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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CCL20
check button Gene summary
Basic gene informationGene symbolCCL20
Gene namechemokine (C-C motif) ligand 20
SynonymsCKb4|Exodus|LARC|MIP-3-alpha|MIP-3a|MIP3A|SCYA20|ST38
CytomapUCSC genome browser: 2q36.3
Type of geneprotein-coding
RefGenesNM_001130046.1,
NM_004591.2,
DescriptionC-C motif chemokine 20CC chemokine LARCbeta chemokine exodus-1liver and activation-regulated chemokinemacrophage inflammatory protein 3 alphasmall inducible cytokine subfamily A (Cys-Cys), member 20small-inducible cytokine A20
Modification date20141222
dbXrefs MIM : 601960
HGNC : HGNC
Ensembl : ENSG00000115009
HPRD : 03571
Vega : OTTHUMG00000133189
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CCL20
BioGPS: 6364
PathwayNCI Pathway Interaction Database: CCL20
KEGG: CCL20
REACTOME: CCL20
Pathway Commons: CCL20
ContextiHOP: CCL20
ligand binding site mutation search in PubMed: CCL20
UCL Cancer Institute: CCL20
Assigned class in TissGDB*C
Included tissue-specific gene expression resources
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)ColonLung
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)COADLUAD,LUSC
Reference showing the relevant tissue of CCL20
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:2000406positive regulation of T cell migration23620790
GO:2000406positive regulation of T cell migration23620790


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TissGeneExp for CCL20

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
KIRC2.9555323390.0428017842.9127305561.40E-125.90E-12
THCA-0.18852863-2.6599049022.4713762719.76E-105.66E-09
BRCA-1.445445877-2.519879211.0744333331.48E-063.98E-06
HNSC2.6193349881.5597187091.0596162790.02280.049951315
LIHC3.8253868952.1615808951.6638060.004560.010593891
LUAD3.7395559982.5427853091.196770690.00230.004776759
ESCA5.095399259-0.442891655.5382909091.73E-050.001157788
KICH-1.8079011050.221298895-2.02920.0003530.000832989


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TissGene-miRNA for CCL20

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for CCL20
TissGeneSNV for CCL20

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.G34*SKCM1
p.R86GLUAD1
p.W81CLUAD1
p.L71FHNSC1
p.R38LESCA1
p.F45CSTAD1
p.L70FHNSC1
p.G22SLGG1
p.R39LESCA1
p.R86CLUAD1
p.L34FBRCA1
p.Q79KLUSC1
p.W80CLUAD1
p.S6ILGG1
p.I60NLAML1
p.E25QCESC1


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TissGeneCNV for CCL20

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for CCL20

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for CCL20

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (tumor)CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (normal)
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COAD (tumor)COAD (normal)
CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (tumor)CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (normal)
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HNSC (tumor)HNSC (normal)
CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (tumor)CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (normal)
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KICH (tumor)KICH (normal)
CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (tumor)CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (normal)
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KIRC (tumor)KIRC (normal)
CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (tumor)CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (normal)
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KIRP (tumor)KIRP (normal)
CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (tumor)CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (normal)
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LIHC (tumor)LIHC (normal)
CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (tumor)CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (normal)
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LUAD (tumor)LUAD (normal)
CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (tumor)CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (normal)
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LUSC (tumor)LUSC (normal)
CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (tumor)CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (normal)
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PRAD (tumor)PRAD (normal)
CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (tumor)CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (normal)
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STAD (tumor)STAD (normal)
CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (tumor)CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (normal)
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THCA (tumor)THCA (normal)
CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (tumor)CCL20, TRAF6, RALBP1, NFKB1, VCAN, CCR6, TGFB3 (normal)
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TissGeneProg for CCL20

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for CCL20
TissGeneDrug for CCL20

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for CCL20

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0009402Colorectal Carcinoma8BeFree
umls:C0027627Neoplasm Metastasis8BeFree,LHGDN
umls:C1527249Colorectal Cancer8BeFree
umls:C2239176Liver carcinoma8BeFree,LHGDN
umls:C0003873Rheumatoid Arthritis7BeFree,LHGDN
umls:C0596263Carcinogenesis7BeFree
umls:C0021368Inflammation6LHGDN
umls:C0009324Ulcerative Colitis5BeFree,CTD_human,RGD
umls:C0033860Psoriasis5BeFree
umls:C0494165Secondary malignant neoplasm of liver4BeFree
umls:C0009319Colitis3BeFree
umls:C0021390Inflammatory Bowel Diseases3BeFree
umls:C0242379Malignant neoplasm of lung3BeFree
umls:C0684249Carcinoma of lung3BeFree
umls:C0004096Asthma2BeFree
umls:C0006142Malignant neoplasm of breast2BeFree
umls:C0010346Crohn Disease2BeFree
umls:C0011881Diabetic Nephropathy2BeFree,RGD
umls:C0023895Liver diseases2BeFree
umls:C0026769Multiple Sclerosis2BeFree
umls:C0027430Nasal Polyps2BeFree
umls:C0079773Lymphoma, T-Cell, Cutaneous2BeFree
umls:C0678222Breast Carcinoma2BeFree
umls:C0850666Helicobacter pylori infection2BeFree
umls:C0006413Burkitt Lymphoma1BeFree
umls:C0007113Rectal Carcinoma1BeFree
umls:C0007115Malignant neoplasm of thyroid1BeFree
umls:C0007131Non-Small Cell Lung Carcinoma1BeFree
umls:C0007138Carcinoma, Transitional Cell1BeFree
umls:C0007786Brain Ischemia1RGD
umls:C0007787Transient Ischemic Attack1RGD
umls:C0008312Primary biliary cirrhosis1BeFree
umls:C0009375Colonic Neoplasms1CTD_human
umls:C0011615Dermatitis, Atopic1BeFree
umls:C0011847Diabetes1BeFree
umls:C0011849Diabetes Mellitus1BeFree
umls:C0011853Diabetes Mellitus, Experimental1CTD_human
umls:C0011854Diabetes Mellitus, Insulin-Dependent1CTD_human
umls:C0013595Eczema1BeFree
umls:C0017152Gastritis1BeFree
umls:C0017638Glioma1LHGDN
umls:C0018213Graves Disease1BeFree
umls:C0019158Hepatitis1LHGDN
umls:C0019829Hodgkin Disease1LHGDN
umls:C0020517Hypersensitivity1CTD_human
umls:C0020672Hypothermia, natural1RGD
umls:C0022577Keratoconjunctivitis, Vernal1BeFree
umls:C0023418leukemia1BeFree
umls:C0023493Adult T-Cell Lymphoma/Leukemia1BeFree
umls:C0023903Liver neoplasms1BeFree
umls:C0024117Chronic Obstructive Airway Disease1BeFree
umls:C0026470Monoclonal Gammopathy of Undetermined Significance1BeFree
umls:C0026764Multiple Myeloma1BeFree
umls:C0026946Mycoses1BeFree
umls:C0026948Mycosis Fungoides1BeFree
umls:C0028754Obesity1BeFree
umls:C0029408Degenerative polyarthritis1BeFree
umls:C0030354Papilloma1BeFree
umls:C0031099Periodontitis1BeFree
umls:C0032285Pneumonia1CTD_human
umls:C0036220Kaposi Sarcoma1BeFree
umls:C0037274Dermatologic disorders1CTD_human
umls:C0038525Subarachnoid Hemorrhage1RGD
umls:C0039103Synovitis1BeFree
umls:C0079487Helicobacter Infections1BeFree,LHGDN
umls:C0149521Pancreatitis, Chronic1BeFree
umls:C0149678Epstein-Barr Virus Infections1BeFree
umls:C0152031Joint swelling1BeFree
umls:C0235974Pancreatic carcinoma1BeFree
umls:C0238339Hereditary pancreatitis1BeFree
umls:C0243038Carcinoma, Lewis Lung1BeFree
umls:C0262985Psoriasiform eczema1BeFree
umls:C0263641Epithelial hyperplasia of skin1BeFree
umls:C0311375Arsenic Poisoning1CTD_human
umls:C0333873Squamous intraepithelial lesion1BeFree
umls:C0341486Cystadenoma of pancreas1BeFree
umls:C0343378Helicobacter-associated gastritis1BeFree
umls:C0346647Malignant neoplasm of pancreas1BeFree
umls:C0374997Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site1BeFree
umls:C0376358Malignant neoplasm of prostate1BeFree
umls:C0549473Thyroid carcinoma1BeFree
umls:C0600139Prostate carcinoma1BeFree
umls:C1153706Endometrial adenocarcinoma1BeFree
umls:C1168198Recurrent respiratory papillomatosis1BeFree
umls:C1271104Blood pressure finding1GAD
umls:C1272641Systemic arterial pressure1GAD
umls:C1290884Inflammatory disorder1BeFree
umls:C1458155Mammary Neoplasms1CTD_human
umls:C1851585MYELOPROLIFERATIVE DISORDER, CHRONIC, WITH EOSINOPHILIA1BeFree
umls:C2145472Urothelial Carcinoma1BeFree
umls:C3495559Juvenile arthritis1BeFree
umls:C3714514Infection1LHGDN
umls:C3714757Juvenile rheumatoid arthritis1BeFree