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| TissGeneSummary for SLC2A2 |
 Gene summary |
| Basic gene information | Gene symbol | SLC2A2 |
| Gene name | solute carrier family 2 (facilitated glucose transporter), member 2 | |
| Synonyms | GLUT2 | |
| Cytomap | UCSC genome browser: 3q26.1-q26.2 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000340.1, NM_001278658.1,NM_001278659.1, | |
| Description | glucose transporter type 2, liversolute carrier family 2, facilitated glucose transporter member 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 138160 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000163581 | ||
| HPRD : 00685 | ||
| Vega : OTTHUMG00000158997 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SLC2A2 | |
| BioGPS: 6514 | ||
| Pathway | NCI Pathway Interaction Database: SLC2A2 | |
| KEGG: SLC2A2 | ||
| REACTOME: SLC2A2 | ||
| Pathway Commons: SLC2A2 | ||
| Context | iHOP: SLC2A2 | |
| ligand binding site mutation search in PubMed: SLC2A2 | ||
| UCL Cancer Institute: SLC2A2 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
| Reference showing the relevant tissue of SLC2A2 | ||
| Description by TissGene annotations | Significant down-regulated DEG TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SLC2A2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | -0.778996098 | 4.577075902 | -5.356072 | 1.84E-08 | 9.41E-08 |
| LIHC | 10.6758979 | 13.0134339 | -2.337536 | 2.59E-06 | 1.27E-05 |
| KIRC | 7.587610846 | 5.552624735 | 2.034986111 | 7.92E-05 | 0.000168714 |
| Top |
| TissGene-miRNA for SLC2A2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SLC2A2 |
| TissGeneSNV for SLC2A2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.F393L | UCEC | 2 |
| p.L134M | COAD | 1 |
| p.P463L | OV | 1 |
| p.F427S | LUSC | 1 |
| p.Q429E | LUAD | 1 |
| p.A183T | STAD | 1 |
| p.G462E | SKCM | 1 |
| p.G108E | LUAD | 1 |
| p.Q204X | SKCM | 1 |
| p.R53Q | UCEC | 1 |
| p.D51N | SKCM | 1 |
| p.L222F | STAD | 1 |
| p.G265R | SKCM | 1 |
| p.R53Q | SKCM | 1 |
| p.R365* | STAD | 1 |
| p.P431S | SKCM | 1 |
| p.S374R | UCEC | 1 |
| p.L140V | HNSC | 1 |
| p.S442I | LUAD | 1 |
| p.A333T | BLCA | 1 |
| p.Y398F | HNSC | 1 |
| p.M401I | SKCM | 1 |
| p.G430E | SKCM | 1 |
| p.V137F | LUAD | 1 |
| p.F481L | UCEC | 1 |
| p.F469V | UCEC | 1 |
| p.A183T | HNSC | 1 |
| p.Q315H | SKCM | 1 |
| p.S145L | SKCM | 1 |
| p.K77Q | UCEC | 1 |
| p.F113L | UCEC | 1 |
| p.S317F | KIRP | 1 |
| p.M276I | BLCA | 1 |
| p.A195T | STAD | 1 |
| p.Q204* | SKCM | 1 |
| p.E83K | ESCA | 1 |
| p.H151D | BLCA | 1 |
| p.D272Y | UCEC | 1 |
| p.S21Y | LUAD | 1 |
| p.F481C | CHOL | 1 |
| p.V197I | HNSC | 1 |
| p.T332M | LUSC | 1 |
| p.R365X | STAD | 1 |
| p.Q302E | SARC | 1 |
| p.F393L | PAAD | 1 |
| p.A156D | KIRP | 1 |
| p.E178K | BLCA | 1 |
| p.E275K | SKCM | 1 |
| p.D51G | LUSC | 1 |
| p.L46S | KIRP | 1 |
| p.I176T | STAD | 1 |
| p.G226V | LUAD | 1 |
| p.R366S | HNSC | 1 |
| p.E514K | HNSC | 1 |
| p.I70L | LIHC | 1 |
| p.F22Y | COAD | 1 |
| p.R365* | UCEC | 1 |
| p.G471E | SKCM | 1 |
| p.V197I | OV | 1 |
| p.M401I | CESC | 1 |
| p.R301* | PAAD | 1 |
| p.G489E | SKCM | 1 |
| p.G177S | SKCM | 1 |
| p.E85D | UCEC | 1 |
| p.A229V | SARC | 1 |
| p.L92V | LIHC | 1 |
| p.G265E | HNSC | 1 |
| p.G223V | UCEC | 1 |
| p.E252K | BLCA | 1 |
| p.V513I | BLCA | 1 |
| p.Y245* | UCEC | 1 |
| p.Y300H | LIHC | 1 |
| p.I220V | STAD | 1 |
| Top |
| TissGeneCNV for SLC2A2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SLC2A2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for SLC2A2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (tumor) | SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (normal) |
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| COAD (tumor) | COAD (normal) |
| SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (tumor) | SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (tumor) | SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (normal) |
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| KICH (tumor) | KICH (normal) |
| SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (tumor) | SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (tumor) | SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (tumor) | SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (tumor) | SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (tumor) | SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (tumor) | SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (tumor) | SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (tumor) | SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (tumor) | SLC2A2, KPNA2, PRKACA, HNF1A, PDX1 (normal) |
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| Top |
| TissGeneProg for SLC2A2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SLC2A2 |
| TissGeneDrug for SLC2A2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00428 | Streptozocin | Ligand | Small molecule | Approved |
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| TissGeneDisease for SLC2A2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 32 | BeFree,CLINVAR,CTD_human,GAD,LHGDN,MGD |
| umls:C3495427 | Fanconi-Bickel Syndrome | 26 | BeFree,CLINVAR,ORPHANET,UNIPROT |
| umls:C0011849 | Diabetes Mellitus | 12 | BeFree |
| umls:C0011847 | Diabetes | 11 | BeFree |
| umls:C0020456 | Hyperglycemia | 5 | BeFree |
| umls:C0028754 | Obesity | 4 | BeFree |
| umls:C0158981 | Neonatal diabetes mellitus | 4 | BeFree |
| umls:C0271650 | Impaired glucose tolerance | 4 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 3 | BeFree |
| umls:C0016952 | Galactosemias | 3 | BeFree |
| umls:C0011853 | Diabetes Mellitus, Experimental | 2 | CTD_human,RGD |
| umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 2 | BeFree |
| umls:C0011881 | Diabetic Nephropathy | 2 | BeFree,GAD |
| umls:C0017919 | Glycogen Storage Disease | 2 | BeFree |
| umls:C0020615 | Hypoglycemia | 2 | BeFree |
| umls:C0022658 | Kidney Diseases | 2 | BeFree |
| umls:C0149782 | Squamous cell carcinoma of lung | 2 | BeFree |
| umls:C2239176 | Liver carcinoma | 2 | BeFree,CTD_human |
| umls:C0004153 | Atherosclerosis | 1 | GAD |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0011253 | Delusions | 1 | BeFree |
| umls:C0015624 | Fanconi Syndrome | 1 | CTD_human |
| umls:C0015695 | Fatty Liver | 1 | CTD_human |
| umls:C0017980 | Glycosuria, Renal | 1 | BeFree |
| umls:C0019209 | Hepatomegaly | 1 | BeFree |
| umls:C0020503 | Hyperparathyroidism, Secondary | 1 | GAD |
| umls:C0021670 | insulinoma | 1 | BeFree |
| umls:C0032000 | Pituitary Adenoma | 1 | BeFree |
| umls:C0032002 | Pituitary Diseases | 1 | BeFree |
| umls:C0032019 | Pituitary Neoplasms | 1 | BeFree |
| umls:C0042769 | Virus Diseases | 1 | BeFree |
| umls:C0079731 | B-Cell Lymphomas | 1 | BeFree |
| umls:C0221032 | Familial generalized lipodystrophy | 1 | BeFree |
| umls:C0242363 | Islet Cell Tumor | 1 | BeFree |
| umls:C0268186 | Congenital glucose-galactose malabsorption | 1 | BeFree |
| umls:C0268731 | Renal glomerular disease | 1 | BeFree |
| umls:C0342273 | Transient neonatal diabetes mellitus | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C0858600 | Taste sweet | 1 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 1 | CTD_human |
| umls:C1833104 | DIABETES MELLITUS, PERMANENT NEONATAL | 1 | BeFree |
| umls:C3245525 | Familial renal glucosuria | 1 | BeFree |
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