TissGeneSummary for CXCL5 |
Gene summary |
Basic gene information | Gene symbol | CXCL5 |
Gene name | chemokine (C-X-C motif) ligand 5 | |
Synonyms | ENA-78|SCYB5 | |
Cytomap | UCSC genome browser: 4q13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_002994.4, | |
Description | C-X-C motif chemokine 5epithelial-derived neutrophil-activating protein 78neutrophil-activating peptide ENA-78neutrophil-activating protein 78small inducible cytokine subfamily B (Cys-X-Cys), member 5 (epithelial-derived neutrophil-activating peptide | |
Modification date | 20141222 | |
dbXrefs | MIM : 600324 | |
HGNC : HGNC | ||
Ensembl : ENSG00000163735 | ||
HPRD : 08976 | ||
Vega : OTTHUMG00000160871 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CXCL5 | |
BioGPS: 6374 | ||
Pathway | NCI Pathway Interaction Database: CXCL5 | |
KEGG: CXCL5 | ||
REACTOME: CXCL5 | ||
Pathway Commons: CXCL5 | ||
Context | iHOP: CXCL5 | |
ligand binding site mutation search in PubMed: CXCL5 | ||
UCL Cancer Institute: CXCL5 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | LungSkin | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSCSKCM | |
Reference showing the relevant tissue of CXCL5 | ||
Description by TissGene annotations | Have significant anti-correlated miRNA |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CXCL5 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
COAD | 1.738701487 | -2.471548513 | 4.21025 | 9.45E-09 | 8.42E-08 |
BRCA | -3.132785828 | -1.070033196 | -2.062752632 | 1.43E-12 | 6.37E-12 |
KICH | -4.706109898 | -3.470717898 | -1.235392 | 1.98E-05 | 5.91E-05 |
LUSC | 0.47655473 | 3.568791985 | -3.092237255 | 5.55E-11 | 2.15E-10 |
KIRC | -0.716387509 | -3.00524862 | 2.288861111 | 7.62E-08 | 2.15E-07 |
THCA | -2.753983389 | -4.711127457 | 1.957144068 | 1.94E-09 | 1.08E-08 |
LIHC | -2.755859898 | -1.688485898 | -1.067374 | 0.0244 | 0.046318291 |
BLCA | -1.003061266 | -3.168224424 | 2.165163158 | 0.00653 | 0.032272711 |
STAD | 3.319823602 | 0.621092352 | 2.69873125 | 0.00576 | 0.021845261 |
HNSC | 0.328365172 | -1.694646456 | 2.023011628 | 0.00103 | 0.0034538 |
KIRP | -1.179926398 | -3.390820148 | 2.21089375 | 0.00126 | 0.003379091 |
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TissGene-miRNA for CXCL5 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
LUAD | hsa-miR-23a-3p | MIMAT0000078 | 0.023 | -0.3 | 60 |
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TissGeneMut for CXCL5 |
TissGeneSNV for CXCL5 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E89K | SKCM | 2 |
p.G72V | LUSC | 1 |
p.K105T | COAD | 1 |
p.C75Y | COAD | 1 |
p.I63S | UCEC | 1 |
p.G87R | HNSC | 1 |
p.L26P | LIHC | 1 |
p.L84P | UCEC | 1 |
p.G57R | SKCM | 1 |
p.E89K | LUSC | 1 |
p.D108N | LGG | 1 |
p.S83F | SKCM | 1 |
p.P94A | BLCA | 1 |
p.S6I | COAD | 1 |
p.Q53H | READ | 1 |
p.A20T | COAD | 1 |
p.L92I | KICH | 1 |
p.G87R | SKCM | 1 |
p.A41V | UCEC | 1 |
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TissGeneCNV for CXCL5 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CXCL5 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for CXCL5 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CXCL5 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CXCL5 |
TissGeneDrug for CXCL5 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CXCL5 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0178874 | Tumor Progression | 4 | BeFree |
umls:C0678222 | Breast Carcinoma | 4 | BeFree |
umls:C2239176 | Liver carcinoma | 4 | BeFree |
umls:C0001418 | Adenocarcinoma | 3 | BeFree |
umls:C0003873 | Rheumatoid Arthritis | 3 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
umls:C0009324 | Ulcerative Colitis | 3 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 3 | BeFree |
umls:C0028754 | Obesity | 3 | BeFree |
umls:C0032285 | Pneumonia | 3 | BeFree,CTD_human |
umls:C0036202 | Sarcoidosis | 3 | BeFree,GAD |
umls:C0596263 | Carcinogenesis | 3 | BeFree |
umls:C3714514 | Infection | 3 | LHGDN |
umls:C0004096 | Asthma | 2 | BeFree,GAD |
umls:C0007222 | Cardiovascular Diseases | 2 | BeFree |
umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
umls:C0009404 | Colorectal Neoplasms | 2 | LHGDN |
umls:C0010346 | Crohn Disease | 2 | BeFree |
umls:C0011847 | Diabetes | 2 | BeFree |
umls:C0011849 | Diabetes Mellitus | 2 | BeFree |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | BeFree,GAD |
umls:C0014175 | Endometriosis | 2 | BeFree,LHGDN |
umls:C0019693 | HIV Infections | 2 | BeFree |
umls:C0021390 | Inflammatory Bowel Diseases | 2 | BeFree |
umls:C0024121 | Lung Neoplasms | 2 | BeFree |
umls:C0042769 | Virus Diseases | 2 | BeFree |
umls:C0235974 | Pancreatic carcinoma | 2 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
umls:C3665444 | Neutrophilia (disorder) | 2 | BeFree |
umls:C0001430 | Adenoma | 1 | BeFree |
umls:C0002874 | Aplastic Anemia | 1 | BeFree |
umls:C0004352 | Autistic Disorder | 1 | BeFree |
umls:C0004364 | Autoimmune Diseases | 1 | BeFree |
umls:C0006274 | Bronchiolitis, Viral | 1 | GAD |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
umls:C0009319 | Colitis | 1 | BeFree |
umls:C0010278 | Craniosynostosis | 1 | BeFree |
umls:C0011334 | Dental caries | 1 | BeFree |
umls:C0014743 | Erythema Nodosum | 1 | GAD |
umls:C0020517 | Hypersensitivity | 1 | CTD_human |
umls:C0023281 | Leishmaniasis | 1 | BeFree |
umls:C0023283 | Leishmaniasis, Cutaneous | 1 | BeFree |
umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
umls:C0023890 | Liver Cirrhosis | 1 | BeFree |
umls:C0024115 | Lung diseases | 1 | BeFree |
umls:C0024530 | Malaria | 1 | BeFree |
umls:C0024623 | Malignant neoplasm of stomach | 1 | BeFree |
umls:C0025202 | melanoma | 1 | BeFree |
umls:C0030286 | Pancreatic Diseases | 1 | BeFree |
umls:C0031154 | Peritonitis | 1 | BeFree |
umls:C0031157 | Peritonsillar Abscess | 1 | BeFree |
umls:C0032269 | Pneumococcal Infections | 1 | BeFree |
umls:C0033578 | Prostatic Neoplasms | 1 | BeFree |
umls:C0034152 | Henoch-Schoenlein Purpura | 1 | BeFree |
umls:C0035235 | Respiratory Syncytial Virus Infections | 1 | GAD |
umls:C0036205 | Sarcoidosis, Pulmonary | 1 | BeFree,LHGDN |
umls:C0038356 | Stomach Neoplasms | 1 | LHGDN |
umls:C0085437 | Meningitis, Bacterial | 1 | LHGDN |
umls:C0149521 | Pancreatitis, Chronic | 1 | BeFree |
umls:C0151526 | Premature Birth | 1 | LHGDN |
umls:C0206698 | Cholangiocarcinoma | 1 | BeFree |
umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
umls:C0275522 | Asymptomatic Infections | 1 | BeFree |
umls:C0275524 | Coinfection | 1 | BeFree |
umls:C0341439 | Chronic liver disease | 1 | BeFree |
umls:C0345905 | Intrahepatic Cholangiocarcinoma | 1 | BeFree |
umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
umls:C0392164 | Pulmonary Cystic Fibrosis | 1 | BeFree |
umls:C0521158 | Recurrent tumor | 1 | BeFree |
umls:C0600139 | Prostate carcinoma | 1 | BeFree |
umls:C0684249 | Carcinoma of lung | 1 | BeFree |
umls:C0699791 | Stomach Carcinoma | 1 | BeFree |
umls:C0743188 | diarrhea persistent | 1 | BeFree |
umls:C0745744 | End Stage Liver Disease | 1 | BeFree |
umls:C0879615 | Stromal Neoplasm | 1 | BeFree |
umls:C0948089 | Acute Coronary Syndrome | 1 | GAD,LHGDN |
umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |
umls:C1175175 | Severe Acute Respiratory Syndrome | 1 | GAD |
umls:C1302401 | Adenoma of large intestine | 1 | BeFree |
umls:C1458155 | Mammary Neoplasms | 1 | BeFree |
umls:C1519670 | Tumor Angiogenesis | 1 | BeFree |
umls:C1527249 | Colorectal Cancer | 1 | BeFree,GAD |
umls:C1623038 | Cirrhosis | 1 | BeFree |
umls:C1654637 | androgen independent prostate cancer | 1 | BeFree |
umls:C1800706 | Idiopathic Pulmonary Fibrosis | 1 | GAD |
umls:C1956346 | Coronary Artery Disease | 1 | BeFree |
umls:C2931173 | Pediatric ulcerative colitis | 1 | BeFree |
umls:C3714636 | Pneumonitis | 1 | BeFree |