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| TissGeneSummary for NEUROD6 |
 Gene summary |
| Basic gene information | Gene symbol | NEUROD6 |
| Gene name | neuronal differentiation 6 | |
| Synonyms | Atoh2|MATH2|Math-2|NEX1M|Nex1|bHLHa2 | |
| Cytomap | UCSC genome browser: 7p14.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_022728.3, | |
| Description | brain my051 proteinclass A basic helix-loop-helix protein 2neurogenic differentiation factor 6protein atonal homolog 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 611513 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000164600 | ||
| HPRD : 11387 | ||
| Vega : OTTHUMG00000022865 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_NEUROD6 | |
| BioGPS: 63974 | ||
| Pathway | NCI Pathway Interaction Database: NEUROD6 | |
| KEGG: NEUROD6 | ||
| REACTOME: NEUROD6 | ||
| Pathway Commons: NEUROD6 | ||
| Context | iHOP: NEUROD6 | |
| ligand binding site mutation search in PubMed: NEUROD6 | ||
| UCL Cancer Institute: NEUROD6 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
| Reference showing the relevant tissue of NEUROD6 | ||
| Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for NEUROD6 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for NEUROD6 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for NEUROD6 |
| TissGeneSNV for NEUROD6 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E66K | SKCM | 3 |
| p.E245K | SKCM | 2 |
| p.R321C | UCEC | 1 |
| p.R50K | SKCM | 1 |
| p.R321C | LGG | 1 |
| p.A239V | BRCA | 1 |
| p.D311H | HNSC | 1 |
| p.R155K | HNSC | 1 |
| p.G53R | SKCM | 1 |
| p.P259L | SKCM | 1 |
| p.E148V | KIRP | 1 |
| p.F243V | LUAD | 1 |
| p.D226H | OV | 1 |
| p.A304V | PAAD | 1 |
| p.R321H | BRCA | 1 |
| p.K33N | BLCA | 1 |
| p.Q30X | DLBC | 1 |
| p.E70K | SKCM | 1 |
| p.E195D | UCEC | 1 |
| p.L165F | LUAD | 1 |
| p.L4I | LUAD | 1 |
| p.D317N | OV | 1 |
| p.E277X | COAD | 1 |
| p.Q192K | ESCA | 1 |
| p.E276* | HNSC | 1 |
| p.A139T | PAAD | 1 |
| p.L43P | BRCA | 1 |
| p.G288D | BLCA | 1 |
| p.E70* | HNSC | 1 |
| p.E35Q | HNSC | 1 |
| p.A196D | LUAD | 1 |
| p.L79I | LUAD | 1 |
| p.E148D | KIRP | 1 |
| p.P122L | LUSC | 1 |
| p.E257D | SKCM | 1 |
| p.E62K | BLCA | 1 |
| p.L130V | HNSC | 1 |
| p.P309S | UCEC | 1 |
| p.R104K | LUSC | 1 |
| p.A101T | UCEC | 1 |
| p.F188V | UCEC | 1 |
| p.D226H | BLCA | 1 |
| p.M190I | SKCM | 1 |
| p.L225P | LUAD | 1 |
| p.E103K | READ | 1 |
| p.R50W | BLCA | 1 |
| p.N100S | COAD | 1 |
| p.D69V | LUSC | 1 |
| p.P214A | LUSC | 1 |
| p.L146P | PRAD | 1 |
| p.E70* | UCEC | 1 |
| p.A101V | STAD | 1 |
| p.R137* | UCEC | 1 |
| p.D112N | READ | 1 |
| p.E245G | LUAD | 1 |
| p.S246C | HNSC | 1 |
| p.E134D | LUSC | 1 |
| p.C18S | LIHC | 1 |
| p.F94L | PAAD | 1 |
| p.E148K | SKCM | 1 |
| p.Y142C | UCEC | 1 |
| p.N266K | LUAD | 1 |
| p.Y204* | UCEC | 1 |
| p.E103K | SKCM | 1 |
| p.R321C | PRAD | 1 |
| p.Q28K | HNSC | 1 |
| p.E26* | LUSC | 1 |
| p.S272F | LIHC | 1 |
| p.D115N | COAD | 1 |
| p.R44Q | LUSC | 1 |
| p.N111I | UCEC | 1 |
| p.L158P | STAD | 1 |
| p.N332S | COAD | 1 |
| p.W144X | KIRC | 1 |
| p.D317N | UCEC | 1 |
| p.R75T | BRCA | 1 |
| p.E103K | OV | 1 |
| p.L136S | LUAD | 1 |
| p.E63K | SKCM | 1 |
| p.S202L | SKCM | 1 |
| p.P219L | HNSC | 1 |
| p.P220L | LUSC | 1 |
| p.P219L | SKCM | 1 |
| p.E59X | COAD | 1 |
| p.A239V | UCEC | 1 |
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| TissGeneCNV for NEUROD6 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for NEUROD6 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | DA775505 | NEUROD6-PRKACB | chr7:31380346 | chr1:84644858 | |
| Chimerdb3.0 | ChiTaRs | NA | AK299619 | NEUROD6-CAPN1 | chr7:31380340 | chr11:64974116 |
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| TissGeneNet for NEUROD6 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| NEUROD6, HMGB1 (tumor) | NEUROD6, HMGB1 (normal) |
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| COAD (tumor) | COAD (normal) |
| NEUROD6, HMGB1 (tumor) | NEUROD6, HMGB1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| NEUROD6, HMGB1 (tumor) | NEUROD6, HMGB1 (normal) |
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| KICH (tumor) | KICH (normal) |
| NEUROD6, HMGB1 (tumor) | NEUROD6, HMGB1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| NEUROD6, HMGB1 (tumor) | NEUROD6, HMGB1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| NEUROD6, HMGB1 (tumor) | NEUROD6, HMGB1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| NEUROD6, HMGB1 (tumor) | NEUROD6, HMGB1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| NEUROD6, HMGB1 (tumor) | NEUROD6, HMGB1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| NEUROD6, HMGB1 (tumor) | NEUROD6, HMGB1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| NEUROD6, HMGB1 (tumor) | NEUROD6, HMGB1 (normal) |
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| STAD (tumor) | STAD (normal) |
| NEUROD6, HMGB1 (tumor) | NEUROD6, HMGB1 (normal) |
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| THCA (tumor) | THCA (normal) |
| NEUROD6, HMGB1 (tumor) | NEUROD6, HMGB1 (normal) |
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| TissGeneProg for NEUROD6 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for NEUROD6 |
| TissGeneDrug for NEUROD6 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for NEUROD6 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0002395 | Alzheimer's Disease | 1 | BeFree |
| umls:C0153637 | Malignant neoplasm of parietal lobe | 1 | GAD |
| umls:C1263846 | Attention deficit hyperactivity disorder | 1 | GAD |
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