TissGeneSummary for TEKT3 |
Gene summary |
Basic gene information | Gene symbol | TEKT3 |
Gene name | tektin 3 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 17p12 | |
Type of gene | protein-coding | |
RefGenes | NM_031898.2, | |
Description | tektin-3testicular microtubules-related protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 612683 | |
HGNC : HGNC | ||
Ensembl : ENSG00000125409 | ||
HPRD : 18173 | ||
Vega : OTTHUMG00000058965 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TEKT3 | |
BioGPS: 64518 | ||
Pathway | NCI Pathway Interaction Database: TEKT3 | |
KEGG: TEKT3 | ||
REACTOME: TEKT3 | ||
Pathway Commons: TEKT3 | ||
Context | iHOP: TEKT3 | |
ligand binding site mutation search in PubMed: TEKT3 | ||
UCL Cancer Institute: TEKT3 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TEKT3 | Tektin 3 is required for progressive sperm motility in mice. Mol Reprod Dev. 2009 May;76(5):453-9. doi: 10.1002/mrd.20957. (pmid:18951373) go to article | |
Description by TissGene annotations | Fused withOncogene Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TEKT3 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
THCA | -0.785231263 | 0.443594161 | -1.228825424 | 8.56E-13 | 7.70E-12 |
KICH | -2.74145472 | -1.34598272 | -1.395472 | 2.70E-10 | 1.93E-09 |
LUSC | -1.350817936 | 1.088552652 | -2.439370588 | 2.59E-14 | 1.44E-13 |
LUAD | -0.97859941 | 1.080088521 | -2.058687931 | 2.10E-10 | 1.21E-09 |
STAD | -1.95741622 | -0.95195997 | -1.00545625 | 0.000316 | 0.002078023 |
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TissGene-miRNA for TEKT3 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TEKT3 |
TissGeneSNV for TEKT3 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E371K | SKCM | 2 |
p.R315L | HNSC | 1 |
p.R419C | STAD | 1 |
p.A319T | LGG | 1 |
p.Q218H | LUAD | 1 |
p.T263M | HNSC | 1 |
p.P82L | SKCM | 1 |
p.R485Q | PRAD | 1 |
p.S117L | BLCA | 1 |
p.P49S | BLCA | 1 |
p.L411V | LUAD | 1 |
p.G282A | COAD | 1 |
p.D388V | LUAD | 1 |
p.S117L | UCEC | 1 |
p.E163V | OV | 1 |
p.L309I | SKCM | 1 |
p.G154R | SKCM | 1 |
p.R310C | STAD | 1 |
p.E423K | SKCM | 1 |
p.D209N | ESCA | 1 |
p.I468T | STAD | 1 |
p.R437C | LUAD | 1 |
p.R136I | UCEC | 1 |
p.R136I | COAD | 1 |
p.A190T | SKCM | 1 |
p.R196Q | UCEC | 1 |
p.N116T | COAD | 1 |
p.N86S | HNSC | 1 |
p.S117L | READ | 1 |
p.Q339* | BLCA | 1 |
p.R350H | STAD | 1 |
p.R183W | BLCA | 1 |
p.R36L | LUSC | 1 |
p.Q339K | SKCM | 1 |
p.F489L | KIRC | 1 |
p.Q470H | LUSC | 1 |
p.R266Q | OV | 1 |
p.D213N | SKCM | 1 |
p.V65M | OV | 1 |
p.R36H | THYM | 1 |
p.L418Q | LIHC | 1 |
p.R196Q | COAD | 1 |
p.L120Q | LIHC | 1 |
p.D209N | UCEC | 1 |
p.G147R | SKCM | 1 |
p.N21K | SKCM | 1 |
p.A13T | PRAD | 1 |
p.R180G | LIHC | 1 |
p.H115N | LUSC | 1 |
p.R126G | LUAD | 1 |
p.R485W | SKCM | 1 |
p.T221M | HNSC | 1 |
p.R114Q | READ | 1 |
p.S76F | LUAD | 1 |
p.R439M | BLCA | 1 |
p.R275H | STAD | 1 |
p.D209Y | ESCA | 1 |
p.Q397R | STAD | 1 |
p.A249E | TGCT | 1 |
p.R16K | LUSC | 1 |
p.G282S | HNSC | 1 |
p.M167V | COAD | 1 |
p.A30V | UCEC | 1 |
p.K234M | ESCA | 1 |
p.S102F | SKCM | 1 |
p.T20I | SARC | 1 |
p.K239R | SKCM | 1 |
p.Q339* | LUAD | 1 |
p.S53N | UCEC | 1 |
p.E371D | UCEC | 1 |
p.P38S | SKCM | 1 |
p.R477H | UCEC | 1 |
p.H201Y | SKCM | 1 |
p.Q374H | ESCA | 1 |
p.Q108E | PRAD | 1 |
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TissGeneCNV for TEKT3 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TEKT3 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | SARC | TCGA-HB-A2OT-01A | MYH10-TEKT3 | In-Frame | chr17:8492398 | chr17:15217547 |
Chimerdb3.0 | FusionScan | BRCA | TCGA-BH-A1EW-01A | PTPN12-TEKT3 | 5'UTR-5'UTR | chr7:77166962 | chr17:15234931 |
TCGAfusionPortal | PRADA | BRCA | TCGA-AR-A5QN-01A | COPS3-TEKT3 | Out-of-frame | Chr17:17163615 | Chr17:15217547 |
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TissGeneNet for TEKT3 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TEKT3 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TEKT3 |
TissGeneDrug for TEKT3 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TEKT3 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |