TissGeneSummary for SCTR |
Gene summary |
Basic gene information | Gene symbol | SCTR |
Gene name | secretin receptor | |
Synonyms | SR | |
Cytomap | UCSC genome browser: 2q14.1 | |
Type of gene | protein-coding | |
RefGenes | NM_002980.2, | |
Description | pancreatic secretin receptor | |
Modification date | 20141207 | |
dbXrefs | MIM : 182098 | |
HGNC : HGNC | ||
Ensembl : ENSG00000080293 | ||
HPRD : 01628 | ||
Vega : OTTHUMG00000131407 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SCTR | |
BioGPS: 6344 | ||
Pathway | NCI Pathway Interaction Database: SCTR | |
KEGG: SCTR | ||
REACTOME: SCTR | ||
Pathway Commons: SCTR | ||
Context | iHOP: SCTR | |
ligand binding site mutation search in PubMed: SCTR | ||
UCL Cancer Institute: SCTR | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LungPancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSCPAAD | |
Reference showing the relevant tissue of SCTR | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SCTR |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
STAD | -1.048720303 | 2.216289072 | -3.265009375 | 3.07E-07 | 6.56E-06 |
KICH | -1.730251803 | 4.536780197 | -6.267032 | 1.33E-17 | 5.86E-16 |
KIRP | -0.437029678 | 3.805192197 | -4.242221875 | 1.74E-15 | 5.07E-14 |
KIRC | 1.179964419 | 3.805419974 | -2.625455556 | 5.48E-20 | 4.32E-19 |
LUAD | 2.5643353 | 5.124204266 | -2.559868966 | 8.34E-09 | 3.79E-08 |
BRCA | -2.988849031 | -1.736750786 | -1.252098246 | 5.88E-17 | 3.43E-16 |
COAD | -2.946823188 | -1.712892419 | -1.233930769 | 1.69E-08 | 1.41E-07 |
LUSC | 0.359239255 | 5.146027491 | -4.786788235 | 1.11E-18 | 1.10E-17 |
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TissGene-miRNA for SCTR |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SCTR |
TissGeneSNV for SCTR |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S152F | SKCM | 2 |
p.R135W | STAD | 2 |
p.H211Y | SKCM | 1 |
p.G257E | SKCM | 1 |
p.S343F | SKCM | 1 |
p.R174H | READ | 1 |
p.I297M | LUAD | 1 |
p.R188C | SKCM | 1 |
p.P81S | SKCM | 1 |
p.R299C | COAD | 1 |
p.Q432H | SKCM | 1 |
p.A385V | LIHC | 1 |
p.H171Y | SKCM | 1 |
p.R299C | CESC | 1 |
p.A292T | COAD | 1 |
p.R339H | LAML | 1 |
p.A425V | BLCA | 1 |
p.R94W | SKCM | 1 |
p.R299C | SARC | 1 |
p.P81L | SKCM | 1 |
p.A359T | UCEC | 1 |
p.T97N | PRAD | 1 |
p.A417T | LGG | 1 |
p.G58V | LUSC | 1 |
p.Y355H | KIRC | 1 |
p.I163L | SARC | 1 |
p.I194S | HNSC | 1 |
p.W295C | LUAD | 1 |
p.H354D | HNSC | 1 |
p.R105Q | SKCM | 1 |
p.P77S | STAD | 1 |
p.V357I | UCEC | 1 |
p.D209N | SKCM | 1 |
p.E133D | BLCA | 1 |
p.H178Q | STAD | 1 |
p.C45F | THYM | 1 |
p.G82S | COAD | 1 |
p.F104L | SKCM | 1 |
p.S247F | SKCM | 1 |
p.E373Q | BLCA | 1 |
p.R91I | UCEC | 1 |
p.G264C | LUAD | 1 |
p.R322G | LUAD | 1 |
p.G331E | SKCM | 1 |
p.G68W | STAD | 1 |
p.L317I | UCEC | 1 |
p.R83Q | ESCA | 1 |
p.H241Y | LUAD | 1 |
p.E410K | BLCA | 1 |
p.N192S | SARC | 1 |
p.A276V | PRAD | 1 |
p.R30* | UCEC | 1 |
p.S78F | SKCM | 1 |
p.G393R | DLBC | 1 |
p.W112C | OV | 1 |
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TissGeneCNV for SCTR |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SCTR |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | PRAD | TCGA-G9-6333-01A | VIPR2-SCTR | Out-of-Frame | chr7:158826903 | chr2:120199175 |
Chimerdb3.0 | FusionScan | LGG | TCGA-DU-6404-01A | VIPR2-SCTR | Out-of-Frame | chr7:158826903 | chr2:120199175 |
Chimerdb3.0 | FusionScan | LGG | TCGA-DB-A4XA-01A | VIPR2-SCTR | Out-of-Frame | chr7:158826903 | chr2:120199175 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-E9-A227-01A | VIPR2-SCTR | Out-of-Frame | chr7:158826903 | chr2:120199175 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-E2-A1IL-01A | VIPR2-SCTR | Out-of-Frame | chr7:158826903 | chr2:120199175 |
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TissGeneNet for SCTR |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SCTR |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SCTR |
TissGeneDrug for SCTR |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
DB00021 | Secretin | Agonist | Biotech | Approved|Investigational |
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TissGeneDisease for SCTR |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007095 | Carcinoid Tumor | 2 | BeFree,LHGDN |
umls:C0017150 | Gastrinoma | 2 | BeFree,LHGDN |
umls:C0235974 | Pancreatic carcinoma | 2 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 2 | BeFree |
umls:C1709246 | Non-Neoplastic Disorder | 2 | BeFree |
umls:C0001418 | Adenocarcinoma | 1 | BeFree |
umls:C0001430 | Adenoma | 1 | BeFree |
umls:C0005396 | Bile Duct Neoplasms | 1 | LHGDN |
umls:C0014132 | Endocrine Gland Neoplasms | 1 | BeFree |
umls:C0030297 | Pancreatic Neoplasm | 1 | BeFree |
umls:C0031511 | Pheochromocytoma | 1 | BeFree |
umls:C0206698 | Cholangiocarcinoma | 1 | BeFree,LHGDN |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0279000 | Liver and Intrahepatic Biliary Tract Carcinoma | 1 | BeFree |
umls:C0281361 | Adenocarcinoma of pancreas | 1 | BeFree |
umls:C0345904 | Malignant neoplasm of liver | 1 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
umls:C0600139 | Prostate carcinoma | 1 | BeFree |
umls:C0740277 | Bile duct carcinoma | 1 | BeFree |
umls:C1257877 | Pheochromocytoma, Extra-Adrenal | 1 | BeFree |
umls:C2239176 | Liver carcinoma | 1 | BeFree,LHGDN |