LIHC | 1 |
p.R9H | COAD | 1 |
p.G4E | SKCM | 1 |
p.E170K | BLCA | 1 |
Top |
TissGeneCNV for RLBP1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for RLBP1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | W28826 | RLBP1-RLBP1 | chr15:89762220 | chr15:89762211 |
Top |
TissGeneNet for RLBP1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for RLBP1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for RLBP1 |
TissGeneDrug for RLBP1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
DB00162 | Vitamin A | Small molecule | Approved|Nutraceutical|Vet_approved |
Top |
TissGeneDisease for RLBP1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C1405854 | Retinitis punctata albescens (disorder) | 12 | BeFree,CLINVAR,GAD |
umls:C0035334 | Retinitis Pigmentosa | 7 | BeFree,CTD_human,GAD,LHGDN,ORPHANET,UNIPROT |
umls:C0339526 | Autosomal recessive retinitis pigmentosa | 7 | BeFree |
umls:C0035309 | Retinal Diseases | 4 | BeFree,GAD |
umls:C0311338 | Fundus Albipunctatus | 3 | BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT |
umls:C0854723 | Retinal Dystrophies | 3 | BeFree |
umls:C0035304 | Retinal Degeneration | 2 | BeFree |
umls:C0035333 | Retinitis | 2 | LHGDN |
umls:C0015398 | Eye Diseases, Hereditary | 1 | CTD_human |
umls:C0032580 | Adenomatous Polyposis Coli | 1 | BeFree |
umls:C0036341 | Schizophrenia | 1 | LHGDN |
umls:C0042164 | Uveitis | 1 | LHGDN |
umls:C0730290 | Cone dystrophy | 1 | BeFree |
umls:C1260959 | Drusen | 1 | BeFree |
umls:C1843815 | Newfoundland Rod-Cone Dystrophy | 1 | BeFree,CLINVAR,CTD_human |
umls:C1843816 | Bothnia Retinal Dystrophy | 1 | CLINVAR,CTD_human,MGD,ORPHANET,UNIPROT |