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TissGeneSummary for ALDH8A1 |
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Basic gene information | Gene symbol | ALDH8A1 |
Gene name | aldehyde dehydrogenase 8 family, member A1 | |
Synonyms | ALDH12|DJ352A20.2 | |
Cytomap | UCSC genome browser: 6q23.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001193480.1, NM_022568.3,NM_170771.2, | |
Description | aldehyde dehydrogenase 12aldehyde dehydrogenase family 8 member A1aldehyde dehydrogenase family protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 606467 | |
HGNC : HGNC | ||
Ensembl : ENSG00000118514 | ||
HPRD : 06974 | ||
Vega : OTTHUMG00000015623 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ALDH8A1 | |
BioGPS: 64577 | ||
Pathway | NCI Pathway Interaction Database: ALDH8A1 | |
KEGG: ALDH8A1 | ||
REACTOME: ALDH8A1 | ||
Pathway Commons: ALDH8A1 | ||
Context | iHOP: ALDH8A1 | |
ligand binding site mutation search in PubMed: ALDH8A1 | ||
UCL Cancer Institute: ALDH8A1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
Reference showing the relevant tissue of ALDH8A1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID | GO:0042573 | retinoic acid metabolic process | 11007799 | GO:0042574 | retinal metabolic process | 11007799 | GO:0042573 | retinoic acid metabolic process | 11007799 | GO:0042574 | retinal metabolic process | 11007799 |
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TissGeneExp for ALDH8A1 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 3.797616731 | 5.082376453 | -1.284759722 | 2.86E-05 | 6.42E-05 |
LIHC | 4.948159508 | 7.669549508 | -2.72139 | 3.86E-11 | 5.37E-10 |
KICH | -1.919484492 | 4.514271508 | -6.433756 | 1.97E-21 | 1.89E-19 |
BLCA | -3.526722597 | -2.434380492 | -1.092342105 | 0.0057 | 0.029075229 |
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TissGene-miRNA for ALDH8A1 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ALDH8A1 |
TissGeneSNV for ALDH8A1 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.T376M | UCEC | 2 |
p.P395Q | STAD | 1 |
p.D94Y | UCEC | 1 |
p.I381S | OV | 1 |
p.G466S | SARC | 1 |
p.N5S | DLBC | 1 |
p.L346V | BLCA | 1 |
p.P375L | LUAD | 1 |
p.R109Q | ESCA | 1 |
p.P319L | SKCM | 1 |
p.D383N | LUAD | 1 |
p.I286S | LGG | 1 |
p.T129M | UCEC | 1 |
p.V147F | BRCA | 1 |
p.R64H | LIHC | 1 |
p.R109L | LUAD | 1 |
p.V72A | LIHC | 1 |
p.T140M | PRAD | 1 |
p.R344G | LIHC | 1 |
p.S228F | SKCM | 1 |
p.I450M | BLCA | 1 |
p.S23L | SKCM | 1 |
p.G441V | LUAD | 1 |
p.R142W | COAD | 1 |
p.I272V | LIHC | 1 |
p.G256D | LUAD | 1 |
p.E56K | SKCM | 1 |
p.E223D | SKCM | 1 |
p.P108S | SKCM | 1 |
p.L252V | LUAD | 1 |
p.E479K | CESC | 1 |
p.E405K | HNSC | 1 |
p.A328S | LUAD | 1 |
p.D475N | SKCM | 1 |
p.H487L | LUAD | 1 |
p.C21R | STAD | 1 |
p.A274P | OV | 1 |
p.D475N | BRCA | 1 |
p.S340R | STAD | 1 |
p.A170V | UCEC | 1 |
p.A281T | SARC | 1 |
p.F402L | STAD | 1 |
p.A244S | BLCA | 1 |
p.R69C | PRAD | 1 |
p.P144L | SKCM | 1 |
p.S362C | LUSC | 1 |
p.S425F | BLCA | 1 |
p.Y417C | LUAD | 1 |
p.P269L | SKCM | 1 |
p.R451W | DLBC | 1 |
p.L449F | STAD | 1 |
p.M1I | LUSC | 1 |
p.R262S | COAD | 1 |
p.A50T | ESCA | 1 |
p.C191Y | THYM | 1 |
p.L218P | UCEC | 1 |
p.L252M | KIRC | 1 |
p.A2S | LUSC | 1 |
p.T140M | LUAD | 1 |
p.L242M | COAD | 1 |
p.I165T | KIRP | 1 |
p.A6T | STAD | 1 |
p.W163X | READ | 1 |
p.P144T | LUAD | 1 |
p.D29N | UCS | 1 |
p.G429V | LUAD | 1 |
p.P234L | LUAD | 1 |
p.R142Q | HNSC | 1 |
p.A6T | DLBC | 1 |
p.D383N | SKCM | 1 |
p.T210A | SKCM | 1 |
p.P259R | KIRC | 1 |
p.Q296H | CESC | 1 |
p.S22I | LUAD | 1 |
p.A53V | SKCM | 1 |
p.L438M | ACC | 1 |
p.W448* | UCEC | 1 |
p.T4I | HNSC | 1 |
p.T140M | PAAD | 1 |
p.E181* | UCEC | 1 |
p.S425F | LUAD | 1 |
p.G458R | BRCA | 1 |
p.G96E | BLCA | 1 |
p.G441D | THYM | 1 |
p.T376M | LUAD | 1 |
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TissGeneCNV for ALDH8A1 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ALDH8A1 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for ALDH8A1 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ALDH8A1 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ALDH8A1 |
TissGeneDrug for ALDH8A1 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ALDH8A1 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |