 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for CELA2A |
 Gene summary |
| Basic gene information | Gene symbol | CELA2A |
| Gene name | chymotrypsin-like elastase family, member 2A | |
| Synonyms | ELA2A|PE-1 | |
| Cytomap | UCSC genome browser: 1p36.21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_033440.2, | |
| Description | chymotrypsin-like elastase family member 2Aelastase 2Aelastase-2Apancreatic elastase 2pancreatic elastase IIA | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 609443 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000142615 | ||
| HPRD : 06495 | ||
| Vega : OTTHUMG00000002258 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CELA2A | |
| BioGPS: 63036 | ||
| Pathway | NCI Pathway Interaction Database: CELA2A | |
| KEGG: CELA2A | ||
| REACTOME: CELA2A | ||
| Pathway Commons: CELA2A | ||
| Context | iHOP: CELA2A | |
| ligand binding site mutation search in PubMed: CELA2A | ||
| UCL Cancer Institute: CELA2A | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Pancreas | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAAD | |
| Reference showing the relevant tissue of CELA2A | ||
| Description by TissGene annotations | TissgsKTS CNV gained TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
| Top |
| TissGeneExp for CELA2A |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| Top |
| TissGene-miRNA for CELA2A |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for CELA2A |
| TissGeneSNV for CELA2A |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R79K | SKCM | 2 |
| p.K53Q | BLCA | 1 |
| p.V131D | LUAD | 1 |
| p.S239A | STAD | 1 |
| p.Q230* | KIRP | 1 |
| p.V255D | LUAD | 1 |
| p.Y246C | OV | 1 |
| p.G119W | STAD | 1 |
| p.V107M | SKCM | 1 |
| p.Q138H | SARC | 1 |
| p.L69Q | LUSC | 1 |
| p.T4M | PRAD | 1 |
| p.V29L | SKCM | 1 |
| p.Y55H | ESCA | 1 |
| p.S45F | BLCA | 1 |
| p.S97L | STAD | 1 |
| p.S66I | BRCA | 1 |
| p.N114K | KIRP | 1 |
| p.L90I | LGG | 1 |
| p.F252C | SKCM | 1 |
| p.G238R | SKCM | 1 |
| p.R79T | HNSC | 1 |
| p.V208M | LUAD | 1 |
| p.D135N | UCS | 1 |
| p.E33Q | HNSC | 1 |
| p.K126T | COAD | 1 |
| p.L179V | LUSC | 1 |
| p.W67C | HNSC | 1 |
| Top |
| TissGeneCNV for CELA2A |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for CELA2A |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | LGG | TCGA-DU-8161-01A | PER3-CELA2A | In-frame | Chr1:7845646 | Chr1:15792494 |
| Top |
| TissGeneNet for CELA2A |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| Top |
| TissGeneProg for CELA2A |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for CELA2A |
| TissGeneDrug for CELA2A |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for CELA2A |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0020538 | Hypertensive disease | 1 | CTD_human |
| umls:C0242350 | Erectile dysfunction | 1 | GAD |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |