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| TissGeneSummary for RPL38 |
 Gene summary |
| Basic gene information | Gene symbol | RPL38 |
| Gene name | ribosomal protein L38 | |
| Synonyms | L38 | |
| Cytomap | UCSC genome browser: 17q25.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000999.3, NM_001035258.1, | |
| Description | 60S ribosomal protein L38 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 604182 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000172809 | ||
| HPRD : 16048 | ||
| Vega : OTTHUMG00000166016 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RPL38 | |
| BioGPS: 6169 | ||
| Pathway | NCI Pathway Interaction Database: RPL38 | |
| KEGG: RPL38 | ||
| REACTOME: RPL38 | ||
| Pathway Commons: RPL38 | ||
| Context | iHOP: RPL38 | |
| ligand binding site mutation search in PubMed: RPL38 | ||
| UCL Cancer Institute: RPL38 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Bone marrowOvary | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LAMLOV | |
| Reference showing the relevant tissue of RPL38 | ||
| Description by TissGene annotations | TissgsLTS Fused withTSGene Fused withOncogene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for RPL38 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for RPL38 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for RPL38 |
| TissGeneSNV for RPL38 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.K33T | UCS | 1 |
| p.R37* | UCEC | 1 |
| p.V32M | STAD | 1 |
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| TissGeneCNV for RPL38 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for RPL38 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BX101889 | TEK-RPL38 | chr9:27190586 | chr17:72205325 | |
| Chimerdb3.0 | ChiTaRs | NA | AK075017 | UBE2J2-RPL38 | chr1:1209212 | chr17:72205942 | |
| Chimerdb3.0 | ChiTaRs | NA | BI861689 | SUPT7L-RPL38 | chr2:27878441 | chr17:72200077 | |
| Chimerdb3.0 | ChiTaRs | NA | CR746137 | SURF6-RPL38 | chr9:136199561 | chr17:72199817 | |
| Chimerdb3.0 | ChiTaRs | NA | BC046153 | PMS2P3-RPL38 | chr7:75157428 | chr17:72205948 | |
| Chimerdb3.0 | ChiTaRs | NA | CK004088 | NDRG2-RPL38 | chr14:21488735 | chr17:72200288 | |
| Chimerdb3.0 | ChiTaRs | NA | BE388615 | RPL38-CITED1 | chr17:72206007 | chrX:71526489 | |
| Chimerdb3.0 | ChiTaRs | NA | BE409397 | RPL38-CITED1 | chr17:72206007 | chrX:71525968 | |
| Chimerdb3.0 | ChiTaRs | NA | R50162 | RPL38-TEK | chr17:72206054 | chr9:27185554 | |
| Chimerdb3.0 | ChiTaRs | NA | AV742653 | PRR13-RPL38 | chr12:53837268 | chr17:72199826 | |
| Chimerdb3.0 | ChiTaRs | NA | BE391347 | RPL38-CITED1 | chr17:72206007 | chrX:71526441 | |
| Chimerdb3.0 | ChiTaRs | NA | BE797621 | RPL38-DONSON | chr17:72206008 | chr21:35276247 | |
| Chimerdb3.0 | ChiTaRs | NA | CA313275 | MNT-RPL38 | chr17:2287508 | chr17:72199818 | |
| Chimerdb3.0 | ChiTaRs | NA | BP222381 | RPL38-PHF20 | chr17:72205423 | chr20:34359946 | |
| Chimerdb3.0 | ChiTaRs | NA | BF696633 | RPL38-SNX3 | chr17:72199886 | chr6:108532890 | |
| Chimerdb3.0 | ChiTaRs | NA | CD368190 | RPL38-RPL3 | chr17:72206019 | chr22:39710181 | |
| Chimerdb3.0 | ChiTaRs | NA | CA432338 | RPL38-TRMT5 | chr17:72206019 | chr14:61442204 | |
| Chimerdb3.0 | ChiTaRs | NA | DA794650 | RPL38-HSP90AA1 | chr17:72205450 | chr14:102552631 | |
| Chimerdb3.0 | ChiTaRs | NA | BM968470 | RPL38-RPL38 | chr17:72206019 | chr17:72205326 | |
| Chimerdb3.0 | ChiTaRs | NA | AA034452 | PXN-RPL38 | chr12:120655460 | chr17:72205394 | |
| Chimerdb3.0 | ChiTaRs | NA | AA017134 | RPL38-DST | chr17:72206019 | chr6:56328425 | |
| Chimerdb3.0 | ChiTaRs | NA | BM810069 | RPL38-NCAPH2 | chr17:72206019 | chr22:50962352 | |
| Chimerdb3.0 | ChiTaRs | NA | DB371044 | RPL38-UBE2J2 | chr17:72206017 | chr1:1189857 | |
| Chimerdb3.0 | ChiTaRs | NA | AA977713 | RPL38-TRAPPC6B | chr17:72206019 | chr14:39619329 | |
| Chimerdb3.0 | TopHat-Fusion | UCEC | TCGA-BK-A4ZD-01A | ARHGAP44-RPL38 | In-Frame | chr17:12707446 | chr17:72200328 |
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| TissGeneNet for RPL38 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| RPL38, NME2, SIRT7, COPS6, CAND1, CUL5, CUL2, TRAF6, YWHAZ, RUVBL2, HLA-B, TSC22D1, COPS5, MEPCE, TNFRSF1B, EPB41, CUL4A, NME1-NME2, AP2M1, DCC, TFE3 (tumor) | RPL38, NME2, SIRT7, COPS6, CAND1, CUL5, CUL2, TRAF6, RUVBL2, HLA-B, CUL3, COPS5, MEPCE, RIPK2, PHLDA3, EPB41, CUL4A, NME1-NME2, AP2M1, DCC, CHMP5 (normal) |
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| COAD (tumor) | COAD (normal) |
| RPL38, NME2, SIRT7, COPS6, CUL5, CUL2, TRAF6, YWHAZ, RUVBL2, CUL3, CUL1, COPS5, MEPCE, RIPK2, TNFRSF1B, PXN, EPB41, AP2M1, DCC, TFE3, CHMP5 (tumor) | RPL38, NME2, SIRT7, COPS6, CAND1, CUL5, TRAF6, RUVBL2, HLA-B, TSC22D1, COPS5, MEPCE, RIPK2, TNFRSF1B, EPB41, CUL4A, NME1-NME2, AP2M1, DCC, TFE3, CHMP5 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| RPL38, NME2, SIRT7, COPS6, CAND1, CUL5, CUL2, TRAF6, RUVBL2, HLA-B, CUL3, COPS5, MEPCE, TNFRSF1B, PHLDA3, EPB41, CUL4A, NME1-NME2, AP2M1, DCC, TFE3 (tumor) | RPL38, NME2, SIRT7, COPS6, CAND1, CUL5, CUL2, TRAF6, RUVBL2, CUL3, COPS5, MEPCE, TNFRSF1B, PHLDA3, EPB41, CUL4A, NME1-NME2, AP2M1, DCC, TFE3, CHMP5 (normal) |
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| KICH (tumor) | KICH (normal) |
| RPL38, NME2, SIRT7, COPS6, CAND1, CUL5, CUL2, TRAF6, YWHAZ, RUVBL2, CUL3, TSC22D1, COPS5, MEPCE, TNFRSF1B, PXN, EPB41, CUL4A, NME1-NME2, TFE3, CHMP5 (tumor) | RPL38, NME2, SIRT7, COPS6, CAND1, CUL5, TRAF6, YWHAZ, RUVBL2, HLA-B, CUL3, TSC22D1, CUL1, COPS5, RIPK2, PHLDA3, PXN, EPB41, CUL4A, NME1-NME2, AP2M1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| RPL38, NME2, SIRT7, COPS6, CAND1, CUL5, TRAF6, YWHAZ, RUVBL2, HLA-B, CUL3, CUL1, COPS5, TNFRSF1B, PHLDA3, EPB41, CUL4A, NME1-NME2, AP2M1, TFE3, CHMP5 (tumor) | RPL38, NME2, SIRT7, COPS6, CAND1, CUL5, CUL2, TRAF6, YWHAZ, RUVBL2, CUL3, COPS5, MEPCE, RIPK2, PHLDA3, PXN, CUL4A, NME1-NME2, AP2M1, DCC, CHMP5 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| RPL38, NME2, SIRT7, COPS6, CAND1, CUL5, TRAF6, YWHAZ, RUVBL2, HLA-B, TSC22D1, CUL1, COPS5, RIPK2, PHLDA3, EPB41, CUL4A, NME1-NME2, AP2M1, DCC, CHMP5 (tumor) | RPL38, NME2, SIRT7, COPS6, CAND1, CUL5, CUL2, TRAF6, RUVBL2, HLA-B, CUL3, TSC22D1, COPS5, MEPCE, RIPK2, PHLDA3, EPB41, CUL4A, NME1-NME2, AP2M1, CHMP5 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| RPL38, NME2, SIRT7, COPS6, CAND1, CUL5, CUL2, TRAF6, YWHAZ, RUVBL2, CUL3, CUL1, COPS5, MEPCE, PHLDA3, EPB41, CUL4A, NME1-NME2, AP2M1, DCC, CHMP5 (tumor) | RPL38, NME2, SIRT7, COPS6, CAND1, CUL5, CUL2, TRAF6, RUVBL2, CUL3, TSC22D1, CUL1, COPS5, MEPCE, RIPK2, EPB41, CUL4A, NME1-NME2, AP2M1, TFE3, CHMP5 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| RPL38, NME2, COPS6, CUL2, TRAF6, YWHAZ, RUVBL2, HLA-B, TSC22D1, COPS5, MEPCE, TNFRSF1B, PHLDA3, PXN, EPB41, CUL4A, NME1-NME2, AP2M1, DCC, TFE3, CHMP5 (tumor) | RPL38, NME2, SIRT7, COPS6, CUL5, CUL2, TRAF6, YWHAZ, RUVBL2, CUL3, COPS5, RIPK2, TNFRSF1B, PHLDA3, PXN, EPB41, CUL4A, NME1-NME2, DCC, TFE3, CHMP5 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| RPL38, NME2, SIRT7, COPS6, CUL5, CUL2, TRAF6, YWHAZ, CUL3, TSC22D1, CUL1, COPS5, MEPCE, TNFRSF1B, PHLDA3, PXN, EPB41, AP2M1, DCC, TFE3, CHMP5 (tumor) | RPL38, NME2, SIRT7, COPS6, CUL2, TRAF6, YWHAZ, RUVBL2, HLA-B, CUL1, COPS5, RIPK2, TNFRSF1B, PHLDA3, PXN, EPB41, CUL4A, NME1-NME2, DCC, TFE3, CHMP5 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| RPL38, NME2, SIRT7, COPS6, CAND1, CUL5, TRAF6, YWHAZ, RUVBL2, HLA-B, TSC22D1, COPS5, RIPK2, TNFRSF1B, PHLDA3, EPB41, NME1-NME2, AP2M1, DCC, TFE3, CHMP5 (tumor) | RPL38, NME2, SIRT7, COPS6, CAND1, CUL5, CUL2, TRAF6, YWHAZ, RUVBL2, CUL3, CUL1, COPS5, MEPCE, PHLDA3, EPB41, CUL4A, NME1-NME2, AP2M1, DCC, TFE3 (normal) |
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| STAD (tumor) | STAD (normal) |
| RPL38, NME2, SIRT7, COPS6, CAND1, CUL5, CUL2, TRAF6, TSC22D1, CUL1, COPS5, MEPCE, RIPK2, PHLDA3, PXN, EPB41, NME1-NME2, AP2M1, DCC, TFE3, CHMP5 (tumor) | RPL38, NME2, SIRT7, COPS6, CAND1, CUL5, CUL2, TRAF6, YWHAZ, RUVBL2, CUL3, COPS5, MEPCE, RIPK2, TNFRSF1B, PXN, EPB41, NME1-NME2, DCC, TFE3, CHMP5 (normal) |
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| THCA (tumor) | THCA (normal) |
| RPL38, NME2, SIRT7, COPS6, CAND1, CUL5, CUL2, TRAF6, RUVBL2, HLA-B, CUL3, COPS5, MEPCE, RIPK2, TNFRSF1B, PHLDA3, PXN, CUL4A, NME1-NME2, AP2M1, TFE3 (tumor) | RPL38, NME2, SIRT7, COPS6, CAND1, CUL5, CUL2, TRAF6, RUVBL2, HLA-B, CUL3, CUL1, COPS5, MEPCE, PHLDA3, EPB41, CUL4A, NME1-NME2, AP2M1, TFE3, CHMP5 (normal) |
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| TissGeneProg for RPL38 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for RPL38 |
| TissGeneDrug for RPL38 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for RPL38 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0029882 | Otitis Media | 1 | BeFree |
| umls:C2242816 | Chronic secretory otitis media | 1 | BeFree |
| umls:C2827407 | Infectious Otitis Media | 1 | BeFree |
| umls:C1833692 | OTITIS MEDIA, SUSCEPTIBILITY TO (finding) | 0 | MGD |
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