TissGeneSummary for SPANXC |
Gene summary |
Basic gene information | Gene symbol | SPANXC |
Gene name | SPANX family, member C | |
Synonyms | C|CT11.3|CTp11|SPANX-C | |
Cytomap | UCSC genome browser: Xq27.1 | |
Type of gene | protein-coding | |
RefGenes | NM_022661.3, | |
Description | SPAN-Xc proteincancer-testis-associated protein CTp11cancer/testis antigen 11.3cancer/testis antigen family 11, member 3cancer/testis-associated protein CTp11cancer/testis-associated protein of 11 kDnuclear-associated protein SPAN-Xcsperm protein a | |
Modification date | 20141207 | |
dbXrefs | MIM : 300330 | |
HGNC : HGNC | ||
Ensembl : ENSG00000198573 | ||
HPRD : 02270 | ||
Vega : OTTHUMG00000022556 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SPANXC | |
BioGPS: 64663 | ||
Pathway | NCI Pathway Interaction Database: SPANXC | |
KEGG: SPANXC | ||
REACTOME: SPANXC | ||
Pathway Commons: SPANXC | ||
Context | iHOP: SPANXC | |
ligand binding site mutation search in PubMed: SPANXC | ||
UCL Cancer Institute: SPANXC | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SPANXC | ||
Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SPANXC |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
HNSC | -0.23828367 | -1.733637159 | 1.495353488 | 4.09E-05 | 0.000201368 |
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TissGene-miRNA for SPANXC |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SPANXC |
TissGeneSNV for SPANXC |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E66K | SKCM | 3 |
p.D70N | SKCM | 1 |
p.L51Q | HNSC | 1 |
p.R54C | STAD | 1 |
p.E17* | LUAD | 1 |
p.E65Q | ESCA | 1 |
p.V14F | LUAD | 1 |
p.E20D | LUSC | 1 |
p.R73Q | SKCM | 1 |
p.R61I | READ | 1 |
p.R57K | PAAD | 1 |
p.M42I | CESC | 1 |
p.E20K | BLCA | 1 |
p.R61G | ESCA | 1 |
p.P79S | SKCM | 1 |
p.S48L | SKCM | 1 |
p.V14I | STAD | 1 |
p.G9W | LUAD | 1 |
p.N19I | ESCA | 1 |
p.E20X | LIHC | 1 |
p.A7D | LUAD | 1 |
p.R54H | BRCA | 1 |
p.S47F | LUAD | 1 |
p.R73* | LGG | 1 |
p.A7S | ACC | 1 |
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TissGeneCNV for SPANXC |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SPANXC |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SPANXC |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SPANXC |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SPANXC |
TissGeneDrug for SPANXC |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SPANXC |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C2239176 | Liver carcinoma | 3 | BeFree |
umls:C0025202 | melanoma | 2 | BeFree,LHGDN |
umls:C0153594 | Malignant neoplasm of testis | 2 | BeFree |
umls:C0004509 | Azoospermia | 1 | GAD |
umls:C0021364 | Male infertility | 1 | GAD |
umls:C0028960 | Oligospermia | 1 | GAD |
umls:C1271104 | Blood pressure finding | 1 | GAD |
umls:C1272641 | Systemic arterial pressure | 1 | GAD |