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| TissGeneSummary for S100A2 |
 Gene summary |
| Basic gene information | Gene symbol | S100A2 |
| Gene name | S100 calcium binding protein A2 | |
| Synonyms | CAN19|S100L | |
| Cytomap | UCSC genome browser: 1q21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_005978.3, | |
| Description | S100 calcium-binding protein A2protein S100-A2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 176993 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000196754 | ||
| HPRD : 01508 | ||
| Vega : OTTHUMG00000035031 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_S100A2 | |
| BioGPS: 6273 | ||
| Pathway | NCI Pathway Interaction Database: S100A2 | |
| KEGG: S100A2 | ||
| REACTOME: S100A2 | ||
| Pathway Commons: S100A2 | ||
| Context | iHOP: S100A2 | |
| ligand binding site mutation search in PubMed: S100A2 | ||
| UCL Cancer Institute: S100A2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | ||
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BladderEsophagus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BLCAESCA | |
| Reference showing the relevant tissue of S100A2 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for S100A2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 4.662254339 | -1.152224092 | 5.814478431 | 6.19E-21 | 8.40E-20 |
| COAD | -1.157438044 | -4.417338044 | 3.2599 | 1.91E-14 | 7.87E-13 |
| PRAD | -1.768786121 | -0.074130352 | -1.694655769 | 1.42E-05 | 7.51E-05 |
| LUAD | 0.284250417 | -1.839425445 | 2.123675862 | 1.38E-08 | 6.06E-08 |
| KIRC | -1.966084305 | 2.405400417 | -4.371484722 | 1.42E-38 | 5.30E-37 |
| KICH | -0.885541583 | 2.908634417 | -3.794176 | 6.08E-09 | 3.39E-08 |
| KIRP | -0.551215208 | 2.353066042 | -2.90428125 | 1.54E-13 | 2.93E-12 |
| THCA | 0.865426689 | -0.46319365 | 1.328620339 | 3.37E-06 | 1.19E-05 |
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| TissGene-miRNA for S100A2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-25-3p | MIMAT0000081 | 0.039 | -0.28 | 56 |
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| TissGeneMut for S100A2 |
| TissGeneSNV for S100A2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.D25N | UCEC | 1 |
| p.L38V | HNSC | 1 |
| p.D63E | COAD | 1 |
| p.S61N | DLBC | 1 |
| p.H17Y | SKCM | 1 |
| p.N87S | OV | 1 |
| p.S30I | UCEC | 1 |
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| TissGeneCNV for S100A2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for S100A2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | CA313696 | S100A2-SGK223 | chr1:153533877 | chr8:8175298 | |
| Chimerdb3.0 | ChiTaRs | NA | BE122841 | S100A2-EIF3D | chr1:153536246 | chr22:36908615 | |
| Chimerdb3.0 | ChiTaRs | NA | BE122809 | EIF3D-S100A2 | chr22:36912655 | chr1:153533821 | |
| TCGAfusionPortal | PRADA | LGG | TCGA-HT-7477-01B | RPRD2-S100A2 | CDS-5UTR | Chr1:150390201 | Chr1:153536363 |
| TCGAfusionPortal | PRADA | LUAD | TCGA-L9-A444-01A | MID1-S100A2 | 5UTR-5UTR | ChrX:10588330 | Chr1:153536363 |
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| TissGeneNet for S100A2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (tumor) | S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (normal) |
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| COAD (tumor) | COAD (normal) |
| S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (tumor) | S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (normal) |
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| HNSC (tumor) | HNSC (normal) |
| S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (tumor) | S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (normal) |
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| KICH (tumor) | KICH (normal) |
| S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (tumor) | S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (normal) |
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| KIRC (tumor) | KIRC (normal) |
| S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (tumor) | S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (normal) |
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| KIRP (tumor) | KIRP (normal) |
| S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (tumor) | S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (normal) |
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| LIHC (tumor) | LIHC (normal) |
| S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (tumor) | S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (normal) |
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| LUAD (tumor) | LUAD (normal) |
| S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (tumor) | S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (normal) |
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| LUSC (tumor) | LUSC (normal) |
| S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (tumor) | S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (normal) |
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| PRAD (tumor) | PRAD (normal) |
| S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (tumor) | S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (normal) |
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| STAD (tumor) | STAD (normal) |
| S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (tumor) | S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (normal) |
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| THCA (tumor) | THCA (normal) |
| S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (tumor) | S100A2, TP53, FKBP4, MDM2, TPM3, AREG, TPM2, TPM1, S100P (normal) |
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| TissGeneProg for S100A2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for S100A2 |
| TissGeneDrug for S100A2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00768 | Olopatadine | Antagonist | Small molecule | Approved |
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| TissGeneDisease for S100A2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 10 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 10 | BeFree,LHGDN |
| umls:C0001418 | Adenocarcinoma | 9 | BeFree,LHGDN |
| umls:C0007137 | Squamous cell carcinoma | 9 | BeFree,LHGDN |
| umls:C0242379 | Malignant neoplasm of lung | 6 | BeFree,GAD |
| umls:C0684249 | Carcinoma of lung | 6 | BeFree |
| umls:C0596263 | Carcinogenesis | 4 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
| umls:C0178874 | Tumor Progression | 3 | BeFree |
| umls:C0678222 | Breast Carcinoma | 3 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 3 | BeFree |
| umls:C0011615 | Dermatitis, Atopic | 2 | BeFree,GAD |
| umls:C0024121 | Lung Neoplasms | 2 | LHGDN |
| umls:C0024623 | Malignant neoplasm of stomach | 2 | BeFree |
| umls:C0025202 | melanoma | 2 | BeFree |
| umls:C0152013 | Adenocarcinoma of lung (disorder) | 2 | BeFree |
| umls:C0153381 | Malignant neoplasm of mouth | 2 | BeFree |
| umls:C0220641 | Lip and Oral Cavity Carcinoma | 2 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 2 | BeFree |
| umls:C0279626 | Squamous cell carcinoma of esophagus | 2 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 2 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 2 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 2 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 2 | BeFree |
| umls:C0007107 | Malignant neoplasm of larynx | 1 | BeFree |
| umls:C0007120 | Bronchioloalveolar Adenocarcinoma | 1 | BeFree |
| umls:C0014474 | Ependymoma | 1 | BeFree |
| umls:C0018671 | Head and Neck Neoplasms | 1 | LHGDN |
| umls:C0022578 | Keratoconus | 1 | LHGDN |
| umls:C0025149 | Medulloblastoma | 1 | BeFree |
| umls:C0026640 | Mouth Neoplasms | 1 | LHGDN |
| umls:C0027404 | Narcolepsy | 1 | GAD |
| umls:C0153676 | Secondary malignant neoplasm of lung | 1 | BeFree |
| umls:C0220633 | Uveal melanoma | 1 | BeFree |
| umls:C0278504 | Non-small cell lung cancer stage I | 1 | BeFree |
| umls:C0278996 | Cancer of Head and Neck | 1 | BeFree |
| umls:C0280217 | stage, non-small cell lung cancer | 1 | BeFree |
| umls:C0346957 | Disseminated Malignant Neoplasm | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0521158 | Recurrent tumor | 1 | BeFree |
| umls:C0595989 | Carcinoma of larynx | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0677776 | Hereditary Breast and Ovarian Cancer Syndrome | 1 | BeFree |
| umls:C1449563 | Cardiomyopathy, Familial Idiopathic | 1 | BeFree |
| umls:C1704272 | Benign Prostatic Hyperplasia | 1 | BeFree |
| umls:C1709246 | Non-Neoplastic Disorder | 1 | BeFree |
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