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| TissGeneSummary for ALDH8A1 |
 Gene summary |
| Basic gene information | Gene symbol | ALDH8A1 |
| Gene name | aldehyde dehydrogenase 8 family, member A1 | |
| Synonyms | ALDH12|DJ352A20.2 | |
| Cytomap | UCSC genome browser: 6q23.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001193480.1, NM_022568.3,NM_170771.2, | |
| Description | aldehyde dehydrogenase 12aldehyde dehydrogenase family 8 member A1aldehyde dehydrogenase family protein | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606467 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000118514 | ||
| HPRD : 06974 | ||
| Vega : OTTHUMG00000015623 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ALDH8A1 | |
| BioGPS: 64577 | ||
| Pathway | NCI Pathway Interaction Database: ALDH8A1 | |
| KEGG: ALDH8A1 | ||
| REACTOME: ALDH8A1 | ||
| Pathway Commons: ALDH8A1 | ||
| Context | iHOP: ALDH8A1 | |
| ligand binding site mutation search in PubMed: ALDH8A1 | ||
| UCL Cancer Institute: ALDH8A1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
| Reference showing the relevant tissue of ALDH8A1 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0042573 | retinoic acid metabolic process | 11007799 | GO:0042574 | retinal metabolic process | 11007799 | GO:0042573 | retinoic acid metabolic process | 11007799 | GO:0042574 | retinal metabolic process | 11007799 |
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| TissGeneExp for ALDH8A1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 3.797616731 | 5.082376453 | -1.284759722 | 2.86E-05 | 6.42E-05 |
| LIHC | 4.948159508 | 7.669549508 | -2.72139 | 3.86E-11 | 5.37E-10 |
| KICH | -1.919484492 | 4.514271508 | -6.433756 | 1.97E-21 | 1.89E-19 |
| BLCA | -3.526722597 | -2.434380492 | -1.092342105 | 0.0057 | 0.029075229 |
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| TissGene-miRNA for ALDH8A1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ALDH8A1 |
| TissGeneSNV for ALDH8A1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.T376M | UCEC | 2 |
| p.P395Q | STAD | 1 |
| p.D94Y | UCEC | 1 |
| p.I381S | OV | 1 |
| p.G466S | SARC | 1 |
| p.N5S | DLBC | 1 |
| p.L346V | BLCA | 1 |
| p.P375L | LUAD | 1 |
| p.R109Q | ESCA | 1 |
| p.P319L | SKCM | 1 |
| p.D383N | LUAD | 1 |
| p.I286S | LGG | 1 |
| p.T129M | UCEC | 1 |
| p.V147F | BRCA | 1 |
| p.R64H | LIHC | 1 |
| p.R109L | LUAD | 1 |
| p.V72A | LIHC | 1 |
| p.T140M | PRAD | 1 |
| p.R344G | LIHC | 1 |
| p.S228F | SKCM | 1 |
| p.I450M | BLCA | 1 |
| p.S23L | SKCM | 1 |
| p.G441V | LUAD | 1 |
| p.R142W | COAD | 1 |
| p.I272V | LIHC | 1 |
| p.G256D | LUAD | 1 |
| p.E56K | SKCM | 1 |
| p.E223D | SKCM | 1 |
| p.P108S | SKCM | 1 |
| p.L252V | LUAD | 1 |
| p.E479K | CESC | 1 |
| p.E405K | HNSC | 1 |
| p.A328S | LUAD | 1 |
| p.D475N | SKCM | 1 |
| p.H487L | LUAD | 1 |
| p.C21R | STAD | 1 |
| p.A274P | OV | 1 |
| p.D475N | BRCA | 1 |
| p.S340R | STAD | 1 |
| p.A170V | UCEC | 1 |
| p.A281T | SARC | 1 |
| p.F402L | STAD | 1 |
| p.A244S | BLCA | 1 |
| p.R69C | PRAD | 1 |
| p.P144L | SKCM | 1 |
| p.S362C | LUSC | 1 |
| p.S425F | BLCA | 1 |
| p.Y417C | LUAD | 1 |
| p.P269L | SKCM | 1 |
| p.R451W | DLBC | 1 |
| p.L449F | STAD | 1 |
| p.M1I | LUSC | 1 |
| p.R262S | COAD | 1 |
| p.A50T | ESCA | 1 |
| p.C191Y | THYM | 1 |
| p.L218P | UCEC | 1 |
| p.L252M | KIRC | 1 |
| p.A2S | LUSC | 1 |
| p.T140M | LUAD | 1 |
| p.L242M | COAD | 1 |
| p.I165T | KIRP | 1 |
| p.A6T | STAD | 1 |
| p.W163X | READ | 1 |
| p.P144T | LUAD | 1 |
| p.D29N | UCS | 1 |
| p.G429V | LUAD | 1 |
| p.P234L | LUAD | 1 |
| p.R142Q | HNSC | 1 |
| p.A6T | DLBC | 1 |
| p.D383N | SKCM | 1 |
| p.T210A | SKCM | 1 |
| p.P259R | KIRC | 1 |
| p.Q296H | CESC | 1 |
| p.S22I | LUAD | 1 |
| p.A53V | SKCM | 1 |
| p.L438M | ACC | 1 |
| p.W448* | UCEC | 1 |
| p.T4I | HNSC | 1 |
| p.T140M | PAAD | 1 |
| p.E181* | UCEC | 1 |
| p.S425F | LUAD | 1 |
| p.G458R | BRCA | 1 |
| p.G96E | BLCA | 1 |
| p.G441D | THYM | 1 |
| p.T376M | LUAD | 1 |
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| TissGeneCNV for ALDH8A1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ALDH8A1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for ALDH8A1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ALDH8A1, HNF4A (tumor) | ALDH8A1, HNF4A (normal) |
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| COAD (tumor) | COAD (normal) |
| ALDH8A1, HNF4A (tumor) | ALDH8A1, HNF4A (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ALDH8A1, HNF4A (tumor) | ALDH8A1, HNF4A (normal) |
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| KICH (tumor) | KICH (normal) |
| ALDH8A1, HNF4A (tumor) | ALDH8A1, HNF4A (normal) |
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| KIRC (tumor) | KIRC (normal) |
| ALDH8A1, HNF4A (tumor) | ALDH8A1, HNF4A (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ALDH8A1, HNF4A (tumor) | ALDH8A1, HNF4A (normal) |
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| LIHC (tumor) | LIHC (normal) |
| ALDH8A1, HNF4A (tumor) | ALDH8A1, HNF4A (normal) |
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| LUAD (tumor) | LUAD (normal) |
| ALDH8A1, HNF4A (tumor) | ALDH8A1, HNF4A (normal) |
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| LUSC (tumor) | LUSC (normal) |
| ALDH8A1, HNF4A (tumor) | ALDH8A1, HNF4A (normal) |
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| PRAD (tumor) | PRAD (normal) |
| ALDH8A1, HNF4A (tumor) | ALDH8A1, HNF4A (normal) |
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| STAD (tumor) | STAD (normal) |
| ALDH8A1, HNF4A (tumor) | ALDH8A1, HNF4A (normal) |
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| THCA (tumor) | THCA (normal) |
| ALDH8A1, HNF4A (tumor) | ALDH8A1, HNF4A (normal) |
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| TissGeneProg for ALDH8A1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ALDH8A1 |
| TissGeneDrug for ALDH8A1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ALDH8A1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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