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| TissGeneSummary for GZF1 |
 Gene summary |
| Basic gene information | Gene symbol | GZF1 |
| Gene name | GDNF-inducible zinc finger protein 1 | |
| Synonyms | ZBTB23|ZNF336 | |
| Cytomap | UCSC genome browser: 20p11.21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_022482.3, | |
| Description | zinc finger and BTB domain-containing protein 23zinc finger protein 336 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 613842 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000125812 | ||
| HPRD : 15778 | ||
| Vega : OTTHUMG00000032069 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GZF1 | |
| BioGPS: 64412 | ||
| Pathway | NCI Pathway Interaction Database: GZF1 | |
| KEGG: GZF1 | ||
| REACTOME: GZF1 | ||
| Pathway Commons: GZF1 | ||
| Context | iHOP: GZF1 | |
| ligand binding site mutation search in PubMed: GZF1 | ||
| UCL Cancer Institute: GZF1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of GZF1 | ||
| Description by TissGene annotations | TissgsLTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 16049025 | GO:0045892 | negative regulation of transcription, DNA-templated | 16049025 | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 16049025 | GO:0045892 | negative regulation of transcription, DNA-templated | 16049025 |
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| TissGeneExp for GZF1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for GZF1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for GZF1 |
| TissGeneSNV for GZF1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E289Q | BLCA | 1 |
| p.L639R | KIRC | 1 |
| p.R489T | LUSC | 1 |
| p.T514A | SARC | 1 |
| p.I609N | UCEC | 1 |
| p.R423Q | STAD | 1 |
| p.P236S | PAAD | 1 |
| p.Q275P | COAD | 1 |
| p.L562I | COAD | 1 |
| p.T452M | STAD | 1 |
| p.S516F | SKCM | 1 |
| p.E374K | LUSC | 1 |
| p.R566H | STAD | 1 |
| p.M454I | LUAD | 1 |
| p.A449T | STAD | 1 |
| p.S635L | LIHC | 1 |
| p.L682F | LGG | 1 |
| p.F377L | STAD | 1 |
| p.G553S | SKCM | 1 |
| p.W603* | BLCA | 1 |
| p.H340R | PAAD | 1 |
| p.E627K | BLCA | 1 |
| p.R25C | SKCM | 1 |
| p.R564C | ESCA | 1 |
| p.M47I | SARC | 1 |
| p.K599T | PAAD | 1 |
| p.G619R | LGG | 1 |
| p.R591W | PAAD | 1 |
| p.R566H | DLBC | 1 |
| p.S152C | ESCA | 1 |
| p.R423Q | LUAD | 1 |
| p.D32N | LUAD | 1 |
| p.L244I | BRCA | 1 |
| p.S10F | HNSC | 1 |
| p.T697A | UCEC | 1 |
| p.R564H | STAD | 1 |
| p.D611N | HNSC | 1 |
| p.I538T | THCA | 1 |
| p.K213T | COAD | 1 |
| p.F143L | UCEC | 1 |
| p.S57N | LIHC | 1 |
| p.S640Y | UCEC | 1 |
| p.T169A | STAD | 1 |
| p.R545H | OV | 1 |
| p.I479N | PRAD | 1 |
| p.D636H | LUAD | 1 |
| p.D195Y | KIRC | 1 |
| p.R242T | LGG | 1 |
| p.S122* | LUSC | 1 |
| p.S89L | HNSC | 1 |
| p.R105W | COAD | 1 |
| p.K498N | ESCA | 1 |
| p.A529T | BLCA | 1 |
| p.Q141* | HNSC | 1 |
| p.T428I | STAD | 1 |
| p.D586N | COAD | 1 |
| p.M660L | SKCM | 1 |
| p.E210K | SKCM | 1 |
| p.G253C | LUAD | 1 |
| p.A561T | COAD | 1 |
| p.R545L | ESCA | 1 |
| p.G191D | STAD | 1 |
| p.R406Q | STAD | 1 |
| p.R105G | ESCA | 1 |
| p.A449M | STAD | 1 |
| p.V151L | HNSC | 1 |
| p.S265I | THYM | 1 |
| p.N560D | STAD | 1 |
| p.F46L | COAD | 1 |
| p.V346M | UCEC | 1 |
| p.R427H | STAD | 1 |
| p.V37L | UCEC | 1 |
| p.T241M | COAD | 1 |
| p.S152G | CHOL | 1 |
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| TissGeneCNV for GZF1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for GZF1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | CB243150 | GZF1-PTRH2 | chr20:23352890 | chr17:57774669 |
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| TissGeneNet for GZF1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for GZF1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for GZF1 |
| TissGeneDrug for GZF1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for GZF1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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