TissGeneSummary for IQCH |
Gene summary |
Basic gene information | Gene symbol | IQCH |
Gene name | IQ motif containing H | |
Synonyms | NYDSP5 | |
Cytomap | UCSC genome browser: 15q23 | |
Type of gene | protein-coding | |
RefGenes | NM_001031715.2, NM_001284347.1,NM_001284348.1,NM_001284349.1,NM_022784.2, | |
Description | IQ domain-containing protein Htestis development protein NYD-SP5 | |
Modification date | 20141207 | |
dbXrefs | MIM : 612523 | |
HGNC : HGNC | ||
Ensembl : ENSG00000103599 | ||
HPRD : 07773 | ||
Vega : OTTHUMG00000133231 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_IQCH | |
BioGPS: 64799 | ||
Pathway | NCI Pathway Interaction Database: IQCH | |
KEGG: IQCH | ||
REACTOME: IQCH | ||
Pathway Commons: IQCH | ||
Context | iHOP: IQCH | |
ligand binding site mutation search in PubMed: IQCH | ||
UCL Cancer Institute: IQCH | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of IQCH | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for IQCH |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -0.065393255 | 2.200606745 | -2.266 | 1.71E-13 | 2.34E-12 |
THCA | 1.47627583 | 2.606321593 | -1.130045763 | 1.51E-15 | 2.10E-14 |
KIRC | 0.757283245 | 2.122181856 | -1.364898611 | 1.77E-20 | 1.46E-19 |
COAD | 0.071032284 | -0.972240793 | 1.043273077 | 7.30E-05 | 0.000275289 |
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TissGene-miRNA for IQCH |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for IQCH |
TissGeneSNV for IQCH |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S456L | SKCM | 2 |
p.P155L | SKCM | 2 |
p.G109C | ESCA | 1 |
p.F103L | SKCM | 1 |
p.D1018N | BLCA | 1 |
p.K336I | READ | 1 |
p.Q105E | CESC | 1 |
p.S344L | HNSC | 1 |
p.V623F | HNSC | 1 |
p.D469N | UCEC | 1 |
p.D646G | LUAD | 1 |
p.A711G | LUAD | 1 |
p.R219W | SKCM | 1 |
p.P126S | SKCM | 1 |
p.N78Y | SKCM | 1 |
p.A167S | UCEC | 1 |
p.D589N | BLCA | 1 |
p.V615A | BLCA | 1 |
p.Y507X | COAD | 1 |
p.S610Y | UCEC | 1 |
p.H151N | HNSC | 1 |
p.E220K | UCEC | 1 |
p.L942S | BRCA | 1 |
p.E80K | SKCM | 1 |
p.Y857H | STAD | 1 |
p.A702S | UCEC | 1 |
p.R393H | STAD | 1 |
p.A184S | UCEC | 1 |
p.S830N | BLCA | 1 |
p.R414Q | BLCA | 1 |
p.E744K | SKCM | 1 |
p.T903S | LUAD | 1 |
p.Q70* | HNSC | 1 |
p.L343F | SKCM | 1 |
p.G239W | HNSC | 1 |
p.R448M | PAAD | 1 |
p.V305I | UCEC | 1 |
p.R614C | HNSC | 1 |
p.V162A | BLCA | 1 |
p.R250K | BRCA | 1 |
p.R662Q | CESC | 1 |
p.R948K | SKCM | 1 |
p.E502K | READ | 1 |
p.I978V | HNSC | 1 |
p.S241G | KICH | 1 |
p.S577R | LUSC | 1 |
p.H498Y | HNSC | 1 |
p.S300Y | UCEC | 1 |
p.E27D | UCEC | 1 |
p.P223S | CESC | 1 |
p.F388V | UCEC | 1 |
p.P181Q | SKCM | 1 |
p.M636I | BLCA | 1 |
p.R969H | LUSC | 1 |
p.P796S | SKCM | 1 |
p.R449S | STAD | 1 |
p.V876G | HNSC | 1 |
p.P182S | READ | 1 |
p.R219W | BLCA | 1 |
p.R116I | BLCA | 1 |
p.G773E | SKCM | 1 |
p.V681M | PRAD | 1 |
p.A294P | HNSC | 1 |
p.R386K | SKCM | 1 |
p.E601K | SKCM | 1 |
p.P537R | OV | 1 |
p.I564T | COAD | 1 |
p.S422* | CESC | 1 |
p.R431C | SKCM | 1 |
p.E428X | THYM | 1 |
p.E289K | SKCM | 1 |
p.M657I | SKCM | 1 |
p.K695N | READ | 1 |
p.S370L | BRCA | 1 |
p.R725W | HNSC | 1 |
p.K387T | UCEC | 1 |
p.R652H | UCEC | 1 |
p.S793L | LUAD | 1 |
p.E289* | LGG | 1 |
p.V794M | SKCM | 1 |
p.H945R | STAD | 1 |
p.P624L | SKCM | 1 |
p.K396T | STAD | 1 |
p.S1023C | BLCA | 1 |
p.V836A | HNSC | 1 |
p.S33L | SKCM | 1 |
p.M499I | BLCA | 1 |
p.R614C | UCEC | 1 |
p.K766N | SKCM | 1 |
p.F470V | COAD | 1 |
p.D931N | STAD | 1 |
p.D469Y | ESCA | 1 |
p.T84I | BRCA | 1 |
p.W729X | SKCM | 1 |
p.E502A | SKCM | 1 |
p.P790L | SKCM | 1 |
p.M1008I | SKCM | 1 |
p.Y688C | STAD | 1 |
p.S120L | LUSC | 1 |
p.P690S | SKCM | 1 |
p.L25V | STAD | 1 |
p.V67F | LUAD | 1 |
p.R898H | PRAD | 1 |
p.L358F | SKCM | 1 |
p.A925V | PRAD | 1 |
p.Y674H | DLBC | 1 |
p.W729* | SKCM | 1 |
p.S133L | STAD | 1 |
p.E39* | LUAD | 1 |
p.E428K | SKCM | 1 |
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TissGeneCNV for IQCH |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for IQCH |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BE079513 | IQCH-IQCH | chr15:67713764 | chr15:67692503 | |
Chimerdb3.0 | FusionScan | CESC | TCGA-C5-A7X3-01A | MAP2K5-IQCH | In-Frame | chr15:67885312 | chr15:67782340 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-2H-A9GQ-01A | IQCH-MAP2K5 | In-Frame | chr15:67553732 | chr15:68098983 |
TCGAfusionPortal | PRADA | PRAD | TCGA-KK-A8ID-01A | RPTOR-IQCH | In-frame | Chr17:78829347 | Chr15:67692452 |
TCGAfusionPortal | PRADA | PRAD | TCGA-EJ-A46G-01A | MAP2K5-IQCH | In-frame | Chr15:68020283 | Chr15:67757465 |
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TissGeneNet for IQCH |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for IQCH |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for IQCH |
TissGeneDrug for IQCH |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for IQCH |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0025202 | melanoma | 1 | CTD_human |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |