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| TissGeneSummary for CEACAM1 |
 Gene summary |
| Basic gene information | Gene symbol | CEACAM1 |
| Gene name | carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein) | |
| Synonyms | BGP|BGP1|BGPI | |
| Cytomap | UCSC genome browser: 19q13.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001024912.2, NM_001184813.1,NM_001184815.1,NM_001184816.1,NM_001205344.1, NM_001712.4, | |
| Description | CD66a antigenantigen CD66carcinoembryonic antigen-related cell adhesion molecule 1 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 109770 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000079385 | ||
| HPRD : 00191 | ||
| Vega : OTTHUMG00000151078 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CEACAM1 | |
| BioGPS: 634 | ||
| Pathway | NCI Pathway Interaction Database: CEACAM1 | |
| KEGG: CEACAM1 | ||
| REACTOME: CEACAM1 | ||
| Pathway Commons: CEACAM1 | ||
| Context | iHOP: CEACAM1 | |
| ligand binding site mutation search in PubMed: CEACAM1 | ||
| UCL Cancer Institute: CEACAM1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Colon | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | COAD | |
| Reference showing the relevant tissue of CEACAM1 | ||
| Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CEACAM1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| HNSC | -0.759285042 | 2.167689377 | -2.926974419 | 2.17E-12 | 7.18E-11 |
| LUAD | 0.719427187 | -0.936586606 | 1.656013793 | 6.07E-14 | 5.47E-13 |
| COAD | 2.847532758 | 4.950501988 | -2.102969231 | 4.38E-10 | 5.22E-09 |
| KICH | -0.778851089 | 0.809740911 | -1.588592 | 6.27E-07 | 2.44E-06 |
| KIRC | -0.121171089 | 0.925891411 | -1.0470625 | 4.47E-13 | 1.97E-12 |
| KIRP | -1.650108589 | 0.760416411 | -2.410525 | 5.35E-16 | 1.82E-14 |
| ESCA | 2.307674366 | -0.579943816 | 2.887618182 | 0.00351 | 0.031604211 |
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| TissGene-miRNA for CEACAM1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-30c-5p | MIMAT0000244 | 0.028 | -0.3 | 56 |
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| TissGeneMut for CEACAM1 |
| TissGeneSNV for CEACAM1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.T100I | KIRC | 2 |
| p.A223V | BLCA | 1 |
| p.I357L | STAD | 1 |
| p.S349C | LUAD | 1 |
| p.G85E | SKCM | 1 |
| p.D408N | SKCM | 1 |
| p.N475K | HNSC | 1 |
| p.D465G | STAD | 1 |
| p.L4R | STAD | 1 |
| p.G252E | SKCM | 1 |
| p.L443V | BLCA | 1 |
| p.C308G | OV | 1 |
| p.P367Q | THCA | 1 |
| p.R12C | SARC | 1 |
| p.Q114K | PRAD | 1 |
| p.L366F | UCEC | 1 |
| p.W28* | BLCA | 1 |
| p.G118E | LUAD | 1 |
| p.S349Y | THYM | 1 |
| p.A83V | DLBC | 1 |
| p.S188C | LIHC | 1 |
| p.S151I | LUAD | 1 |
| p.M488I | LUAD | 1 |
| p.A164V | STAD | 1 |
| p.E168K | SKCM | 1 |
| p.T350I | STAD | 1 |
| p.Q35K | DLBC | 1 |
| p.R225C | UCEC | 1 |
| p.P385T | UCEC | 1 |
| p.N181Y | SKCM | 1 |
| p.R225L | STAD | 1 |
| p.R12C | COAD | 1 |
| p.G377D | SKCM | 1 |
| p.G252R | SKCM | 1 |
| p.T100I | DLBC | 1 |
| p.T117I | COAD | 1 |
| p.G136E | SKCM | 1 |
| p.G48E | SKCM | 1 |
| p.R310S | HNSC | 1 |
| p.T311I | SKCM | 1 |
| p.G75D | COAD | 1 |
| p.S343F | SKCM | 1 |
| p.S222N | LGG | 1 |
| p.D462V | MESO | 1 |
| p.S106F | SKCM | 1 |
| p.G97S | UCEC | 1 |
| p.Q172R | STAD | 1 |
| p.R98* | SKCM | 1 |
| p.Q183* | SKCM | 1 |
| p.T393M | STAD | 1 |
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| TissGeneCNV for CEACAM1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CEACAM1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for CEACAM1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CEACAM1, PTPN6, TFAP2A, SRC, SHC1, PTPN11, CEACAM5, IRF1, ANXA2, ITGB3, USF1, INSR, HNF4G, MAP3K10, CLEC4M, CARTPT, CEACAM3, CEACAM7, CEACAM6, CD209, CEACAM8 (tumor) | CEACAM1, PTPN6, SRC, SHC1, CEACAM5, IRF1, ANXA2, EGFR, ITGB3, USF1, INSR, PXN, HNF4G, MAP3K10, CLEC4M, CARTPT, CEACAM3, CEACAM7, CEACAM6, CD209, CEACAM8 (normal) |
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| COAD (tumor) | COAD (normal) |
| CEACAM1, PTPN6, HNF4A, SRC, FLNA, PTPN11, CEACAM5, IRF1, ANXA2, EGFR, ITGB3, USF1, PXN, HNF4G, MAP3K10, CLEC4M, CARTPT, CEACAM7, CEACAM6, CD209, CEACAM8 (tumor) | CEACAM1, PTPN6, HNF4A, TFAP2A, SRC, SHC1, FLNA, CEACAM5, IRF1, ANXA2, EGFR, USF1, PXN, HNF4G, MAP3K10, CLEC4M, CARTPT, CEACAM3, CEACAM7, CEACAM6, CEACAM8 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CEACAM1, PTPN6, HNF4A, TFAP2A, SRC, FLNA, PTPN11, CEACAM5, ANXA2, EGFR, ITGB3, USF1, INSR, PXN, HNF4G, MAP3K10, CLEC4M, CEACAM3, CEACAM7, CEACAM6, CD209 (tumor) | CEACAM1, PTPN6, TFAP2A, SRC, SHC1, FLNA, CEACAM5, IRF1, EGFR, ITGB3, USF1, INSR, PXN, HNF4G, MAP3K10, CLEC4M, CEACAM3, CEACAM7, CEACAM6, CD209, CEACAM8 (normal) |
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| KICH (tumor) | KICH (normal) |
| CEACAM1, HNF4A, TFAP2A, SRC, SHC1, FLNA, PTPN11, CEACAM5, ANXA2, EGFR, ITGB3, INSR, PXN, HNF4G, MAP3K10, CLEC4M, CARTPT, CEACAM3, CEACAM7, CD209, CEACAM8 (tumor) | CEACAM1, PTPN6, HNF4A, TFAP2A, SRC, SHC1, FLNA, IRF1, EGFR, ITGB3, USF1, INSR, PXN, HNF4G, MAP3K10, CLEC4M, CARTPT, CEACAM3, CEACAM7, CEACAM6, CEACAM8 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CEACAM1, PTPN6, HNF4A, TFAP2A, SRC, PTPN11, CEACAM5, IRF1, ANXA2, EGFR, ITGB3, USF1, INSR, PXN, HNF4G, MAP3K10, CLEC4M, CEACAM3, CEACAM7, CD209, CEACAM8 (tumor) | CEACAM1, PTPN6, HNF4A, TFAP2A, SRC, SHC1, FLNA, PTPN11, IRF1, ANXA2, EGFR, ITGB3, USF1, INSR, PXN, HNF4G, MAP3K10, CLEC4M, CARTPT, CEACAM6, CD209 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CEACAM1, PTPN6, HNF4A, TFAP2A, SRC, PTPN11, IRF1, ANXA2, EGFR, ITGB3, USF1, INSR, PXN, HNF4G, MAP3K10, CLEC4M, CARTPT, CEACAM3, CEACAM6, CD209, CEACAM8 (tumor) | CEACAM1, HNF4A, TFAP2A, SRC, SHC1, FLNA, PTPN11, CEACAM5, IRF1, ANXA2, EGFR, INSR, PXN, HNF4G, MAP3K10, CLEC4M, CARTPT, CEACAM3, CEACAM7, CEACAM6, CD209 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CEACAM1, HNF4A, TFAP2A, SRC, SHC1, FLNA, PTPN11, CEACAM5, IRF1, ANXA2, EGFR, ITGB3, USF1, INSR, PXN, HNF4G, CLEC4M, CARTPT, CEACAM7, CEACAM6, CD209 (tumor) | CEACAM1, PTPN6, HNF4A, TFAP2A, SRC, SHC1, FLNA, PTPN11, CEACAM5, IRF1, ANXA2, EGFR, ITGB3, INSR, PXN, HNF4G, MAP3K10, CLEC4M, CEACAM7, CEACAM6, CD209 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CEACAM1, PTPN6, HNF4A, TFAP2A, SRC, SHC1, PTPN11, CEACAM5, IRF1, ANXA2, EGFR, USF1, INSR, PXN, MAP3K10, CLEC4M, CARTPT, CEACAM3, CEACAM7, CD209, CEACAM8 (tumor) | CEACAM1, PTPN6, HNF4A, SRC, SHC1, FLNA, PTPN11, CEACAM5, IRF1, EGFR, USF1, INSR, PXN, HNF4G, CLEC4M, CARTPT, CEACAM3, CEACAM7, CEACAM6, CD209, CEACAM8 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CEACAM1, PTPN6, HNF4A, TFAP2A, SRC, SHC1, FLNA, PTPN11, CEACAM5, IRF1, EGFR, ITGB3, INSR, HNF4G, MAP3K10, CLEC4M, CARTPT, CEACAM3, CEACAM6, CD209, CEACAM8 (tumor) | CEACAM1, PTPN6, HNF4A, SRC, SHC1, PTPN11, CEACAM5, IRF1, ANXA2, EGFR, ITGB3, USF1, PXN, HNF4G, MAP3K10, CLEC4M, CEACAM3, CEACAM7, CEACAM6, CD209, CEACAM8 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CEACAM1, PTPN6, HNF4A, TFAP2A, SRC, SHC1, PTPN11, CEACAM5, IRF1, ANXA2, EGFR, ITGB3, PXN, HNF4G, MAP3K10, CLEC4M, CARTPT, CEACAM3, CEACAM7, CEACAM6, CD209 (tumor) | CEACAM1, PTPN6, TFAP2A, SRC, SHC1, FLNA, PTPN11, CEACAM5, IRF1, ANXA2, EGFR, ITGB3, USF1, INSR, PXN, MAP3K10, CLEC4M, CEACAM3, CEACAM7, CEACAM6, CD209 (normal) |
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| STAD (tumor) | STAD (normal) |
| CEACAM1, PTPN6, HNF4A, TFAP2A, SRC, SHC1, FLNA, PTPN11, CEACAM5, IRF1, ANXA2, ITGB3, USF1, INSR, HNF4G, MAP3K10, CARTPT, CEACAM3, CEACAM7, CEACAM6, CD209 (tumor) | CEACAM1, PTPN6, HNF4A, TFAP2A, SRC, SHC1, FLNA, PTPN11, CEACAM5, IRF1, ANXA2, ITGB3, INSR, HNF4G, CLEC4M, CARTPT, CEACAM3, CEACAM7, CEACAM6, CD209, CEACAM8 (normal) |
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| THCA (tumor) | THCA (normal) |
| CEACAM1, PTPN6, TFAP2A, SRC, SHC1, FLNA, CEACAM5, IRF1, EGFR, ITGB3, USF1, PXN, HNF4G, MAP3K10, CLEC4M, CARTPT, CEACAM3, CEACAM7, CEACAM6, CD209, CEACAM8 (tumor) | CEACAM1, PTPN6, TFAP2A, SHC1, FLNA, PTPN11, CEACAM5, IRF1, ANXA2, EGFR, ITGB3, INSR, PXN, HNF4G, CLEC4M, CARTPT, CEACAM3, CEACAM7, CEACAM6, CD209, CEACAM8 (normal) |
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| TissGeneProg for CEACAM1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CEACAM1 |
| TissGeneDrug for CEACAM1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00113 | Arcitumomab | Other/unknown | Biotech | Approved|Investigational |
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| TissGeneDisease for CEACAM1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 8 | BeFree |
| umls:C0025202 | melanoma | 8 | BeFree,LHGDN |
| umls:C0027627 | Neoplasm Metastasis | 7 | BeFree,LHGDN |
| umls:C0678222 | Breast Carcinoma | 6 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 5 | BeFree |
| umls:C0596263 | Carcinogenesis | 5 | BeFree |
| umls:C0600139 | Prostate carcinoma | 5 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 4 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 4 | BeFree |
| umls:C0009375 | Colonic Neoplasms | 4 | BeFree,LHGDN |
| umls:C0699790 | Colon Carcinoma | 4 | BeFree |
| umls:C1527249 | Colorectal Cancer | 4 | BeFree |
| umls:C0001418 | Adenocarcinoma | 3 | BeFree,CTD_human |
| umls:C0001430 | Adenoma | 3 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 3 | BeFree |
| umls:C0024121 | Lung Neoplasms | 3 | BeFree,CTD_human,LHGDN |
| umls:C0033578 | Prostatic Neoplasms | 3 | BeFree,LHGDN |
| umls:C2239176 | Liver carcinoma | 3 | BeFree |
| umls:C0004364 | Autoimmune Diseases | 2 | BeFree,LHGDN |
| umls:C0005695 | Bladder Neoplasm | 2 | LHGDN |
| umls:C0021368 | Inflammation | 2 | LHGDN |
| umls:C0023449 | Acute lymphocytic leukemia | 2 | BeFree |
| umls:C0023903 | Liver neoplasms | 2 | BeFree |
| umls:C0025303 | Meningococcal Infections | 2 | BeFree,GAD |
| umls:C0029456 | Osteoporosis | 2 | BeFree |
| umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 2 | BeFree |
| umls:C3714514 | Infection | 2 | LHGDN |
| umls:C0000786 | Spontaneous abortion | 1 | CTD_human |
| umls:C0004623 | Bacterial Infections | 1 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
| umls:C0007115 | Malignant neoplasm of thyroid | 1 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
| umls:C0007785 | Cerebral Infarction | 1 | BeFree |
| umls:C0014170 | Endometrial Neoplasms | 1 | LHGDN |
| umls:C0019158 | Hepatitis | 1 | LHGDN |
| umls:C0023448 | Lymphoid leukemia | 1 | BeFree |
| umls:C0026946 | Mycoses | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0029442 | Osteomalacia | 1 | BeFree |
| umls:C0032584 | polyps | 1 | LHGDN |
| umls:C0036631 | Seminoma | 1 | BeFree |
| umls:C0037284 | Skin lesion | 1 | BeFree |
| umls:C0038356 | Stomach Neoplasms | 1 | LHGDN |
| umls:C0038454 | Cerebrovascular accident | 1 | BeFree |
| umls:C0040136 | Thyroid Neoplasm | 1 | BeFree |
| umls:C0149521 | Pancreatitis, Chronic | 1 | BeFree |
| umls:C0206139 | Lichen Planus, Oral | 1 | BeFree |
| umls:C0235946 | Cerebral atrophy | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0281361 | Adenocarcinoma of pancreas | 1 | BeFree |
| umls:C0334267 | Transitional cell carcinoma in situ | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0349566 | Squamous cell carcinoma of tongue | 1 | BeFree |
| umls:C0476089 | Endometrial Carcinoma | 1 | BeFree |
| umls:C0494165 | Secondary malignant neoplasm of liver | 1 | BeFree |
| umls:C0549473 | Thyroid carcinoma | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C0917798 | Cerebral Ischemia | 1 | BeFree |
| umls:C0948008 | Ischemic stroke | 1 | BeFree |
| umls:C1153706 | Endometrial adenocarcinoma | 1 | BeFree |
| umls:C1336527 | Carcinoma of urinary bladder, superficial | 1 | BeFree |
| umls:C1519670 | Tumor Angiogenesis | 1 | BeFree |
| umls:C3272363 | Ischemic Cerebrovascular Accident | 1 | BeFree |
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