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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for S100P
check button Gene summary
Basic gene informationGene symbolS100P
Gene nameS100 calcium binding protein P
SynonymsMIG9
CytomapUCSC genome browser: 4p16
Type of geneprotein-coding
RefGenesNM_005980.2,
DescriptionS100 calcium-binding protein Pmigration-inducing gene 9 proteinprotein S100-Eprotein S100-P
Modification date20141207
dbXrefs MIM : 600614
HGNC : HGNC
HPRD : 02792
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_S100P
BioGPS: 6286
PathwayNCI Pathway Interaction Database: S100P
KEGG: S100P
REACTOME: S100P
Pathway Commons: S100P
ContextiHOP: S100P
ligand binding site mutation search in PubMed: S100P
UCL Cancer Institute: S100P
Assigned class in TissGDB*C
Included tissue-specific gene expression resources
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Stomach
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)STAD
Reference showing the relevant tissue of S100P
Description by TissGene annotationsCancer gene
Fused withTSGene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for S100P

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LUAD3.9541644191.1673937292.786770699.47E-083.72E-07
COAD6.2232538093.7245038092.498754.92E-072.98E-06
BRCA2.489818653-1.9021436274.3919622811.13E-271.29E-26
LIHC0.882581039-1.3590029612.2415840.001070.002908776


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TissGene-miRNA for S100P

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for S100P
TissGeneSNV for S100P

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.A7DESCA1
p.K39TSKCM1
p.A63STHYM1
p.T82MCOAD1
p.A7VUCEC1
p.V54MCOAD1


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TissGeneCNV for S100P

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for S100P

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0FusionScanPRADTCGA-EJ-8474-01AFAM13C-S100PIn-Framechr10:61112029chr4:6698619
Chimerdb3.0TopHat-FusionPRADTCGA-EJ-8474-01AFAM13C-S100PIn-Framechr10:61112029chr4:6698619
TCGAfusionPortalPRADABRCATCGA-AR-A1AK-01AS100P-CHD1NAChr4:6698896Chr5:98219587


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TissGeneNet for S100P

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (tumor)S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (normal)
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COAD (tumor)COAD (normal)
S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (tumor)S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (normal)
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HNSC (tumor)HNSC (normal)
S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (tumor)S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (normal)
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KICH (tumor)KICH (normal)
S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (tumor)S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (normal)
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KIRC (tumor)KIRC (normal)
S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (tumor)S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (normal)
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KIRP (tumor)KIRP (normal)
S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (tumor)S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (normal)
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LIHC (tumor)LIHC (normal)
S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (tumor)S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (normal)
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LUAD (tumor)LUAD (normal)
S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (tumor)S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (normal)
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LUSC (tumor)LUSC (normal)
S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (tumor)S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (normal)
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PRAD (tumor)PRAD (normal)
S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (tumor)S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (normal)
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STAD (tumor)STAD (normal)
S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (tumor)S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (normal)
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THCA (tumor)THCA (normal)
S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (tumor)S100P, EZR, MYH9, TERF2IP, AGER, S100A1, CACYBP, SUGT1, S100A2, S100A4, S100Z (normal)
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TissGeneProg for S100P

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for S100P
TissGeneDrug for S100P

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status
DB01003Cromoglicic acidAntagonistSmall moleculeApproved


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TissGeneDisease for S100P

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0027627Neoplasm Metastasis13BeFree
umls:C0235974Pancreatic carcinoma7BeFree
umls:C0346647Malignant neoplasm of pancreas7BeFree
umls:C0001418Adenocarcinoma5BeFree,LHGDN
umls:C0024623Malignant neoplasm of stomach5BeFree
umls:C0596263Carcinogenesis5BeFree
umls:C0699791Stomach Carcinoma5BeFree
umls:C0006142Malignant neoplasm of breast4BeFree
umls:C0030297Pancreatic Neoplasm4LHGDN
umls:C0678222Breast Carcinoma4BeFree
umls:C0007102Malignant tumor of colon3BeFree
umls:C0007131Non-Small Cell Lung Carcinoma3BeFree
umls:C0009402Colorectal Carcinoma3BeFree
umls:C0376358Malignant neoplasm of prostate3BeFree
umls:C0600139Prostate carcinoma3BeFree
umls:C0699790Colon Carcinoma3BeFree
umls:C1527249Colorectal Cancer3BeFree
umls:C0007138Carcinoma, Transitional Cell2BeFree
umls:C0029925Ovarian Carcinoma2BeFree
umls:C0033578Prostatic Neoplasms2BeFree,LHGDN
umls:C0178874Tumor Progression2BeFree
umls:C0206698Cholangiocarcinoma2BeFree
umls:C0302592Cervix carcinoma2BeFree
umls:C0936223Metastatic Prostate Carcinoma2BeFree
umls:C1140680Malignant neoplasm of ovary2BeFree
umls:C1335302Pancreatic Ductal Adenocarcinoma2BeFree
umls:C2145472Urothelial Carcinoma2BeFree
umls:C2239176Liver carcinoma2BeFree
umls:C0001430Adenoma1BeFree
umls:C0004134Ataxia1BeFree
umls:C0007134Renal Cell Carcinoma1BeFree
umls:C0009324Ulcerative Colitis1BeFree
umls:C0009375Colonic Neoplasms1BeFree
umls:C0013421Dystonia1BeFree
umls:C0014175Endometriosis1BeFree
umls:C0021390Inflammatory Bowel Diseases1BeFree
umls:C0022665Kidney Neoplasm1BeFree
umls:C0026948Mycosis Fungoides1BeFree
umls:C0032460Polycystic Ovary Syndrome1CTD_human
umls:C0042065Genitourinary Neoplasms1BeFree
umls:C0153676Secondary malignant neoplasm of lung1BeFree
umls:C0279000Liver and Intrahepatic Biliary Tract Carcinoma1BeFree
umls:C0279626Squamous cell carcinoma of esophagus1BeFree
umls:C0280100Solid tumour1BeFree
umls:C0280217stage, non-small cell lung cancer1BeFree
umls:C0281361Adenocarcinoma of pancreas1BeFree
umls:C0345904Malignant neoplasm of liver1BeFree
umls:C0393593Dystonia Disorders1BeFree
umls:C0597984Biliary stricture1BeFree
umls:C0677898invasive cancer1BeFree
umls:C0878500Intraepithelial Neoplasia1BeFree
umls:C0919267ovarian neoplasm1LHGDN
umls:C1512409Hepatocarcinogenesis1BeFree
umls:C1516170Cancer Cell Growth1BeFree
umls:C1519670Tumor Angiogenesis1BeFree
umls:C3539878Triple Negative Breast Neoplasms1BeFree