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| TissGeneSummary for SEMG1 |
 Gene summary |
| Basic gene information | Gene symbol | SEMG1 |
| Gene name | semenogelin I | |
| Synonyms | CT103|SEMG|SGI|dJ172H20.2 | |
| Cytomap | UCSC genome browser: 20q12-q13.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003007.3, NM_198139.1, | |
| Description | SgI-29cancer/testis antigen 103semen coagulating proteinsemenogelin-1 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 182140 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000124233 | ||
| HPRD : 01641 | ||
| Vega : OTTHUMG00000032565 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SEMG1 | |
| BioGPS: 6406 | ||
| Pathway | NCI Pathway Interaction Database: SEMG1 | |
| KEGG: SEMG1 | ||
| REACTOME: SEMG1 | ||
| Pathway Commons: SEMG1 | ||
| Context | iHOP: SEMG1 | |
| ligand binding site mutation search in PubMed: SEMG1 | ||
| UCL Cancer Institute: SEMG1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Prostate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRAD | |
| Reference showing the relevant tissue of SEMG1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SEMG1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | -2.050597289 | -0.676494511 | -1.374102778 | 1.26E-12 | 5.34E-12 |
| KICH | -2.1102824 | -0.3406944 | -1.769588 | 5.14E-08 | 2.48E-07 |
| PRAD | 1.100720446 | 5.44903583 | -4.348315385 | 8.40E-05 | 0.00035856 |
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| TissGene-miRNA for SEMG1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SEMG1 |
| TissGeneSNV for SEMG1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.S37F | SKCM | 3 |
| p.T93M | LGG | 2 |
| p.R80Q | SKCM | 2 |
| p.E354K | SKCM | 2 |
| p.H248Y | STAD | 1 |
| p.S231* | CESC | 1 |
| p.V178I | ACC | 1 |
| p.D435N | SKCM | 1 |
| p.H169Y | SKCM | 1 |
| p.P240S | SKCM | 1 |
| p.R372L | DLBC | 1 |
| p.Q269E | HNSC | 1 |
| p.E319K | HNSC | 1 |
| p.R372S | LGG | 1 |
| p.L417I | HNSC | 1 |
| p.S316C | LIHC | 1 |
| p.S290F | SKCM | 1 |
| p.P142L | SKCM | 1 |
| p.R372C | SKCM | 1 |
| p.R372S | SKCM | 1 |
| p.H124Y | SKCM | 1 |
| p.H116Y | LUAD | 1 |
| p.R457Q | SKCM | 1 |
| p.T318N | BRCA | 1 |
| p.A20V | COAD | 1 |
| p.R357X | STAD | 1 |
| p.S350C | SARC | 1 |
| p.L9F | LUAD | 1 |
| p.E414K | SKCM | 1 |
| p.Q415H | SKCM | 1 |
| p.D435G | UCS | 1 |
| p.Q78E | LUAD | 1 |
| p.S340G | LUAD | 1 |
| p.Q341* | SKCM | 1 |
| p.A241V | SARC | 1 |
| p.R372S | BLCA | 1 |
| p.S119L | SKCM | 1 |
| p.S49F | SKCM | 1 |
| p.R372C | STAD | 1 |
| p.R281* | SKCM | 1 |
| p.E338D | THYM | 1 |
| p.L100Q | DLBC | 1 |
| p.L273I | BLCA | 1 |
| p.K110N | SKCM | 1 |
| p.G132R | SKCM | 1 |
| p.S352N | LUAD | 1 |
| p.A241V | BLCA | 1 |
| p.R413K | SKCM | 1 |
| p.V178I | LGG | 1 |
| p.K245R | BLCA | 1 |
| p.G102E | SKCM | 1 |
| p.H116Y | SKCM | 1 |
| p.G170E | TGCT | 1 |
| p.G400A | LUAD | 1 |
| p.R137H | STAD | 1 |
| p.S250F | SKCM | 1 |
| p.T353M | BLCA | 1 |
| p.D443N | SKCM | 1 |
| p.K404I | SKCM | 1 |
| p.N222H | UCS | 1 |
| p.V71A | BRCA | 1 |
| p.S10Y | THYM | 1 |
| p.R447C | COAD | 1 |
| p.E295K | SKCM | 1 |
| p.R357* | BRCA | 1 |
| p.S316R | STAD | 1 |
| p.S59F | SKCM | 1 |
| p.G301E | SKCM | 1 |
| p.A383V | BLCA | 1 |
| p.N212D | BLCA | 1 |
| p.R125M | STAD | 1 |
| p.R357* | STAD | 1 |
| p.S407Y | UCEC | 1 |
| p.L260F | UCEC | 1 |
| p.F39C | UCEC | 1 |
| p.S79Y | LUAD | 1 |
| p.P40S | SKCM | 1 |
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| TissGeneCNV for SEMG1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SEMG1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-HC-7745-11A | MYH11-SEMG1 | Out-of-Frame | chr16:15826490 | chr20:43836173 |
| Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-HC-8258-11A | PCBD2-SEMG1 | Out-of-Frame | chr5:134262466 | chr20:43836613 |
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| TissGeneNet for SEMG1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (tumor) | SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (normal) |
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| COAD (tumor) | COAD (normal) |
| SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (tumor) | SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (tumor) | SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (normal) |
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| KICH (tumor) | KICH (normal) |
| SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (tumor) | SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (tumor) | SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (tumor) | SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (tumor) | SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (tumor) | SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (tumor) | SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (tumor) | SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (normal) |
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| STAD (tumor) | STAD (normal) |
| SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (tumor) | SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (normal) |
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| THCA (tumor) | THCA (normal) |
| SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (tumor) | SEMG1, UBC, PRKCA, UBQLN4, KLK3, KLK2, TGM1, SEMG2 (normal) |
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| TissGeneProg for SEMG1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SEMG1 |
| TissGeneDrug for SEMG1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SEMG1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0023434 | Chronic Lymphocytic Leukemia | 3 | BeFree |
| umls:C0153594 | Malignant neoplasm of testis | 3 | BeFree |
| umls:C0026764 | Multiple Myeloma | 2 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
| umls:C0178874 | Tumor Progression | 2 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 2 | BeFree |
| umls:C0004509 | Azoospermia | 1 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | LHGDN |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 1 | BeFree |
| umls:C0023473 | Myeloid Leukemia, Chronic | 1 | BeFree |
| umls:C0278601 | Inflammatory Breast Carcinoma | 1 | BeFree |
| umls:C0280248 | stage, chronic lymphocytic leukemia | 1 | BeFree |
| umls:C0334634 | Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse | 1 | BeFree |
| umls:C0376545 | Hematologic Neoplasms | 1 | BeFree |
| umls:C0403814 | Congenital bilateral aplasia of vas deferens | 1 | BeFree |
| umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
| umls:C1279296 | Chronic leukemia (category) | 1 | BeFree |
| umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
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