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| TissGeneSummary for SFTPD |
 Gene summary |
| Basic gene information | Gene symbol | SFTPD |
| Gene name | surfactant protein D | |
| Synonyms | COLEC7|PSP-D|SFTP4|SP-D | |
| Cytomap | UCSC genome browser: 10q22.2-q23.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003019.4, | |
| Description | collectin 7collectin-7lung surfactant protein Dpulmonary surfactant apoproteinpulmonary surfactant-associated protein Dsurfactant, pulmonary-associated protein Dsurfactant-associated protein, pulmonary 4 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 178635 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000133661 | ||
| HPRD : 01522 | ||
| Vega : OTTHUMG00000018590 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SFTPD | |
| BioGPS: 6441 | ||
| Pathway | NCI Pathway Interaction Database: SFTPD | |
| KEGG: SFTPD | ||
| REACTOME: SFTPD | ||
| Pathway Commons: SFTPD | ||
| Context | iHOP: SFTPD | |
| ligand binding site mutation search in PubMed: SFTPD | ||
| UCL Cancer Institute: SFTPD | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Lung | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LUAD,LUSC | |
| Reference showing the relevant tissue of SFTPD | The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling. Lindskog C, Fagerberg L, Hallström B, Edlund K, Hellwig B, Rahnenführer J, Kampf C, Uhlén M, Pontén F, Micke P. FASEB J. 2014 Dec;28(12):5184-96. doi: 10.1096/fj.14-254862. Epub 2014 Aug 28 (pmid:25169055) go to article | |
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SFTPD |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUSC | 2.37777544 | 8.763571518 | -6.385796078 | 8.02E-19 | 8.10E-18 |
| KICH | -2.240675619 | 0.084984381 | -2.32566 | 1.72E-06 | 6.28E-06 |
| KIRP | -1.762162244 | -0.210790369 | -1.551371875 | 6.64E-08 | 4.17E-07 |
| LUAD | 4.842523208 | 8.965130105 | -4.122606897 | 2.60E-16 | 3.02E-15 |
| COAD | -4.488921619 | -2.923652388 | -1.565269231 | 3.54E-07 | 2.20E-06 |
| LIHC | -2.472635619 | -0.858981619 | -1.613654 | 2.44E-07 | 1.54E-06 |
| ESCA | -3.344253437 | -1.392798892 | -1.951454545 | 0.00212 | 0.02334099 |
| STAD | -3.333912244 | -1.544137244 | -1.789775 | 2.42E-05 | 0.00023871 |
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| TissGene-miRNA for SFTPD |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SFTPD |
| TissGeneSNV for SFTPD |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G193E | SKCM | 2 |
| p.L6F | SKCM | 2 |
| p.P177S | SKCM | 1 |
| p.F375L | UCEC | 1 |
| p.W337X | SKCM | 1 |
| p.G97E | SKCM | 1 |
| p.P83S | SKCM | 1 |
| p.A182T | STAD | 1 |
| p.R174C | STAD | 1 |
| p.E62D | BRCA | 1 |
| p.S92F | SKCM | 1 |
| p.V170A | CESC | 1 |
| p.G193R | SKCM | 1 |
| p.P135S | UCEC | 1 |
| p.P210S | SKCM | 1 |
| p.E62K | COAD | 1 |
| p.S335F | SKCM | 1 |
| p.P108S | SKCM | 1 |
| p.G136D | SKCM | 1 |
| p.G130E | SKCM | 1 |
| p.T275A | LUAD | 1 |
| p.G139E | SKCM | 1 |
| p.D51N | SKCM | 1 |
| p.W337* | SKCM | 1 |
| p.G184_splice | LUSC | 1 |
| p.G118E | SKCM | 1 |
| p.K250T | UCEC | 1 |
| p.K266N | COAD | 1 |
| p.E374K | SKCM | 1 |
| p.A141D | PAAD | 1 |
| p.D89G | COAD | 1 |
| p.G127E | SKCM | 1 |
| p.N336S | HNSC | 1 |
| p.T180R | BRCA | 1 |
| p.H240R | COAD | 1 |
| p.S290T | COAD | 1 |
| p.G166R | SKCM | 1 |
| p.R53Q | HNSC | 1 |
| p.P327L | SKCM | 1 |
| p.K24N | STAD | 1 |
| p.M31I | UCEC | 1 |
| p.P327L | ACC | 1 |
| p.G145E | SKCM | 1 |
| p.G181E | SKCM | 1 |
| p.G106E | DLBC | 1 |
| p.S7F | HNSC | 1 |
| p.D51N | READ | 1 |
| p.V305I | STAD | 1 |
| p.R50C | SKCM | 1 |
| p.G190S | GBM | 1 |
| p.D344N | SKCM | 1 |
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| TissGeneCNV for SFTPD |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SFTPD |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | BRCA | TCGA-C8-A12P-01A | ZMIZ1-SFTPD | 5'UTR-5'UTR | chr10:80829027 | chr10:81706418 |
| Chimerdb3.0 | FusionScan | UCEC | TCGA-5B-A90C-01A | GBF1-SFTPD | 5'UTR-CDS | chr10:104005538 | chr10:81700544 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-D8-A1XK-01A | TSPAN14-SFTPD | 5UTR-CDS | Chr10:82228443 | Chr10:81702635 |
| TCGAfusionPortal | PRADA | LUSC | TCGA-43-6770-01A | VCL-SFTPD | CDS-5UTR | Chr10:75834661 | Chr10:81706418 |
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| TissGeneNet for SFTPD |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (tumor) | SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (normal) |
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| COAD (tumor) | COAD (normal) |
| SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (tumor) | SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (tumor) | SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (normal) |
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| KICH (tumor) | KICH (normal) |
| SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (tumor) | SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (tumor) | SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (tumor) | SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (tumor) | SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (tumor) | SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (tumor) | SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (tumor) | SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (normal) |
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| STAD (tumor) | STAD (normal) |
| SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (tumor) | SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (normal) |
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| THCA (tumor) | THCA (normal) |
| SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (tumor) | SFTPD, CEBPB, LY96, SFTPA1, FOXA1, TLR2, JUND, TLR4, FOSL1, JUNB, MPO, DCN, DMBT1, MFAP4 (normal) |
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| TissGeneProg for SFTPD |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SFTPD |
| TissGeneDrug for SFTPD |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SFTPD |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0024115 | Lung diseases | 15 | BeFree,GAD,LHGDN,RGD |
| umls:C0024117 | Chronic Obstructive Airway Disease | 14 | BeFree,GAD,GWASCAT,LHGDN,RGD |
| umls:C0035220 | Respiratory Distress Syndrome, Newborn | 8 | BeFree,GAD,RGD |
| umls:C0034067 | Pulmonary Emphysema | 7 | BeFree |
| umls:C0035222 | Respiratory Distress Syndrome, Adult | 7 | BeFree,LHGDN |
| umls:C0375023 | Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site | 7 | BeFree |
| umls:C0004096 | Asthma | 6 | BeFree,GAD,LHGDN,RGD |
| umls:C0006287 | Bronchopulmonary Dysplasia | 6 | BeFree,GAD |
| umls:C0021400 | Influenza | 5 | BeFree,LHGDN,RGD |
| umls:C0032285 | Pneumonia | 5 | BeFree,GAD,LHGDN |
| umls:C0003873 | Rheumatoid Arthritis | 4 | BeFree,GAD,GWASCAT,LHGDN |
| umls:C0010674 | Cystic Fibrosis | 4 | BeFree,GAD,LHGDN |
| umls:C0024121 | Lung Neoplasms | 4 | CTD_human,LHGDN |
| umls:C0035235 | Respiratory Syncytial Virus Infections | 4 | BeFree,GAD |
| umls:C0242379 | Malignant neoplasm of lung | 4 | BeFree,GAD |
| umls:C0684249 | Carcinoma of lung | 4 | BeFree |
| umls:C0034050 | Pulmonary Alveolar Proteinosis | 3 | BeFree,LHGDN |
| umls:C0155877 | Allergic asthma | 3 | BeFree |
| umls:C0276653 | Invasive Pulmonary Aspergillosis | 3 | BeFree |
| umls:C3539909 | Allergic disposition | 3 | BeFree |
| umls:C3714514 | Infection | 3 | LHGDN |
| umls:C0001418 | Adenocarcinoma | 2 | BeFree |
| umls:C0003850 | Arteriosclerosis | 2 | BeFree |
| umls:C0004153 | Atherosclerosis | 2 | BeFree |
| umls:C0006271 | Bronchiolitis | 2 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
| umls:C0009324 | Ulcerative Colitis | 2 | BeFree,GAD |
| umls:C0021368 | Inflammation | 2 | GAD,LHGDN |
| umls:C0021390 | Inflammatory Bowel Diseases | 2 | BeFree |
| umls:C0026946 | Mycoses | 2 | BeFree |
| umls:C0034186 | Pyelonephritis | 2 | BeFree |
| umls:C0035204 | Respiration Disorders | 2 | BeFree |
| umls:C0041296 | Tuberculosis | 2 | BeFree |
| umls:C0206062 | Lung Diseases, Interstitial | 2 | BeFree |
| umls:C0242706 | Hyperoxia | 2 | RGD |
| umls:C0243026 | Sepsis | 2 | GAD,LHGDN |
| umls:C0476273 | Respiratory distress | 2 | BeFree |
| umls:C1800706 | Idiopathic Pulmonary Fibrosis | 2 | BeFree |
| umls:C0001175 | Acquired Immunodeficiency Syndrome | 1 | LHGDN |
| umls:C0003864 | Arthritis | 1 | BeFree |
| umls:C0004626 | Pneumonia, Bacterial | 1 | RGD |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | GAD |
| umls:C0006267 | Bronchiectasis | 1 | BeFree |
| umls:C0006272 | Bronchiolitis Obliterans | 1 | LHGDN |
| umls:C0006274 | Bronchiolitis, Viral | 1 | GAD |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0007785 | Cerebral Infarction | 1 | BeFree |
| umls:C0008677 | Bronchitis, Chronic | 1 | LHGDN |
| umls:C0010043 | Corneal Ulcer | 1 | BeFree |
| umls:C0010068 | Coronary heart disease | 1 | BeFree,GAD |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 1 | BeFree |
| umls:C0013238 | Dry Eye Syndromes | 1 | BeFree |
| umls:C0019357 | Keratitis, Herpetic | 1 | BeFree |
| umls:C0019693 | HIV Infections | 1 | BeFree |
| umls:C0020517 | Hypersensitivity | 1 | LHGDN |
| umls:C0021313 | Infection of kidney | 1 | BeFree |
| umls:C0022116 | Ischemia | 1 | BeFree |
| umls:C0023530 | Leukopenia | 1 | BeFree |
| umls:C0023794 | Lipoidosis | 1 | BeFree |
| umls:C0024141 | Lupus Erythematosus, Systemic | 1 | BeFree |
| umls:C0031099 | Periodontitis | 1 | GAD |
| umls:C0034069 | Pulmonary Fibrosis | 1 | GAD |
| umls:C0035457 | Rhinitis, Allergic, Perennial | 1 | GAD |
| umls:C0037116 | Silicosis | 1 | LHGDN |
| umls:C0038454 | Cerebrovascular accident | 1 | BeFree |
| umls:C0038644 | Sudden infant death syndrome | 1 | BeFree,GAD |
| umls:C0085129 | Bronchial Hyperreactivity | 1 | RGD |
| umls:C0151449 | Primary Sj�gren's syndrome | 1 | BeFree |
| umls:C0206061 | Pneumonia, Interstitial | 1 | BeFree |
| umls:C0206750 | Coronavirus Infections | 1 | RGD |
| umls:C0242231 | Coronary Stenosis | 1 | BeFree,LHGDN |
| umls:C0264220 | Chronic disease of respiratory system | 1 | BeFree |
| umls:C0264408 | Childhood asthma | 1 | BeFree |
| umls:C0266929 | Chronic Periodontitis | 1 | BeFree |
| umls:C0314719 | Dryness of eye | 1 | BeFree |
| umls:C0694549 | Community acquired pneumonia | 1 | BeFree |
| umls:C0740391 | Middle Cerebral Artery Occlusion | 1 | BeFree |
| umls:C0741796 | Recurrent bronchitis | 1 | BeFree |
| umls:C0850666 | Helicobacter pylori infection | 1 | BeFree |
| umls:C0876973 | Infectious disease of lung | 1 | BeFree |
| umls:C0917798 | Cerebral Ischemia | 1 | BeFree |
| umls:C1262005 | Ischaemic cerebral infarction | 1 | BeFree |
| umls:C1262091 | Lymphocytic infiltration | 1 | BeFree |
| umls:C1271104 | Blood pressure finding | 1 | GAD |
| umls:C1272641 | Systemic arterial pressure | 1 | GAD |
| umls:C1290886 | Chronic inflammatory disorder | 1 | BeFree |
| umls:C3711368 | Surfactant Dysfunction | 1 | BeFree |
| umls:C3714636 | Pneumonitis | 1 | BeFree |
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