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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for PDIA2
check button Gene summary
Basic gene informationGene symbolPDIA2
Gene nameprotein disulfide isomerase family A, member 2
SynonymsPDA2|PDI|PDIP|PDIR
CytomapUCSC genome browser: 16p13.3
Type of geneprotein-coding
RefGenesNM_006849.2,
DescriptionRho GDP dissociation inhibitor gammapancreas-specific protein disulfide isomerasepancreatic protein disulfide isomeraseprotein disulfide isomerase A2protein disulfide isomerase, pancreaticprotein disulfide isomerase-associated 2protein disulfide-iso
Modification date20141222
dbXrefs MIM : 608012
HGNC : HGNC
Ensembl : ENSG00000185615
HPRD : 07617
Vega : OTTHUMG00000064891
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_PDIA2
BioGPS: 64714
PathwayNCI Pathway Interaction Database: PDIA2
KEGG: PDIA2
REACTOME: PDIA2
Pathway Commons: PDIA2
ContextiHOP: PDIA2
ligand binding site mutation search in PubMed: PDIA2
UCL Cancer Institute: PDIA2
Assigned class in TissGDB*A
Included tissue-specific gene expression resourcesHPA,TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Pancreas
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)PAAD
Reference showing the relevant tissue of PDIA2CTLA-4 suppresses the pathogenicity of self antigen-specific T cells by cell-intrinsic and cell-extrinsic mechanisms. Ise W, Kohyama M, Nutsch KM, Lee HM, Suri A, Unanue ER, Murphy TL, Murphy KM. Nat Immunol. 2010 Feb;11(2):129-35. doi: 10.1038/ni.1835. Epub 2009 Dec 27 (pmid:20037585)
go to article
Description by TissGene annotations
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for PDIA2

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
LIHC-0.514547957-2.7904419572.2758942.43E-061.20E-05
BLCA-1.00309522-2.5964373261.5933421050.004240.023457114
PRAD-0.621147649-1.6835034191.0623557690.000230.000884099
LUAD-0.76172444-2.2152658191.4535413790.0001060.000267444
LUSC-0.4942978-1.9538134861.4595156866.30E-050.000133342


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TissGene-miRNA for PDIA2

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for PDIA2
TissGeneSNV for PDIA2

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.L276HLUAD1
p.L276FCOAD1
p.P502SCOAD1
p.R388QCOAD1
p.E452KKIRC1
p.E185KCOAD1
p.A188TGBM1
p.G72VCOAD1
p.P502SBRCA1
p.F262LBLCA1
p.A348ELUSC1
p.T135AUCEC1
p.G296DKIRP1
p.E32QBLCA1
p.S30WTHCA1
p.N319KACC1
p.D196NSKCM1
p.A272THNSC1
p.A89GLUAD1
p.E145KACC1
p.P60LSKCM1
p.A78VCOAD1
p.G460SCOAD1
p.L376IUCEC1
p.R303CSKCM1
p.R231WCOAD1
p.G395DSTAD1
p.E405KSKCM1
p.L97MUCEC1
p.E261KSKCM1
p.A402DCOAD1
p.E505KSKCM1
p.P498HSTAD1
p.G395SSKCM1
p.A515TKIRC1
p.L158PCHOL1
p.L45FSKCM1
p.L63MLUAD1
p.R149QSKCM1
p.F304LLIHC1
p.Q379KESCA1
p.T129MUCEC1
p.I270FLIHC1
p.D206NSKCM1
p.E331QLUSC1
p.W428SHNSC1
p.R249PLUSC1
p.T481ILGG1
p.K412ESTAD1
p.R291WPAAD1
p.R171WCOAD1
p.R124LSTAD1
p.V252GSTAD1
p.P60SSKCM1
p.A104VBLCA1
p.R124CACC1


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TissGeneCNV for PDIA2

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for PDIA2

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


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TissGeneNet for PDIA2

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (tumor)PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (normal)
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COAD (tumor)COAD (normal)
PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (tumor)PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (normal)
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HNSC (tumor)HNSC (normal)
PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (tumor)PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (normal)
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KICH (tumor)KICH (normal)
PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (tumor)PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (normal)
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KIRC (tumor)KIRC (normal)
PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (tumor)PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (normal)
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KIRP (tumor)KIRP (normal)
PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (tumor)PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (normal)
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LIHC (tumor)LIHC (normal)
PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (tumor)PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (normal)
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LUAD (tumor)LUAD (normal)
PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (tumor)PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (normal)
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LUSC (tumor)LUSC (normal)
PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (tumor)PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (normal)
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PRAD (tumor)PRAD (normal)
PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (tumor)PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (normal)
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STAD (tumor)STAD (normal)
PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (tumor)PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (normal)
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THCA (tumor)THCA (normal)
PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (tumor)PDIA2, NCK1, PLCG1, GRB2, SRC, CUL3, GAPDH, AMFR, FYN, PIK3R1, ABL1, CALR, CRK, SYVN1, LRP1, TAP1, P4HA3 (normal)
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TissGeneProg for PDIA2

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for PDIA2
TissGeneDrug for PDIA2

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for PDIA2

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0003130Anoxia1LHGDN
umls:C0003850Arteriosclerosis1BeFree
umls:C0004153Atherosclerosis1BeFree
umls:C0006142Malignant neoplasm of breast1BeFree
umls:C0011847Diabetes1BeFree
umls:C0011849Diabetes Mellitus1BeFree
umls:C0011860Diabetes Mellitus, Non-Insulin-Dependent1BeFree
umls:C0018798Congenital Heart Defects1GAD
umls:C0027627Neoplasm Metastasis1BeFree
umls:C0027819Neuroblastoma1BeFree
umls:C0079504Hermanski-Pudlak Syndrome1BeFree
umls:C0149630Bicuspid aortic valve1BeFree
umls:C0375023Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site1BeFree
umls:C0678222Breast Carcinoma1BeFree
umls:C0700095Central neuroblastoma1BeFree
umls:C2239176Liver carcinoma1BeFree
umls:C3542024AORTIC VALVE DISEASE 21BeFree