TissGeneSummary for CCL16 |
Gene summary |
Basic gene information | Gene symbol | CCL16 |
Gene name | chemokine (C-C motif) ligand 16 | |
Synonyms | CKb12|HCC-4|ILINCK|LCC-1|LEC|LMC|Mtn-1|NCC-4|NCC4|SCYA16|SCYL4 | |
Cytomap | UCSC genome browser: 17q11.2 | |
Type of gene | protein-coding | |
RefGenes | NM_004590.2, | |
Description | C-C motif chemokine 16IL-10-inducible chemokinechemokine CC-4chemokine LECliver CC chemokine-1liver-expressed chemokinelymphocyte and monocyte chemoattractantmonotactin-1new CC chemokine 4small inducible cytokine subfamily A (Cys-Cys), member 16 | |
Modification date | 20141207 | |
dbXrefs | MIM : 601394 | |
HGNC : HGNC | ||
Ensembl : ENSG00000275152 | ||
HPRD : 03233 | ||
Vega : OTTHUMG00000188402 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCL16 | |
BioGPS: 6360 | ||
Pathway | NCI Pathway Interaction Database: CCL16 | |
KEGG: CCL16 | ||
REACTOME: CCL16 | ||
Pathway Commons: CCL16 | ||
Context | iHOP: CCL16 | |
ligand binding site mutation search in PubMed: CCL16 | ||
UCL Cancer Institute: CCL16 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of CCL16 | ||
Description by TissGene annotations | TissgsKTS CNV gained TissGeneKTS Fused withOncogene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0050918 | positive chemotaxis | 15001559 | GO:0050918 | positive chemotaxis | 15001559 |
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TissGeneExp for CCL16 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | -1.750884852 | 0.27941778 | -2.030302632 | 1.71E-46 | 8.57E-45 |
KIRP | -2.079968733 | -0.585862483 | -1.49410625 | 3.85E-14 | 8.38E-13 |
LUSC | -2.11385415 | -0.515969836 | -1.597884314 | 7.98E-15 | 4.78E-14 |
LIHC | 7.506496517 | 8.981080517 | -1.474584 | 0.00217 | 0.005483015 |
BLCA | -1.956440115 | -0.671913799 | -1.284526316 | 2.01E-05 | 0.000328694 |
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TissGene-miRNA for CCL16 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CCL16 |
TissGeneSNV for CCL16 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A64V | STAD | 1 |
p.T18I | LAML | 1 |
p.I107N | COAD | 1 |
p.A57T | READ | 1 |
p.E43K | LUAD | 1 |
p.T77N | LUAD | 1 |
p.S19* | SARC | 1 |
p.E43K | LUSC | 1 |
p.P91L | LGG | 1 |
p.M1I | BLCA | 1 |
p.L39P | ESCA | 1 |
p.S9P | ESCA | 1 |
p.S19L | READ | 1 |
p.P114S | UCEC | 1 |
p.L10F | SKCM | 1 |
p.P79S | STAD | 1 |
p.S19L | PAAD | 1 |
p.G53E | SKCM | 1 |
p.N72H | LIHC | 1 |
p.D82N | LUAD | 1 |
p.R55I | COAD | 1 |
p.S23C | HNSC | 1 |
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TissGeneCNV for CCL16 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CCL16 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-A2-A0T3-01A | ETV4-CCL16 | In-frame | Chr17:41610042 | Chr17:34305299 |
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TissGeneNet for CCL16 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CCL16 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CCL16 |
TissGeneDrug for CCL16 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CCL16 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0019158 | Hepatitis | 5 | BeFree,GAD |
umls:C0019159 | Hepatitis A | 4 | BeFree |
umls:C2239176 | Liver carcinoma | 4 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
umls:C0023890 | Liver Cirrhosis | 2 | BeFree |
umls:C0023895 | Liver diseases | 2 | BeFree |
umls:C0678222 | Breast Carcinoma | 2 | BeFree |
umls:C0001857 | AIDS related complex | 1 | BeFree |
umls:C0004096 | Asthma | 1 | GAD |
umls:C0006274 | Bronchiolitis, Viral | 1 | GAD |
umls:C0011603 | Dermatitis | 1 | BeFree |
umls:C0023290 | Leishmaniasis, Visceral | 1 | GAD |
umls:C0023473 | Myeloid Leukemia, Chronic | 1 | BeFree |
umls:C0023903 | Liver neoplasms | 1 | BeFree |
umls:C0024232 | Lymphatic Metastasis | 1 | BeFree |
umls:C0025202 | melanoma | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | BeFree |
umls:C0035235 | Respiratory Syncytial Virus Infections | 1 | GAD |
umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
umls:C0302332 | Poisoning syndrome | 1 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
umls:C1290884 | Inflammatory disorder | 1 | BeFree |
umls:C1444680 | Posterior capsule opacification | 1 | BeFree |
umls:C3241937 | Nonalcoholic Steatohepatitis | 1 | BeFree |