TissGeneSummary for PBLD |
Gene summary |
Basic gene information | Gene symbol | PBLD |
Gene name | phenazine biosynthesis-like protein domain containing | |
Synonyms | MAWBP|MAWDBP | |
Cytomap | UCSC genome browser: 10q21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001033083.1, NM_022129.3, | |
Description | MAWD-binding proteinphenazine biosynthesis-like domain-containing protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 612189 | |
HGNC : HGNC | ||
Ensembl : ENSG00000108187 | ||
HPRD : 14366 | ||
Vega : OTTHUMG00000073949 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_PBLD | |
BioGPS: 64081 | ||
Pathway | NCI Pathway Interaction Database: PBLD | |
KEGG: PBLD | ||
REACTOME: PBLD | ||
Pathway Commons: PBLD | ||
Context | iHOP: PBLD | |
ligand binding site mutation search in PubMed: PBLD | ||
UCL Cancer Institute: PBLD | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
Reference showing the relevant tissue of PBLD | ||
Description by TissGene annotations | Protective TissGene in OS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for PBLD |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 2.448037525 | 3.486559747 | -1.038522222 | 2.65E-07 | 7.11E-07 |
LIHC | 2.266966858 | 4.721494858 | -2.454528 | 1.38E-15 | 4.57E-14 |
COAD | 0.120820858 | 2.330951628 | -2.210130769 | 2.62E-11 | 4.45E-10 |
KICH | -0.418555142 | 3.122128858 | -3.540684 | 2.31E-14 | 3.80E-13 |
KIRP | 1.483427108 | 3.758152108 | -2.274725 | 2.66E-09 | 2.27E-08 |
BLCA | -1.603263352 | -0.560937036 | -1.042326316 | 0.000337 | 0.002974159 |
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TissGene-miRNA for PBLD |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for PBLD |
TissGeneSNV for PBLD |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.L198V | BLCA | 1 |
p.R216T | BLCA | 1 |
p.E249D | KIRC | 1 |
p.Q254* | BLCA | 1 |
p.P72L | SKCM | 1 |
p.A210E | COAD | 1 |
p.P268T | LUSC | 1 |
p.M42I | LUAD | 1 |
p.Q159E | LUSC | 1 |
p.S266L | HNSC | 1 |
p.S215L | BLCA | 1 |
p.R17C | DLBC | 1 |
p.D57Y | LGG | 1 |
p.S266L | UCEC | 1 |
p.G263E | SKCM | 1 |
p.V89G | KIRC | 1 |
p.I5V | BLCA | 1 |
p.G270R | ESCA | 1 |
p.A82V | PAAD | 1 |
p.E182D | BLCA | 1 |
p.A112D | OV | 1 |
p.R258G | HNSC | 1 |
p.P20L | CESC | 1 |
p.G270R | COAD | 1 |
p.H244L | HNSC | 1 |
p.G202R | SKCM | 1 |
p.R171_splice | UCEC | 1 |
p.P268S | SKCM | 1 |
p.F65I | SKCM | 1 |
p.T100M | STAD | 1 |
p.V272I | UCEC | 1 |
p.E203K | CESC | 1 |
p.W221L | LUAD | 1 |
p.R275K | LUAD | 1 |
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TissGeneCNV for PBLD |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for PBLD |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | L32610 | PBLD-PBLD | chr10:70091927 | chr10:70091940 | |
Chimerdb3.0 | FusionScan | BRCA | TCGA-AO-A03P-01A | PBLD-LRRC28 | CDS-5'UTR | chr10:70048239 | chr15:99796102 |
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TissGeneNet for PBLD |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for PBLD |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for PBLD |
TissGeneDrug for PBLD |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for PBLD |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0014518 | Toxic Epidermal Necrolysis | 1 | BeFree |
umls:C0032927 | Precancerous Conditions | 1 | CTD_human |
umls:C0038325 | Stevens-Johnson Syndrome | 1 | BeFree |