Basic gene information | Gene symbol | SFTPC |
Gene name | surfactant protein C |
Synonyms | BRICD6|PSP-C|SFTP2|SMDP2|SP-C |
Cytomap | UCSC genome browser: 8p21 |
Type of gene | protein-coding |
RefGenes | NM_001172357.1, NM_001172410.1,NM_003018.3, |
Description | BRICHOS domain containing 6SP5pulmonary surfactant apoprotein-2 SP-Cpulmonary surfactant-associated protein Cpulmonary surfactant-associated proteolipid SPL(Val) |
Modification date | 20141219 |
dbXrefs | MIM : 178620 |
HGNC : HGNC |
Ensembl : ENSG00000168484 |
HPRD : 01520 |
Vega : OTTHUMG00000163775 |
Protein | UniProt: go to UniProt's Cross Reference DB Table |
Expression | CleanEX: HS_SFTPC |
BioGPS: 6440 |
Pathway | NCI Pathway Interaction Database: SFTPC |
KEGG: SFTPC |
REACTOME: SFTPC |
Pathway Commons: SFTPC |
Context | iHOP: SFTPC |
ligand binding site mutation search in PubMed: SFTPC |
UCL Cancer Institute: SFTPC |
Assigned class in TissGDB* | A |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Lung |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSC |
Reference showing the relevant tissue of SFTPC | Clinical and ultrastructural spectrum of diffuse lung disease associated with surfactant protein C mutations. Peca D, Boldrini R, Johannson J, Shieh JT, Citti A, Petrini S, Salerno T, Cazzato S, Testa R, Messina F, Onofri A, Cenacchi G, Westermark P, Ullmann N, Cogo P, Cutrera R, Danhaive O. Eur J Hum Genet. 2015 Aug;23(8):1033-41. doi: 10.1038/ejhg.2015.45. Epub 2015 Mar 18 (pmid:25782673) go to article |
Description by TissGene annotations | Cancer gene
|
BRCA (tumor) | BRCA (normal) |
SFTPC, WWP2, NEDD4, WWP1, PQBP1 (tumor) | SFTPC, WWP2, NEDD4, WWP1, PQBP1 (normal) |
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COAD (tumor) | COAD (normal) |
SFTPC, WWP2, NEDD4, WWP1, PQBP1 (tumor) | SFTPC, WWP2, NEDD4, WWP1, PQBP1 (normal) |
 |  |
|
HNSC (tumor) | HNSC (normal) |
SFTPC, WWP2, NEDD4, WWP1, PQBP1 (tumor) | SFTPC, WWP2, NEDD4, WWP1, PQBP1 (normal) |
 |  |
|
KICH (tumor) | KICH (normal) |
SFTPC, WWP2, NEDD4, WWP1, PQBP1 (tumor) | SFTPC, WWP2, NEDD4, WWP1, PQBP1 (normal) |
 |  |
|
KIRC (tumor) | KIRC (normal) |
SFTPC, WWP2, NEDD4, WWP1, PQBP1 (tumor) | SFTPC, WWP2, NEDD4, WWP1, PQBP1 (normal) |
 |  |
|
KIRP (tumor) | KIRP (normal) |
SFTPC, WWP2, NEDD4, WWP1, PQBP1 (tumor) | SFTPC, WWP2, NEDD4, WWP1, PQBP1 (normal) |
 |  |
|
LIHC (tumor) | LIHC (normal) |
SFTPC, WWP2, NEDD4, WWP1, PQBP1 (tumor) | SFTPC, WWP2, NEDD4, WWP1, PQBP1 (normal) |
 |  |
|
LUAD (tumor) | LUAD (normal) |
SFTPC, WWP2, NEDD4, WWP1, PQBP1 (tumor) | SFTPC, WWP2, NEDD4, WWP1, PQBP1 (normal) |
 |  |
|
LUSC (tumor) | LUSC (normal) |
SFTPC, WWP2, NEDD4, WWP1, PQBP1 (tumor) | SFTPC, WWP2, NEDD4, WWP1, PQBP1 (normal) |
 |  |
|
PRAD (tumor) | PRAD (normal) |
SFTPC, WWP2, NEDD4, WWP1, PQBP1 (tumor) | SFTPC, WWP2, NEDD4, WWP1, PQBP1 (normal) |
 |  |
|
STAD (tumor) | STAD (normal) |
SFTPC, WWP2, NEDD4, WWP1, PQBP1 (tumor) | SFTPC, WWP2, NEDD4, WWP1, PQBP1 (normal) |
 |  |
|
THCA (tumor) | THCA (normal) |
SFTPC, WWP2, NEDD4, WWP1, PQBP1 (tumor) | SFTPC, WWP2, NEDD4, WWP1, PQBP1 (normal) |
 |  |
|
Disease ID | Disease name | # pubmeds | Source |
umls:C0206062 | Lung Diseases, Interstitial | 36 | BeFree,GAD,LHGDN |
umls:C0024115 | Lung diseases | 19 | BeFree,GAD,LHGDN |
umls:C0034069 | Pulmonary Fibrosis | 14 | BeFree,GAD |
umls:C0035220 | Respiratory Distress Syndrome, Newborn | 13 | BeFree,GAD,RGD |
umls:C1800706 | Idiopathic Pulmonary Fibrosis | 12 | BeFree,CTD_human,ORPHANET |
umls:C0035222 | Respiratory Distress Syndrome, Adult | 10 | BeFree |
umls:C0206061 | Pneumonia, Interstitial | 7 | BeFree |
umls:C0006287 | Bronchopulmonary Dysplasia | 5 | BeFree,GAD |
umls:C0085786 | Hamman-Rich syndrome | 5 | BeFree |
umls:C0375023 | Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 5 | BeFree |
umls:C1970470 | SURFACTANT METABOLISM DYSFUNCTION, PULMONARY, 2 (disorder) | 5 | CLINVAR,CTD_human,ORPHANET,UNIPROT |
umls:C0024121 | Lung Neoplasms | 4 | BeFree |
umls:C1145670 | Respiratory Failure | 4 | BeFree |
umls:C0001418 | Adenocarcinoma | 3 | BeFree |
umls:C0032285 | Pneumonia | 3 | BeFree |
umls:C0152013 | Adenocarcinoma of lung (disorder) | 3 | BeFree |
umls:C0746102 | Chronic lung disease | 3 | BeFree |
umls:C0004096 | Asthma | 2 | BeFree,GAD,LHGDN |
umls:C0006012 | Borderline Personality Disorder | 2 | BeFree |
umls:C0008479 | Chondrosarcoma | 2 | BeFree |
umls:C0020542 | Pulmonary Hypertension | 2 | BeFree |
umls:C0024117 | Chronic Obstructive Airway Disease | 2 | BeFree,GAD |
umls:C0034050 | Pulmonary Alveolar Proteinosis | 2 | BeFree |
umls:C0035235 | Respiratory Syncytial Virus Infections | 2 | BeFree,GAD |
umls:C0476273 | Respiratory distress | 2 | BeFree |
umls:C0521648 | Neonatal respiratory failure | 2 | BeFree |
umls:C0746105 | Chronic interstitial lung disease | 2 | BeFree |
umls:C1290344 | Nonspecific interstitial pneumonia | 2 | BeFree |
umls:C2350236 | Idiopathic Interstitial Pneumonias | 2 | BeFree |
umls:C2931829 | RDS - infants | 2 | BeFree |
umls:C3711368 | Surfactant Dysfunction | 2 | BeFree |
umls:C0004626 | Pneumonia, Bacterial | 1 | RGD |
umls:C0006274 | Bronchiolitis, Viral | 1 | GAD |
umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
umls:C0010633 | Cystadenoma | 1 | BeFree |
umls:C0016059 | Fibrosis | 1 | LHGDN |
umls:C0019284 | Diaphragmatic Hernia | 1 | CTD_human |
umls:C0020459 | Hyperinsulinism | 1 | BeFree |
umls:C0023795 | Lipoid Proteinosis of Urbach and Wiethe | 1 | BeFree |
umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
umls:C0032460 | Polycystic Ovary Syndrome | 1 | CTD_human |
umls:C0034063 | Pulmonary Edema | 1 | BeFree |
umls:C0034067 | Pulmonary Emphysema | 1 | GAD |
umls:C0035126 | Reperfusion Injury | 1 | RGD |
umls:C0035204 | Respiration Disorders | 1 | BeFree |
umls:C0035242 | Respiratory Tract Diseases | 1 | BeFree |
umls:C0042769 | Virus Diseases | 1 | BeFree |
umls:C0149725 | Lower respiratory tract infection | 1 | BeFree |
umls:C0149925 | Small cell carcinoma of lung | 1 | BeFree |
umls:C0152171 | Idiopathic pulmonary hypertension | 1 | BeFree |
umls:C0153676 | Secondary malignant neoplasm of lung | 1 | BeFree |
umls:C0221227 | Centriacinar Emphysema | 1 | BeFree |
umls:C0235833 | Congenital diaphragmatic hernia | 1 | BeFree |
umls:C0242706 | Hyperoxia | 1 | RGD |
umls:C0278504 | Non-small cell lung cancer stage I | 1 | BeFree |
umls:C0394006 | Dysequilibrium syndrome | 1 | BeFree |
umls:C0555214 | Multiple lung cysts | 1 | BeFree |
umls:C0596263 | Carcinogenesis | 1 | BeFree |
umls:C0600260 | Lung Diseases, Obstructive | 1 | BeFree |
umls:C0751071 | Familial Dementia | 1 | BeFree |
umls:C0876973 | Infectious disease of lung | 1 | BeFree |
umls:C1135361 | Persistent pulmonary hypertension | 1 | BeFree |
umls:C1301752 | Respiratory morbidity | 1 | BeFree |
umls:C1566302 | Preterm Premature Rupture of Fetal Membranes | 1 | BeFree |
umls:C2973725 | Pulmonary arterial hypertension | 1 | BeFree |
umls:C3714514 | Infection | 1 | LHGDN |
umls:C3714636 | Pneumonitis | 1 | BeFree |
umls:C3714844 | Pulmonary Hypertension, Primary, 1, With Hereditary Hemorrhagic Telangiectasia | 1 | BeFree |
umls:C0238378 | Desquamative interstitial pneumonia | 0 | MGD,ORPHANET |
umls:C1968593 | Respiratory Distress Syndrome In Premature Infants | 0 | ORPHANET |
umls:C1968602 | Surfactant Metabolism Dysfunction, Pulmonary, 1 | 0 | CTD_human |