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| TissGeneSummary for CIDEC |
 Gene summary |
| Basic gene information | Gene symbol | CIDEC |
| Gene name | cell death-inducing DFFA-like effector c | |
| Synonyms | CIDE-3|CIDE3|FPLD5|FSP27 | |
| Cytomap | UCSC genome browser: 3p25.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001199551.1, NM_001199552.1,NM_001199623.1,NM_022094.3, | |
| Description | cell death activator CIDE-3fat specific protein 27 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 612120 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000187288 | ||
| HPRD : 13060 | ||
| Vega : OTTHUMG00000128522 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CIDEC | |
| BioGPS: 63924 | ||
| Pathway | NCI Pathway Interaction Database: CIDEC | |
| KEGG: CIDEC | ||
| REACTOME: CIDEC | ||
| Pathway Commons: CIDEC | ||
| Context | iHOP: CIDEC | |
| ligand binding site mutation search in PubMed: CIDEC | ||
| UCL Cancer Institute: CIDEC | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | BreastSoft tissue | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | BRCASARC | |
| Reference showing the relevant tissue of CIDEC | ||
| Description by TissGene annotations | Fused withTSGene Fused withOncogene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006915 | apoptotic process | 12429024 | GO:0097194 | execution phase of apoptosis | 12429024 | GO:0006915 | apoptotic process | 12429024 | GO:0097194 | execution phase of apoptosis | 12429024 |
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| TissGeneExp for CIDEC |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| HNSC | -0.651871336 | 2.961747268 | -3.613618605 | 1.41E-11 | 3.56E-10 |
| BRCA | 2.731797513 | 8.992722952 | -6.260925439 | 7.46E-40 | 2.21E-38 |
| THCA | -1.386443745 | 0.095813882 | -1.482257627 | 3.83E-09 | 2.04E-08 |
| COAD | 2.510578485 | 5.156270792 | -2.645692308 | 3.19E-07 | 2.01E-06 |
| PRAD | -0.7504119 | 1.448403485 | -2.198815385 | 2.55E-12 | 1.19E-10 |
| KICH | -1.441578592 | -0.370274592 | -1.071304 | 0.00743 | 0.013692074 |
| BLCA | -0.599320908 | 2.30194225 | -2.901263158 | 0.00074 | 0.005485867 |
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| TissGene-miRNA for CIDEC |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CIDEC |
| TissGeneSNV for CIDEC |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.T62M | PCPG | 2 |
| p.R155C | UCEC | 1 |
| p.V54M | KICH | 1 |
| p.E2K | SKCM | 1 |
| p.E87K | CESC | 1 |
| p.R59C | KIRC | 1 |
| p.P44T | UCEC | 1 |
| p.D154H | LGG | 1 |
| p.P131A | KIRP | 1 |
| p.E218K | SKCM | 1 |
| p.P244A | LUSC | 1 |
| p.E96K | SKCM | 1 |
| p.P119Q | LUAD | 1 |
| p.D214N | COAD | 1 |
| p.V67M | KICH | 1 |
| p.T144K | BLCA | 1 |
| p.L171F | PRAD | 1 |
| p.R142C | UCEC | 1 |
| p.Y74H | UCS | 1 |
| p.D104G | COAD | 1 |
| p.T12I | STAD | 1 |
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| TissGeneCNV for CIDEC |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CIDEC |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | H05466 | SPTAN1-CIDEC | chr9:131395941 | chr3:9989230 | |
| Chimerdb3.0 | ChiTaRs | NA | AW085572 | CIDEC-THBS1 | chr3:10011457 | chr15:39881405 | |
| Chimerdb3.0 | ChiTaRs | NA | BC021072 | BVES-CIDEC | chr6:105547328 | chr3:10005162 | |
| Chimerdb3.0 | ChiTaRs | NA | BF924179 | PDS5B-CIDEC | chr13:33346591 | chr3:9986421 | |
| Chimerdb3.0 | ChiTaRs | NA | BE935009 | PTPN6-CIDEC | chr12:7064648 | chr3:10035912 | |
| Chimerdb3.0 | ChiTaRs | NA | BI713036 | ERG-CIDEC | chr21:39870355 | chr3:10048206 |
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| TissGeneNet for CIDEC |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for CIDEC |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CIDEC |
| TissGeneDrug for CIDEC |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CIDEC |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0028754 | Obesity | 6 | BeFree |
| umls:C0015695 | Fatty Liver | 1 | BeFree |
| umls:C0019187 | Hepatitis, Alcoholic | 1 | BeFree |
| umls:C0023787 | Lipodystrophy | 1 | BeFree |
| umls:C0023903 | Liver neoplasms | 1 | BeFree |
| umls:C0162820 | Dermatitis, Allergic Contact | 1 | CTD_human |
| umls:C0220989 | Acquired partial lipodystrophy | 1 | BeFree |
| umls:C0854110 | Insulin resistant diabetes | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
| umls:C2711227 | Steatohepatitis | 1 | BeFree |
| umls:C2718067 | Alcoholic Steatohepatitis | 1 | BeFree |
| umls:C3808940 | LIPODYSTROPHY, FAMILIAL PARTIAL, TYPE 5 | 0 | CLINVAR,ORPHANET |
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