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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for CXCL5
check button Gene summary
Basic gene informationGene symbolCXCL5
Gene namechemokine (C-X-C motif) ligand 5
SynonymsENA-78|SCYB5
CytomapUCSC genome browser: 4q13.3
Type of geneprotein-coding
RefGenesNM_002994.4,
DescriptionC-X-C motif chemokine 5epithelial-derived neutrophil-activating protein 78neutrophil-activating peptide ENA-78neutrophil-activating protein 78small inducible cytokine subfamily B (Cys-X-Cys), member 5 (epithelial-derived neutrophil-activating peptide
Modification date20141222
dbXrefs MIM : 600324
HGNC : HGNC
Ensembl : ENSG00000163735
HPRD : 08976
Vega : OTTHUMG00000160871
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_CXCL5
BioGPS: 6374
PathwayNCI Pathway Interaction Database: CXCL5
KEGG: CXCL5
REACTOME: CXCL5
Pathway Commons: CXCL5
ContextiHOP: CXCL5
ligand binding site mutation search in PubMed: CXCL5
UCL Cancer Institute: CXCL5
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)LungSkin
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LUAD,LUSCSKCM
Reference showing the relevant tissue of CXCL5
Description by TissGene annotationsHave significant anti-correlated miRNA
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for CXCL5

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
COAD1.738701487-2.4715485134.210259.45E-098.42E-08
BRCA-3.132785828-1.070033196-2.0627526321.43E-126.37E-12
KICH-4.706109898-3.470717898-1.2353921.98E-055.91E-05
LUSC0.476554733.568791985-3.0922372555.55E-112.15E-10
KIRC-0.716387509-3.005248622.2888611117.62E-082.15E-07
THCA-2.753983389-4.7111274571.9571440681.94E-091.08E-08
LIHC-2.755859898-1.688485898-1.0673740.02440.046318291
BLCA-1.003061266-3.1682244242.1651631580.006530.032272711
STAD3.3198236020.6210923522.698731250.005760.021845261
HNSC0.328365172-1.6946464562.0230116280.001030.0034538
KIRP-1.179926398-3.3908201482.210893750.001260.003379091


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TissGene-miRNA for CXCL5

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
LUADhsa-miR-23a-3pMIMAT00000780.023-0.360


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TissGeneMut for CXCL5
TissGeneSNV for CXCL5

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.E89KSKCM2
p.G72VLUSC1
p.K105TCOAD1
p.C75YCOAD1
p.I63SUCEC1
p.G87RHNSC1
p.L26PLIHC1
p.L84PUCEC1
p.G57RSKCM1
p.E89KLUSC1
p.D108NLGG1
p.S83FSKCM1
p.P94ABLCA1
p.S6ICOAD1
p.Q53HREAD1
p.A20TCOAD1
p.L92IKICH1
p.G87RSKCM1
p.A41VUCEC1


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TissGeneCNV for CXCL5

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for CXCL5

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for CXCL5

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (tumor)CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (normal)
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COAD (tumor)COAD (normal)
CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (tumor)CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (normal)
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HNSC (tumor)HNSC (normal)
CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (tumor)CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (normal)
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KICH (tumor)KICH (normal)
CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (tumor)CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (normal)
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KIRC (tumor)KIRC (normal)
CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (tumor)CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (normal)
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KIRP (tumor)KIRP (normal)
CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (tumor)CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (normal)
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LIHC (tumor)LIHC (normal)
CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (tumor)CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (normal)
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LUAD (tumor)LUAD (normal)
CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (tumor)CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (normal)
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LUSC (tumor)LUSC (normal)
CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (tumor)CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (normal)
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PRAD (tumor)PRAD (normal)
CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (tumor)CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (normal)
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STAD (tumor)STAD (normal)
CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (tumor)CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (normal)
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THCA (tumor)THCA (normal)
CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (tumor)CXCL5, SP1, HNRNPD, SP3, DARC, CXCR1, ZNF148, MMP9, IL8, CXCR2, PIGR (normal)
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TissGeneProg for CXCL5

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for CXCL5
TissGeneDrug for CXCL5

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for CXCL5

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0178874Tumor Progression4BeFree
umls:C0678222Breast Carcinoma4BeFree
umls:C2239176Liver carcinoma4BeFree
umls:C0001418Adenocarcinoma3BeFree
umls:C0003873Rheumatoid Arthritis3BeFree
umls:C0006142Malignant neoplasm of breast3BeFree
umls:C0009324Ulcerative Colitis3BeFree
umls:C0027627Neoplasm Metastasis3BeFree
umls:C0028754Obesity3BeFree
umls:C0032285Pneumonia3BeFree,CTD_human
umls:C0036202Sarcoidosis3BeFree,GAD
umls:C0596263Carcinogenesis3BeFree
umls:C3714514Infection3LHGDN
umls:C0004096Asthma2BeFree,GAD
umls:C0007222Cardiovascular Diseases2BeFree
umls:C0009402Colorectal Carcinoma2BeFree
umls:C0009404Colorectal Neoplasms2LHGDN
umls:C0010346Crohn Disease2BeFree
umls:C0011847Diabetes2BeFree
umls:C0011849Diabetes Mellitus2BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent2BeFree,GAD
umls:C0014175Endometriosis2BeFree,LHGDN
umls:C0019693HIV Infections2BeFree
umls:C0021390Inflammatory Bowel Diseases2BeFree
umls:C0024121Lung Neoplasms2BeFree
umls:C0042769Virus Diseases2BeFree
umls:C0235974Pancreatic carcinoma2BeFree
umls:C0376358Malignant neoplasm of prostate2BeFree
umls:C3665444Neutrophilia (disorder)2BeFree
umls:C0001430Adenoma1BeFree
umls:C0002874Aplastic Anemia1BeFree
umls:C0004352Autistic Disorder1BeFree
umls:C0004364Autoimmune Diseases1BeFree
umls:C0006274Bronchiolitis, Viral1GAD
umls:C0007131Non-Small Cell Lung Carcinoma1BeFree
umls:C0007137Squamous cell carcinoma1BeFree
umls:C0009319Colitis1BeFree
umls:C0010278Craniosynostosis1BeFree
umls:C0011334Dental caries1BeFree
umls:C0014743Erythema Nodosum1GAD
umls:C0020517Hypersensitivity1CTD_human
umls:C0023281Leishmaniasis1BeFree
umls:C0023283Leishmaniasis, Cutaneous1BeFree
umls:C0023467Leukemia, Myelocytic, Acute1BeFree
umls:C0023890Liver Cirrhosis1BeFree
umls:C0024115Lung diseases1BeFree
umls:C0024530Malaria1BeFree
umls:C0024623Malignant neoplasm of stomach1BeFree
umls:C0025202melanoma1BeFree
umls:C0030286Pancreatic Diseases1BeFree
umls:C0031154Peritonitis1BeFree
umls:C0031157Peritonsillar Abscess1BeFree
umls:C0032269Pneumococcal Infections1BeFree
umls:C0033578Prostatic Neoplasms1BeFree
umls:C0034152Henoch-Schoenlein Purpura1BeFree
umls:C0035235Respiratory Syncytial Virus Infections1GAD
umls:C0036205Sarcoidosis, Pulmonary1BeFree,LHGDN
umls:C0038356Stomach Neoplasms1LHGDN
umls:C0085437Meningitis, Bacterial1LHGDN
umls:C0149521Pancreatitis, Chronic1BeFree
umls:C0151526Premature Birth1LHGDN
umls:C0206698Cholangiocarcinoma1BeFree
umls:C0242379Malignant neoplasm of lung1BeFree
umls:C0275522Asymptomatic Infections1BeFree
umls:C0275524Coinfection1BeFree
umls:C0341439Chronic liver disease1BeFree
umls:C0345905Intrahepatic Cholangiocarcinoma1BeFree
umls:C0346647Malignant neoplasm of pancreas1BeFree
umls:C0392164Pulmonary Cystic Fibrosis1BeFree
umls:C0521158Recurrent tumor1BeFree
umls:C0600139Prostate carcinoma1BeFree
umls:C0684249Carcinoma of lung1BeFree
umls:C0699791Stomach Carcinoma1BeFree
umls:C0743188diarrhea persistent1BeFree
umls:C0745744End Stage Liver Disease1BeFree
umls:C0879615Stromal Neoplasm1BeFree
umls:C0948089Acute Coronary Syndrome1GAD,LHGDN
umls:C1168401Squamous cell carcinoma of the head and neck1BeFree
umls:C1175175Severe Acute Respiratory Syndrome1GAD
umls:C1302401Adenoma of large intestine1BeFree
umls:C1458155Mammary Neoplasms1BeFree
umls:C1519670Tumor Angiogenesis1BeFree
umls:C1527249Colorectal Cancer1BeFree,GAD
umls:C1623038Cirrhosis1BeFree
umls:C1654637androgen independent prostate cancer1BeFree
umls:C1800706Idiopathic Pulmonary Fibrosis1GAD
umls:C1956346Coronary Artery Disease1BeFree
umls:C2931173Pediatric ulcerative colitis1BeFree
umls:C3714636Pneumonitis1BeFree